Wellington Cardoso | Profiles RNS

Wellington V. Cardoso, MD, PhD

Adjunct Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Universidade de Brasília
PhD, Universidade de São Paulo

Websites

	Cardoso Lab
	Columbia Medical Center Profile

ORCID : 0000-0002-2550-3697

My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

BU Research
NIH RePORTER Research

Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
1 R01 HL105971 01A1

Regulation of Airway Progenitor Cell Fate in Development and Regeneration
07/01/2011 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL105971-03

Retinoic Acid Regulation of Airway Smooth Muscle Differentiation in the Developing Lung
12/01/2013 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
1F32HL117529-01A1

Regulation of Airway Smooth Muscle Differentiation by Retinoic Acid in the Developing Lung
07/01/2013 - 06/30/2014 (PI)
American Lung Association

Determinants of Cell Fate and Differentiation in the Developing Lung
07/01/1998 - 01/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5P01HL047049-20

Retinoic Acid Regulation of Lung Development
03/01/2012 - 09/30/2013 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL067129-10

Heparan Sulfate - Fgf 10 Interactions in Lung Morphogenesis
07/01/2005 - 06/30/2008 (Co-PI)
Parker B. Francis Foundation

Retinoic Acid Signaling in Lung Morphogenesis Initiation
07/01/2005 - 06/30/2006 (Dept Sponsor)
PI: Felicia Chen, MD
NIH/National Heart, Lung, and Blood Institute
1 F32 HL80846 01

Basic Mechanism of Lung Development
09/15/1999 - 08/31/2001 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R13 HL62941 02

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Regulation of Progenitor Cell Plasticity in Lung Development and Disease-Repair	5R35HL166661-02
2024	Local translation and viral infection in the airway epithelium	5R01AI170904-02
2023	Regulation of Progenitor Cell Plasticity in Lung Development and Disease-Repair	1R35HL166661-01
2023	Local translation and viral infection in the airway epithelium	1R01AI170904-01A1
2023	Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease	5R35HL135834-07
2022	Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease	5R35HL135834-06
2021	Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease	5R35HL135834-05	10
2020	Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease	3R35HL135834-04S1	10
2020	Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease	5R35HL135834-04	10
2020	Subclinical Interstitial Lung Disease in MESA and FAR-ILD	5R01HL103676-08	36

Showing 10 of 67 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Dirvin B, Noh H, Tomassoni L, Cao D, Zhou Y, Ke X, Qian J, Schotsaert M, García-Sastre A, Karan C, Califano A, Cardoso WV. Identification and Targeting of Regulators of SARS-CoV-2-Host interactions in the Airway Epithelium. bioRxiv. 2024 Oct 14. PMID: 39464067; PMCID: PMC11507692; DOI: 10.1101/2024.10.11.617898;

Mori M, Cardoso WV. Can a Rat Breathe through a Mouse's Lung? Am J Respir Crit Care Med. 2024 Jul 15; 210(2):133-134. PMID: 38701370; PMCID: PMC11273309; DOI: 10.1164/rccm.202404-0706ED;

Hannan A, Wang Q, Wu Y, Makrides N, Qu X, Mao J, Que J, Cardoso W, Zhang X. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv. 2024 Jul 01. PMID: 39005335; PMCID: PMC11244872; DOI: 10.1101/2024.06.27.601065;

van Soldt BJ, Metscher BD, Richardson MK, Cardoso WV. Sox9 is associated with two distinct patterning events during snake lung morphogenesis. Dev Biol. 2024 Feb; 506:7-19. PMID: 37995917; PMCID: PMC10872300; DOI: 10.1016/j.ydbio.2023.11.006;

Neptune ER, Cardoso WV. Unravelling the expanding role of FGF10 signalling in lung homeostasis and maintenance. Eur Respir J. 2023 Nov; 62(5). PMID: 37945046

Liu H, Li H, Jiang Z, Jin S, Song R, Yang Y, Li J, Huang J, Zhang X, Dong X, Mori M, Fritzler MJ, He L, Cardoso WV, Lu J. A local translation program regulates centriole amplification in the airway epithelium. Sci Rep. 2023 May 01; 13(1):7090. PMID: 37127654; PMCID: PMC10151349; DOI: 10.1038/s41598-023-34365-8;

