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PhD, Brandeis University
BA, Brandeis University

Websites

	Biomedical Engineering Faculty
	Biochemistry Faculty
	Ophthalmology Faculty

ORCID : 0000-0002-8630-4712

Research
Publications

BU Research
NIH RePORTER Research

VEGF-ECM Interactions in Choroidal Neovascularization
07/01/2012 - 06/30/2014 (PI)
American Health Assistance Foundation

Elastase Injury of Pulmonary Extracellular Matrix
12/01/2007 - 11/30/2013 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL088572-05

Growth Factors in Vascular Biology
01/01/1997 - 06/30/2010 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL56200 12

Lung Connective Tissue--Response to Injury and Repair
12/03/1991 - 11/30/2007 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 P01 HL46902 15

Role of Metalloproteinases in Flow-Induced Smooth Muscle Cell Migration in Rat Vascular Grafts
03/01/2003 - 06/30/2005 (Dept Sponsor)
American Heart Association

Nuclear Localization of Heparan Sulfate Proteoglycans
04/01/2002 - 03/31/2005 (PI)
NIH/National Eye Institute
5 R03 EY14007 03

Role of Proteoglycans in Elastolytic Lung Injury
04/01/2000 - 03/31/2003 (Dept Sponsor)
NIH/National Heart, Lung, and Blood Institute
5 F32 HL10332 03

Regulation of Extracellular Matrix in the Corneal Stroma
08/01/1996 - 07/31/2000 (PI)
NIH/National Eye Institute
5 R01 EY11004 04

Title

Yr	Title	Project-Sub Proj	Pubs
2016	Modulating Protein Activity with Heparan Sulfate	1R15GM120702-01	3
2012	Elastase Injury of Pulmonary Extracellular Matrix	5R01HL088572-05	17
2011	STRUCTURE-FUNCTION RELATIONSHIPS OF HEPARAN SULFATES IN VASCULOGENESIS	5P41RR010888-15-5124	259
2011	Elastase Injury of Pulmonary Extracellular Matrix	5R01HL088572-04	17
2010	STRUCTURE-FUNCTION RELATIONSHIPS OF HEPARAN SULFATES IN VASCULOGENESIS	5P41RR010888-14-6826	259
2010	Elastase Injury of Pulmonary Extracellular Matrix	5R01HL088572-03	17
2009	Elastase Injury of Pulmonary Extracellular Matrix	5R01HL088572-02	17
2008	Elastase Injury of Pulmonary Extracellular Matrix	1R01HL088572-01A1	17
2008	Growth Factors in Vascular Biology	5R01HL056200-12	29
2007	Growth Factors in Vascular Biology	5R01HL056200-11	29

Showing 10 of 32 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Sack KD, Teran M, Nugent MA. Extracellular Matrix Stiffness Controls VEGF Signaling and Processing in Endothelial Cells. J Cell Physiol. 2016 Sep; 231(9):2026-39. PMID: 26773314; DOI: 10.1002/jcp.25312;

Hubbard B, Buczek-Thomas JA, Nugent MA, Smith ML. Fibronectin Fiber Extension Decreases Cell Spreading and Migration. J Cell Physiol. 2016 Aug; 231(8):1728-36.View Related Profiles.

Nugent, Matthew
Smith, Michael

PMID: 26621030; DOI: 10.1002/jcp.25271;

Kurtagic E, Rich CB, Buczek-Thomas JA, Nugent MA. Neutrophil Elastase-Generated Fragment of Vascular Endothelial Growth Factor-A Stimulates Macrophage and Endothelial Progenitor Cell Migration. PLoS One. 2015; 10(12):e0145115. PMID: 26672607; PMCID: PMC4682631; DOI: 10.1371/journal.pone.0145115;

Derricks KE, Trinkaus-Randall V, Nugent MA. Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis. Integr Biol (Camb). 2015 Sep; 7(9):1011-25.View Related Profiles.

