Keywords
Last Name

Ivana Delalle, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
DivisionAnatomic Pathology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 414-7014
ORCID ORCID Icon0000-0002-1873-3064
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentNeurology

 Research Expertise & Professional Interests
I. During the progression of AD, hippocampal neurons show degenerative as well as regenerative changes, possibly influenced by the set of molecular regulators that may modify brain reserve, the ability of brain to tolerate pathological changes in AD before manifesting clinical signs and symptoms. My group hypothesizes that expression of these molecules in the hippocampal neurons will correlate with the cognitive function of the participants of the Framingham Heart Study.
II. Small non-coding RNA molecules (microRNAs, miRNAs) are known to regulate genes involved in brain functions negatively affected in neuropsychiatric disorders. My group hypothesizes that exosomes, secretory vesicles recently shown to comprise miRNAs, harbor differential miRNA content in the postmortem brain tissue of patients diagnosed with either bipolar disorder (BD) or schizophrenia (SCH), or of normal controls. The results of our analysis may help elucidate neuropathological mechanisms underlying BD and SCH as well as identify biological markers for BD and SCH.

 Self-Described Keywords
  • biomarkers
  • bipolar disorder
  • cytoskeleton
  • exosomal miRNAs
  • neurodegeneration
  • schizophrenia
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Adams SL, Tilton K, Kozubek JA, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2016 Aug; 75(8):779-790. PMID: 27346750.
    View in: PubMed
  2. Šimic G, Babic Leko M, Wray S, Harrington CR, Delalle I, Jovanov-Miloševic N, Bažadona D, Buée L, de Silva R, Di Giovanni G, Wischik CM, Hof PR. Monoaminergic neuropathology in Alzheimer's disease. Prog Neurobiol. 2016 Apr 12. PMID: 27084356.
    View in: PubMed
  3. Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. 2016 Mar 16; 89(6):1208-22. PMID: 26924435.
    View in: PubMed
  4. Šimic G, Babic Leko M, Wray S, Harrington C, Delalle I, Jovanov-Miloševic N, Bažadona D, Buée L, de Silva R, Di Giovanni G, Wischik C, Hof PR. Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies. Biomolecules. 2016 Jan 06; 6(1):6. PMID: 26751493.
    View in: PubMed
  5. Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH. Activity-dependent p25 generation regulates synaptic plasticity and Aß-induced cognitive impairment. Cell. 2014 Apr 10; 157(2):486-98. PMID: 24725413.
    View in: PubMed
  6. Qin B, Tabbara AK, Delalle I, Holsapple J, Hohler A. An enigmatic brainstem posterior fossa ganglioglioma in an adult. Int J Neurosci. 2014 Sep; 124(9):704-6. PMID: 24405263.
    View in: PubMed
  7. Berkowitz AL, Sheu SH, Rose MF, Delalle I, Folkerth RD. Bilirubin labeling of borderzone and anterior cerebral artery territory infarction. Neurology. 2013 Oct 1; 81(14):1272-3. PMID: 24081962.
    View in: PubMed
  8. Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A. Insulin growth factor binding protein 7 is a novel target to treat dementia. Neurobiol Dis. 2014 Feb; 62:135-43. PMID: 24075854.
    View in: PubMed
  9. Thaci B, Burns JD, Delalle I, Vu T, Davies KG. Intractable hiccups resolved after resection of a cavernous malformation of the medulla oblongata. Clin Neurol Neurosurg. 2013 Oct; 115(10):2247-50. PMID: 23932467.
    View in: PubMed
  10. Banigan MG, Kao PF, Kozubek JA, Winslow AR, Medina J, Costa J, Schmitt A, Schneider A, Cabral H, Cagsal-Getkin O, Vanderburg CR, Delalle I. Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients. PLoS One. 2013; 8(1):e48814. PMID: 23382797.
    View in: PubMed
  11. Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64. PMID: 22710966.
    View in: PubMed
  12. Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature. 2012 Mar 8; 483(7388):222-6. PMID: 22388814.
