Maria Medalla, PhD
Assistant Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University




Dr. Medalla’s work combines cellular in vitro electrophysiological methods with multi-scale anatomic techniques to understand the biophysical and synaptic properties of neurons within prefrontal cortical (PFC) networks in non-human primate and rodent animal models. Her expertise includes patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling techniques for light and electron microscopy (EM), 3D serial EM, and confocal microscopy. The major goal of her work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the PFC – the central executive of the brain. Her current focus is on the medial prefrontal anterior cingulate cortex (ACC) in rhesus monkeys, an area important for attention, emotions and context-to-action transformations, and is selectively disrupted in many affective disorders such as depression and anxiety disorders.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2018 Boston University: Spivack Emerging Leader


Circuit structure and dynamics in prefrontal-limbic networks
04/01/2019 - 01/31/2024 (PI)
NIH/National Institute of Mental Health
5R01MH116008-03

The efficacy of curcumin to facilitate recovery of function in a rhesus monkey model of cortical injury
09/30/2018 - 08/31/2021 (Multi-PI)
PI: Maria Medalla, PhD
NIH/National Institute on Aging
1R56AG059693-01

Physiology and Structure of Prefrontal Projections to Memory and Motor Circuits
09/23/2015 - 06/30/2019 (PI)
NIH/National Institute of Mental Health
5R00MH101234-05

Physiology and Structure of Prefrontal Projections to Memory and Motor Circuits
08/15/2013 - 07/31/2015 (PI)
NIH/National Institute of Mental Health
5K99MH101234-02



Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Bottenfield KR, Bowley BGE, Pessina MA, Medalla M, Rosene DL, Moore TL. Sex differences in recovery of motor function in a rhesus monkey model of cortical injury. Biol Sex Differ. 2021 Oct 09; 12(1):54.View Related Profiles. PMID: 34627376; PMCID: PMC8502310; DOI: 10.1186/s13293-021-00398-9;
     
  2. Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2021 Oct 06.View Related Profiles. PMID: 34613380
     
  3. Chang W, Weaver CM, Medalla M, Moore TL, Luebke JI. Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin. Neurobiol Aging. 2021 Sep 16; 109:113-124.View Related Profiles. PMID: 34715442
     
  4. Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci Transl Med. 2021 09 15; 13(611):eabe8455.View Related Profiles. PMID: 34524859
     
  5. Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, Kanaan NM, Wolozin B. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci U S A. 2021 03 02; 118(9).View Related Profiles. PMID: 33619090; PMCID: PMC7936275; DOI: 10.1073/pnas.2014188118;
     
  6. Go V, Sarikaya D, Zhou Y, Bowley BGE, Pessina MA, Rosene DL, Zhang ZG, Chopp M, Finklestein SP, Medalla M, Buller B, Moore TL. Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. Exp Neurol. 2021 03; 337:113540.View Related Profiles. PMID: 33264634; PMCID: PMC7946396; DOI: 10.1016/j.expneurol.2020.113540;
     
  7. Calderazzo SM, Busch SE, Moore TL, Rosene DL, Medalla M. Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex. J Comp Neurol. 2021 03; 529(4):885-904.View Related Profiles. PMID: 32677044; PMCID: PMC8214921; DOI: 10.1002/cne.24986;
     
  8. Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles. PMID: 32301581; PMCID: PMC7293582; DOI: 10.1002/alz.12089;
     
  9. LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 2020; 14:285.View Related Profiles. PMID: 32327969; PMCID: PMC7161592; DOI: 10.3389/fnins.2020.00285;
     
  10. Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, Moore TL. Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci. 2020 04 22; 40(17):3385-3407.View Related Profiles. PMID: 32241837; PMCID: PMC7178914; DOI: 10.1523/JNEUROSCI.2226-19.2020;
     
Showing 10 of 31 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 31 publications over 14 distinct years, with a maximum of 6 publications in 2020

YearPublications
20051
20061
20071
20091
20101
20121
20132
20141
20153
20174
20181
20193
20206
20215

Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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