Derricks, Kelsey
Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 26183123; PMCID: PMC4558347; DOI: 10.1039/c5ib00140d;

Teran M, Nugent MA. Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity. J Biol Chem. 2015 Jun 26; 290(26):16451-62. PMID: 25979342; PMCID: PMC4481241; DOI: 10.1074/jbc.M114.627372;

Sazonova OV, Isenberg BC, Herrmann J, Lee KL, Purwada A, Valentine AD, Buczek-Thomas JA, Wong JY, Nugent MA. Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction. Matrix Biol. 2015 Jan; 41:36-43.View Related Profiles.

Wong, Joyce
Nugent, Matthew

PMID: 25448408; DOI: 10.1016/j.matbio.2014.11.001;

Mao Y, Huang Y, Buczek-Thomas JA, Ethen CM, Nugent MA, Wu ZL, Zaia J. A liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase. J Biol Chem. 2014 Dec 5; 289(49):34141-51.View Related Profiles.

Zaia, Joseph
Nugent, Matthew
Mao, Yang
Huang, Yu

PMID: 25336655; PMCID: PMC4256347; DOI: 10.1074/jbc.M114.589630;

Huang Y, Mao Y, Buczek-Thomas JA, Nugent MA, Zaia J. Oligosaccharide substrate preferences of human extracellular sulfatase Sulf2 using liquid chromatography-mass spectrometry based glycomics approaches. PLoS One. 2014; 9(8):e105143.View Related Profiles.

Zaia, Joseph
Nugent, Matthew
Mao, Yang
Huang, Yu

PMID: 25127119; PMCID: PMC4134258; DOI: 10.1371/journal.pone.0105143;

Mottarella SE, Beglov D, Beglova N, Nugent MA, Kozakov D, Vajda S. Docking server for the identification of heparin binding sites on proteins. J Chem Inf Model. 2014 Jul 28; 54(7):2068-78.View Related Profiles.

Beglov, Dmitri
Nugent, Matthew
Vajda, Sandor

PMID: 24974889; PMCID: PMC4184157; DOI: 10.1021/ci500115j;

Lee A, Derricks K, Minns M, Ji S, Chi C, Nugent MA, Trinkaus-Randall V. Hypoxia-induced changes in Ca(2+) mobilization and protein phosphorylation implicated in impaired wound healing. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C972-85.View Related Profiles.

Derricks, Kelsey
Minns, Martin
Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 24671101; PMCID: PMC4024710; DOI: 10.1152/ajpcell.00110.2013;

Showing 10 of 99 results. Show More

Tumelty KE, Smith BD, Nugent MA, Layne MD. Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor ß receptor-dependent and -independent pathways. J Biol Chem. 2014 Jan 31; 289(5):2526-36.View Related Profiles.

Smith, Barbara
Tumelty, Kathleen
Nugent, Matthew
Layne, Matthew

PMID: 24344132; PMCID: PMC3908388; DOI: 10.1074/jbc.M113.502617;

Hubbard B, Buczek-Thomas JA, Nugent MA, Smith ML. Heparin-dependent regulation of fibronectin matrix conformation. Matrix Biol. 2014 Feb; 34:124-31.View Related Profiles.

Nugent, Matthew
Smith, Michael

PMID: 24148804; PMCID: PMC3992196; DOI: 10.1016/j.matbio.2013.10.006;

Nugent MA, Zaia J, Spencer JL. Heparan sulfate-protein binding specificity. Biochemistry (Mosc). 2013 Jul; 78(7):726-35.View Related Profiles.

Spencer, Jean
Zaia, Joseph
Nugent, Matthew

PMID: 24010836; PMCID: PMC4108213; DOI: 10.1134/S0006297913070055;

Derricks KE, Rich CB, Buczek-Thomas JA, Nugent MA. Ascorbate enhances elastin synthesis in 3D tissue-engineered pulmonary fibroblasts constructs. Tissue Cell. 2013 Aug; 45(4):253-60.View Related Profiles.

Buczek-Thomas, JoAnn
Derricks, Kelsey
Nugent, Matthew

PMID: 23648172; PMCID: PMC3746313; DOI: 10.1016/j.tice.2013.03.001;

Imsirovic J, Derricks K, Buczek-Thomas JA, Rich CB, Nugent MA, Suki B. A novel device to stretch multiple tissue samples with variable patterns: application for mRNA regulation in tissue-engineered constructs. Biomatter. 2013 Jul-Sep; 3(3).View Related Profiles.

