Xingbin Ai, PhD
Adjunct Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

PhD, Case Western Reserve University



Expertise and interests include:

REGULATION OF STEM CELL FUNCTION AND AGING BY HEPARAN SULFATE AND SULFS:
Environmental signals play crucial roles in self-renewal of stem cells, tissue regeneration and aging. Ai lab investigates heparan sulfate-dependent mechanisms that regulate extracellular signaling during stem cell maintenance and regeneration of the skeletal muscle. Our study is focused on two heparan sulfate-modifying enzymes called Sulfs.

NEUROGENESIS AND NEUROPLASTICITY IN PULMONARY DISEASES:
The respiratory tract is known to be innervated by two groups of neurons. The intrinsic neurons have cell bodies located within the tissue, while the extrinsic neurons have their cell bodies located in the central and peripheral nervous system and their axons innervating airway smooth muscle and neuroendocrine cells. Ai lab investigates neurotrophic signals that regulate neurogenesis in developing lung and neuroplasticity in pulmonary diseases. Our goal is to understand physiological roles of neural innervation in respiratory function, diseases and regeneration.

AIRWAY SMOOTH MUSCLE DEVELOPMENT AND REMODELING IN ASTHMA:
Airway smooth muscle hyperplasia and hyper-reactivity are key features of asthma. Ai lab, in collaboration with Dr. Alan Fine’s lab, investigates mechanisms underlying the formation and remodeling of airway smooth muscle. We are particularly interested in the sonic hedgehog pathway in control of airway smooth muscle development.


The Fetal Lung Mesothelial Differentiation Program
08/05/2013 - 05/31/2017 (SP Co-PI of Sub-Project / SP)
PI: Alan Fine, MD
NIH/National Heart, Lung, and Blood Inst
5R01HL116163-03

Identifying the Molecular Phenotype of Normal and Asthmatic Bronchial Smooth Muscle
01/01/2012 - 12/31/2015 (PI)
NIH/National Heart, Lung, and Blood Inst
5R21HL112619-02

Linking Increased Innervation to Persistent BSM Hyper-reactivity
07/01/2012 - 07/31/2014 (PI)
American Asthma Foundation

Identification of Sulfs as Therapeutic Targets for the Treatment of Age-Impaired Skeletal Muscle Regeneration
03/15/2010 - 07/31/2014 (PI)
NIH/National Institute on Aging
5R01AG034939-05




Yr Title Project-Sub Proj Pubs
2017 Development of PNEC innervation and neuroplasticity after early life insult 1R01HL132991-01A1
2016 The Fetal Lung Mesothelial Differentiation Program 4R01HL116163-04 3
2014 Identification of Sulfs as therapeutic targets for the treatment of age-impaired skeletal muscle regeneration 7R01AG034939-06 3
2014 The Fetal Lung Mesothelial Differentiation Program 5R01HL116163-02 3
2014 Identification of Sulfs as therapeutic targets for the treatment of age-impaired 5R01AG034939-05 3
2013 The Fetal Lung Mesothelial Differentiation Program 1R01HL116163-01A1 3
2013 Identifying Molecular Phenotype of Normal and Asthmatic Bronchial Smooth Muscle 5R21HL112619-02 4
2013 Identification of Sulfs as therapeutic targets for the treatment of age-impaired 5R01AG034939-04 3
2012 Identifying the Molecular Phenotype of Normal and Asthmatic Bronchial Smooth Musc 1R21HL112619-01 4
2012 Identification of Sulfs as therapeutic targets for the treatment of age-impaired 5R01AG034939-03 3
Showing 10 of 19 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Patel KR, Bai Y, Trieu KG, Barrios J, Ai X. Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma. FASEB J. 2017 Jun 15.View Related Profiles. PMID: 28619712.
  2. Jiang Z, Knudsen NH, Wang G, Qiu W, Naing ZZC, Bai Y, Ai X, Lee CH, Zhou X. Genetic Control of Fatty Acid ß-Oxidation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2017 Jun; 56(6):738-748. PMID: 28199134; DOI: 10.1165/rcmb.2016-0282OC;.
  3. Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 Sep; 31(9):4117-4128.View Related Profiles. PMID: 28566470.
  4. Bai Y, Krishnamoorthy N, Patel KR, Rosas I, Sanderson MJ, Ai X. Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking. A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists. Am J Respir Cell Mol Biol. 2016 May; 54(5):656-63.View Related Profiles. PMID: 26550921; PMCID: PMC4942196; DOI: 10.1165/rcmb.2015-0290MA;.
  5. Patel KR, Aven L, Shao F, Krishnamoorthy N, Duvall MG, Levy BD, Ai X. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life. Mucosal Immunol. 2016 Nov; 9(6):1466-1476.View Related Profiles. PMID: 26860818; DOI: 10.1038/mi.2016.11;.
  6. Jiang Z, Cushing L, Ai X, Lü J. miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):273-83.View Related Profiles. PMID: 24617895; PMCID: PMC4148035; DOI: 10.1165/rcmb.2013-0127OC;.
  7. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81.View Related Profiles. PMID: 24313705; PMCID: PMC4068941; DOI: 10.1165/rcmb.2013-0166MA;.
  8. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907.View Related Profiles. PMID: 24221086; PMCID: PMC3898648; DOI: 10.1096/fj.13-238212;.
  9. Dixit R, Ai X, Fine A. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development. 2013 Nov; 140(21):4398-406.View Related Profiles. PMID: 24130328.
  10. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469.View Related Profiles. PMID: 24040256; PMCID: PMC3767675; DOI: 10.1371/journal.pone.0074469;.
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 12 distinct years, with a maximum of 5 publications in 2013

YearPublications
20031
20041
20051
20062
20073
20102
20114
20121
20135
20142
20162
20173
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

developmental biology
heparan sulfate
neurobiology
neuroscience
skeletal muscle regeneration
stem cell biology
Contact for Mentoring:


72 E. Concord St Housman (R)
Boston MA 02118
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