Keywords
Last Name

Xingbin Ai, PhD

TitleAdjunct Assistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 414-3291
ORCID ORCID Icon0000-0002-2178-0080
 Research Expertise & Professional Interests
Expertise and interests include:

REGULATION OF STEM CELL FUNCTION AND AGING BY HEPARAN SULFATE AND SULFS:
Environmental signals play crucial roles in self-renewal of stem cells, tissue regeneration and aging. Ai lab investigates heparan sulfate-dependent mechanisms that regulate extracellular signaling during stem cell maintenance and regeneration of the skeletal muscle. Our study is focused on two heparan sulfate-modifying enzymes called Sulfs.

NEUROGENESIS AND NEUROPLASTICITY IN PULMONARY DISEASES:
The respiratory tract is known to be innervated by two groups of neurons. The intrinsic neurons have cell bodies located within the tissue, while the extrinsic neurons have their cell bodies located in the central and peripheral nervous system and their axons innervating airway smooth muscle and neuroendocrine cells. Ai lab investigates neurotrophic signals that regulate neurogenesis in developing lung and neuroplasticity in pulmonary diseases. Our goal is to understand physiological roles of neural innervation in respiratory function, diseases and regeneration.

AIRWAY SMOOTH MUSCLE DEVELOPMENT AND REMODELING IN ASTHMA:
Airway smooth muscle hyperplasia and hyper-reactivity are key features of asthma. Ai lab, in collaboration with Dr. Alan Fine’s lab, investigates mechanisms underlying the formation and remodeling of airway smooth muscle. We are particularly interested in the sonic hedgehog pathway in control of airway smooth muscle development.

 Self-Described Keywords
  • developmental biology
  • heparan sulfate
  • neurobiology
  • neuroscience
  • skeletal muscle regeneration
  • stem cell biology
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Bai Y, Krishnamoorthy N, Patel KR, Rosas I, Sanderson MJ, Ai X. Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking. A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists. Am J Respir Cell Mol Biol. 2016 May; 54(5):656-63. PMID: 26550921.
    View in: PubMed
  2. Patel KR, Aven L, Shao F, Krishnamoorthy N, Duvall MG, Levy BD, Ai X. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life. Mucosal Immunol. 2016 Nov; 9(6):1466-1476. PMID: 26860818.
    View in: PubMed
  3. Jiang Z, Cushing L, Ai X, Lü J. miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):273-83. PMID: 24617895.
    View in: PubMed
  4. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81. PMID: 24313705.
    View in: PubMed
  5. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907. PMID: 24221086.
    View in: PubMed
  6. Dixit R, Ai X, Fine A. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development. 2013 Nov; 140(21):4398-406. PMID: 24130328.
    View in: PubMed
  7. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469. PMID: 24040256.
    View in: PubMed
  8. Aven L, Ai X. Mechanisms of respiratory innervation during embryonic development. Organogenesis. 2013 Jul-Sep; 9(3):194-8. PMID: 23974176.
    View in: PubMed
  9. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
    View in: PubMed
  10. Tran TH, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012 Sep 21; 287(39):32651-64. PMID: 22865881.
    View in: PubMed
  11. Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17; 287(8):5979-87. PMID: 22187428.
    View in: PubMed
  12. Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K, Lu J, Fine A, Ai X. A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci. 2011 Oct 26; 31(43):15407-15. PMID: 22031887.
    View in: PubMed
  13. Schumacher VA, Schlötzer-Schrehardt U, Karumanchi SA, Shi X, Zaia J, Jeruschke S, Zhang D, Pavenstädt H, Pavenstaedt H, Drenckhan A, Amann K, Ng C, Hartwig S, Ng KH, Ho J, Kreidberg JA, Taglienti M, Royer-Pokora B, Ai X. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol. 2011 Jul; 22(7):1286-96. PMID: 21719793.
    View in: PubMed
  14. Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87. PMID: 21536678.
    View in: PubMed
  15. Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61. PMID: 20855470.
    View in: PubMed
  16. Langsdorf A, Radzikinas K, Kroten A, Jain S, Ai X. Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):293-301. PMID: 20139349.
    View in: PubMed
  17. Ambasta RK, Ai X, Emerson CP. Quail Sulf1 function requires asparagine-linked glycosylation. J Biol Chem. 2007 Nov 23; 282(47):34492-9. PMID: 17855356.
    View in: PubMed
  18. Langsdorf A, Do AT, Kusche-Gullberg M, Emerson CP, Ai X. Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration. Dev Biol. 2007 Nov 15; 311(2):464-77. PMID: 17920055.
    View in: PubMed
  19. Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development. 2007 Sep; 134(18):3327-38. PMID: 17720696.
    View in: PubMed
  20. Danesin C, Agius E, Escalas N, Ai X, Emerson C, Cochard P, Soula C. Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord. J Neurosci. 2006 May 10; 26(19):5037-48. PMID: 16687495.
    View in: PubMed
  21. Riobó NA, Lu K, Ai X, Haines GM, Emerson CP. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4505-10. PMID: 16537363.
    View in: PubMed
  22. Ai X, Do AT, Kusche-Gullberg M, Lindahl U, Lu K, Emerson CP. Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2. J Biol Chem. 2006 Feb 24; 281(8):4969-76. PMID: 16377625.
    View in: PubMed
  23. Braquart-Varnier C, Danesin C, Clouscard-Martinato C, Agius E, Escalas N, Benazeraf B, Ai X, Emerson C, Cochard P, Soula C. A subtractive approach to characterize genes with regionalized expression in the gliogenic ventral neuroepithelium: identification of chick sulfatase 1 as a new oligodendrocyte lineage gene. Mol Cell Neurosci. 2004 Apr; 25(4):612-28. PMID: 15080891.
    View in: PubMed
  24. Wang S, Ai X, Freeman SD, Pownall ME, Lu Q, Kessler DS, Emerson CP. QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):4833-8. PMID: 15051888.
    View in: PubMed
  25. Ai X, Do AT, Lozynska O, Kusche-Gullberg M, Lindahl U, Emerson CP. QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling. J Cell Biol. 2003 Jul 21; 162(2):341-51. PMID: 12860968.
    View in: PubMed
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