Zhou Y, Yang Y, Guo L, Qian J, Ge J, Sinner D, Ding H, Califano A, Cardoso WV. Airway basal cells show regionally distinct potential to undergo metaplastic differentiation. Elife. 2022 Sep 30; 11. PMID: 36178196; PMCID: PMC9578702; DOI: 10.7554/eLife.80083;

Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H, Que J. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. Elife. 2022 Sep 21; 11. PMID: 36129169; PMCID: PMC9553211; DOI: 10.7554/eLife.78217;

Serra CFH, Liu H, Qian J, Mori M, Lu J, Cardoso WV. Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium. iScience. 2022 Aug 19; 25(8):104751. PMID: 35942101; PMCID: PMC9356082; DOI: 10.1016/j.isci.2022.104751;

Huang CY, Huang HC, Chen MH, Lai TT, Chou HC, Chen CY, Yen TA, Cardoso WV, Tsao PN. Intravitreal Bevacizumab Is Associated With Prolonged Ventilatory Support in Preterm Infants With Bronchopulmonary Dysplasia. Chest. 2022 Dec; 162(6):1328-1337. PMID: 35753385

Showing 10 of 109 results. Show More

Cardoso WV. Maturation for regeneration. Cell Stem Cell. 2021 10 07; 28(10):1680-1682. PMID: 34624228; PMCID: PMC8637042; DOI: 10.1016/j.stem.2021.09.007;

Hazan R, Mori M, Danielian PS, Guen VJ, Rubin SM, Cardoso WV, Lees JA. E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. Mol Biol Cell. 2021 10 01; 32(20):ar1. PMID: 34260288; PMCID: PMC8684742; DOI: 10.1091/mbc.E21-01-0039;

Shui JE, Wang W, Liu H, Stepanova A, Liao G, Qian J, Ai X, Ten V, Lu J, Cardoso WV. Prematurity alters the progenitor cell program of the upper respiratory tract of neonates. Sci Rep. 2021 05 24; 11(1):10799.View Related Profiles.

Cardoso, Wellington
Ai, Xingbin

PMID: 34031475; PMCID: PMC8144386; DOI: 10.1038/s41598-021-90093-x;

Suzuki M, Wang T, Garretto D, Isasi CR, Cardoso WV, Greally JM, Quadro L. Disproportionate Vitamin A Deficiency in Women of Specific Ethnicities Linked to Differences in Allele Frequencies of Vitamin A-Related Polymorphisms. Nutrients. 2021 May 21; 13(6). PMID: 34063790; PMCID: PMC8223783; DOI: 10.3390/nu13061743;

Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 04 20; 35(3):109011.View Related Profiles.

Fine, Alan
Cardoso, Wellington
Ai, Xingbin

PMID: 33882306; PMCID: PMC8140387; DOI: 10.1016/j.celrep.2021.109011;

van Soldt BJ, Cardoso WV. Hippo-Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior. Wiley Interdiscip Rev Dev Biol. 2020 05; 9(3):e371. PMID: 31828974; PMCID: PMC9216164; DOI: 10.1002/wdev.371;

Bailey DD, Zhang Y, van Soldt BJ, Jiang M, Suresh S, Nakagawa H, Rustgi AK, Aceves SS, Cardoso WV, Que J. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. Development. 2019 12 04; 146(23). PMID: 31748205; PMCID: PMC6918786; DOI: 10.1242/dev.178855;

Mori M, Furuhashi K, Danielsson JA, Hirata Y, Kakiuchi M, Lin CS, Ohta M, Riccio P, Takahashi Y, Xu X, Emala CW, Lu C, Nakauchi H, Cardoso WV. Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells. Nat Med. 2019 11; 25(11):1691-1698. PMID: 31700187; PMCID: PMC9169232; DOI: 10.1038/s41591-019-0635-8;

