Keywords
Last Name

Wellington V. Cardoso, MD, PhD

TitleAdjunct Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-6198
ORCID ORCID Icon0000-0002-2550-3697
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

 Research Expertise & Professional Interests
My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

 Self-Described Keywords
  • cell fate
  • growth factors
  • lung development
  • lung disease
  • morphogenesis
  • organogenesis
  • progenitor cell
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9.
    View in: PubMed
  2. Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV. The hippo pathway effector yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014 Jul 28; 30(2):137-50.
    View in: PubMed
  3. Guha A, Vasconcelos M, Zhao R, Gower AC, Rajagopal J, Cardoso WV. Analysis of notch signaling-dependent gene expression in developing airways reveals diversity of clara cells. PLoS One. 2014; 9(2):e88848.
    View in: PubMed
  4. Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11.
    View in: PubMed
  5. Hamvas A, Deterding R, Balch WE, Schwartz DA, Albertine KH, Whitsett JA, Cardoso WV, Kotton DN, Kourembanas S, Hagood JS. Diffuse lung disease in children: Summary of a scientific conference. Pediatr Pulmonol. 2014 Apr; 49(4):400-9.
    View in: PubMed
  6. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6.
    View in: PubMed
  7. Guha A, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, Li G, Dickel L, Johnson JE, Kimura S, Guo J, McMahon J, McMahon AP, Cardoso WV. Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12592-7.
    View in: PubMed
  8. Manoli SE, Smith LA, Vyhlidal CA, An CH, Porrata Y, Cardoso WV, Baron RM, Haley KJ. Maternal smoking and the retinoid pathway in the developing lung. Respir Res. 2012; 13:42.
    View in: PubMed
  9. Golan-Gerstl R, Wallach-Dayan SB, Zisman P, Cardoso WV, Goldstein RH, Breuer R. Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis. Am J Respir Cell Mol Biol. 2012 Sep; 47(3):271-9.
    View in: PubMed
  10. Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17; 287(8):5979-87.
    View in: PubMed
  11. Tsao PN, Wei SC, Wu MF, Huang MT, Lin HY, Lee MC, Lin KM, Wang IJ, Kaartinen V, Yang LT, Cardoso WV. Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development. Development. 2011 Aug; 138(16):3533-43.
    View in: PubMed
  12. Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87.
    View in: PubMed
  13. Qu X, Carbe C, Tao C, Powers A, Lawrence R, van Kuppevelt TH, Cardoso WV, Grobe K, Esko JD, Zhang X. Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. J Biol Chem. 2011 Apr 22; 286(16):14435-44.
    View in: PubMed
  14. Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV, Lü J. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):287-94.
    View in: PubMed
  15. Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8.
    View in: PubMed
  16. Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle. 2010 May; 9(9):1809-18.
    View in: PubMed
  17. Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63.
    View in: PubMed
  18. Stanford KI, Wang L, Castagnola J, Song D, Bishop JR, Brown JR, Lawrence R, Bai X, Habuchi H, Tanaka M, Cardoso WV, Kimata K, Esko JD. Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem. 2010 Jan 1; 285(1):286-94.
    View in: PubMed
  19. Musson MC, Jepeal LI, Mabray PD, Zhdanova IV, Cardoso WV, Wolfe MM. Expression of glucose-dependent insulinotropic polypeptide in the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2009 Dec; 297(6):R1803-12.
    View in: PubMed
  20. Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV. Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development. 2009 Jul; 136(13):2297-307.
    View in: PubMed
  21. Trompouki E, Tsagaratou A, Kosmidis SK, Dollé P, Qian J, Kontoyiannis DL, Cardoso WV, Mosialos G. Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia. 2009 May; 11(5):469-76.
    View in: PubMed
  22. Cardoso WV, Whitsett JA. Resident cellular components of the lung: developmental aspects. Proc Am Thorac Soc. 2008 Sep 15; 5(7):767-71.
    View in: PubMed
  23. Franks TJ, Colby TV, Travis WD, Tuder RM, Reynolds HY, Brody AR, Cardoso WV, Crystal RG, Drake CJ, Engelhardt J, Frid M, Herzog E, Mason R, Phan SH, Randell SH, Rose MC, Stevens T, Serge J, Sunday ME, Voynow JA, Weinstein BM, Whitsett J, Williams MC. Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. Proc Am Thorac Soc. 2008 Sep 15; 5(7):763-6.
    View in: PubMed
  24. Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44.
    View in: PubMed
  25. Jean JC, Lü J, Joyce-Brady M, Cardoso WV. Regulation of Fgf10 gene expression in murine mesenchymal cells. J Cell Biochem. 2008 Apr 15; 103(6):1886-94.
