Wellington V. Cardoso, MD, PhD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

MD, Universidade de Brasília
PhD, Universidade de São Paulo



My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Pathology & Laboratory Medicine




Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
1 R01 HL105971 01A1

Retinoic Acid Regulation of Airway Smooth Muscle Differentiation in the Developing Lung
12/01/2013 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Inst
1F32HL117529-01A1

Regulation of Airway Smooth Muscle Differentiation by Retinoic Acid in the Developing Lung
07/01/2013 - 06/30/2014 (PI)
American Lung Association


Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2014 (PI)
NIH/National Heart, Lung, and Blood Inst
5R01HL105971-03

Determinants of Cell Fate and Differentiation in the Developing Lung
07/01/1998 - 01/31/2014 (PI)
NIH/National Heart, Lung, and Blood Inst
5P01HL047049-20

Retinoic Acid Regulation of Lung Development
03/01/2012 - 09/30/2013 (PI)
NIH/National Heart, Lung, and Blood Inst
5R01HL067129-10

Heparan Sulfate - Fgf 10 Interactions in Lung Morphogenesis
07/01/2005 - 06/30/2008 (Co-PI)
Parker B. Francis Foundation

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (Dept Sponsor)
PI: Felicia Chen, MD
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01

Basic Mechanism of Lung Development
09/15/1999 - 08/31/2001 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R13 HL62941 02




Yr Title Project-Sub Proj Pubs
2017 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 3R01HL103676-05S1 12
2017 Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease 1R35HL135834-01
2017 The Trinucleotide Repeat Containing 6a-Mediated miRNA Activities in the Ciliogenesis of Airway Epithelium 5R01HL131422-02
2017 Subclinical Interstitial Lung Disease in MESA and FAR-ILD 2R01HL103676-05 12
2016 The Trinucleotide Repeat Containing 6a-Mediated miRNA Activities in the Ciliogenesis of Airway Epithelium 1R01HL131422-01
2016 REGULATION OF THE CILIATED CELL PROGRAM IN AIRWAY PROGENITORS 5R01HL119836-03 1
2015 RETINOIC ACID REGULATION OF LUNG DEVELOPMENT 5R01HL067129-12 10
2014 REGULATION OF THE CILIATED CELL PROGRAM IN AIRWAY PROGENITORS 1R01HL119836-01A1 1
2014 REGULATION OF AIRWAY PROGENITOR CELL FATE IN DEVELOPMENT AND REGENERATION 7R01HL105971-04 8
2014 RETINOIC ACID REGULATION OF LUNG DEVELOPMENT 7R01HL067129-11 10
Showing 10 of 53 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2017 Jul 04; 8:15857. PMID: 28675157.
  2. Stupnikov MR, Cardoso WV. Sensing oxygen inside and out. Elife. 2017 May 19; 6. PMID: 28525315.
  3. Marquez HA, Cardoso WV. Vitamin A-retinoid signaling in pulmonary development and disease. Mol Cell Pediatr. 2016 Dec; 3(1):28.View Related Profiles. PMID: 27480876; DOI: 10.1186/s40348-016-0054-6;.
  4. Wagner DE, Cardoso WV, Gilpin SE, Majka S, Ott H, Randell SH, Thébaud B, Waddell T, Weiss DJ. An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases. Ann Am Thorac Soc. 2016 Aug; 13(8):S259-78. PMID: 27509163; DOI: 10.1513/AnnalsATS.201606-466ST;.
  5. Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. Erratum: Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016 Jul 27; 48(8):970. PMID: 27463400; DOI: 10.1038/ng0816-970a;.
  6. Tsao PN, Matsuoka C, Wei SC, Sato A, Sato S, Hasegawa K, Chen HK, Ling TY, Mori M, Cardoso WV, Morimoto M. Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A. 2016 Jul 19; 113(29):8242-7. PMID: 27364009; PMCID: PMC4961178; DOI: 10.1073/pnas.1511236113;.
  7. Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016 May; 48(5):575-80. PMID: 27064252; PMCID: PMC4848136; DOI: 10.1038/ng.3542;.
  8. Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10; 34(3):283-96.View Related Profiles. PMID: 26235047; PMCID: PMC4536126; DOI: 10.1016/j.devcel.2015.06.020;.
  9. Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15; 142(2):258-67.View Related Profiles. PMID: 25564622; PMCID: PMC4302835; DOI: 10.1242/dev.116855;.
  10. Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9.View Related Profiles. PMID: 25245693; DOI: 10.1007/978-1-4939-1164-6_11;.
Showing 10 of 80 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 79 publications over 27 distinct years, with a maximum of 5 publications in 2001 and 2004 and 2008 and 2009 and 2016

YearPublications
19873
19892
19911
19921
19933
19953
19962
19971
19982
19991
20004
20015
20034
20045
20051
20063
20073
20085
20095
20103
20114
20123
20132
20143
20153
20165
20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cell fate
growth factors
lung development
lung disease
morphogenesis
organogenesis
progenitor cell
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72 E. Concord St Housman (R)
Boston MA 02118
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