Stupnikov MR, Yang Y, Mori M, Lu J, Cardoso WV. Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation. Elife. 2019 10 21; 8. PMID: 31631837; PMCID: PMC6887486; DOI: 10.7554/eLife.50487;

Lee S, Ahad A, Luu M, Moon S, Caesar J, Cardoso WV, Grant MB, Chaqour B. CCN1-Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis. Mol Cell Biol. 2019 09 15; 39(18). PMID: 31262999; PMCID: PMC6712939; DOI: 10.1128/MCB.00107-19;

van Soldt BJ, Qian J, Li J, Tang N, Lu J, Cardoso WV. Yap and its subcellular localization have distinct compartment-specific roles in the developing lung. Development. 2019 05 01; 146(9). PMID: 30944105; PMCID: PMC6526715; DOI: 10.1242/dev.175810;

Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Author Correction: Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2018 11 19; 9:16157. PMID: 30451964; PMCID: PMC6243136; DOI: 10.1038/ncomms16157;

Qiu H, Shi S, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-Hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L. A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Nat Methods. 2018 11; 15(11):889-899.View Related Profiles.

Cardoso, Wellington
Ai, Xingbin

PMID: 30377379; PMCID: PMC6214364; DOI: 10.1038/s41592-018-0189-6;

Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 10 04; 23(4):516-529.e5. PMID: 30244870; PMCID: PMC6282026; DOI: 10.1016/j.stem.2018.08.009;

de Barros Mendes Lopes T, Groth EE, Veras M, Furuya TK, de Souza Xavier Costa N, Ribeiro Júnior G, Lopes FD, de Almeida FM, Cardoso WV, Saldiva PHN, Chammas R, Mauad T. Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life. Environ Pollut. 2018 Oct; 241:511-520. PMID: 29883952; PMCID: PMC6407120; DOI: 10.1016/j.envpol.2018.05.055;

Yang Y, Cardoso WV. Stem Cells Sheltered from Air-Raids Repair Airways. Cell Stem Cell. 2018 05 03; 22(5):613-614. PMID: 29727674; PMCID: PMC6368341; DOI: 10.1016/j.stem.2018.04.010;

Yang Y, Riccio P, Schotsaert M, Mori M, Lu J, Lee DK, García-Sastre A, Xu J, Cardoso WV. Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways. Dev Cell. 2018 03 26; 44(6):752-761.e4. PMID: 29587145; PMCID: PMC5875454; DOI: 10.1016/j.devcel.2018.03.001;

Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR, Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Nguyen JN, Prince MR, Rennard S, Rich SS, Simon L, Sun Y, Watson KE, Woodruff PG, Baglole CJ, Barr RG. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E974-E981. PMID: 29339516; PMCID: PMC5798356; DOI: 10.1073/pnas.1715564115;

Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun. 2017 07 04; 8:15857. PMID: 28675157; PMCID: PMC5500891; DOI: 10.1038/ncomms15857;

Stupnikov MR, Cardoso WV. Sensing oxygen inside and out. Elife. 2017 05 19; 6. PMID: 28525315; PMCID: PMC5438245; DOI: 10.7554/eLife.27467;

Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV. Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair. Cell Rep. 2017 Apr 11; 19(2):246-254.View Related Profiles.

Guha, Arjun
Sebastiani, Paola
Cardoso, Wellington

PMID: 28402849; DOI: 10.1016/j.celrep.2017.03.051;

Wagner DE, Cardoso WV, Gilpin SE, Majka S, Ott H, Randell SH, Thébaud B, Waddell T, Weiss DJ. An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases. Ann Am Thorac Soc. 2016 Aug; 13(8):S259-78. PMID: 27509163; PMCID: PMC6944399; DOI: 10.1513/AnnalsATS.201606-466ST;

Marquez HA, Cardoso WV. Vitamin A-retinoid signaling in pulmonary development and disease. Mol Cell Pediatr. 2016 Dec; 3(1):28.View Related Profiles.

