Keywords
Last Name

Peter R. Polgar, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-4717
ORCID ORCID Icon0000-0002-9112-1101
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Green DS, Rupasinghe C, Warburton R, Wilson JL, Sallum CO, Taylor L, Yatawara A, Mierke D, Polgar P, Hill N. A cell permeable Peptide targeting the intracellular loop 2 of endothelin B receptor reduces pulmonary hypertension in a hypoxic rat model. PLoS One. 2013; 8(11):e81309.
    View in: PubMed
  2. Yatawara A, Wilson JL, Taylor L, Polgar P, Mierke DF. C-terminus of ETA/ETB receptors regulate endothelin-1 signal transmission. J Pept Sci. 2013 Apr; 19(4):257-62.
    View in: PubMed
  3. Yu J, Taylor L, Wilson J, Comhair S, Erzurum S, Polgar P. Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension. J Cell Physiol. 2013 Feb; 228(2):322-9.
    View in: PubMed
  4. Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64.
    View in: PubMed
  5. Sallum CO, Wilson JL, Rupasinghe C, Berg E, Yu J, Green DS, Taylor L, Mierke D, Polgar P. Enhancing and limiting endothelin-1 signaling with a cell-penetrating peptide mimicking the third intracellular loop of the ETB receptor. Chem Biol Drug Des. 2012 Sep; 80(3):374-81.
    View in: PubMed
  6. Yu J, Taylor L, Rich C, Toselli P, Stone P, Green D, Warburton R, Hill N, Goldstein R, Polgar P. Transgenic expression of an altered angiotensin type I AT1 receptor resulting in marked modulation of vascular type I collagen. J Cell Physiol. 2012 May; 227(5):2013-21.
    View in: PubMed
  7. Wilson JL, Taylor L, Polgar P. Endothelin-1 activation of ETB receptors leads to a reduced cellular proliferative rate and an increased cellular footprint. Exp Cell Res. 2012 Jun 10; 318(10):1125-33.
    View in: PubMed
  8. Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1554-62.
    View in: PubMed
  9. Yu J, Taylor L, Mierke D, Berg E, Shia M, Fishman J, Sallum C, Polgar P. Limiting angiotensin II signaling with a cell-penetrating peptide mimicking the second intracellular loop of the angiotensin II type-I receptor. Chem Biol Drug Des. 2010 Jul; 76(1):70-6.
    View in: PubMed
  10. Huang Z, Yu J, Toselli P, Bhawan J, Sudireddy V, Taylor L, Polgar P. Angiotensin II type 1 and bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells. J Cell Physiol. 2007 Jun; 211(3):816-25.
    View in: PubMed
  11. Yu J, Lubinsky D, Tsomaia N, Huang Z, Taylor L, Mierke D, Navarro J, Miraz O, Polgar P. Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells. J Cell Biochem. 2007 May 1; 101(1):192-204.
    View in: PubMed
  12. Huang Z, Taylor L, Liu B, Yu J, Polgar P. Modulation by bradykinin of angiotensin type 1 receptor-evoked RhoA activation of connective tissue growth factor expression in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1291-9.
    View in: PubMed
  13. Liu B, Yu J, Taylor L, Zhou X, Polgar P. Microarray and phosphokinase screenings leading to studies on ERK and JNK regulation of connective tissue growth factor expression by angiotensin II 1a and bradykinin B2 receptors in Rat1 fibroblasts. J Cell Biochem. 2006 Apr 1; 97(5):1104-20.
    View in: PubMed
  14. Yu J, Polgar P, Lubinsky D, Gupta M, Wang L, Mierke D, Taylor L. Coulombic and hydrophobic interactions in the first intracellular loop are vital for bradykinin B2 receptor ligand binding and consequent signal transduction. Biochemistry. 2005 Apr 12; 44(14):5295-306.
    View in: PubMed
  15. Piserchio A, Zelesky V, Yu J, Taylor L, Polgar P, Mierke DF. Bradykinin B2 receptor signaling: structural and functional characterization of the C-terminus. Biopolymers. 2005; 80(2-3):367-73.
    View in: PubMed
  16. Yu J, Liu B, Eramian D, Mierke D, Taylor L, Polgar P. K317, R319, and E320 within the proximal C-terminus of the bradykinin B2 receptor form a motif important for phospholipase C and phospholipase A2 but not connective tissue growth factor related signaling. J Cell Biochem. 2004 Jun 1; 92(3):547-59.
