Keywords
Last Name

Nader Rahimi, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 638-5011
ORCID ORCID Icon0000-0002-6745-1725
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentOphthalmology

 Research Expertise & Professional Interests
I have a broad expertise in cell signaling in particular in receptor tyrosine kinases, protein modification (phosphorylation, methylation, ubiquitination, acetylation and proteolytic cleavage modifications). We are also expert in various mouse and cell culture based angiogenesis and tumor models.

 Self-Described Keywords
  • Pathological angiogenesis
  • Tumor Biology
  • Signal transduction
  • Post-translational modifications
  • Protein phosphorylation
  • Protein methylation
  • Ubiquitination
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Chandler KB, Leon DR, Meyer RD, Rahimi N, Costello CE. Site-Specific N-Glycosylation of Endothelial Cell Receptor Tyrosine Kinase VEGFR-2. J Proteome Res. 2017 Feb 03; 16(2):677-688. PMID: 27966990.
    View in: PubMed
  2. Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, Mehta M, Laver NM, Costello CE, Rahimi N. IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. J Mol Biol. 2016 Dec 04; 428(24 Pt B):5019-5033. PMID: 27838321.
    View in: PubMed
  3. Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear ß-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 11 01; 7(44):71136-71150. PMID: 27661103.
    View in: PubMed
  4. Nader Rahimi 24.03.2016. THERAPEUTIC AND RESEARCH APPLICATION OF PDCL3. 2016.
    View in: External Website
  5. Maghsoudlou A, Meyer RD, Rezazadeh K, Arafa E, Pudney J, Hartsough E, Rahimi N. RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2. Traffic. 2016 Mar; 17(3):289-300. PMID: 26602861.
    View in: PubMed
  6. Huang Z, Marsiglia WM, Basu Roy U, Rahimi N, Ilghari D, Wang H, Chen H, Gai W, Blais S, Neubert TA, Mansukhani A, Traaseth NJ, Li X, Mohammadi M. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C?. Mol Cell. 2016 Jan 7; 61(1):98-110. PMID: 26687682.
    View in: PubMed
  7. Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, Schwartz JH, Chitalia V, Rahimi N. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. Am J Pathol. 2015 Oct; 185(10):2757-67. PMID: 26342724.
    View in: PubMed
  8. Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62. PMID: 26059764.
    View in: PubMed
  9. Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. The c-Cbl ubiquitin ligase regulates nuclear ß-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. J Biol Chem. 2015 May 15; 290(20):12537-46. PMID: 25784557.
    View in: PubMed
  10. Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P. Targeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cells. Chem Biol Drug Des. 2015 May; 85(5):586-97. PMID: 25298192.
    View in: PubMed
  11. Rahimi N, Costello CE. Emerging roles of post-translational modifications in signal transduction and angiogenesis. Proteomics. 2015 Jan; 15(2-3):300-9. PMID: 25161153.
    View in: PubMed
  12. Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N. Lysine methylation promotes VEGFR-2 activation and angiogenesis. Sci Signal. 2013 Dec 3; 6(304):ra104. PMID: 24300896.
    View in: PubMed
  13. Srinivasan S, Meyer RD, Lugo R, Rahimi N. Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2. J Biol Chem. 2013 Aug 9; 288(32):23171-81. PMID: 23792958.
    View in: PubMed
  14. Chitalia V, Shivanna S, Martorell J, Meyer R, Edelman E, Rahimi N. c-Cbl, a ubiquitin E3 ligase that targets active ß-catenin: a novel layer of Wnt signaling regulation. J Biol Chem. 2013 Aug 9; 288(32):23505-17. PMID: 23744067.
    View in: PubMed
  15. Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J Biol Chem. 2013 Apr 12; 288(15):10265-74. PMID: 23393131.
    View in: PubMed
  16. Rahimi N, Rezazadeh K, Mahoney JE, Hartsough E, Meyer RD. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. Mol Biol Cell. 2012 May; 23(9):1646-56. PMID: 22419821.
