Tarik Haydar, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Maryland School of Medicine



Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).

2008 CNMC: Master Mentor
1997 University of Maryland School of Medicine: Graduate Merit Award
1996-1997 University of Maryland School of Medicine: Neuroscience Program Fellowship
1994-1996 University of Maryland School of Medicine: Membrane Biology Program Fellowship


Assessment of infection route and vulnerability of neural precursor classes to Zika virus
09/30/2016 - 08/31/2018 (PI)
NIH/National Institute of Neurological D
1R21NS101151-01

Heterogeneity of Forebrain Neural Precursors
09/30/2015 - 06/30/2018 (PI)
NIH/National Institute of Neurological D
5R01NS095654-02

Role of FOXR1 in Mammalian Brain Development
07/01/2015 - 06/30/2018 (Co-PI)
NIH/National Institute of General Medica
5R21GM114629-02

Altered development and function of the spinal cord in Down syndrome
04/01/2016 - 03/31/2018 (PI)
NIH/National Institute of Neurological D
5R21NS095340-02

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (PI)
NIH/National Institute of Neurological D
5R21NS089340-02

Rescue of Forebrain Defects in Mouse Models of Down Syndrome
09/19/2011 - 08/31/2017 (PI)
NIH/National Institute of Neurological D
5R01NS076503-07

Role of CLASP2 in Neurodevelopment
12/01/2013 - 11/30/2016 (Co-PI)
NIH/National Institute of Mental Health
5R21MH100581-02

Heterogeneity of forebrain neural precursors
01/15/2010 - 12/31/2015 (PI)
NIH/National Institute of Neurological D
5R01NS051852-11




Yr Title Project-Sub Proj Pubs
2017 Assessment of infection route and vulnerability of neural precursor classes to Zika virus 5R21NS101151-02
2017 Altered development and function of the spinal cord in Down syndrome 5R21NS095340-02
2017 Heterogeneity of Forebrain Neural Precursors 5R01NS095654-03 1
2016 Assessment of infection route and vulnerability of neural precursor classes to Zika virus 1R21NS101151-01
2016 Altered development and function of the spinal cord in Down syndrome 1R21NS095340-01A1
2016 Heterogeneity of Forebrain Neural Precursors 5R01NS095654-02 1
2015 Heterogeneity of Forebrain Neural Precursors 1R01NS095654-01 1
2015 Effects of neural precursor lineage on pyramidal neuron function and morphology 5R21NS089340-02
2015 Rescue of Forebrain Defects in Mouse Models of Down syndrome 5R01NS076503-07 7
2014 Effects of neural precursor lineage on pyramidal neuron function and morphology 1R21NS089340-01A1
Showing 10 of 34 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A. CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Neuron. 2017 Mar 22; 93(6):1344-1358.e5.View Related Profiles. PMID: 28285824; DOI: 10.1016/j.neuron.2017.02.039;.
  2. Goodliffe JW, Olmos-Serrano JL, Aziz NM, Pennings JL, Guedj F, Bianchi DW, Haydar TF. Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome. J Neurosci. 2016 Mar 9; 36(10):2926-44.View Related Profiles. PMID: 26961948; PMCID: PMC4783496; DOI: 10.1523/JNEUROSCI.2513-15.2016;.
  3. Olmos-Serrano JL, Tyler WA, Cabral HJ, Haydar TF. Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome. Exp Neurol. 2016 May; 279:40-56.View Related Profiles. PMID: 26854932; DOI: 10.1016/j.expneurol.2016.02.005;.
  4. Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. J Neurosci. 2015 Oct 14; 35(41):13843-52. PMID: 26468184; DOI: 10.1523/JNEUROSCI.2775-15.2015;.
  5. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles. PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.
  6. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52.View Related Profiles. PMID: 25878286; PMCID: PMC4397608; DOI: 10.1523/JNEUROSCI.0335-15.2015;.
  7. Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer''s disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72.View Related Profiles. PMID: 24218590; PMCID: PMC3845152; DOI: 10.1073/pnas.1319297110;.
  8. Tyler WA, Haydar TF. Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome. J Neurosci. 2013 Mar 20; 33(12):5106-19.View Related Profiles. PMID: 23516277; PMCID: PMC3785112; DOI: 10.1523/JNEUROSCI.5380-12.2013;.
  9. Haydar TF, Reeves RH. Trisomy 21 and early brain development. Trends Neurosci. 2012 Feb; 35(2):81-91. PMID: 22169531; PMCID: PMC3273608; DOI: 10.1016/j.tins.2011.11.001;.
  10. Best TK, Cramer NP, Chakrabarti L, Haydar TF, Galdzicki Z. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Exp Neurol. 2012 Feb; 233(2):749-57. PMID: 22178330; DOI: 10.1016/j.expneurol.2011.11.033;.
Showing 10 of 46 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 19 distinct years, with a maximum of 6 publications in 2011

YearPublications
19931
19961
19981
19993
20003
20011
20033
20041
20052
20062
20075
20084
20092
20103
20116
20132
20153
20162
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

confocal
development
DNA regulation
in utero electroporation
neocortex
time-lapse imaging
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