Keywords
Last Name

Joseph Zaia, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 638-6762
ORCID ORCID Icon0000-0001-9497-8701
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

TitleCenter Faculty Member
InstitutionBoston University School of Medicine
DepartmentMass Spectrometry

 Research Expertise & Professional Interests
The manner in which a cell responds to many growth factor stimuli depends on interactions between glycosaminoglycans (GAGs), growth factors, and growth factor receptors. Extracellular matrix GAGs binds growth factors, creating morphogens gradients essential to tissue patterning. Because these events depend on the fine structure of the GAG chains present, regulation of GAG biosynthesis is a key factor for understanding normal and disease related cellular growth
The key to exploiting an understanding of GAG structure-function relationships for human disease therapy is to winnow oligosaccharide-protein binding patterns from heterogeneous biological preparations. Toward this end, we have developed mass spectral methods for GAGs that enable comparison of structures as a function of biological variables.

The long term research aims are (1) to develop a fundamental understanding of the manner in which glycosaminoglycan expression is varied according to the cellular growth environment related to human disease and (2) to identify HS chain structures useful as therapeutic targets.

New bioinformatics methods are essential to realizing these goals. The data produced using our methods are information rich and not amenable to manual interpretation. Further, the methods needed are distinct from those used in genomics and proteomics. We are developing bioinformatics methods appropriate for interpretation of structural data on glycosaminoglycans and other carbohydrates to identify targets for disease therapy.

 Self-Described Keywords
  • glycomics
  • glycosaminoglycan
  • heparan sulfate
  • heparin
  • mass spectrometry
  • proteoglycan
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Mao Y, Huang Y, Buczek-Thomas JA, Ethen CM, Nugent MA, Wu ZL, Zaia J. A Liquid Chromatography-Mass Spectrometry-based Approach to Characterize the Substrate Specificity of Mammalian Heparanase. J Biol Chem. 2014 Dec 5; 289(49):34141-51.
    View in: PubMed
  2. Turiák L, Shao C, Meng L, Khatri K, Leymarie N, Wang Q, Pantazopoulos H, Leon DR, Zaia J. Workflow for combined proteomics and glycomics profiling from histological tissues. Anal Chem. 2014 Oct 7; 86(19):9670-8.
    View in: PubMed
  3. Khatri K, Staples GO, Leymarie N, Leon DR, Turiák L, Huang Y, Yip S, Hu H, Heckendorf CF, Zaia J. Confident assignment of site-specific glycosylation in complex glycoproteins in a single step. J Proteome Res. 2014 Oct 3; 13(10):4347-55.
    View in: PubMed
  4. Huang Y, Mao Y, Buczek-Thomas JA, Nugent MA, Zaia J. Oligosaccharide substrate preferences of human extracellular sulfatase sulf2 using liquid chromatography-mass spectrometry based glycomics approaches. PLoS One. 2014; 9(8):e105143.
    View in: PubMed
  5. Hu H, Huang Y, Mao Y, Yu X, Xu Y, Liu J, Zong C, Boons GJ, Lin C, Xia Y, Zaia J. A Computational Framework for Heparan Sulfate Sequencing Using High-resolution Tandem Mass Spectra. Mol Cell Proteomics. 2014 Sep; 13(9):2490-502.
    View in: PubMed
  6. Wu ZL, Robey MT, Tatge T, Lin C, Leymarie N, Zou Y, Zaia J. Detecting O-GlcNAc using in vitro sulfation. Glycobiology. 2014 Aug; 24(8):740-7.
    View in: PubMed
  7. York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, Khoo KH, Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C. MIRAGE: The minimum information required for a glycomics experiment. Glycobiology. 2014 May; 24(5):402-6.
    View in: PubMed
  8. Hu H, Dittwald P, Zaia J, Valkenborg D. Comment on "computation of isotopic peak center-mass distribution by fourier transform". Anal Chem. 2013 Dec 17; 85(24):12189-92.
    View in: PubMed
  9. Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86.
