Maria Medalla, PhD
Assistant Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University



Dr. Medalla’s work combines cellular in vitro electrophysiological methods with multi-scale anatomic techniques to understand the biophysical and synaptic properties of neurons within prefrontal cortical (PFC) networks in non-human primate and rodent animal models. Her expertise includes patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling techniques for light and electron microscopy (EM), 3D serial EM, and confocal microscopy. The major goal of her work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the PFC – the central executive of the brain. Her current focus is on the medial prefrontal anterior cingulate cortex (ACC) in rhesus monkeys, an area important for attention, emotions and context-to-action transformations, and is selectively disrupted in many affective disorders such as depression and anxiety disorders.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



2018 Boston University: Spivack Emerging Leader


PHYSIOLOGY AND STRUCTURE OF PREFRONTAL PROJECTIONS TO MEMORY AND MOTOR CIRCUITS
09/23/2015 - 06/30/2019 (PI)
NIH/National Institute of Mental Health
5R00MH101234-05

PHYSIOLOGY AND STRUCTURE OF PREFRONTAL PROJECTIONS TO MEMORY AND MOTOR CIRCUITS
08/15/2013 - 07/31/2015 (PI)
NIH/National Institute of Mental Health
5K99MH101234-02




Yr Title Project-Sub Proj Pubs
2016 Physiology and structure of prefrontal projections to memory and motor circuits 5R00MH101234-04 1
2015 Physiology and structure of prefrontal projections to memory and motor circuits 4R00MH101234-03 1
2014 Physiology and structure of prefrontal projections to memory and motor circuits 5K99MH101234-02 3
2013 Physiology and structure of prefrontal projections to memory and motor circuits 1K99MH101234-01 3
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One. 2018; 13(8):e0200626.View Related Profiles. PMID: 30118496.
     
  2. Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2018 Feb 03.View Related Profiles. PMID: 29415216.
     
  3. Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 Jan; 21(1):72-80.View Related Profiles. PMID: 29273772.
     
  4. Medalla M, Gilman JP, Wang JY, Luebke JI. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017 May 03; 37(18):4717-4734.View Related Profiles. PMID: 28381592; DOI: 10.1523/JNEUROSCI.3757-16.2017;.
     
  5. Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15; 525(9):2175-2191.View Related Profiles. PMID: 28256708; DOI: 10.1002/cne.24196;.
     
  6. Gilman JP, Medalla M, Luebke JI. Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2017 Mar 01; 27(3):2078-2094.View Related Profiles. PMID: 26965903; DOI: 10.1093/cercor/bhw062;.
     
  7. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles. PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.
     
  8. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52.View Related Profiles. PMID: 25878286; PMCID: PMC4397608; DOI: 10.1523/JNEUROSCI.0335-15.2015;.
     
  9. Medalla M, Luebke JI. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015 Jan 7; 35(1):112-27.View Related Profiles. PMID: 25568107; PMCID: PMC4287137; DOI: 10.1523/JNEUROSCI.3426-14.2015;.
     
  10. Medalla M, Barbas H. Specialized prefrontal "auditory fields": organization of primate prefrontal-temporal pathways. Front Neurosci. 2014; 8:77. PMID: 24795553; PMCID: PMC3997038; DOI: 10.3389/fnins.2014.00077;.
     
Showing 10 of 18 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 11 distinct years, with a maximum of 4 publications in 2017

YearPublications
20051
20061
20071
20091
20101
20121
20132
20141
20153
20174
20182
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