Suki, Bela
Derricks, Kelsey
Nugent, Matthew

PMID: 23628870; PMCID: PMC3749279; DOI: 10.4161/biom.24650;

Fannon M, Forsten-Williams K, Zhao B, Bach E, Parekh PP, Chu CL, Goerges-Wildt AL, Buczek-Thomas JA, Nugent MA. Facilitated diffusion of VEGF165 through descemet's membrane with sucrose octasulfate. J Cell Physiol. 2012 Nov; 227(11):3693-700.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew

PMID: 22378222; DOI: 10.1002/jcp.24077;

Bais MV, Nugent MA, Stephens DN, Sume SS, Kirsch KH, Sonenshein GE, Trackman PC. Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. PLoS One. 2012; 7(2):e31188.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Bais, Manish
Nugent, Matthew
Trackman, Philip
Sume, Siddika

PMID: 22363577; PMCID: PMC3280126; DOI: 10.1371/journal.pone.0031188;

Forsten-Williams K, Kurtagic E, Nugent MA. Complex receptor-ligand dynamics control the response of the VEGF system to protease injury. BMC Syst Biol. 2011; 5:170. PMID: 22014244; PMCID: PMC3253741; DOI: 10.1186/1752-0509-5-170;

Sazonova OV, Lee KL, Isenberg BC, Rich CB, Nugent MA, Wong JY. Cell-cell interactions mediate the response of vascular smooth muscle cells to substrate stiffness. Biophys J. 2011 Aug 3; 101(3):622-30.View Related Profiles.

Wong, Joyce
Nugent, Matthew

PMID: 21806930; PMCID: PMC3145282; DOI: 10.1016/j.bpj.2011.06.051;

Araújo AD, Majumdar A, Parameswaran H, Yi E, Spencer JL, Nugent MA, Suki B. Dynamics of enzymatic digestion of elastic fibers and networks under tension. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9414-9.View Related Profiles.

Suki, Bela
Spencer, Jean
Nugent, Matthew

PMID: 21606336; PMCID: PMC3111325; DOI: 10.1073/pnas.1019188108;

Naimy H, Buczek-Thomas JA, Nugent MA, Leymarie N, Zaia J. Highly sulfated nonreducing end-derived heparan sulfate domains bind fibroblast growth factor-2 with high affinity and are enriched in biologically active fractions. J Biol Chem. 2011 Jun 3; 286(22):19311-9.View Related Profiles.

Buczek-Thomas, JoAnn
Zaia, Joseph
Nugent, Matthew
Leymarie, Nancy

PMID: 21471211; PMCID: PMC3103309; DOI: 10.1074/jbc.M110.204693;

Symes K, Smith EM, Mitsi M, Nugent MA. Sweet cues: How heparan sulfate modification of fibronectin enables growth factor guided migration of embryonic cells. Cell Adh Migr. 2010 Oct-Dec; 4(4):507-10.View Related Profiles.

Smith, Erin
Symes, Karen
Nugent, Matthew

PMID: 20562530; PMCID: PMC3011263; DOI: 10.4161/cam.4.4.12427;

Guarnieri F, Spencer JL, Lucey EC, Nugent MA, Stone PJ. A human surfactant peptide-elastase inhibitor construct as a treatment for emphysema. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10661-6.View Related Profiles.

Spencer, Jean
Nugent, Matthew
Stone, Phillip

PMID: 20534582; PMCID: PMC2890802; DOI: 10.1073/pnas.1001349107;

Spencer JL, Bernanke JA, Buczek-Thomas JA, Nugent MA. A computational approach for deciphering the organization of glycosaminoglycans. PLoS One. 2010; 5(2):e9389.View Related Profiles.

Spencer, Jean
Buczek-Thomas, JoAnn
Nugent, Matthew

PMID: 20186334; PMCID: PMC2826411; DOI: 10.1371/journal.pone.0009389;

Vora SR, Palamakumbura AH, Mitsi M, Guo Y, Pischon N, Nugent MA, Trackman PC. Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts. J Biol Chem. 2010 Mar 5; 285(10):7384-93.View Related Profiles.