    View in: PubMed
  10. Mathias DK, Pastrana-Mena R, Ranucci E, Tao D, Ferruti P, Ortega C, Staples GO, Zaia J, Takashima E, Tsuboi T, Borg NA, Verotta L, Dinglasan RR. A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. PLoS Pathog. 2013 Nov; 9(11):e1003757.
    View in: PubMed
  11. Ramachandra R, Namburi RB, Ortega-Martinez O, Shi X, Zaia J, Dupont ST, Thorndyke MC, Lindahl U, Spillmann D. Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling. Glycobiology. 2014 Feb; 24(2):195-207.
    View in: PubMed
  12. Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.
    View in: PubMed
  13. Shao C, Shi X, Phillips JJ, Zaia J. Mass spectral profiling of glycosaminoglycans from histological tissue surfaces. Anal Chem. 2013 Nov 19; 85(22):10984-91.
    View in: PubMed
  14. Nugent MA, Zaia J, Spencer JL. Heparan sulfate-protein binding specificity. Biochemistry (Mosc). 2013 Jul; 78(7):726-35.
    View in: PubMed
  15. Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51.
    View in: PubMed
  16. Shi X, Shao C, Mao Y, Huang Y, Wu ZL, Zaia J. LC-MS and LC-MS/MS studies of incorporation of 34SO3 into glycosaminoglycan chains by sulfotransferases. Glycobiology. 2013 Aug; 23(8):969-79.
    View in: PubMed
  17. Shao C, Shi X, White M, Huang Y, Hartshorn K, Zaia J. Comparative glycomics of leukocyte glycosaminoglycans. FEBS J. 2013 May; 280(10):2447-61.
    View in: PubMed
  18. Kolarich D, Rapp E, Struwe WB, Haslam SM, Zaia J, McBride R, Agravat S, Campbell MP, Kato M, Ranzinger R, Kettner C, York WS. The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting mass-spectrometry-based glycoanalytic data. Mol Cell Proteomics. 2013 Apr; 12(4):991-5.
    View in: PubMed
  19. Zaia J. Glycosaminoglycan glycomics using mass spectrometry. Mol Cell Proteomics. 2013 Apr; 12(4):885-92.
    View in: PubMed
  20. Gill VL, Aich U, Rao S, Pohl C, Zaia J. Disaccharide analysis of glycosaminoglycans using hydrophilic interaction chromatography and mass spectrometry. Anal Chem. 2013 Jan 15; 85(2):1138-45.
    View in: PubMed
  21. Zaia J. Capillary electrophoresis-mass spectrometry of carbohydrates. Methods Mol Biol. 2013; 984:13-25.
    View in: PubMed
  22. Maxwell E, Tan Y, Tan Y, Hu H, Benson G, Aizikov K, Conley S, Staples GO, Slysz GW, Smith RD, Zaia J. GlycReSoft: a software package for automated recognition of glycans from LC/MS data. PLoS One. 2012; 7(9):e45474.
    View in: PubMed
  23. Li L, Zhang F, Zaia J, Linhardt RJ. Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS. Anal Chem. 2012 Oct 16; 84(20):8822-9.
    View in: PubMed
  24. Gill VL, Wang Q, Shi X, Zaia J. Mass spectrometric method for determining the uronic acid epimerization in heparan sulfate disaccharides generated using nitrous acid. Anal Chem. 2012 Sep 4; 84(17):7539-46.
    View in: PubMed
  25. Tran TH, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012 Sep 21; 287(39):32651-64.
    View in: PubMed
  26. Shi X, Huang Y, Mao Y, Naimy H, Zaia J. Tandem mass spectrometry of heparan sulfate negative ions: sulfate loss patterns and chemical modification methods for improvement of product ion profiles. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1498-511.
    View in: PubMed
  27. Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60.
    View in: PubMed
  28. Leymarie N, Zaia J. Effective use of mass spectrometry for glycan and glycopeptide structural analysis. Anal Chem. 2012 Apr 3; 84(7):3040-8.
    View in: PubMed
  29. Thelin MA, Svensson KJ, Shi X, Bagher M, Axelsson J, Isinger-Ekstrand A, van Kuppevelt TH, Johansson J, Nilbert M, Zaia J, Belting M, Maccarana M, Malmström A. Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. Cancer Res. 2012 Apr 15; 72(8):1943-52.