Marquez, Hector
Cardoso, Wellington

PMID: 27480876; PMCID: PMC4969253; DOI: 10.1186/s40348-016-0054-6;

Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. Erratum: Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016 07 27; 48(8):970. PMID: 27463400; DOI: 10.1038/ng0816-970a;

Tsao PN, Matsuoka C, Wei SC, Sato A, Sato S, Hasegawa K, Chen HK, Ling TY, Mori M, Cardoso WV, Morimoto M. Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8242-7. PMID: 27364009; PMCID: PMC4961178; DOI: 10.1073/pnas.1511236113;

Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016 May; 48(5):575-80. PMID: 27064252; PMCID: PMC4848136; DOI: 10.1038/ng.3542;

Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10; 34(3):283-96.View Related Profiles.

Szymaniak, Aleksander
Cardoso, Wellington
Varelas, Xaralabos

PMID: 26235047; PMCID: PMC4536126; DOI: 10.1016/j.devcel.2015.06.020;

Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15; 142(2):258-67.View Related Profiles.

Szymaniak, Aleksander
Paez-Cortez, Jesus
Cardoso, Wellington
Varelas, Xaralabos

PMID: 25564622; PMCID: PMC4302835; DOI: 10.1242/dev.116855;

Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9.View Related Profiles.

Chen, Felicia
Cardoso, Wellington

PMID: 25245693; DOI: 10.1007/978-1-4939-1164-6_11;

Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014 Jul 28; 30(2):137-50.View Related Profiles.

Szymaniak, Aleksander
Cardoso, Wellington
Varelas, Xaralabos

PMID: 25043473; PMCID: PMC6331061; DOI: 10.1016/j.devcel.2014.06.003;

Guha A, Vasconcelos M, Zhao R, Gower AC, Rajagopal J, Cardoso WV. Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells. PLoS One. 2014; 9(2):e88848.View Related Profiles.

Gower, Adam
Guha, Arjun
Cardoso, Wellington

PMID: 24586412; PMCID: PMC3931645; DOI: 10.1371/journal.pone.0088848;

Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11.View Related Profiles.

Fine, Alan
Chen, Felicia
Marquez, Hector
Cardoso, Wellington
Cruikshank, William

PMID: 24401276; PMCID: PMC3904614; DOI: 10.1172/JCI70291;

Hamvas A, Deterding R, Balch WE, Schwartz DA, Albertine KH, Whitsett JA, Cardoso WV, Kotton DN, Kourembanas S, Hagood JS. Diffuse lung disease in children: summary of a scientific conference. Pediatr Pulmonol. 2014 Apr; 49(4):400-9.View Related Profiles.

Kotton, Darrell
Cardoso, Wellington

PMID: 23798474; PMCID: PMC4145861; DOI: 10.1002/ppul.22805;

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6.View Related Profiles.

Cardoso, Wellington
Ai, Xingbin

PMID: 23607856; PMCID: PMC3955361; DOI: 10.1513/AnnalsATS.201207-036OT;

Guha A, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, Li G, Dickel L, Johnson JE, Kimura S, Guo J, McMahon J, McMahon AP, Cardoso WV. Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12592-7.View Related Profiles.

Guha, Arjun
Qian, Jun
Cardoso, Wellington

PMID: 22797898; PMCID: PMC3412014; DOI: 10.1073/pnas.1204710109;

Manoli SE, Smith LA, Vyhlidal CA, An CH, Porrata Y, Cardoso WV, Baron RM, Haley KJ. Maternal smoking and the retinoid pathway in the developing lung. Respir Res. 2012; 13:42. PMID: 22651576; PMCID: PMC3479035; DOI: 10.1186/1465-9921-13-42;

Golan-Gerstl R, Wallach-Dayan SB, Zisman P, Cardoso WV, Goldstein RH, Breuer R. Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis. Am J Respir Cell Mol Biol. 2012 Sep; 47(3):271-9.View Related Profiles.

Goldstein, Ronald
Cardoso, Wellington

PMID: 22582174; PMCID: PMC5460908; DOI: 10.1165/rcmb.2010-0284RC;

Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17; 287(8):5979-87.View Related Profiles.