Nugent, Matthew
Trackman, Philip

PMID: 20048148; PMCID: PMC2844187; DOI: 10.1074/jbc.M109.033597;

Smith EM, Mitsi M, Nugent MA, Symes K. PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21683-8.View Related Profiles.

Smith, Erin
Symes, Karen
Nugent, Matthew

PMID: 19966216; PMCID: PMC2799789; DOI: 10.1073/pnas.0902510106;

Palamakumbura AH, Vora SR, Nugent MA, Kirsch KH, Sonenshein GE, Trackman PC. Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling. Oncogene. 2009 Sep 24; 28(38):3390-400.View Related Profiles.

Sonenshein, Gail
Kirsch, Kathrin
Nugent, Matthew
Trackman, Philip

PMID: 19597471; PMCID: PMC2753565; DOI: 10.1038/onc.2009.203;

Ritter MC, Jesudason R, Majumdar A, Stamenovic D, Buczek-Thomas JA, Stone PJ, Nugent MA, Suki B. A zipper network model of the failure mechanics of extracellular matrices. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1081-6.View Related Profiles.

Suki, Bela
Stamenovic, Dimitrije
Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip

PMID: 19144920; PMCID: PMC2633546; DOI: 10.1073/pnas.0808414106;

Kurtagic E, Jedrychowski MP, Nugent MA. Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity. Am J Physiol Lung Cell Mol Physiol. 2009 Mar; 296(3):L534-46. PMID: 19136576; PMCID: PMC2660218; DOI: 10.1152/ajplung.90505.2008;

Mitsi M, Forsten-Williams K, Gopalakrishnan M, Nugent MA. A catalytic role of heparin within the extracellular matrix. J Biol Chem. 2008 Dec 12; 283(50):34796-807. PMID: 18845539; PMCID: PMC2596404; DOI: 10.1074/jbc.M806692200;

Forsten-Williams K, Chu CL, Fannon M, Buczek-Thomas JA, Nugent MA. Control of growth factor networks by heparan sulfate proteoglycans. Ann Biomed Eng. 2008 Dec; 36(12):2134-48.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew

PMID: 18839312; PMCID: PMC2606109; DOI: 10.1007/s10439-008-9575-z;

Buczek-Thomas JA, Hsia E, Rich CB, Foster JA, Nugent MA. Inhibition of histone acetyltransferase by glycosaminoglycans. J Cell Biochem. 2008 Sep 1; 105(1):108-20.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew

PMID: 18459114; PMCID: PMC2596351; DOI: 10.1002/jcb.21803;

Baker AB, Ettenson DS, Jonas M, Nugent MA, Iozzo RV, Edelman ER. Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway. Circ Res. 2008 Aug 1; 103(3):289-97. PMID: 18583708; PMCID: PMC2766078; DOI: 10.1161/CIRCRESAHA.108.179465;

Fannon M, Forsten-Williams K, Nugent MA, Gregory KJ, Chu CL, Goerges-Wildt AL, Panigrahy D, Kaipainen A, Barnes C, Lapp C, Shing Y. Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: potential for regulation of tumor growth. J Cell Physiol. 2008 May; 215(2):434-41. PMID: 18163458; PMCID: PMC2585800; DOI: 10.1002/jcp.21327;

Yang S, Nugent MA, Panchenko MP. EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L143-51.View Related Profiles.

Panchenko, Maria
Nugent, Matthew

PMID: 18441095; PMCID: PMC2494790; DOI: 10.1152/ajplung.00289.2007;

Suki B, Majumdar A, Nugent MA, Bates JH. In silico modeling of interstitial lung mechanics: implications for disease development and repair. Drug Discov Today Dis Models. 2007; 4(3):139-145.View Related Profiles.

Suki, Bela
Nugent, Matthew

PMID: 18709177

Mitsi M, Hong Z, Costello CE, Nugent MA. Heparin-mediated conformational changes in fibronectin expose vascular endothelial growth factor binding sites. Biochemistry. 2006 Aug 29; 45(34):10319-28.View Related Profiles.