    View in: PubMed
  26. Izvolsky KI, Lu J, Martin G, Albrecht KH, Cardoso WV. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan; 46(1):8-18.
    View in: PubMed
  27. Liu P, Lu J, Cardoso WV, Vaziri C. The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell. 2008 Jan; 19(1):248-61.
    View in: PubMed
  28. Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79.
    View in: PubMed
  29. Lü J, Qian J, Keppler D, Cardoso WV. Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J Biol Chem. 2007 Jul 27; 282(30):22176-84.
    View in: PubMed
  30. Wang Z, Dollé P, Cardoso WV, Niederreither K. Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives. Dev Biol. 2006 Sep 15; 297(2):433-45.
    View in: PubMed
  31. Cardoso WV, Lü J. Regulation of early lung morphogenesis: questions, facts and controversies. Development. 2006 May; 133(9):1611-24.
    View in: PubMed
  32. Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24.
    View in: PubMed
  33. Lü J, Qian J, Chen F, Tang X, Li C, Cardoso WV. Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):319-23.
    View in: PubMed
  34. Sedita J, Izvolsky K, Cardoso WV. Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis. Dev Dyn. 2004 Dec; 231(4):782-94.
    View in: PubMed
  35. Lü J, Izvolsky KI, Qian J, Cardoso WV. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J Biol Chem. 2005 Feb 11; 280(6):4834-41.
    View in: PubMed
  36. Lü J, Qian J, Izvolsky KI, Cardoso WV. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004 Sep 15; 273(2):418-35.
    View in: PubMed
  37. Desai TJ, Malpel S, Flentke GR, Smith SM, Cardoso WV. Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut. Dev Biol. 2004 Sep 15; 273(2):402-15.
    View in: PubMed
  38. Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang YY. Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H1775-84.
    View in: PubMed
  39. Hochgreb T, Linhares VL, Menezes DC, Sampaio AC, Yan CY, Cardoso WV, Rosenthal N, Xavier-Neto J. A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. Development. 2003 Nov; 130(22):5363-74.
    View in: PubMed
  40. Wongtrakool C, Malpel S, Gorenstein J, Sedita J, Ramirez MI, Underhill TM, Cardoso WV. Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung. J Biol Chem. 2003 Nov 21; 278(47):46911-8.
    View in: PubMed
  41. Izvolsky KI, Zhong L, Wei L, Yu Q, Nugent MA, Cardoso WV. Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching. Am J Physiol Lung Cell Mol Physiol. 2003 Oct; 285(4):L838-46.
    View in: PubMed
  42. Izvolsky KI, Shoykhet D, Yang Y, Yu Q, Nugent MA, Cardoso WV. Heparan sulfate-FGF10 interactions during lung morphogenesis. Dev Biol. 2003 Jun 1; 258(1):185-200.
    View in: PubMed
  43. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A. Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development. 2001 Dec; 128(24):5181-8.
    View in: PubMed
  44. Desai TJ, Cardoso WV. Growth factors in lung development and disease: friends or foe? Respir Res. 2002; 3:2.
    View in: PubMed
  45. Cardoso WV, Williams MC. Basic mechanisms of lung development: Eighth Woods Hole Conference on Lung Cell Biology 2000. Am J Respir Cell Mol Biol. 2001 Aug; 25(2):137-40.
    View in: PubMed
  46. Gouw-Soares S, Tanji E, Haypek P, Cardoso W, Eduardo CP. The use of Er:YAG, Nd:YAG and Ga-Al-As lasers in periapical surgery: a 3-year clinical study. J Clin Laser Med Surg. 2001 Aug; 19(4):193-8.
    View in: PubMed
  47. Cardoso WV. Molecular regulation of lung development. Annu Rev Physiol. 2001; 63:471-94.
    View in: PubMed
  48. Healy AM, Morgenthau L, Zhu X, Farber HW, Cardoso WV. VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev Dyn. 2000 Nov; 219(3):341-52.
    View in: PubMed
  49. Cardoso WV. Lung morphogenesis revisited: old facts, current ideas. Dev Dyn. 2000 Oct; 219(2):121-30.
    View in: PubMed
  50. Malpel S, Mendelsohn C, Cardoso WV. Regulation of retinoic acid signaling during lung morphogenesis. Development. 2000 Jul; 127(14):3057-67.
    View in: PubMed
  51. Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV. The molecular basis of lung morphogenesis. Mech Dev. 2000 Mar 15; 92(1):55-81.
    View in: PubMed
  52. Lebeche D, Malpel S, Cardoso WV. Fibroblast growth factor interactions in the developing lung. Mech Dev. 1999 Aug; 86(1-2):125-36.