    View in: PubMed
  30. Staples GO, Zaia J. Analysis of Glycosaminoglycans Using Mass Spectrometry. Curr Proteomics. 2011; 8:325-336.
    View in: External Website
  31. Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50.
    View in: PubMed
  32. Huang Y, Shi X, Yu X, Leymarie N, Staples GO, Yin H, Killeen K, Zaia J. Improved liquid chromatography-MS/MS of heparan sulfate oligosaccharides via chip-based pulsed makeup flow. Anal Chem. 2011 Nov 1; 83(21):8222-9.
    View in: PubMed
  33. Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL. Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo. J Biol Chem. 2011 Nov 25; 286(47):40681-92.
    View in: PubMed
  34. Bielik AM, Zaia J. Multistage Tandem Mass Spectrometry of Chondroitin Sulfate and Dermatan Sulfate. Int J Mass Spectrom. 2011 Aug 15; 305(2-3):131-137.
    View in: PubMed
  35. Leymarie N, McComb ME, Naimy H, Staples GO, Zaia J. Differential Characterization and Classification of Tissue Specific Glycosaminoglycans by Tandem Mass Spectrometry and Statistical Methods. Int J Mass Spectrom. 2012 Feb 15; 312:144-154.
    View in: PubMed
  36. Schumacher VA, Schlötzer-Schrehardt U, Karumanchi SA, Shi X, Zaia J, Jeruschke S, Zhang D, Pavenstädt H, Pavenstaedt H, Drenckhan A, Amann K, Ng C, Hartwig S, Ng KH, Ho J, Kreidberg JA, Taglienti M, Royer-Pokora B, Ai X. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol. 2011 Jul; 22(7):1286-96.
    View in: PubMed
  37. Naimy H, Buczek-Thomas JA, Nugent MA, Leymarie N, Zaia J. Highly sulfated nonreducing end-derived heparan sulfate domains bind fibroblast growth factor-2 with high affinity and are enriched in biologically active fractions. J Biol Chem. 2011 Jun 3; 286(22):19311-9.
    View in: PubMed
  38. Staples GO, Shi X, Zaia J. Glycomics analysis of mammalian heparan sulfates modified by the human extracellular sulfatase HSulf2. PLoS One. 2011; 6(2):e16689.
    View in: PubMed
  39. Staples GO, Zaia J. In Carbohydrate Recognition; Wang B, Boons GJ, Eds. John Wiley & Sons, Inc. Hoboken. 2011; 257-300.
  40. Zaia J. At last, functional glycomics. Nat Methods. 2011 Jan; 8(1):55-7.
    View in: PubMed
  41. Dreyfuss JM, Jacobs C, Gindin Y, Benson G, Staples GO, Zaia J. Targeted analysis of glycomics liquid chromatography/mass spectrometry data. Anal Bioanal Chem. 2011 Jan; 399(2):727-35.
    View in: PubMed
  42. Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61.
    View in: PubMed
  43. Zaia J. Mass spectrometry and glycomics. OMICS. 2010 Aug; 14(4):401-18.
    View in: PubMed
  44. Naimy H, Leymarie N, Zaia J. Screening for anticoagulant heparan sulfate octasaccharides and fine structure characterization using tandem mass spectrometry. Biochemistry. 2010 May 4; 49(17):3743-52.
    View in: PubMed
  45. Staples GO, Shi X, Zaia J. Extended N-sulfated domains reside at the nonreducing end of heparan sulfate chains. J Biol Chem. 2010 Jun 11; 285(24):18336-43.
    View in: PubMed
  46. Bowman MJ, Zaia J. Comparative glycomics using a tetraplex stable-isotope coded tag. Anal Chem. 2010 Apr 1; 82(7):3023-31.
    View in: PubMed
  47. Staples GO, Naimy H, Yin H, Kileen K, Kraiczek K, Costello CE, Zaia J. Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup flow. Anal Chem. 2010 Jan 15; 82(2):516-22.
