Keywords
Last Name

Tarik Haydar, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4209
ORCID ORCID Icon0000-0001-6772-3076
 Awards and Honors

Start-EndDescription
1994-1996University of Maryland School of Medicine: Membrane Biology Program Fellowship
1996-1997University of Maryland School of Medicine: Neuroscience Program Fellowship
1997University of Maryland School of Medicine: Graduate Merit Award
2008CNMC: Master Mentor
 Research Expertise & Professional Interests
Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).

 Self-Described Keywords
  • confocal
  • development
  • DNA regulation
  • in utero electroporation
  • neocortex
  • time-lapse imaging
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Goodliffe JW, Olmos-Serrano JL, Aziz NM, Pennings JL, Guedj F, Bianchi DW, Haydar TF. Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome. J Neurosci. 2016 Mar 9; 36(10):2926-44. PMID: 26961948.
    View in: PubMed
  2. Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. 2016 Mar 16; 89(6):1208-22. PMID: 26924435.
    View in: PubMed
  3. Olmos-Serrano JL, Tyler WA, Cabral HJ, Haydar TF. Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome. Exp Neurol. 2016 May; 279:40-56. PMID: 26854932.
    View in: PubMed
  4. Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. J Neurosci. 2015 Oct 14; 35(41):13843-52. PMID: 26468184.
    View in: PubMed
  5. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93. PMID: 26436904.
    View in: PubMed
  6. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52. PMID: 25878286.
    View in: PubMed
  7. Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72. PMID: 24218590.
    View in: PubMed
  8. Tyler WA, Haydar TF. Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome. J Neurosci. 2013 Mar 20; 33(12):5106-19. PMID: 23516277.
    View in: PubMed
  9. Haydar TF, Reeves RH. Trisomy 21 and early brain development. Trends Neurosci. 2012 Feb; 35(2):81-91. PMID: 22169531.
    View in: PubMed
  10. Best TK, Cramer NP, Chakrabarti L, Haydar TF, Galdzicki Z. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Exp Neurol. 2012 Feb; 233(2):749-57. PMID: 22178330.
    View in: PubMed
  11. Hevner RF, Haydar TF. The (not necessarily) convoluted role of basal radial glia in cortical neurogenesis. Cereb Cortex. 2012 Feb; 22(2):465-8. PMID: 22116731.
    View in: PubMed
  12. Chakrabarti L, Scafidi J, Gallo V, Haydar TF. Environmental enrichment rescues postnatal neurogenesis defect in the male and female Ts65Dn mouse model of Down syndrome. Dev Neurosci. 2011; 33(5):428-41. PMID: 21865665.
    View in: PubMed
  13. Breunig JJ, Haydar TF, Rakic P. Neural stem cells: historical perspective and future prospects. Neuron. 2011 May 26; 70(4):614-25. PMID: 21609820.
    View in: PubMed
  14. Cocas LA, Georgala PA, Mangin JM, Clegg JM, Kessaris N, Haydar TF, Gallo V, Price DJ, Corbin JG. Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system. J Neurosci. 2011 Apr 6; 31(14):5313-24. PMID: 21471366.
    View in: PubMed
  15. Chakrabarti L, Best TK, Cramer NP, Carney RS, Isaac JT, Galdzicki Z, Haydar TF. Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci. 2010 Aug; 13(8):927-34. PMID: 20639873.
    View in: PubMed
  16. Tyler WA, Haydar TF. A new contribution to brain convolution: progenitor cell logistics during cortex development. Nat Neurosci. 2010 Jun; 13(6):656-7. PMID: 20498684.
    View in: PubMed
  17. Stancik EK, Navarro-Quiroga I, Sellke R, Haydar TF. Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex. J Neurosci. 2010 May 19; 30(20):7028-36. PMID: 20484645.
    View in: PubMed
  18. Loulier K, Lathia JD, Marthiens V, Relucio J, Mughal MR, Tang SC, Coksaygan T, Hall PE, Chigurupati S, Patton B, Colognato H, Rao MS, Mattson MP, Haydar TF, Ffrench-Constant C. beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol. 2009 Aug; 7(8):e1000176. PMID: 19688041.
    View in: PubMed
  19. Gadea A, Aguirre A, Haydar TF, Gallo V. Endothelin-1 regulates oligodendrocyte development. J Neurosci. 2009 Aug 12; 29(32):10047-62. PMID: 19675238.
    View in: PubMed
  20. Ma JS, Haydar TF, Radoja S. Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity. J Immunol. 2008 Oct 1; 181(7):4716-22. PMID: 18802074.
    View in: PubMed
  21. Corbin JG, Gaiano N, Juliano SL, Poluch S, Stancik E, Haydar TF. Regulation of neural progenitor cell development in the nervous system. J Neurochem. 2008 Sep; 106(6):2272-87. PMID: 18819190.
    View in: PubMed
  22. Liu X, Hashimoto-Torii K, Torii M, Haydar TF, Rakic P. The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11802-7. PMID: 18689674.
    View in: PubMed
