Barbara Smith | Profiles RNS

Barbara D. Smith, PhD

Emeritus Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Boston University
MS, Boston University
BS, Simmons College

Websites

	Biochemistry Faculty
	ResearchGate

ORCID : 0000-0002-5375-7627

Dr. Smith is Emeritus Professor of Biochemistry at Chobanian and Avedisian School of Medicine. Her research interests include- collagen gene expression associated with inflammation, atherosclerosis, tumors, and fibrotic diseases including systemic sclerosis. Collagen, a family of extracellular proteins, plays a critical role in remodeling after injury. Progressive deposition of excess extracellular matrix (ECM), occurs in a large group of diseases with no effective therapy including cardiovascular disease, pulmonary fibrosis, diabetic nephropathy, systemic sclerosis, and liver cirrhosis. Fibrosis (excessive scarring) is a progressive deposition of excess collagen-rich extracellular matrix produced by activated myofibroblasts leading to impairment and finally failure of affected organs. In normal healing following injury, fibroblasts differentiate into myofibroblasts. If progression to fibrosis occurs, these myofibroblasts do not undergo apoptosis but instead continue to proliferate and produce excess amounts of ECM. Isolated primary fibroblasts from fibrotic lesions maintain their activated myofibroblast phenotype containing abundant stress fibers with smooth muscle actin (SMA). Myocardin related transcription factors (MRTF-A, MRTF-B), members of the myocardin family, link actin dynamics with gene transcription. Our data indicate that MRTF-A dramatically (100 fold) activates collagen transcription. Fibroblasts with knockdown of MRTFA have different morphology and produce less collagen and SMA. We hypothesize that MRTFA plays a central role in activation and perpetuation of myofibroblast during the development of fibrotic disease.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Collagen Regulation in Systemic Sclerosis
01/15/2012 - 12/31/2013 (PI)
Scleroderma Foundation

The Role of the Arterial Wall in Atherosclerosis
09/01/1976 - 08/31/2009 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 P01 HL13262 34

Post-Translational Modifications of RFX5 and CIITA in Collagen Repression During Artherosclerotic Injury
07/01/2005 - 06/30/2007 (Dept Sponsor)
American Heart Association

Pathogenic Mechanisms of Venous Disease
05/01/2000 - 04/30/2005 (PI)
Roger Williams Hospital NIH NCI

Collagen Gene Expression and Atherosclerosis
05/01/2003 - 09/30/2003 (PI)
NIH/National Heart, Lung, and Blood Institute
1 R01 HL72996 01

Title

Yr	Title	Project-Sub Proj	Pubs
2009	Collagen Transcription and Lung Fibrosis	5R01HL068094-09	14
2008	Collagen Transcription and Lung Fibrosis	5R01HL068094-08	14
2007	Collagen Transcription and Lung Fibrosis	5R01HL068094-07	14
2006	Collagen Transcription and Lung Fibrosis	5R01HL068094-06	14
2005	Collagen Transcription and Lung Fibrosis	2R01HL068094-05A1	14
2004	Collagen transcription and lung fibrosis	5R01HL068094-04	14
2003	Collagen Gene Expression and Atherosclerosis	2P01HL013262-30A1-38	164
2003	Collagen Gene Expression and Atherosclerosis	1R01HL072996-01	1
2003	Collagen transcription and lung fibrosis	5R01HL068094-03	14
2002	Collagen transcription and lung fibrosis	5R01HL068094-02	14

Showing 10 of 30 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Tam A, Xu S, Lopez H, Ahmed B, Khan K, Rosario H, Arumalla N, Gibson M, Denton C, Abraham D, Smith BD, Stratton RJ. O42 Investigating Mechanical Stress-Responsive Macrophages in Scleroderma. Rheumatology. 2016; 55(suppl 1):i54-i55. View Publication
Tam A, Shiwen X, Lopez H, Khan K, Ahmed-Abdi B, Rosario H, Arumalla N, Gibson M, Denton C, Abraham D, Smith BD, Stratton RJ. SAT0193 Macrophages Responding To Mechanical Stress in Scleroderma. Annals of the Rheumatic Diseases. 2016; 75(suppl 2):738. View Publication

Shiwen X, Stratton R, Nikitorowicz-Buniak J, Ahmed-Abdi B, Ponticos M, Denton C, Abraham D, Takahashi A, Suki B, Layne MD, Lafyatis R, Smith BD. A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. PLoS One. 2015; 10(5):e0126015.View Related Profiles.