    View in: PubMed
  17. Pal-Ghosh R, Yu J, Prado GN, Taylor L, Mierke DF, Polgar P. Chimeric exchanges within the bradykinin B2 receptor intracellular face with the prostaglandin EP2 receptor as the donor: importance of the second intracellular loop for cAMP synthesis. Arch Biochem Biophys. 2003 Jul 1; 415(1):54-62.
    View in: PubMed
  18. Yu J, Prado GN, Taylor L, Pal-Ghosh R, Polgar P. Hybrid formation between the intracellular faces of the bradykinin B2 and angiotensin II AT1 receptors and signal transduction. Int Immunopharmacol. 2002 Dec; 2(13-14):1807-22.
    View in: PubMed
  19. Prado GN, Taylor L, Zhou X, Ricupero D, Mierke DF, Polgar P. Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors. J Cell Physiol. 2002 Dec; 193(3):275-86.
    View in: PubMed
  20. Yu J, Prado GN, Schreiber B, Polgar P, Polgar P, Taylor L. Role of prostaglandin E(2) EP receptors and cAMP in the expression of connective tissue growth factor. Arch Biochem Biophys. 2002 Aug 15; 404(2):302-8.
    View in: PubMed
  21. Piserchio A, Prado GN, Zhang R, Yu J, Taylor L, Polgar P, Mierke DF. Structural insight into the role of the second intracellular loop of the bradykinin 2 receptor in signaling and internalization. Biopolymers. 2002 Apr 5; 63(4):239-46.
    View in: PubMed
  22. Yu J, Prado GN, Taylor L, Piserchio A, Gupta A, Mierke DF, Polgar P. Global chimeric exchanges within the intracellular face of the bradykinin B2 receptor with corresponding angiotensin II type Ia receptor regions: generation of fully functional hybrids showing characteristic signaling of the AT1a receptor. J Cell Biochem. 2002; 85(4):809-19.
    View in: PubMed
  23. Prado GN, Mierke DF, LeBlanc T, Manseau M, Taylor L, Yu J, Zhang R, Pal-Ghosh R, Polgar P. Role of hydroxyl containing residues in the intracellular region of rat bradykinin B(2) receptor in signal transduction, receptor internalization, and resensitization. J Cell Biochem. 2001 Aug 21-Sep 5; 83(3):435-47.
    View in: PubMed
  24. Yang X, Taylor L, Yu J, Fenton MJ, Polgar P. Mediator caused induction of a human bradykinin B1 receptor minigene: participation of c-Jun in the process. J Cell Biochem. 2001 Apr 2-27; 82(1):163-70.
    View in: PubMed
  25. Yang X, Taylor L, Polgar P. p53 down-regulates human bradykinin B1 receptor gene expression. J Cell Biochem. 2001 Apr 2-27; 82(1):38-45.
    View in: PubMed
  26. Zhou X, Prado GN, Taylor L, Yang X, Polgar P. Regulation of inducible bradykinin B1 receptor gene expression through absence of internalization and resensitization. J Cell Biochem. 2000 Jun 6; 78(3):351-62.
    View in: PubMed
  27. Yang X, Taylor L, Polgar P. Effect of the G-protein, G alpha(i2), and G alpha(i3) subunit knockdown on bradykinin-induced signal transduction in rat-1 cells. Mol Cell Biol Res Commun. 1999 Jun; 1(3):227-36.
    View in: PubMed
  28. Zhou X, Prado GN, Chai M, Yang X, Taylor L, Polgar P. Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region. Mol Cell Biol Res Commun. 1999 Apr; 1(1):29-35.
    View in: PubMed
  29. Prado GN, Mierke DF, Pellegrini M, Taylor L, Polgar P. Motif mutation of bradykinin B2 receptor second intracellular loop and proximal C terminus is critical for signal transduction, internalization, and resensitization. J Biol Chem. 1998 Dec 11; 273(50):33548-55.
    View in: PubMed
  30. Choung J, Taylor L, Thomas K, Zhou X, Kagan H, Yang X, Polgar P. Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts. J Cell Biochem. 1998 Nov 1; 71(2):254-63.
    View in: PubMed
  31. Yang X, Taylor L, Polgar P. Mechanisms in the transcriptional regulation of bradykinin B1 receptor gene expression. Identification of a minimum cell-type specific enhancer. J Biol Chem. 1998 Apr 24; 273(17):10763-70.
    View in: PubMed
  32. Zhou X, Polgar P, Taylor L. Roles for interleukin-1beta, phorbol ester and a post-transcriptional regulator in the control of bradykinin B1 receptor gene expression. Biochem J. 1998 Feb 15; 330 ( Pt 1):361-6.