    View in: PubMed
  13. Stapleton CJ, Walcott BP, Kahle KT, Codd PJ, Nahed BV, Chen L, Robison NJ, Delalle I, Goumnerova LC, Jackson EM. Diffuse central neurocytoma with craniospinal dissemination. J Clin Neurosci. 2012 Jan; 19(1):163-6. PMID: 22088950.
    View in: PubMed
  14. Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A. microRNA-34c is a novel target to treat dementias. EMBO J. 2011 Oct 19; 30(20):4299-308. PMID: 21946562.
    View in: PubMed
  15. Toshkezi G, Edalat F, O'Hara C, Delalle I, Chin LS. Primary intramedullary histiocytic sarcoma. World Neurosurg. 2010 Oct-Nov; 74(4-5):523-7. PMID: 21492606.
    View in: PubMed
  16. Kao PF, Davis DA, Banigan MG, Vanderburg CR, Seshadri S, Delalle I. Modulators of cytoskeletal reorganization in CA1 hippocampal neurons show increased expression in patients at mid-stage Alzheimer's disease. PLoS One. 2010; 5(10):e13337. PMID: 20967212.
    View in: PubMed
  17. Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol. 2009 Oct; 7(10):e1000208. PMID: 19806181.
    View in: PubMed
  18. Saad A, Tuli S, Ali EN, Houtchens M, Delalle I, Kesari S. Pilocytic astrocytoma of the spinal cord in an adult. J Neurooncol. 2008 Jun; 88(2):189-91. PMID: 18340405.
    View in: PubMed
  19. Saad AG, Jayarao M, Chin LS, Delalle I. Ganglioglioma associated with cerebral cortical dysplasia: an unusual case with extensive leptomeningeal involvement. Pediatr Dev Pathol. 2008 Nov-Dec; 11(6):474-8. PMID: 18338935.
    View in: PubMed
  20. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79. PMID: 17581637.
    View in: PubMed
  21. Delalle I, Pfleger CM, Buff E, Lueras P, Hariharan IK. Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration. Genetics. 2005 Dec; 171(4):1757-65. PMID: 16143599.
    View in: PubMed
  22. Alderson LM, Delalle I. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-2002. A 52-year-old woman with recurrent unsteadiness, slurred speech, and fatigue. N Engl J Med. 2002 Mar 28; 346(13):1009-15. PMID: 11919311.
    View in: PubMed
  23. Brouns MR, Matheson SF, Hu KQ, Delalle I, Caviness VS, Silver J, Bronson RT, Settleman J. The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development. 2000 Nov; 127(22):4891-903. PMID: 11044403.
    View in: PubMed
  24. Delalle I, Takahashi T, Nowakowski RS, Tsai LH, Caviness VS. Cyclin E-p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE: a quantitative analysis of mRNA in situ hybridization. Cereb Cortex. 1999 Dec; 9(8):824-32. PMID: 10601001.
    View in: PubMed
  25. Delalle I, Bhide PG, Caviness VS, Tsai LH. Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J Neurocytol. 1997 May; 26(5):283-96. PMID: 9192293.
    View in: PubMed
  26. Delalle I, Evers P, Kostovic I, Uylings HB. Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development. J Comp Neurol. 1997 Mar 24; 379(4):515-22. PMID: 9067840.
    View in: PubMed
  27. Uylings HB, Delalle I. Morphology of neuropeptide Y-immunoreactive neurons and fibers in human prefrontal cortex during prenatal and postnatal development. J Comp Neurol. 1997 Mar 24; 379(4):523-40. PMID: 9067841.
    View in: PubMed
  28. Caviness VS, Takahashi T, Miyama S, Nowakowski RS, Delalle I. Regulation of normal proliferation in the developing cerebrum potential actions of trophic factors. Exp Neurol. 1996 Feb; 137(2):357-66. PMID: 8635552.
    View in: PubMed
  29. Tsai LH, Delalle I, Caviness VS, Chae T, Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature. 1994 Sep 29; 371(6496):419-23. PMID: 8090221.
    View in: PubMed
  30. Kostovic I, Judas M, Kostovic-Knezevic L, Simic G, Delalle I, Chudy D, Sajin B, Petanjek Z. Zagreb research collection of human brains for developmental neurobiologists and clinical neuroscientists. Int J Dev Biol. 1991 Sep; 35(3):215-30. PMID: 1687658.
    View in: PubMed
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