Smith, Barbara
Suki, Bela
Layne, Matthew
Lafyatis, Robert

PMID: 25955164; PMCID: PMC4425676; DOI: 10.1371/journal.pone.0126015;

McDonald ME, Li C, Bian H, Smith BD, Layne MD, Farmer SR. Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes. Cell. 2015 Jan 15; 160(1-2):105-18.View Related Profiles.

Smith, Barbara
Li, Chendi
Bian, Hejiao
Layne, Matthew
Farmer, Stephen

PMID: 25579684; PMCID: PMC4384505; DOI: 10.1016/j.cell.2014.12.005;

Stratton RJ, Xu S, Nikitorowicz J, Abdi-Ahmed B, Ponticos M, Denton CP, Abraham D, Smith BD. 309. Investigating the Role of MRTF-A in Systemic Sclerosis. Rheumatology. 2014; 53(suppl 1):i175. View Publication
Ponticos, M., and B.D. Smith. Journal of biomedical research. Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis. 2014; 28(1):25-39..

Tumelty KE, Smith BD, Nugent MA, Layne MD. Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor ß receptor-dependent and -independent pathways. J Biol Chem. 2014 Jan 31; 289(5):2526-36.View Related Profiles.

Smith, Barbara
Tumelty, Kathleen
Nugent, Matthew
Layne, Matthew

PMID: 24344132; PMCID: PMC3908388; DOI: 10.1074/jbc.M113.502617;

Ponticos M, Smith BD. Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis. J Biomed Res. 2014 Jan; 28(1):25-39. PMID: 24474961; PMCID: PMC3904172; DOI: 10.7555/JBR.27.20130064;

Luchsinger LL, Patenaude CA, Smith BD, Layne MD. Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts. J Biol Chem. 2011 Dec 23; 286(51):44116-25.View Related Profiles.

Smith, Barbara
Layne, Matthew

PMID: 22049076; PMCID: PMC3243519; DOI: 10.1074/jbc.M111.276931;

Xu Y, Luchsinger L, Lucey EC, Smith BD. The effect of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):898-905. PMID: 20705943; PMCID: PMC3135849; DOI: 10.1165/rcmb.2009-0416OC;

Showing 10 of 72 results. Show More

Wu X, Kong X, Luchsinger L, Smith BD, Xu Y. Regulating the activity of class II transactivator by posttranslational modifications: exploring the possibilities. Mol Cell Biol. 2009 Nov; 29(21):5639-44. PMID: 19720744; PMCID: PMC2772741; DOI: 10.1128/MCB.00661-09;

St Hilaire C, Koupenova M, Carroll SH, Smith BD, Ravid K. TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):292-6.View Related Profiles.

Smith, Barbara
Ravid, Katya
Koupenova-Zamor, Milka

PMID: 18647598; PMCID: PMC2583397; DOI: 10.1016/j.bbrc.2008.07.059;

Xu Y, Ravid K, Smith BD. Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling. J Biol Chem. 2008 May 23; 283(21):14213-20.View Related Profiles.

Smith, Barbara
Ravid, Katya

PMID: 18359773; PMCID: PMC2386913; DOI: 10.1074/jbc.M708657200;

Luchsinger L, Smith BD. The protein arginine methyltransferase (PRMT5) associates with class II transactivator (CIITA) to repress collagen transcription. Matrix Biology. 2008; 27:20. View Publication

Xu Y, Harton JA, Smith BD. CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. J Biol Chem. 2008 Jan 18; 283(3):1243-56. PMID: 17991736

Xu Y, Farmer SR, Smith BD. Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression. J Biol Chem. 2007 Sep 7; 282(36):26046-56.View Related Profiles.

Smith, Barbara
Farmer, Stephen

PMID: 17611194

Xu Y, McDonald J, Perloff E, Butticè G, Schreiber BM, Smith BD. Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice. Mol Immunol. 2007 Mar; 44(7):1709-21.View Related Profiles.