Costello, Catherine
Nugent, Matthew
Hong, Zhenning

PMID: 16922507

Spencer JL, Stone PJ, Nugent MA. New insights into the inhibition of human neutrophil elastase by heparin. Biochemistry. 2006 Aug 1; 45(30):9104-20.View Related Profiles.

Spencer, Jean
Nugent, Matthew
Stone, Phillip

PMID: 16866356

DiCamillo SJ, Yang S, Panchenko MV, Toselli PA, Naggar EF, Rich CB, Stone PJ, Nugent MA, Panchenko MP. Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L232-43.View Related Profiles.

Panchenko, Maria
Nugent, Matthew
Toselli, Paul
Stone, Phillip

PMID: 16473861

Chu CL, Goerges AL, Nugent MA. Identification of common and specific growth factor binding sites in heparan sulfate proteoglycans. Biochemistry. 2005 Sep 13; 44(36):12203-13. PMID: 16142919

Gopalakrishnan M, Forsten-Williams K, Nugent MA, Täuber UC. Effects of receptor clustering on ligand dissociation kinetics: theory and simulations. Biophys J. 2005 Dec; 89(6):3686-700. PMID: 16150967; PMCID: PMC1366939

Galcheva-Gargova Z, Qi YW, Geisler S, Zhidkova N, Nugent MA, Venkataraman G. Genetically engineered mouse melanoma and mouse Lewis lung carcinoma models. Int J Oncol. 2005 May; 26(5):1233-9. PMID: 15809714

Black LD, Brewer KK, Morris SM, Schreiber BM, Toselli P, Nugent MA, Suki B, Stone PJ. Effects of elastase on the mechanical and failure properties of engineered elastin-rich matrices. J Appl Physiol (1985). 2005 Apr; 98(4):1434-41.View Related Profiles.

Schreiber, Barbara
Suki, Bela
Nugent, Matthew
Toselli, Paul
Stone, Phillip

PMID: 15640390

Forsten-Williams K, Chua CC, Nugent MA. The kinetics of FGF-2 binding to heparan sulfate proteoglycans and MAP kinase signaling. J Theor Biol. 2005 Apr 21; 233(4):483-99. PMID: 15748910

Buczek-Thomas JA, Lucey EC, Stone PJ, Chu CL, Rich CB, Carreras I, Goldstein RH, Foster JA, Nugent MA. Elastase mediates the release of growth factors from lung in vivo. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):344-50.View Related Profiles.

Carreras, Isabel
Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip
Goldstein, Ronald

PMID: 15191913

Chu CL, Buczek-Thomas JA, Nugent MA. Heparan sulphate proteoglycans modulate fibroblast growth factor-2 binding through a lipid raft-mediated mechanism. Biochem J. 2004 Apr 15; 379(Pt 2):331-41.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew

PMID: 14717658; PMCID: PMC1224079

Chua CC, Rahimi N, Forsten-Williams K, Nugent MA. Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2. Circ Res. 2004 Feb 20; 94(3):316-23.View Related Profiles.

Nugent, Matthew
Rahimi, Nader

PMID: 14684627

Goerges AL, Nugent MA. pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release. J Biol Chem. 2004 Jan 16; 279(3):2307-15. PMID: 14570917

Liu J, Rich CB, Buczek-Thomas JA, Nugent MA, Panchenko MP, Foster JA. Heparin-binding EGF-like growth factor regulates elastin and FGF-2 expression in pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2003 Nov; 285(5):L1106-15.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew

PMID: 12882762

Izvolsky KI, Zhong L, Wei L, Yu Q, Nugent MA, Cardoso WV. Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching. Am J Physiol Lung Cell Mol Physiol. 2003 Oct; 285(4):L838-46.View Related Profiles.

Nugent, Matthew
Cardoso, Wellington

PMID: 12818887

Izvolsky KI, Shoykhet D, Yang Y, Yu Q, Nugent MA, Cardoso WV. Heparan sulfate-FGF10 interactions during lung morphogenesis. Dev Biol. 2003 Jun 1; 258(1):185-200.View Related Profiles.