Chui, David
Lu, Jining
Cardoso, Wellington
Ai, Xingbin
Jiang, Zhihua

PMID: 22187428; PMCID: PMC3285365; DOI: 10.1074/jbc.M111.297937;

Tsao PN, Wei SC, Wu MF, Huang MT, Lin HY, Lee MC, Lin KM, Wang IJ, Kaartinen V, Yang LT, Cardoso WV. Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development. Development. 2011 Aug; 138(16):3533-43. PMID: 21791528; PMCID: PMC3148592; DOI: 10.1242/dev.063727;

Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87.View Related Profiles.

Fine, Alan
Paez-Cortez, Jesus
Ghosh, Shamik
Cardoso, Wellington
Ai, Xingbin

PMID: 21536678; PMCID: PMC3121411; DOI: 10.1074/jbc.M111.241224;

Qu X, Carbe C, Tao C, Powers A, Lawrence R, van Kuppevelt TH, Cardoso WV, Grobe K, Esko JD, Zhang X. Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. J Biol Chem. 2011 Apr 22; 286(16):14435-44. PMID: 21357686; PMCID: PMC3077643; DOI: 10.1074/jbc.M111.225003;

Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV, Lü J. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):287-94.View Related Profiles.

Little, Frederic
Lu, Jining
Qian, Jun
Wu, Junjie
Cushing, Leah
Kuang, Ping-Ping
Cardoso, Wellington

PMID: 20971881; PMCID: PMC3175558; DOI: 10.1165/rcmb.2010-0323OC;

Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8.View Related Profiles.

Chen, Felicia
Qian, Jun
Cardoso, Wellington
Cao, Yu-Xia

PMID: 20484817; PMCID: PMC2877937; DOI: 10.1172/JCI40253;

Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle. 2010 May; 9(9):1809-18.View Related Profiles.

Spira, Avrum
Anderlind, Christina
Vaziri, Cyrus
Kotton, Darrell
Lu, Jining
Qian, Jun
Wu, Junjie
Cardoso, Wellington

PMID: 20404570

Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63.View Related Profiles.

Chen, Felicia
Cardoso, Wellington

PMID: 19934349; PMCID: PMC3266050; DOI: 10.1513/pats.200905-031RM;

Stanford KI, Wang L, Castagnola J, Song D, Bishop JR, Brown JR, Lawrence R, Bai X, Habuchi H, Tanaka M, Cardoso WV, Kimata K, Esko JD. Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem. 2010 Jan 1; 285(1):286-94. PMID: 19889634; PMCID: PMC2804175; DOI: 10.1074/jbc.M109.063701;

Musson MC, Jepeal LI, Mabray PD, Zhdanova IV, Cardoso WV, Wolfe MM. Expression of glucose-dependent insulinotropic polypeptide in the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2009 Dec; 297(6):R1803-12.View Related Profiles.

Zhdanova, Irina
Wolfe, M.
Mabray, Patrick
Cardoso, Wellington

PMID: 19793957; PMCID: PMC2803629; DOI: 10.1152/ajpregu.00288.2009;

Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV. Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development. 2009 Jul; 136(13):2297-307.View Related Profiles.

Lu, Jining
Qian, Jun
Cardoso, Wellington

PMID: 19502490; PMCID: PMC2729343; DOI: 10.1242/dev.034884;

Trompouki E, Tsagaratou A, Kosmidis SK, Dollé P, Qian J, Kontoyiannis DL, Cardoso WV, Mosialos G. Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia. 2009 May; 11(5):469-76. PMID: 19412431; PMCID: PMC2671692; DOI: 10.1593/neo.81424;

Cardoso WV, Whitsett JA. Resident cellular components of the lung: developmental aspects. Proc Am Thorac Soc. 2008 Sep 15; 5(7):767-71. PMID: 18757315; PMCID: PMC2645264; DOI: 10.1513/pats.200803-026HR;

Franks TJ, Colby TV, Travis WD, Tuder RM, Reynolds HY, Brody AR, Cardoso WV, Crystal RG, Drake CJ, Engelhardt J, Frid M, Herzog E, Mason R, Phan SH, Randell SH, Rose MC, Stevens T, Serge J, Sunday ME, Voynow JA, Weinstein BM, Whitsett J, Williams MC. Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. Proc Am Thorac Soc. 2008 Sep 15; 5(7):763-6. PMID: 18757314; DOI: 10.1513/pats.200803-025HR;

Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44.View Related Profiles.