  23. Haydar TF, Chakrabarti L. Disorders of histogenesis: Neuron Proliferation: Downs syndrome. L.R. Squire (Editor). New Encyclopedia of Neuroscience. Elsevier Ltd. UK. 2008.
  24. Slotkin JR, Chakrabarti L, Dai HN, Carney RS, Hirata T, Bregman BS, Gallicano GI, Corbin JG, Haydar TF. In vivo quantum dot labeling of mammalian stem and progenitor cells. Dev Dyn. 2007 Dec; 236(12):3393-401. PMID: 17626285.
    View in: PubMed
  25. Chakrabarti L, Galdzicki Z, Haydar TF. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci. 2007 Oct 24; 27(43):11483-95. PMID: 17959791.
    View in: PubMed
  26. Corbin JG, Haydar TF. Quantum dots for neuroscience research: new tools for old problems? Nanomedicine (Lond). 2007 Oct; 2(5):579-81. PMID: 17976020.
    View in: PubMed
  27. Ma JS, Monu N, Shen DT, Mecklenbräuker I, Radoja N, Haydar TF, Leitges M, Frey AB, Vukmanovic S, Radoja S. Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL. J Immunol. 2007 Jun 15; 178(12):7814-21. PMID: 17548619.
    View in: PubMed
  28. Navarro-Quiroga I, Chittajallu R, Gallo V, Haydar TF. Long-term, selective gene expression in developing and adult hippocampal pyramidal neurons using focal in utero electroporation. J Neurosci. 2007 May 9; 27(19):5007-11. PMID: 17494686.
    View in: PubMed
  29. Harashima C, Jacobowitz DM, Stoffel M, Chakrabarti L, Haydar TF, Siarey RJ, Galdzicki Z. Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):719-34. PMID: 16783527.
    View in: PubMed
  30. Gal JS, Morozov YM, Ayoub AE, Chatterjee M, Rakic P, Haydar TF. Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci. 2006 Jan 18; 26(3):1045-56. PMID: 16421324.
    View in: PubMed
  31. Liu X, Wang Q, Haydar TF, Bordey A. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat Neurosci. 2005 Sep; 8(9):1179-87. PMID: 16116450.
    View in: PubMed
  32. Haydar TF. Advanced microscopic imaging methods to investigate cortical development and the etiology of mental retardation. Ment Retard Dev Disabil Res Rev. 2005; 11(4):303-16. PMID: 16240412.
    View in: PubMed
  33. Cheng A, Haydar TF, Yarowsky PJ, Krueger BK. Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex. Dev Neurosci. 2004 Mar-Aug; 26(2-4):255-65. PMID: 15711065.
    View in: PubMed
  34. Ang ES, Haydar TF, Gluncic V, Rakic P. Four-dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex. J Neurosci. 2003 Jul 2; 23(13):5805-15. PMID: 12843285.
    View in: PubMed
  35. Gallo V, Haydar T. GABA: exciting again in its own right. J Physiol. 2003 Aug 1; 550(Pt 3):665. PMID: 12807982.
    View in: PubMed
  36. Haydar TF, Ang E, Rakic P. Mitotic spindle rotation and mode of cell division in the developing telencephalon. Proc Natl Acad Sci U S A. 2003 Mar 4; 100(5):2890-5. PMID: 12589023.
    View in: PubMed
  37. Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 2001 Sep 15; 15(18):2421-32. PMID: 11562351.
    View in: PubMed
  38. Haydar TF, Wang F, Schwartz ML, Rakic P. Differential modulation of proliferation in the neocortical ventricular and subventricular zones. J Neurosci. 2000 Aug 1; 20(15):5764-74. PMID: 10908617.
    View in: PubMed
  39. Haydar TF, Nowakowski RS, Yarowsky PJ, Krueger BK. Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. J Neurosci. 2000 Jun 1; 20(11):4156-64. PMID: 10818151.
    View in: PubMed
  40. Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P. Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc Natl Acad Sci U S A. 2000 Jan 4; 97(1):466-71. PMID: 10618441.
    View in: PubMed
  41. Haydar TF, Bambrick LL, Krueger BK, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex. Brain Res Brain Res Protoc. 1999 Dec; 4(3):425-37. PMID: 10592354.
    View in: PubMed
  42. Haydar TF, Kuan CY, Flavell RA, Rakic P. The role of cell death in regulating the size and shape of the mammalian forebrain. Cereb Cortex. 1999 Sep; 9(6):621-6. PMID: 10498280.
    View in: PubMed
  43. Flavell RA, Kuida K, Zheng TS, Haydar TF, Kuan C-Y, Su MS, Rakic P. The role of caspases in apoptosis in vivo studied by gene targeting. SKB Symposium. 1999.
  44. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998 Aug 7; 94(3):325-37. PMID: 9708735.
    View in: PubMed
  45. Haydar TF, Blue ME, Molliver ME, Krueger BK, Yarowsky PJ. Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome. J Neurosci. 1996 Oct 1; 16(19):6175-82. PMID: 8815899.
    View in: PubMed
  46. Cascone PJ, Haydar TF, Simon AE. Sequences and structures required for recombination between virus-associated RNAs. Science. 1993 May 7; 260(5109):801-5. PMID: 8484119.
    View in: PubMed
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