Smith, Barbara
Schreiber, Barbara

PMID: 16982097

Xu Y, Sengupta PK, Seto E, Smith BD. Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression. J Biol Chem. 2006 Apr 7; 281(14):9260-70.View Related Profiles.

Smith, Barbara
Sengupta, Pritam

PMID: 16464847; PMCID: PMC1434794; DOI: 10.1074/jbc.M511724200;

Butticè G, Miller J, Wang L, Smith BD. Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells. Circ Res. 2006 Mar 3; 98(4):472-9. PMID: 16439692; PMCID: PMC1388256; DOI: 10.1161/01.RES.0000204725.46332.97;

Sengupta PK, Agarwal A, Smith BD. DNA methylation of collagen genes by RFX1 recruitment of DNMTs. Matrix Biology. 2006; 25. View Publication
Xu Y, Buttice G, Smith BD. CIITA represses collagen transcription and activates MHC II. Matrix Biology. 2006; 25. View Publication

Sengupta P, Xu Y, Wang L, Widom R, Smith BD. Collagen alpha1(I) gene (COL1A1) is repressed by RFX family. J Biol Chem. 2005 Jun 3; 280(22):21004-14.View Related Profiles.

Smith, Barbara
Sengupta, Pritam

PMID: 15788405; PMCID: PMC1382295; DOI: 10.1074/jbc.M413191200;

Xu Y, Wang L, Butticè G, Sengupta PK, Smith BD. Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma). J Biol Chem. 2004 Oct 1; 279(40):41319-32.View Related Profiles.

Smith, Barbara
Sengupta, Pritam

PMID: 15247294

Varley CL, Stahlschmidt J, Smith B, Stower M, Southgate J. Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol. 2004 May; 164(5):1789-98. PMID: 15111325; PMCID: PMC1615665

Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD. Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex. J Biol Chem. 2003 Dec 5; 278(49):49134-44.View Related Profiles.

Smith, Barbara
Sengupta, Pritam

PMID: 12968017

Sengupta PK, Smith EM, Kim K, Murnane MJ, Smith BD. DNA hypermethylation near the transcription start site of collagen alpha2(I) gene occurs in both cancer cell lines and primary colorectal cancers. Cancer Res. 2003 Apr 15; 63(8):1789-97.View Related Profiles.

Smith, Barbara
Smith, Erin
Murnane, Mary
Sengupta, Pritam

PMID: 12702564

Sengupta PK, Fargo J, Smith BD. The RFX family interacts at the collagen (COL1A2) start site and represses transcription. J Biol Chem. 2002 Jul 12; 277(28):24926-37.View Related Profiles.

Smith, Barbara
Sengupta, Pritam

PMID: 11986307

Sun W, Hou F, Panchenko MP, Smith BD. A member of the Y-box protein family interacts with an upstream element in the alpha1(I) collagen gene. Matrix Biol. 2001 Dec; 20(8):527-41. PMID: 11731270

Smith B. Expression and Regulation of the Collagen Family in Skin. In: Wound Healing and the Skin, Falanga, V., Ed. Martin Dunitz Limited. London, UK. 2001; 57-80.

Stoddart JH, Ladd D, Bronson RT, Harmon M, Jaworski J, Pritzker C, Lausen N, Smith BD. Transgenic mice with a mutated collagen promoter display normal response during bleomycin-induced fibrosis and possess neurological abnormalities. J Cell Biochem. 2000 Feb; 77(1):135-48. PMID: 10679824

Sengupta PK, Ehrlich M, Smith BD. A methylation-responsive MDBP/RFX site is in the first exon of the collagen alpha2(I) promoter. J Biol Chem. 1999 Dec 17; 274(51):36649-55.View Related Profiles.

Smith, Barbara
Sengupta, Pritam

PMID: 10593968

Sengupta PK, Smith BD. Methylation in the initiation region of the first exon suppresses collagen pro-alpha2(I) gene transcription. Biochim Biophys Acta. 1998 Nov 26; 1443(1-2):75-89.View Related Profiles.