Chen, Felicia
Lu, Jining
Kukuruzinska, Maria
Cardoso, Wellington

PMID: 18694942; PMCID: PMC2570893; DOI: 10.1074/jbc.M801565200;

Jean JC, Lü J, Joyce-Brady M, Cardoso WV. Regulation of Fgf10 gene expression in murine mesenchymal cells. J Cell Biochem. 2008 Apr 15; 103(6):1886-94.View Related Profiles.

Lu, Jining
Jean, Jyh-Chang
Joyce-Brady, Martin
Cardoso, Wellington

PMID: 18022820

Izvolsky KI, Lu J, Martin G, Albrecht KH, Cardoso WV. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan; 46(1):8-18.View Related Profiles.

Lu, Jining
Albrecht, Kenneth
Cardoso, Wellington

PMID: 18196599; DOI: 10.1002/dvg.20355;

Liu P, Lu J, Cardoso WV, Vaziri C. The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell. 2008 Jan; 19(1):248-61.View Related Profiles.

Vaziri, Cyrus
Lu, Jining
Cardoso, Wellington

PMID: 17989364; PMCID: PMC2174189; DOI: 10.1091/mbc.E07-05-0510;

Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79.View Related Profiles.

Chen, Felicia
Lu, Jining
Qian, Jun
Cardoso, Wellington

PMID: 17634193

Lü J, Qian J, Keppler D, Cardoso WV. Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J Biol Chem. 2007 Jul 27; 282(30):22176-84.View Related Profiles.

Lu, Jining
Qian, Jun
Cardoso, Wellington

PMID: 17500053

Wang Z, Dollé P, Cardoso WV, Niederreither K. Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives. Dev Biol. 2006 Sep 15; 297(2):433-45. PMID: 16806149

Cardoso WV, Lü J. Regulation of early lung morphogenesis: questions, facts and controversies. Development. 2006 May; 133(9):1611-24.View Related Profiles.

Lu, Jining
Cardoso, Wellington

PMID: 16613830

Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24.View Related Profiles.

Chen, Felicia
Lu, Jining
Qian, Jun
Cardoso, Wellington

PMID: 16427040

Lü J, Qian J, Chen F, Tang X, Li C, Cardoso WV. Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):319-23.View Related Profiles.

Chen, Felicia
Lu, Jining
Qian, Jun
Cardoso, Wellington
Tang, Xiaoren

PMID: 16036130

Sedita J, Izvolsky K, Cardoso WV. Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis. Dev Dyn. 2004 Dec; 231(4):782-94. PMID: 15499561

Lü J, Izvolsky KI, Qian J, Cardoso WV. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J Biol Chem. 2005 Feb 11; 280(6):4834-41.View Related Profiles.

Lu, Jining
Qian, Jun
Cardoso, Wellington

PMID: 15556938

Lü J, Qian J, Izvolsky KI, Cardoso WV. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004 Sep 15; 273(2):418-35.View Related Profiles.

Lu, Jining
Qian, Jun
Cardoso, Wellington

PMID: 15328023

Desai TJ, Malpel S, Flentke GR, Smith SM, Cardoso WV. Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut. Dev Biol. 2004 Sep 15; 273(2):402-15. PMID: 15328022

Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang YY. Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H1775-84. PMID: 14726295

Hochgreb T, Linhares VL, Menezes DC, Sampaio AC, Yan CY, Cardoso WV, Rosenthal N, Xavier-Neto J. A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. Development. 2003 Nov; 130(22):5363-74. PMID: 13129847

Wongtrakool C, Malpel S, Gorenstein J, Sedita J, Ramirez MI, Underhill TM, Cardoso WV. Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung. J Biol Chem. 2003 Nov 21; 278(47):46911-8.View Related Profiles.

Ramirez, Maria
Cardoso, Wellington

PMID: 12947094; PMCID: PMC2168590

Izvolsky KI, Zhong L, Wei L, Yu Q, Nugent MA, Cardoso WV. Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching. Am J Physiol Lung Cell Mol Physiol. 2003 Oct; 285(4):L838-46.View Related Profiles.