    View in: PubMed
  53. Nogawa H, Morita K, Cardoso WV. Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in vitro. Dev Dyn. 1998 Oct; 213(2):228-35.
    View in: PubMed
  54. Park WY, Miranda B, Lebeche D, Hashimoto G, Cardoso WV. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol. 1998 Sep 15; 201(2):125-34.
    View in: PubMed
  55. Cardoso WV, Itoh A, Nogawa H, Mason I, Brody JS. FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium. Dev Dyn. 1997 Mar; 208(3):398-405.
    View in: PubMed
  56. Meneghetti A, Cardoso WV, Brody JS, Williams MC. Epithelial marker genes are expressed in cultured embryonic rat lung and in vivo with similar spatial and temporal patterns. J Histochem Cytochem. 1996 Oct; 44(10):1173-82.
    View in: PubMed
  57. Cardoso WV, Mitsialis SA, Brody JS, Williams MC. Retinoic acid alters the expression of pattern-related genes in the developing rat lung. Dev Dyn. 1996 Sep; 207(1):47-59.
    View in: PubMed
  58. Cardoso WV. Transcription factors and pattern formation in the developing lung. Am J Physiol. 1995 Oct; 269(4 Pt 1):L429-42.
    View in: PubMed
  59. Ji CM, Cardoso WV, Gebremichael A, Philpot RM, Buckpitt AR, Plopper CG, Pinkerton KE. Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats. Am J Physiol. 1995 Sep; 269(3 Pt 1):L394-402.
    View in: PubMed
  60. Cardoso WV, Williams MC, Mitsialis SA, Joyce-Brady M, Rishi AK, Brody JS. Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro. Am J Respir Cell Mol Biol. 1995 May; 12(5):464-76.
    View in: PubMed
  61. Spouge D, Mayo JR, Cardoso W, Müller NL. Panacinar emphysema: CT and pathologic findings. J Comput Assist Tomogr. 1993 Sep-Oct; 17(5):710-3.
    View in: PubMed
  62. Cardoso WV, Stewart LG, Pinkerton KE, Ji C, Hook GE, Singh G, Katyal SL, Thurlbeck WM, Plopper CG. Secretory product expression during Clara cell differentiation in the rabbit and rat. Am J Physiol. 1993 Jun; 264(6 Pt 1):L543-52.
    View in: PubMed
  63. Cardoso WV, Sekhon HS, Hyde DM, Thurlbeck WM. Collagen and elastin in human pulmonary emphysema. Am Rev Respir Dis. 1993 Apr; 147(4):975-81.
    View in: PubMed
  64. Plopper C, St George J, Cardoso W, Wu R, Pinkerton K, Buckpitt A. Development of airway epithelium. Patterns of expression for markers of differentiation. Chest. 1992 Mar; 101(3 Suppl):2S-5S.
    View in: PubMed
  65. Cardoso WV, Saldiva PH, Criado PM, Sakae RS, Böhm GM, Zin WA. A comparison between the isovolume and the end-inflation occlusion methods for measurement of lung mechanics in rats. J Appl Toxicol. 1991 Apr; 11(2):79-84.
    View in: PubMed
  66. Böhm GM, Saldiva PH, Pasqualucci CA, Massad E, Martins Mde E, Zin WA, Cardoso WV, Criado PM, Komatsuzaki M, Sakae RS, et al. Biological effects of air pollution in São Paulo and Cubatão. Environ Res. 1989 Aug; 49(2):208-16.
    View in: PubMed
  67. Zin WA, Caldeira MP, Cardoso WV, Auler JO, Saldiva PH. Expiratory mechanics before and after uncomplicated heart surgery. Chest. 1989 Jan; 95(1):21-8.
    View in: PubMed
  68. Auler JO, Zin WA, Caldeira MP, Cardoso WV, Saldiva PH. Pre- and postoperative inspiratory mechanics in ischemic and valvular heart disease. Chest. 1987 Dec; 92(6):984-90.
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  69. Saldiva PH, Cardoso WV, Caldeira MP, Zin WA. Mechanics in rats by end-inflation occlusion and single-breath methods. J Appl Physiol (1985). 1987 Nov; 63(5):1711-8.
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  70. Azambuja R, Proença NG, Cardoso WV. [Ulerythema ophryogenes and folliculitis ulerythematosa reticulata]. Hautarzt. 1987 Jul; 38(7):411-3.
    View in: PubMed
  71. Zukerman E, Cardoso W, di Migueli H, Reis Filho I, Schwartzman JS, Bei A, Moreira MH, Giorgi DR, Rotberg A, Reis JB. [Incidence of neurosyphilis and its clinical forms in São Paulo]. Rev Paul Med. 1967 Jun; 70(6):270-4.
    View in: PubMed
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