Smith, Barbara
Sengupta, Pritam

PMID: 9838053

Lim AL, Doyle SA, Balian G, Smith BD. Role of the pro-alpha2(I) COOH-terminal region in assembly of type I collagen: truncation of the last 10 amino acid residues of pro-alpha2(I) chain prevents assembly of type I collagen heterotrimer. J Cell Biochem. 1998 Nov 1; 71(2):216-32. PMID: 9779820

Doyle SA, Smith BD. Role of the pro-alpha2(I) COOH-terminal region in assembly of type I collagen: disruption of two intramolecular disulfide bonds in pro-alpha2(I) blocks assembly of type I collagen. J Cell Biochem. 1998 Nov 1; 71(2):233-42. PMID: 9779821

Smith BD, Svoboda KKH, Schreider B. Selected abstracts of the Seventeenth Annual Meeting of the East Coast Connective Tissue Society. Matrix Biology. 1997; 16(3):117. View Publication

Agarwal AR, Goldstein RH, Lucey E, Ngo HQ, Smith BD. Cell-specific expression of the alpha 1 (I) collagen promoter-CAT transgene in skin and lung: a response to TGF-beta subcutaneous injection and bleomycin endotracheal instillation. J Cell Biochem. 1996 Nov 1; 63(2):135-48.View Related Profiles.

Smith, Barbara
Goldstein, Ronald

PMID: 8913866

Lucey EC, Ngo HQ, Agarwal A, Smith BD, Snider GL, Goldstein RH. Differential expression of elastin and alpha 1(I) collagen mRNA in mice with bleomycin-induced pulmonary fibrosis. Lab Invest. 1996 Jan; 74(1):12-20.View Related Profiles.

Smith, Barbara
Goldstein, Ronald

PMID: 8569173

Fine A, Panchenko MP, Smith BD, Yu Q, Goldstein RH. Discordant regulation of transforming growth factor-beta receptors by prostaglandin E2. Biochim Biophys Acta. 1995 Mar 14; 1261(1):19-24.View Related Profiles.

Fine, Alan
Smith, Barbara
Goldstein, Ronald

PMID: 7893757

Moreland RB, Traish A, McMillin MA, Smith B, Goldstein I, Saenz de Tejada I. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol. 1995 Mar; 153(3 Pt 1):826-34.View Related Profiles.

Traish, Abdulmaged
Smith, Barbara

PMID: 7861547

Lim A, Greenspan DS, Smith BD. Expression of alpha 2 type I collagen in W8 cells increases cell adhesion and decreases colony formation in soft agar. Matrix Biol. 1994 Jan; 14(1):21-30. PMID: 8061917

Ritzenthaler JD, Goldstein RH, Fine A, Smith BD. Regulation of the alpha 1(I) collagen promoter via a transforming growth factor-beta activation element. J Biol Chem. 1993 Jun 25; 268(18):13625-31.View Related Profiles.

Fine, Alan
Smith, Barbara
Goldstein, Ronald

PMID: 8514794

Minto AW, Fogel MA, Natori Y, O'Meara YM, Abrahamson DR, Smith B, Salant DJ. Expression of type I collagen mRNA in glomeruli of rats with passive Heymann nephritis. Kidney Int. 1993 Jan; 43(1):121-7.View Related Profiles.

Smith, Barbara
Salant, David

PMID: 8433551

Guenette DK, Ritzenthaler JD, Foley J, Jackson JD, Smith BD. DNA methylation inhibits transcription of procollagen alpha 2(I) promoters. Biochem J. 1992 May 1; 283 ( Pt 3):699-703. PMID: 1590760; PMCID: PMC1130942

Fine A, Matsui R, Zhan X, Poliks CF, Smith BD, Goldstein RH. Discordant regulation of human type I collagen genes by prostaglandin E2. Biochim Biophys Acta. 1992 Apr 30; 1135(1):67-72.View Related Profiles.

Fine, Alan
Smith, Barbara
Matsui, Reiko
Goldstein, Ronald

PMID: 1375511

Ritzenthaler JD, Goldstein RH, Fine A, Lichtler A, Rowe DW, Smith BD. Transforming-growth-factor-beta activation elements in the distal promoter regions of the rat alpha 1 type I collagen gene. Biochem J. 1991 Nov 15; 280 ( Pt 1):157-62.View Related Profiles.