    View in: PubMed
  33. Ricupero DA, Polgar P, Taylor L, Sowell MO, Gao Y, Bradwin G, Mortensen RM. Enhanced bradykinin-stimulated phospholipase C activity in murine embryonic stem cells lacking the G-protein alphaq-subunit. Biochem J. 1997 Nov 1; 327 ( Pt 3):803-9.
    View in: PubMed
  34. Prado GN, Taylor L, Polgar P. Effects of intracellular tyrosine residue mutation and carboxyl terminus truncation on signal transduction and internalization of the rat bradykinin B2 receptor. J Biol Chem. 1997 Jun 6; 272(23):14638-42.
    View in: PubMed
  35. Yang X, Hou F, Taylor L, Polgar P. Characterization of human cyclooxygenase 2 gene promoter localization of a TGF-beta response element. Biochim Biophys Acta. 1997 Feb 28; 1350(3):287-92.
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  36. Roy R, Polgar P, Wang Y, Goldstein RH, Taylor L, Kagan HM. Regulation of lysyl oxidase and cyclooxygenase expression in human lung fibroblasts: interactions among TGF-beta, IL-1 beta, and prostaglandin E. J Cell Biochem. 1996 Sep 1; 62(3):411-7.
    View in: PubMed
  37. Yang X, Polgar P. Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions. Biochem Biophys Res Commun. 1996 May 24; 222(3):718-25.
    View in: PubMed
  38. Boak AM, Roy R, Berk J, Taylor L, Polgar P, Goldstein RH, Kagan HM. Regulation of lysyl oxidase expression in lung fibroblasts by transforming growth factor-beta 1 and prostaglandin E2. Am J Respir Cell Mol Biol. 1994 Dec; 11(6):751-5.
    View in: PubMed
  39. Jackson BA, Goldstein RH, Roy R, Cozzani M, Taylor L, Polgar P. Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1465-74.
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  40. Ricupero D, Taylor L, Polgar P. Interactions of bradykinin, calcium, G-protein and protein kinase in the activation of phospholipase A2 in bovine pulmonary artery endothelial cells. Agents Actions. 1993 Sep; 40(1-2):110-8.
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  41. Paglin S, Roy R, Polgar P. Characterization of hormonally regulated and particulate-associated phospholipase A2 from bovine endothelial cells. J Biol Chem. 1993 Jun 5; 268(16):11697-702.
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  42. Taylor L, Ricupero D, Jean JC, Jackson BA, Navarro J, Polgar P. Functional expression of the bradykinin-B2 receptor cDNA in Chinese hamster lung CCL39 fibroblasts. Biochem Biophys Res Commun. 1992 Oct 30; 188(2):786-93.
    View in: PubMed
  43. Ricupero D, Taylor L, Tlucko A, Navarro J, Polgar P. Mechanisms in bradykinin stimulated arachidonate release and synthesis of prostaglandin and platelet activating factor. Mediators Inflamm. 1992; 1(2):133-40.
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  44. Goldstein RH, Fine A, Farnsworth LJ, Poliks C, Polgar P. Phorbol ester-induced inhibition of collagen accumulation by human lung fibroblasts. J Biol Chem. 1990 Aug 15; 265(23):13623-8.
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  45. Yang CY, Gonnerman WA, Polgar PR. The action of parathyroid hormone on bone metabolism may be regulated by endogenously synthesized prostaglandin E2. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:435-8.
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  46. Yang CY, Gonnerman WA, Menconi M, Taylor L, Polgar PR. Isolation and culture of two cell populations from chick calvaria by density gradient: prostaglandin synthesis by the cells in culture and coculture. Endocrinology. 1988 Nov; 123(5):2549-56.
    View in: PubMed
  47. Cahill M, Fishman JB, Polgar P. Effect of des arginine9-bradykinin and other bradykinin fragments on the synthesis of prostacyclin and the binding of bradykinin by vascular cells in culture. Agents Actions. 1988 Jul; 24(3-4):224-31.
    View in: PubMed
  48. Bielinski D, McCrory M, Cahill M, Polgar P, Fishman JB. Differential coupling of smooth muscle and liver vasopressin (V1) receptors to guanine nucleotide binding proteins. Biochem Biophys Res Commun. 1988 Mar 30; 151(3):1293-8.
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  49. Heinsohn C, Polgar P, Fishman J, Taylor L. The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. Arch Biochem Biophys. 1987 Sep; 257(2):251-8.
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  50. Taylor L, Foxall T, Auger K, Heinsohn C, Polgar P. Comparison of prostaglandin synthesis by endothelial cells from blood vessels originating in the rat, baboon, calf and human. Atherosclerosis. 1987 Jun; 65(3):227-36.