Nugent, Matthew
Cardoso, Wellington

PMID: 12781692

Hsia E, Richardson TP, Nugent MA. Nuclear localization of basic fibroblast growth factor is mediated by heparan sulfate proteoglycans through protein kinase C signaling. J Cell Biochem. 2003 Apr 15; 88(6):1214-25. PMID: 12647303

Rich CB, Carreras I, Lucey EC, Jaworski JA, Buczek-Thomas JA, Nugent MA, Stone P, Foster JA. Transcriptional regulation of pulmonary elastin gene expression in elastase-induced injury. Am J Physiol Lung Cell Mol Physiol. 2003 Aug; 285(2):L354-62.View Related Profiles.

Carreras, Isabel
Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip

PMID: 12679320

Goerges AL, Nugent MA. Regulation of vascular endothelial growth factor binding and activity by extracellular pH. J Biol Chem. 2003 May 23; 278(21):19518-25. PMID: 12637571

Fannon M, Forsten-Williams K, Dowd CJ, Freedman DA, Folkman J, Nugent MA. Binding inhibition of angiogenic factors by heparan sulfate proteoglycans in aqueous humor: potential mechanism for maintenance of an avascular environment. FASEB J. 2003 May; 17(8):902-4. PMID: 12626427

Li W, Nugent MA, Zhao Y, Chau AN, Li SJ, Chou IN, Liu G, Kagan HM. Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential. J Cell Biochem. 2003 Jan 1; 88(1):152-64.View Related Profiles.

Kagan, Herbert
Nugent, Matthew
Li, Wande
Zhao, Yinzhi

PMID: 12461785

Buczek-Thomas JA, Chu CL, Rich CB, Stone PJ, Foster JA, Nugent MA. Heparan sulfate depletion within pulmonary fibroblasts: implications for elastogenesis and repair. J Cell Physiol. 2002 Sep; 192(3):294-303.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip

PMID: 12124775

Brown CT, Lin P, Walsh MT, Gantz D, Nugent MA, Trinkaus-Randall V. Extraction and purification of decorin from corneal stroma retain structure and biological activity. Protein Expr Purif. 2002 Aug; 25(3):389-99.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 12182818

Song QH, Klepeis VE, Nugent MA, Trinkaus-Randall V. TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing. Mol Pathol. 2002 Jun; 55(3):164-76.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 12032227; PMCID: PMC1187169

DiCamillo SJ, Carreras I, Panchenko MV, Stone PJ, Nugent MA, Foster JA, Panchenko MP. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. J Biol Chem. 2002 May 24; 277(21):18938-46.View Related Profiles.

Carreras, Isabel
Panchenko, Maria
Nugent, Matthew
Stone, Phillip

PMID: 11889128

Richardson TP, Trinkaus-Randall V, Nugent MA. Regulation of heparan sulfate proteoglycan nuclear localization by fibronectin. J Cell Sci. 2001 May; 114(Pt 9):1613-23.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 11309193

Forsten KE, Nugent MA. Binding constant measurements for inhibitors of growth factor binding to heparan sulfate proteoglycans. Methods Mol Biol. 2001; 171:415-26. PMID: 11450256

Csordás G, Santra M, Reed CC, Eichstetter I, McQuillan DJ, Gross D, Nugent MA, Hajnóczky G, Iozzo RV. Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo. J Biol Chem. 2000 Oct 20; 275(42):32879-87. PMID: 10913155

Nugent MA. Heparin sequencing brings structure to the function of complex oligosaccharides. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10301-3. PMID: 10984527; PMCID: PMC34039

Forsten KE, Fannon M, Nugent MA. Potential mechanisms for the regulation of growth factor binding by heparin. J Theor Biol. 2000 Jul 21; 205(2):215-30. PMID: 10873433

Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER. Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proc Natl Acad Sci U S A. 2000 Jun 6; 97(12):6722-7. PMID: 10841569; PMCID: PMC18716