Nugent, Matthew
Cardoso, Wellington

PMID: 12818887

Izvolsky KI, Shoykhet D, Yang Y, Yu Q, Nugent MA, Cardoso WV. Heparan sulfate-FGF10 interactions during lung morphogenesis. Dev Biol. 2003 Jun 1; 258(1):185-200.View Related Profiles.

Nugent, Matthew
Cardoso, Wellington

PMID: 12781692

Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A. Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development. 2001 Dec; 128(24):5181-8.View Related Profiles.

Fine, Alan
Kotton, Darrell
Cardoso, Wellington

PMID: 11748153

Desai TJ, Cardoso WV. Growth factors in lung development and disease: friends or foe? Respir Res. 2002; 3:2. PMID: 11806837; PMCID: PMC64813

Gouw-Soares S, Tanji E, Haypek P, Cardoso W, Eduardo CP. The use of Er:YAG, Nd:YAG and Ga-Al-As lasers in periapical surgery: a 3-year clinical study. J Clin Laser Med Surg. 2001 Aug; 19(4):193-8. PMID: 11523863

Cardoso WV, Williams MC. Basic mechanisms of lung development: Eighth Woods Hole Conference on Lung Cell Biology 2000. Am J Respir Cell Mol Biol. 2001 Aug; 25(2):137-40. PMID: 11509321

Cardoso WV. Molecular regulation of lung development. Annu Rev Physiol. 2001; 63:471-94. PMID: 11181964

Healy AM, Morgenthau L, Zhu X, Farber HW, Cardoso WV. VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev Dyn. 2000 Nov; 219(3):341-52.View Related Profiles.

Farber, Harrison
Cardoso, Wellington

PMID: 11066091

Cardoso WV. Lung morphogenesis revisited: old facts, current ideas. Dev Dyn. 2000 Oct; 219(2):121-30. PMID: 11002333

Malpel S, Mendelsohn C, Cardoso WV. Regulation of retinoic acid signaling during lung morphogenesis. Development. 2000 Jul; 127(14):3057-67. PMID: 10862743

Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV. The molecular basis of lung morphogenesis. Mech Dev. 2000 Mar 15; 92(1):55-81. PMID: 10704888

Lebeche D, Malpel S, Cardoso WV. Fibroblast growth factor interactions in the developing lung. Mech Dev. 1999 Aug; 86(1-2):125-36. PMID: 10446271

Nogawa H, Morita K, Cardoso WV. Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in vitro. Dev Dyn. 1998 Oct; 213(2):228-35. PMID: 9786423

Park WY, Miranda B, Lebeche D, Hashimoto G, Cardoso WV. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol. 1998 Sep 15; 201(2):125-34. PMID: 9740653

Cardoso WV, Itoh A, Nogawa H, Mason I, Brody JS. FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium. Dev Dyn. 1997 Mar; 208(3):398-405.View Related Profiles.

Brody, Jerome
Cardoso, Wellington

PMID: 9056643

Meneghetti A, Cardoso WV, Brody JS, Williams MC. Epithelial marker genes are expressed in cultured embryonic rat lung and in vivo with similar spatial and temporal patterns. J Histochem Cytochem. 1996 Oct; 44(10):1173-82.View Related Profiles.

Brody, Jerome
Cardoso, Wellington

PMID: 8813083

Cardoso WV, Mitsialis SA, Brody JS, Williams MC. Retinoic acid alters the expression of pattern-related genes in the developing rat lung. Dev Dyn. 1996 Sep; 207(1):47-59.View Related Profiles.

Brody, Jerome
Cardoso, Wellington

PMID: 8875075

Cardoso WV. Transcription factors and pattern formation in the developing lung. Am J Physiol. 1995 Oct; 269(4 Pt 1):L429-42. PMID: 7485515

Ji CM, Cardoso WV, Gebremichael A, Philpot RM, Buckpitt AR, Plopper CG, Pinkerton KE. Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats. Am J Physiol. 1995 Sep; 269(3 Pt 1):L394-402. PMID: 7573474

Cardoso WV, Williams MC, Mitsialis SA, Joyce-Brady M, Rishi AK, Brody JS. Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro. Am J Respir Cell Mol Biol. 1995 May; 12(5):464-76.View Related Profiles.