    View in: PubMed
  17. Rahimi N. The ubiquitin-proteasome system meets angiogenesis. Mol Cancer Ther. 2012 Mar; 11(3):538-48. PMID: 22357635.
    View in: PubMed
  18. Meyer RD, Srinivasan S, Singh AJ, Mahoney JE, Gharahassanlou KR, Rahimi N. PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation. Mol Cell Biol. 2011 May; 31(10):2010-25. PMID: 21402774.
    View in: PubMed
  19. Boucher I, Kehasse A, Marcincin M, Rich C, Rahimi N, Trinkaus-Randall V. Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. Am J Pathol. 2011 Mar; 178(3):1092-105. PMID: 21356361.
    View in: PubMed
  20. Meyer RD, Husain D, Rahimi N. c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLC?1. Oncogene. 2011 May 12; 30(19):2198-206. PMID: 21242968.
    View in: PubMed
  21. Husain D, Meyer RD, Mehta M, Pfeifer WM, Chou E, Navruzbekov G, Ahmed E, Rahimi N. Role of c-Cbl-dependent regulation of phospholipase Cgamma1 activation in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6803-9. PMID: 20592236.
    View in: PubMed
  22. Rahimi N. A role for protein ubiquitination in VEGFR-2 signalling and angiogenesis. Biochem Soc Trans. 2009 Dec; 37(Pt 6):1189-92. PMID: 19909244.
    View in: PubMed
  23. Rahimi N, Golde TE, Meyer RD. Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells. Cancer Res. 2009 Mar 15; 69(6):2607-14. PMID: 19276374.
    View in: PubMed
  24. Meyer RD, Sacks DB, Rahimi N. IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PLoS One. 2008; 3(12):e3848. PMID: 19050761.
    View in: PubMed
  25. Singh AJ, Meyer RD, Navruzbekov G, Shelke R, Duan L, Band H, Leeman SE, Rahimi N. A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5413-8. PMID: 17372230.
    View in: PubMed
  26. Rahimi N. Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials. Exp Eye Res. 2006 Nov; 83(5):1005-16. PMID: 16713597.
    View in: PubMed
  27. Meyer RD, Qian X, Guo HC, Rahimi N. Leucine motif-dependent tyrosine autophosphorylation of type III receptor tyrosine kinases. J Biol Chem. 2006 Mar 31; 281(13):8620-7. PMID: 16431914.
    View in: PubMed
  28. Rahimi N. VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Biosci. 2006; 11:818-29. PMID: 16146773.
    View in: PubMed
  29. Meyer RD, Mohammadi M, Rahimi N. A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1. J Biol Chem. 2006 Jan 13; 281(2):867-75. PMID: 16286478.
    View in: PubMed
  30. Singh AJ, Meyer RD, Band H, Rahimi N. The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Mol Biol Cell. 2005 Apr; 16(4):2106-18. PMID: 15673613.
    View in: PubMed
  31. Meyer RD, Singh A, Majnoun F, Latz C, Lashkari K, Rahimi N. Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation. Oncogene. 2004 Jul 15; 23(32):5523-31. PMID: 15107818.
    View in: PubMed
  32. Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem. 2004 May 21; 279(21):22267-75. PMID: 15026417.
    View in: PubMed
  33. Chua CC, Rahimi N, Forsten-Williams K, Nugent MA. Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2. Circ Res. 2004 Feb 20; 94(3):316-23. PMID: 14684627.
    View in: PubMed
  34. Meyer RD, Rahimi N. Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems? Ann N Y Acad Sci. 2003 May; 995:200-7. PMID: 12814952.
    View in: PubMed
  35. Meyer RD, Latz C, Rahimi N. Recruitment and activation of phospholipase Cgamma1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells. J Biol Chem. 2003 May 2; 278(18):16347-55. PMID: 12598525.