Fine, Alan
Smith, Barbara
Goldstein, Ronald

PMID: 1741743; PMCID: PMC1130614

Smith BD. Mechanisms for non-coordinate expression of type 1 collagen alpha chains. In: Structure, Molecular biology and pathology of collagen. Annals NY Acad Sci. 1990; 580:459-461.

Fine A, Poliks CF, Smith BD, Goldstein RH. The accumulation of type I collagen mRNAs in human embryonic lung fibroblasts stimulated by transforming growth factor-beta. Connect Tissue Res. 1990; 24(3-4):237-47.View Related Profiles.

Fine, Alan
Smith, Barbara
Goldstein, Ronald

PMID: 2376126

Baldwin CT, Silbert JE, Humphries DE, Cogburn JN, Smith BD. Increased proteoglycan synthesis following the differentiation of F9 embryonal carcinoma cells: formation of a differentiation-specific proteoheparan sulfate. Matrix. 1989 Nov; 9(5):389-96.View Related Profiles.

Smith, Barbara
Baldwin, Clinton

PMID: 2615695

Fine A, Poliks CF, Donahue LP, Smith BD, Goldstein RH. The differential effect of prostaglandin E2 on transforming growth factor-beta and insulin-induced collagen formation in lung fibroblasts. J Biol Chem. 1989 Oct 15; 264(29):16988-91.View Related Profiles.

Fine, Alan
Smith, Barbara
Goldstein, Ronald

PMID: 2676997

Goldstein RH, Poliks CF, Pilch PF, Smith BD, Fine A. Stimulation of collagen formation by insulin and insulin-like growth factor I in cultures of human lung fibroblasts. Endocrinology. 1989 Feb; 124(2):964-70.View Related Profiles.

Fine, Alan
Smith, Barbara
Pilch, Paul
Goldstein, Ronald

PMID: 2463909

Smith BD, Baldwin CT. Undifferentiated F9 embryonal carcinoma cells produce a short-chain collagen molecule. Biochem J. 1988 Oct 1; 255(1):85-9.View Related Profiles.

Smith, Barbara
Baldwin, Clinton

PMID: 2848513; PMCID: PMC1135193

Lee ST, Smith BD, Greenspan DS. Construction of a full-length cDNA encoding human pro-alpha 2(I) collagen and its expression in pro-alpha 2(I)-deficient W8 rat cells. J Biol Chem. 1988 Sep 15; 263(26):13414-8. PMID: 2843520

Smith BD, Marsilio E. Methylation of the alpha 2(I) collagen gene in chemically transformed rat liver epithelial cells. Biochem J. 1988 Jul 1; 253(1):269-73. PMID: 3421946; PMCID: PMC1149285

Cronlund AL, Smith BD, Kagan HM. Binding of lysyl oxidase to fibrils of type I collagen. Connect Tissue Res. 1985; 14(2):109-19.View Related Profiles.

Smith, Barbara
Kagan, Herbert

PMID: 2866930

Dvorak HF, Form DM, Manseau EJ, Smith BD. Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds. J Natl Cancer Inst. 1984 Nov; 73(5):1195-205. PMID: 6387242

Form DM, VanDeWater L, Dvorak HF, Smith BD. Pathogenesis of tumor desmoplasia. II. Collagens synthesized by line 1 and line 10 guinea pig carcinoma cells and by syngeneic fibroblasts in vitro. J Natl Cancer Inst. 1984 Nov; 73(5):1207-14. PMID: 6092769

Marsilio E, Sobel ME, Smith BD. Absence of procollagen alpha 2(I) mRNA in chemically transformed rat liver epithelial cells. J Biol Chem. 1984 Feb 10; 259(3):1401-4. PMID: 6198325

Smith BD, Mahoney AP, Feldman RS. Inverse correlation of collagen production to anchorage independence and tumorigenicity in W8- and M-cell lines. Cancer Res. 1983 Sep; 43(9):4275-82. PMID: 6871864

Senger DR, Asch BB, Smith BD, Perruzzi CA, Dvorak HF. A secreted phosphoprotein marker for neoplastic transformation of both epithelial and fibroblastic cells. Nature. 1983 Apr 21; 302(5910):714-5. PMID: 6835406

Yue BY, Baum JL, Smith BD. Identification of collagens synthesized by cultures of normal human corneal and keratoconus stromal cells. Biochim Biophys Acta. 1983 Feb 22; 755(3):318-25.View Related Profiles.