Sperinde GV, Nugent MA. Mechanisms of fibroblast growth factor 2 intracellular processing: a kinetic analysis of the role of heparan sulfate proteoglycans. Biochemistry. 2000 Apr 4; 39(13):3788-96. PMID: 10736179

Song QH, Singh RP, Richardson TP, Nugent MA, Trinkaus-Randall V. Transforming growth factor-beta1 expression in cultured corneal fibroblasts in response to injury. J Cell Biochem. 2000 Mar; 77(2):186-99.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 10723086

Fannon M, Forsten KE, Nugent MA. Potentiation and inhibition of bFGF binding by heparin: a model for regulation of cellular response. Biochemistry. 2000 Feb 15; 39(6):1434-45. PMID: 10684625

Nugent MA, Iozzo RV. Fibroblast growth factor-2. Int J Biochem Cell Biol. 2000 Feb; 32(2):115-20. PMID: 10687947

Forsten KE, Wang N, Robinson RM, Nugent MA. A simple assay for evaluating inhibitors of proteoglycan-ligand binding. Ann Biomed Eng. 2000 Jan; 28(1):119-27. PMID: 10645795

Rich CB, Fontanilla MR, Nugent M, Foster JA. Basic fibroblast growth factor decreases elastin gene transcription through an AP1/cAMP-response element hybrid site in the distal promoter. J Biol Chem. 1999 Nov 19; 274(47):33433-9. PMID: 10559225

Nehra A, Gettman MT, Nugent M, Bostwick DG, Barrett DM, Goldstein I, Krane RJ, Moreland RB. Transforming growth factor-beta1 (TGF-beta1) is sufficient to induce fibrosis of rabbit corpus cavernosum in vivo. J Urol. 1999 Sep; 162(3 Pt 1):910-5. PMID: 10458407

Buczek-Thomas JA, Nugent MA. Elastase-mediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures. A mechanism for basic fibroblast growth factor (bFGF) release and attenuation of bfgf binding following elastase-induced injury. J Biol Chem. 1999 Aug 27; 274(35):25167-72.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew

PMID: 10455199

Richardson TP, Trinkaus-Randall V, Nugent MA. Regulation of basic fibroblast growth factor binding and activity by cell density and heparan sulfate. J Biol Chem. 1999 May 7; 274(19):13534-40.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 10224122

Brown CT, Nugent MA, Lau FW, Trinkaus-Randall V. Characterization of proteoglycans synthesized by cultured corneal fibroblasts in response to transforming growth factor beta and fetal calf serum. J Biol Chem. 1999 Mar 12; 274(11):7111-9.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 10066769

Dowd CJ, Cooney CL, Nugent MA. Heparan sulfate mediates bFGF transport through basement membrane by diffusion with rapid reversible binding. J Biol Chem. 1999 Feb 19; 274(8):5236-44. PMID: 9988774

Natke B, Venkataraman G, Nugent MA, Sasisekharan R. Heparinase treatment of bovine smooth muscle cells inhibits fibroblast growth factor-2 binding to fibroblast growth factor receptor but not FGF-2 mediated cellular proliferation. Angiogenesis. 1999; 3(3):249-57. PMID: 14517424

Sharma B, Handler M, Eichstetter I, Whitelock JM, Nugent MA, Iozzo RV. Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. J Clin Invest. 1998 Oct 15; 102(8):1599-608. PMID: 9788974; PMCID: PMC509011

Sperinde GV, Nugent MA. Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells. Biochemistry. 1998 Sep 22; 37(38):13153-64. PMID: 9748322

Kypreos KE, Nugent MA, Sonenshein GE. Basic fibroblast growth factor-induced decrease in type I collagen gene transcription is mediated by B-myb. Cell Growth Differ. 1998 Sep; 9(9):723-30.View Related Profiles.

Sonenshein, Gail
Nugent, Matthew

PMID: 9751116

Trinkaus-Randall V, Nugent MA. Biological response to a synthetic cornea. J Control Release. 1998 Apr 30; 53(1-3):205-14.View Related Profiles.