    View in: PubMed
  48. Bielik AM, Zaia J. Historical overview of glycoanalysis. Methods Mol Biol. 2010; 600:9-30.
    View in: PubMed
  49. Bielik AM, Zaia J. Extraction of chondroitin/dermatan sulfate glycosaminoglycans from connective tissue for mass spectrometric analysis. Methods Mol Biol. 2010; 600:215-25.
    View in: PubMed
  50. Zaia J. On-line separations combined with MS for analysis of glycosaminoglycans. Mass Spectrom Rev. 2009 Mar-Apr; 28(2):254-72.
    View in: PubMed
  51. Shi X, Zaia J. Organ-specific heparan sulfate structural phenotypes. J Biol Chem. 2009 May 1; 284(18):11806-14.
    View in: PubMed
  52. Staples GO, Bowman MJ, Costello CE, Hitchcock AM, Lau JM, Leymarie N, Miller C, Naimy H, Shi X, Zaia J. A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling. Proteomics. 2009 Feb; 9(3):686-95.
    View in: PubMed
  53. Hitchcock AM, Bowman MJ, Staples GO, Zaia J. Improved workup for glycosaminoglycan disaccharide analysis using CE with LIF detection. Electrophoresis. 2008 Nov; 29(22):4538-48.
    View in: PubMed
  54. Zaia J. Mass spectrometry and the emerging field of glycomics. Chem Biol. 2008 Sep 22; 15(9):881-92.
    View in: PubMed
  55. Hitchcock AM, Yates KE, Costello CE, Zaia J. Comparative glycomics of connective tissue glycosaminoglycans. Proteomics. 2008 Apr; 8(7):1384-97.
    View in: PubMed
  56. Naimy H, Leymarie N, Bowman MJ, Zaia J. Characterization of heparin oligosaccharides binding specifically to antithrombin III using mass spectrometry. Biochemistry. 2008 Mar 11; 47(10):3155-61.
    View in: PubMed
  57. Bowman MJ, Zaia J. Tags for the stable isotopic labeling of carbohydrates and quantitative analysis by mass spectrometry. Anal Chem. 2007 Aug 1; 79(15):5777-84.
    View in: PubMed
  58. Zaia J, Miller MJ, Seymour JL, Costello CE. The role of mobile protons in negative ion CID of oligosaccharides. J Am Soc Mass Spectrom. 2007 May; 18(5):952-60.
    View in: PubMed
  59. Hitchcock AM, Yates KE, Shortkroff S, Costello CE, Zaia J. Optimized extraction of glycosaminoglycans from normal and osteoarthritic cartilage for glycomics profiling. Glycobiology. 2007 Jan; 17(1):25-35.
    View in: PubMed
  60. Ziegler A, Zaia J. Size-exclusion chromatography of heparin oligosaccharides at high and low pressure. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6; 837(1-2):76-86.
    View in: PubMed
  61. Seymour JL, Costello CE, Zaia J. The influence of sialylation on glycan negative ion dissociation and energetics. J Am Soc Mass Spectrom. 2006 Jun; 17(6):844-54.
    View in: PubMed
  62. Hitchcock AM, Costello CE, Zaia J. Glycoform quantification of chondroitin/dermatan sulfate using a liquid chromatography-tandem mass spectrometry platform. Biochemistry. 2006 Feb 21; 45(7):2350-61.
    View in: PubMed
  63. Miller MJ, Costello CE, Malmström A, Zaia J. A tandem mass spectrometric approach to determination of chondroitin/dermatan sulfate oligosaccharide glycoforms. Glycobiology. 2006 Jun; 16(6):502-13.
    View in: PubMed
  64. Zaia J. In Ionization Methods; Gross ML, Caprioli RM, Eds. Elsevier. Amsterdam. 2006; 6:889-903.
  65. Zaia J. Principles of Mass Spectrometry of Glycosaminoglycans. Journal of Biomacromolecular Mass Spectrometry. 2005; 1:3-36.
  66. Naggar EF, Costello CE, Zaia J. Competing fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans. J Am Soc Mass Spectrom. 2004 Nov; 15(11):1534-44.
