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Last Name

Maria Medalla, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology
Address72 E. Concord St Housman (R)
Boston MA
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Dr. Medalla’s work combines cellular in vitro electrophysiological methods with multi-scale anatomic techniques to understand the biophysical and synaptic properties of neurons within prefrontal cortical (PFC) networks in non-human primate and rodent animal models. Her expertise includes patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling techniques for light and electron microscopy (EM), 3D serial EM, and confocal microscopy. The major goal of her work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the PFC – the central executive of the brain. Her current focus is on the medial prefrontal anterior cingulate cortex (ACC) in rhesus monkeys, an area important for attention, emotions and context-to-action transformations, and is selectively disrupted in many affective disorders such as depression and anxiety disorders.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Mar 03. PMID: 28256708.
    View in: PubMed
  2. Gilman JP, Medalla M, Luebke JI. Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2016 Mar 10. PMID: 26965903.
    View in: PubMed
  3. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93. PMID: 26436904.
    View in: PubMed
  4. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52. PMID: 25878286.
    View in: PubMed
  5. Medalla M, Luebke JI. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015 Jan 7; 35(1):112-27. PMID: 25568107.
    View in: PubMed
  6. Medalla M, Barbas H. Specialized prefrontal "auditory fields": organization of primate prefrontal-temporal pathways. Front Neurosci. 2014; 8:77. PMID: 24795553.
    View in: PubMed
  7. Luebke JI, Medalla M, Amatrudo JM, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A. Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cereb Cortex. 2015 Jun; 25(6):1454-68. PMID: 24323499.
    View in: PubMed
  8. Barbas H, Bunce JG, and Medalla M. In: Principles of Frontal Lobe Development. Stuss, DT, Knight RT, editors. Prefrontal Pathways that Control Attention. Oxford University Press. 2013; 31-48.
  9. Medalla M, Barbas H. The anterior cingulate cortex may enhance inhibition of lateral prefrontal cortex via m2 cholinergic receptors at dual synaptic sites. J Neurosci. 2012 Oct 31; 32(44):15611-25. PMID: 23115196.
    View in: PubMed
  10. Medalla M, Barbas H. Anterior cingulate synapses in prefrontal areas 10 and 46 suggest differential influence in cognitive control. J Neurosci. 2010 Dec 1; 30(48):16068-81. PMID: 21123554.
    View in: PubMed
  11. Medalla M, Barbas H. Synapses with inhibitory neurons differentiate anterior cingulate from dorsolateral prefrontal pathways associated with cognitive control. Neuron. 2009 Feb 26; 61(4):609-20. PMID: 19249280.
    View in: PubMed
  12. Medalla M, Lera P, Feinberg M, Barbas H. Specificity in inhibitory systems associated with prefrontal pathways to temporal cortex in primates. Cereb Cortex. 2007 Sep; 17 Suppl 1:i136-50. PMID: 17725996.
    View in: PubMed
  13. Medalla M, Barbas H. Diversity of laminar connections linking periarcuate and lateral intraparietal areas depends on cortical structure. Eur J Neurosci. 2006 Jan; 23(1):161-79. PMID: 16420426.
    View in: PubMed
  14. Barbas H, Medalla M, Alade O, Suski J, Zikopoulos B, Lera P. Relationship of prefrontal connections to inhibitory systems in superior temporal areas in the rhesus monkey. Cereb Cortex. 2005 Sep; 15(9):1356-70. PMID: 15635060.
    View in: PubMed
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