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  51. Menconi M, Taylor L, Martin B, Polgar P. A review: prostaglandins, aging, and blood vessels. J Am Geriatr Soc. 1987 Mar; 35(3):239-47.
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  52. Yang CY, Gonnerman WA, Taylor L, Nimberg RB, Polgar PR. Synthetic human parathyroid hormone fragment stimulates prostaglandin E2 synthesis by chick calvariae. Endocrinology. 1987 Jan; 120(1):63-70.
    View in: PubMed
  53. Goldstein RH, Sakowski S, Meeker D, Franzblau C, Polgar P. The effect of prostaglandin E2 (PGE2) on amino acid uptake and protein formation by lung fibroblasts. J Biol Chem. 1986 Jul 5; 261(19):8734-7.
    View in: PubMed
  54. Menconi M, Hahn G, Polgar P. Prostaglandin synthesis by cells comprising the calf pulmonary artery. J Cell Physiol. 1984 Aug; 120(2):163-8.
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  55. Taylor L, Menconi MJ, Polgar P. The participation of hydroperoxides and oxygen radicals in the control of prostaglandin synthesis. J Biol Chem. 1983 Jun 10; 258(11):6855-7.
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  56. Goldstein RH, Miller K, Glassroth J, Linscott R, Snider GL, Franzblau C, Polgar P. Influence of asbestos fibers on collagen and prostaglandin production in fibroblast and macrophage co-cultures. J Lab Clin Med. 1982 Nov; 100(5):778-85.
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  57. Taylor L, Menconi M, Leibowitz MH, Polgar P. The effect of ascorbate, hydroperoxides, and bradykinin on prostaglandin production by corneal and lens cells. Invest Ophthalmol Vis Sci. 1982 Sep; 23(3):378-82.
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  58. Goldstein RH, Polgar P. The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts. J Biol Chem. 1982 Aug 10; 257(15):8630-3.
    View in: PubMed
  59. Taylor L, Polgar P. Cell growth and the regulation of prostaglandin synthesis. Prostaglandins. 1981 Nov; 22(5):723-8.
    View in: PubMed
  60. Taylor L, Schneider E, Smith J, Polgar P. Prostaglandin production and cellular aging. Mech Ageing Dev. 1981; 16(4):311-7.
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  61. Polgar P, Taylor L. Stimulation of prostaglandin synthesis by ascorbic acid via hydrogen peroxide formation. Prostaglandins. 1980 May; 19(5):693-700.
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  62. Polgar P, Taylor L. Alterations in prostaglandin synthesis during senescence of human lung fibroblasts. Mech Ageing Dev. 1980 Apr; 12(4):305-10.
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  63. Polgar P, Douglas WH, Terracio L, Taylor L. Release of arachidonic acid and its conversion to prostaglandins in various diploid cell types in culture. Adv Prostaglandin Thromboxane Res. 1980; 6:225-9.
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  64. Polgar P, Taylor L, Downing D. Unsaturated fatty acid effect on cyclic AMP levels in human embryo lung fibroblasts. Prostaglandins. 1979 Jul; 18(1):43-52.
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  65. Taylor L, Polgar P, McAteer JA, Douglas WH. Prostaglandin production by type II alveolar epithelial cells. Biochim Biophys Acta. 1979 Mar 29; 572(3):502-9.
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  66. Polgar P, Taylor L, Brown L. Plasma membrane associated metabolic parameters and the aging of human diploid fibroblasts. Mech Ageing Dev. 1978 Feb; 7(2):151-61.
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  67. Taylor L, Polgar P. Self regulation of growth by human diploid fibroblasts via prostaglandin production. FEBS Lett. 1977 Jul 1; 79(1):69-72.
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  68. Polgar P, Taylor L. Effects of prostaglandin on substrate uptake and cell division in human diploid fibroblasts. Biochem J. 1977 Jan 15; 162(1):1-8.
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  69. Kuritz MJ, Polgar P, Taylor L, Rutenburg AM. The role of adenosine 3':5'-cyclic monophosphate in the division of WI 38 cells. The cellular response to prostaglandin E1 and the effects of an cyclic adenosine 3':5'-cyclic monophosphate analogue and prostaglandin E1 on cell division. Biochem J. 1974 Aug; 142(2):339-44.
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  70. Polgar PR, Foster JM, Cooperband SR. Glycolysis as an energy source for stimulation of lymphocytes by phytohemagglutinin. Exp Cell Res. 1968 Feb; 49(2):231-7.
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