    View in: PubMed
  67. Zaia J. Mass spectrometry of oligosaccharides. Mass Spectrom Rev. 2004 May-Jun; 23(3):161-227.
    View in: PubMed
  68. Zaia J, Li XQ, Chan SY, Costello CE. Tandem mass spectrometric strategies for determination of sulfation positions and uronic acid epimerization in chondroitin sulfate oligosaccharides. J Am Soc Mass Spectrom. 2003 Nov; 14(11):1270-81.
    View in: PubMed
  69. Zaia J, Costello CE. Tandem mass spectrometry of sulfated heparin-like glycosaminoglycan oligosaccharides. Anal Chem. 2003 May 15; 75(10):2445-55.
    View in: PubMed
  70. McClellan JE, Costello CE, O'Connor PB, Zaia J. Influence of charge state on product ion mass spectra and the determination of 4S/6S sulfation sequence of chondroitin sulfate oligosaccharides. Anal Chem. 2002 Aug 1; 74(15):3760-71.
    View in: PubMed
  71. Zaia J, McClellan JE, Costello CE. Tandem mass spectrometric determination of the 4S/6S sulfation sequence in chondroitin sulfate oligosaccharides. Anal Chem. 2001 Dec 15; 73(24):6030-9.
    View in: PubMed
  72. Barry F, Boynton R, Murphy M, Haynesworth S, Zaia J. The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun. 2001 Nov 30; 289(2):519-24.
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  73. Zaia J, Boynton R, Heinegård D, Barry F. Posttranslational modifications to human bone sialoprotein determined by mass spectrometry. Biochemistry. 2001 Oct 30; 40(43):12983-91.
    View in: PubMed
  74. Zaia J, Costello CE. Compositional analysis of glycosaminoglycans by electrospray mass spectrometry. Anal Chem. 2001 Jan 15; 73(2):233-9.
    View in: PubMed
  75. Cheng X, Cole RN, Zaia J, Hart GW. Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta. Biochemistry. 2000 Sep 26; 39(38):11609-20.
    View in: PubMed
  76. Zaia J, Liu B, Boynton R, Barry F. Structural analysis of cartilage proteoglycans and glycoproteins using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2000 Jan 1; 277(1):94-103.
    View in: PubMed
  77. Barry FP, Boynton RE, Haynesworth S, Murphy JM, Zaia J. The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun. 1999 Nov; 265(1):134-9.
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  78. Fenselau C, Antoine MD, Fabris D, Hathout Y, He T, Zaia J. In Metallothionein IV; Klaasen C, Ed. Birkhauser. Basel. 1999; 577-580.
  79. Zaia J, Fabris D, Wei D, Karpel RL, Fenselau C. Monitoring metal ion flux in reactions of metallothionein and drug-modified metallothionein by electrospray mass spectrometry. Protein Sci. 1998 Nov; 7(11):2398-404.
    View in: PubMed
  80. van den Bos C, Rammes A, Vogl T, Boynton R, Zaia J, Sorg C, Roth J. Copurification of P6, MRP8, and MRP14 from human granulocytes and separation of individual proteins. Protein Expr Purif. 1998 Aug; 13(3):313-8.
    View in: PubMed
  81. Westaway SK, Cagnon L, Chang Z, Li S, Li H, Larson GP, Zaia JA, Rossi JJ. Virion encapsidation of tRNA(3Lys)-ribozyme chimeric RNAs inhibits HIV infection. Antisense Nucleic Acid Drug Dev. 1998 Jun; 8(3):185-97.
    View in: PubMed
  82. Bruder SP, Ricalton NS, Boynton RE, Connolly TJ, Jaiswal N, Zaia J, Barry FP. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation. J Bone Miner Res. 1998 Apr; 13(4):655-63.
    View in: PubMed
  83. Zaia J, Boynton RE, McIntosh A, Marshak DR, Olsson H, Heinegârd D, Barry FP. Post-translational modifications in cartilage oligomeric matrix protein. Characterization of the N-linked oligosaccharides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Biol Chem. 1997 May 30; 272(22):14120-6.