    View in: PubMed
  36. Meyer RD, Dayanir V, Majnoun F, Rahimi N. The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules. J Biol Chem. 2002 Jul 26; 277(30):27081-7. PMID: 12023952.
    View in: PubMed
  37. Dayanir V, Meyer RD, Lashkari K, Rahimi N. Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. J Biol Chem. 2001 May 25; 276(21):17686-92. PMID: 11278468.
    View in: PubMed
  38. Rahimi N, Dayanir V, Lashkari K. Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem. 2000 Jun 2; 275(22):16986-92. PMID: 10747927.
    View in: PubMed
  39. Lashkari K, Hirose T, Yazdany J, McMeel JW, Kazlauskas A, Rahimi N. Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. Am J Pathol. 2000 Apr; 156(4):1337-44. PMID: 10751359.
    View in: PubMed
  40. Qiao H, Saulnier R, Patryzkat A, Rahimi N, Raptis L, Rossiter J, Tremblay E, Elliott B. Cooperative effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for phosphatidylinositol 3-kinase activity. Cell Growth Differ. 2000 Feb; 11(2):123-33. PMID: 10714768.
    View in: PubMed
  41. Rahimi N, Kazlauskas A. A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells. Mol Biol Cell. 1999 Oct; 10(10):3401-7. PMID: 10512875.
    View in: PubMed
  42. Lashkari K, Rahimi N, Kazlauskas A. Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 1999 Jan; 40(1):149-56. PMID: 9888438.
    View in: PubMed
  43. Rahimi N, Hung W, Tremblay E, Saulnier R, Elliott B. c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells. J Biol Chem. 1998 Dec 11; 273(50):33714-21. PMID: 9837958.
    View in: PubMed
  44. Rahimi N, Tremblay E, McAdam L, Roberts A, Elliott B. Autocrine secretion of TGF-beta 1 and TGF-beta 2 by pre-adipocytes and adipocytes: a potent negative regulator of adipocyte differentiation and proliferation of mammary carcinoma cells. In Vitro Cell Dev Biol Anim. 1998 May; 34(5):412-20. PMID: 9639104.
    View in: PubMed
  45. Rahimi N, Tremblay E, Elliott B. Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells. J Biol Chem. 1996 Oct 4; 271(40):24850-5. PMID: 8798760.
    View in: PubMed
  46. Rahimi N, Etchells S, Elliott B. Hepatocyte growth factor (HGF) is a copper-binding protein: a facile probe for purification of HGF by immobilized Cu(II)-affinity chromatography. Protein Expr Purif. 1996 May; 7(3):329-33. PMID: 8860660.
    View in: PubMed
  47. Rahimi N, Tremblay E, McAdam L, Park M, Schwall R, Elliott B. Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma. Cell Growth Differ. 1996 Feb; 7(2):263-70. PMID: 8822210.
    View in: PubMed
  48. Saulnier R, Bhardwaj B, Klassen J, Leopold D, Rahimi N, Tremblay E, Mosher D, Elliott B. Fibronectin fibrils and growth factors stimulate anchorage-independent growth of a murine mammary carcinoma. Exp Cell Res. 1996 Feb 1; 222(2):360-9. PMID: 8598224.
    View in: PubMed
  49. Rahimi N, Saulnier R, Nakamura T, Park M, Elliott B. Role of hepatocyte growth factor in breast cancer: a novel mitogenic factor secreted by adipocytes. DNA Cell Biol. 1994 Dec; 13(12):1189-97. PMID: 7811385.
    View in: PubMed
  50. Nader Rahimi. METHOD FOR CONTROLLING TUMOR GROWTH, ANGIOGENESIS AND METASTASIS USING IMMUNOGLOBULIN CONTAINING AND PROLINE RICH RECEPTOR-1 (IGPR-1).
    View in: External Website
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