Nugent, Matthew
Trinkaus-Randall, Vickery

PMID: 9741928

Forsten KE, Courant NA, Nugent MA. Endothelial proteoglycans inhibit bFGF binding and mitogenesis. J Cell Physiol. 1997 Aug; 172(2):209-20. PMID: 9258342

Nehra A, Goldstein I, Pabby A, Nugent M, Huang YH, de las Morenas A, Krane RJ, Udelson D, Saenz de Tejada I, Moreland RB. Mechanisms of venous leakage: a prospective clinicopathological correlation of corporeal function and structure. J Urol. 1996 Oct; 156(4):1320-9.View Related Profiles.

De Las Morenas, Antonio
Nugent, Matthew

PMID: 8808863

Rich CB, Nugent MA, Stone P, Foster JA. Elastase release of basic fibroblast growth factor in pulmonary fibroblast cultures results in down-regulation of elastin gene transcription. A role for basic fibroblast growth factor in regulating lung repair. J Biol Chem. 1996 Sep 20; 271(38):23043-8. PMID: 8798493

Fannon M, Nugent MA. Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of heparan sulfate. J Biol Chem. 1996 Jul 26; 271(30):17949-56. PMID: 8663512

Nathan A, Nugent MA, Edelman ER. Tissue engineered perivascular endothelial cell implants regulate vascular injury. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8130-4. PMID: 7667257; PMCID: PMC41109

Sasisekharan R, Moses MA, Nugent MA, Cooney CL, Langer R. Heparinase inhibits neovascularization. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1524-8. PMID: 7509076; PMCID: PMC43192

Nugent MA, Karnovsky MJ, Edelman ER. Vascular cell-derived heparan sulfate shows coupled inhibition of basic fibroblast growth factor binding and mitogenesis in vascular smooth muscle cells. Circ Res. 1993 Dec; 73(6):1051-60. PMID: 8222077

Nugent M, Huang SM, Sander M. Characterization of the apurinic endonuclease activity of Drosophila Rrp1. Biochemistry. 1993 Oct 26; 32(42):11445-52. PMID: 7692963

Edelman ER, Nugent MA, Karnovsky MJ. Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1513-7. PMID: 8434012; PMCID: PMC45904

Nugent MA, Edelman ER. Transforming growth factor beta 1 stimulates the production of basic fibroblast growth factor binding proteoglycans in Balb/c3T3 cells. J Biol Chem. 1992 Oct 15; 267(29):21256-64. PMID: 1400436

Nugent MA, Edelman ER. Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperactivity. Biochemistry. 1992 Sep 22; 31(37):8876-83. PMID: 1390674

Edelman ER, Nugent MA, Smith LT, Karnovsky MJ. Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries. J Clin Invest. 1992 Feb; 89(2):465-73. PMID: 1371124; PMCID: PMC442874

Newman MJ, Lane EA, Iannotti AM, Nugent MA, Pepinsky RB, Keski-Oja J. Characterization and purification of a secreted plasminogen activator inhibitor (PAI-1) induced by transforming growth factor-beta 1 in normal rat kidney (NRK) cells: decreased PAI-1 expression in transformed NRK cells. Endocrinology. 1990 Jun; 126(6):2936-46. PMID: 2190800

Nugent MA, Newman MJ. Inhibition of normal rat kidney cell growth by transforming growth factor-beta is mediated by collagen. J Biol Chem. 1989 Oct 25; 264(30):18060-7. PMID: 2553700

Nugent MA, Lane EA, Keski-Oja J, Moses HL, Newman MJ. Growth stimulation, altered regulation of epidermal growth factor receptors, and autocrine transformation of spontaneously transformed normal rat kidney cells by transforming growth factor beta. Cancer Res. 1989 Jul 15; 49(14):3884-90. PMID: 2786745

Biswas C, Nugent MA. Membrane association of collagenase stimulatory factor(s) from B-16 melanoma cells. J Cell Biochem. 1987 Nov; 35(3):247-58. PMID: 2826506

Newman MJ, Lane EA, Nugent MA, Racker E. Induction of anchorage-independent growth by epidermal growth factor and altered sensitivity to type beta transforming growth factor in partially transformed rat kidney cells. Cancer Res. 1986 Nov; 46(11):5842-50. PMID: 3019539

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