Brody, Jerome
Joyce-Brady, Martin
Cardoso, Wellington

PMID: 7742011

Spouge D, Mayo JR, Cardoso W, Müller NL. Panacinar emphysema: CT and pathologic findings. J Comput Assist Tomogr. 1993 Sep-Oct; 17(5):710-3. PMID: 8370825

Cardoso WV, Stewart LG, Pinkerton KE, Ji C, Hook GE, Singh G, Katyal SL, Thurlbeck WM, Plopper CG. Secretory product expression during Clara cell differentiation in the rabbit and rat. Am J Physiol. 1993 Jun; 264(6 Pt 1):L543-52. PMID: 8333547

Cardoso WV, Sekhon HS, Hyde DM, Thurlbeck WM. Collagen and elastin in human pulmonary emphysema. Am Rev Respir Dis. 1993 Apr; 147(4):975-81. PMID: 8466136

Plopper C, St George J, Cardoso W, Wu R, Pinkerton K, Buckpitt A. Development of airway epithelium. Patterns of expression for markers of differentiation. Chest. 1992 Mar; 101(3 Suppl):2S-5S. PMID: 1371732

Cardoso WV, Saldiva PH, Criado PM, Sakae RS, Böhm GM, Zin WA. A comparison between the isovolume and the end-inflation occlusion methods for measurement of lung mechanics in rats. J Appl Toxicol. 1991 Apr; 11(2):79-84. PMID: 2061554

Böhm GM, Saldiva PH, Pasqualucci CA, Massad E, Martins Mde E, Zin WA, Cardoso WV, Criado PM, Komatsuzaki M, Sakae RS, et al. Biological effects of air pollution in São Paulo and Cubatão. Environ Res. 1989 Aug; 49(2):208-16. PMID: 2753007

Zin WA, Caldeira MP, Cardoso WV, Auler JO, Saldiva PH. Expiratory mechanics before and after uncomplicated heart surgery. Chest. 1989 Jan; 95(1):21-8. PMID: 2909337

Auler JO, Zin WA, Caldeira MP, Cardoso WV, Saldiva PH. Pre- and postoperative inspiratory mechanics in ischemic and valvular heart disease. Chest. 1987 Dec; 92(6):984-90. PMID: 3677843

Saldiva PH, Cardoso WV, Caldeira MP, Zin WA. Mechanics in rats by end-inflation occlusion and single-breath methods. J Appl Physiol (1985). 1987 Nov; 63(5):1711-8. PMID: 3693206

Azambuja R, Proença NG, Cardoso WV. [Ulerythema ophryogenes and folliculitis ulerythematosa reticulata]. Hautarzt. 1987 Jul; 38(7):411-3. PMID: 3654209

Zukerman E, Cardoso W, di Migueli H, Reis Filho I, Schwartzman JS, Bei A, Moreira MH, Giorgi DR, Rotberg A, Reis JB. [Incidence of neurosyphilis and its clinical forms in São Paulo]. Rev Paul Med. 1967 Jun; 70(6):270-4. PMID: 5614817

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 108 publications over 33 distinct years, with a maximum of 7 publications in 2018

Bar chart showing 108 publications over 33 distinct years, with a maximum of 7 publications in 2018

Year	Publications
1987	3
1989	2
1991	1
1992	1
1993	3
1995	3
1996	2
1997	1
1998	2
1999	1
2000	4
2001	5
2003	4
2004	5
2005	1
2006	3
2007	3
2008	5
2009	5
2010	3
2011	4
2012	3
2013	2
2014	3
2015	3
2016	5
2017	3
2018	7
2019	6
2021	5
2022	4
2023	3
2024	3

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cell fate
growth factors
lung development
lung disease
morphogenesis
organogenesis
progenitor cell

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