    View in: PubMed
  84. Zaia J, Jiang L, Han MS, Tabb JR, Wu Z, Fabris D, Fenselau C. A binding site for chlorambucil on metallothionein. Biochemistry. 1996 Mar 5; 35(9):2830-5.
    View in: PubMed
  85. Fabris D, Zaia J, Hathout Y, Fenselau C. Retention of thiol protons in two classes of protein zinc ion coordination centers. J Am Chem Soc. 1996; 118:12242-12243.
    View in: External Website
  86. Zaia J. Charged derivatives for peptide sequencing using a magnetic sector instrument. Methods Mol Biol. 1996; 61:29-41.
    View in: PubMed
  87. Zaia J, Biemann K. Comparison of charged derivatives for high energy collision-induced dissociation tandem mass spectrometry. J Am Soc Mass Spectrom. 1995; 6(5):428-436.
    View in: External Website
  88. Westaway SK, Larson GP, Li S, Zaia JA, Rossi JJ. A chimeric tRNA(Lys3)-ribozyme inhibits HIV replication following virion assembly. Nucleic Acids Symp Ser. 1995; (33):194-9.
    View in: PubMed
  89. Zhou C, Bahner IC, Larson GP, Zaia JA, Rossi JJ, Kohn EB. Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene. 1994 Nov 4; 149(1):33-9.
    View in: PubMed
  90. Day BW, Skipper PL, Zaia J, Singh K, Tannenbaum SR. Enantiospecificity of covalent adduct formation by benzo[a]pyrene anti-diol epoxide with human serum albumin. Chem Res Toxicol. 1994 Nov-Dec; 7(6):829-35.
    View in: PubMed
  91. Zaia J, Biemann K. Characteristics of high energy collision-induced dissociation tandem mass spectra of polycyclic aromatic hydrocarbon diolepoxide adducted peptides. J Am Soc Mass Spectrom. 1994; 5(7):649-654.
    View in: External Website
  92. Zaia J, Biemann K. Proteinase K activity inhibited near amino acids carrying large substituents: three PAH diolepoxides covalently modify His-146 human serum albumin residues. J Am Chem Soc. 1994; 116:7407-7408.
    View in: External Website
  93. Zaia J, Annan RS, Biemann K. The correct molecular weight of myoglobin, a common calibrant for mass spectrometry. Rapid Commun Mass Spectrom. 1992 Jan; 6(1):32-6.
    View in: PubMed
  94. Pande H, Campo K, Shanley JD, Creeger ES, Artishevsky A, Gallez-Hawkins G, Zaia JA. Characterization of a 52K protein of murine cytomegalovirus and its immunological cross-reactivity with the DNA-binding protein ICP36 of human cytomegalovirus. J Gen Virol. 1991 Jun; 72 ( Pt 6):1421-7.
    View in: PubMed
  95. Day BW, Skipper PL, Zaia J, Tannenbaum SR. Benzo[a]pyrene anti-diol epoxide covalently modifies human serum albumin carboxylate side chains and imidazole side chains of histidine(146). J Am Chem Soc. 1991; 113:8505-8509.
    View in: External Website
  96. Nicholson-Weller A, Zaia J, Raum MG, Coligan JE. Decay accelerating factor (DAF) peptide sequences share homology with a consensus sequence found in the superfamily of structurally related complement proteins and other proteins including haptoglobin, factor XIII, beta 2-glycoprotein I, and the IL-2 receptor. Immunol Lett. 1987 Apr; 14(4):307-11.
    View in: PubMed
  97. Wenzel TJ, Zaia J. Organic-Soluble Lanthanide Nuclear-Magnetic-Resonance Shift-Reagents for Sulfonium and Isothiouronium Salts. Anal Chem. 1987; 59:562-567.
    View in: External Website
  98. Wenzel TJ, Zaia J. Lanthanide Tetrakis (Beta-Diketonates) as Effective NMR Shift-Reagents for Organic Salts. J Org Chem. 1985; 50:1322-1324.
    View in: External Website
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