Smith, Barbara
Baum, Jules

PMID: 6337647

Smith BD, Silbert CK. Fibronectin and collagen of cultured skin fibroblasts in diabetes mellitus. Biochem Biophys Res Commun. 1981 May 15; 100(1):275-82. PMID: 7259749

Beldekas JC, Smith B, Gerstenfeld LC, Sonenshein GE, Franzblau C. Effects of 17 beta-estradiol on the biosynthesis of collagen in cultured bovine aortic smooth muscle cells. Biochemistry. 1981 Apr 14; 20(8):2162-7.View Related Profiles.

Smith, Barbara
Sonenshein, Gail
Gerstenfeld, Louis

PMID: 6263309

Smith BD, Niles R. Characterization of collagen synthesized by normal and chemically transformed rat liver epithelial cell lines. Biochemistry. 1980 Apr 29; 19(9):1820-5. PMID: 7378375

Smith BD, Biles D, Gonnerman W, Faris B, Levine A, Capparell N, Moolten F, Franzblau C. Collagen synthesis in normal BHK cells and temperature-sensitive chemically transformed BHK cells. In Vitro. 1979 Jun; 15(6):455-62.View Related Profiles.

Smith, Barbara
Gonnerman, Wayne

PMID: 225263

Yue BY, Baum JL, Smith BD. Collagen synthesis by cultures of stromal cells from normal human and keratoconus corneas. Biochem Biophys Res Commun. 1979 Feb 14; 86(3):465-72.View Related Profiles.

Smith, Barbara
Baum, Jules

PMID: 426795

Moro L, Smith BD. Identification of collagen alpha1(I) trimer and normal type I collagen in a polyoma virus-induced mouse tumor. Arch Biochem Biophys. 1977 Jul; 182(1):33-41. PMID: 196556

Smith BD, McKenney KH, Lustberg TJ. Characterization of collagen precursors found in rat skin and rat bone. Biochemistry. 1977 Jun 28; 16(13):2980-5. PMID: 195597

Lichtenstein JR, Byers PH, Smith BD, Martin GR. Identification of the collagenous proteins synthesized by cultured cells from human skin. Biochemistry. 1975 Apr 22; 14(8):1589-94. PMID: 1092340

Smith BD, Martin GR, Miller EJ, Dorfman A, Swarm R. Nature of the collagen synthesized by a transplanted chondrosarcoma. Arch Biochem Biophys. 1975 Jan; 166(1):181-6. PMID: 1122133

Martin GR, Byers PH, Smith BD . On the nature of polypeptide precursors of collagen. In: Biology of the Fibroblast. Kulonen, E. and Pikkarainen, J. (eds.). Academic Press. New York. 1973; 339-342.

Smith BD, Byers PH, Martin GR. Production of procollagen by human fibroblasts in culture. Proc Natl Acad Sci U S A. 1972 Nov; 69(11):3260-2. PMID: 4508318; PMCID: PMC389749

Lent RW, Smith B, Salcedo LL, Faris B, Franzblau C. Studies on the reduction of elastin. II. Evidence for the presence of alpha-aminoadipic acid delta-semialdehyde and its aldol condensation product. Biochemistry. 1969 Jul; 8(7):2837-45. PMID: 5808336

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 33 distinct years, with a maximum of 5 publications in 2006

Bar chart showing 63 publications over 33 distinct years, with a maximum of 5 publications in 2006

Year	Publications
1980	1
1981	2
1983	3
1984	3
1985	1
1988	3
1989	3
1990	2
1991	1
1992	2
1993	2
1994	1
1995	2
1996	2
1997	1
1998	3
1999	1
2000	1
2001	2
2002	1
2003	2
2004	2
2005	1
2006	5
2007	2
2008	3
2009	1
2010	1
2011	1
2013	2
2014	2
2015	2
2016	2

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biochemistry
Collagen
DNA methylation
Extracellular matrix
fibroblasts
growth factors
interferon gamma
Molecular Biology
myocardin family
TGF-beta
transcription factors

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