Maria Medalla, PhD
Assistant Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University




Dr. Medalla’s work combines cellular in vitro electrophysiological methods with multi-scale anatomic techniques to understand the biophysical and synaptic properties of neurons within prefrontal cortical (PFC) networks in non-human primate and rodent animal models. Her expertise includes patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling techniques for light and electron microscopy (EM), 3D serial EM, and confocal microscopy. The major goal of her work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the PFC – the central executive of the brain. Her current focus is on the medial prefrontal anterior cingulate cortex (ACC) in rhesus monkeys, an area important for attention, emotions and context-to-action transformations, and is selectively disrupted in many affective disorders such as depression and anxiety disorders.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2018 Boston University: Spivack Emerging Leader


Circuit structure and dynamics in prefrontal-limbic networks
04/01/2019 - 01/31/2024 (PI)
NIH/National Institute of Mental Health
5R01MH116008-02

The efficacy of curcumin to facilitate recovery of function in a rhesus monkey model of cortical injury
09/30/2018 - 08/31/2020 (Multi-PI)
PI: Maria Medalla, PhD
NIH/National Institute on Aging
1R56AG059693-01

Physiology and Structure of Prefrontal Projections to Memory and Motor Circuits
09/23/2015 - 06/30/2019 (PI)
NIH/National Institute of Mental Health
5R00MH101234-05

Physiology and Structure of Prefrontal Projections to Memory and Motor Circuits
08/15/2013 - 07/31/2015 (PI)
NIH/National Institute of Mental Health
5K99MH101234-02



Title


Yr Title Project-Sub Proj Pubs
2020 Circuit structure and dynamics in prefrontal-limbic networks 5R01MH116008-02
2020 Circuit structure and dynamics in prefrontal-limbic networks 5R01MH116008-02
2019 Circuit structure and dynamics in prefrontal-limbic networks 1R01MH116008-01A1
2018 The efficacy of curcumin to facilitate recovery of function in a rhesus monkey model of cortical injury. 1R56AG059693-01
2017 Physiology and structure of prefrontal projections to memory and motor circuits 5R00MH101234-05 4
2016 Physiology and structure of prefrontal projections to memory and motor circuits 5R00MH101234-04 4
2015 Physiology and structure of prefrontal projections to memory and motor circuits 4R00MH101234-03 4
2014 Physiology and structure of prefrontal projections to memory and motor circuits 5K99MH101234-02 8
2013 Physiology and structure of prefrontal projections to memory and motor circuits 1K99MH101234-01 8

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Go V, Sarikaya D, Zhou Y, Bowley BGE, Pessina MA, Rosene DL, Zhang ZG, Chopp M, Finklestein SP, Medalla M, Buller B, Moore TL. Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. Exp Neurol. 2020 Nov 29; 337:113540.View Related Profiles. PMID: 33264634
     
  2. Calderazzo SM, Busch SE, Moore TL, Rosene DL, Medalla M. Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex. J Comp Neurol. 2021 Mar; 529(4):885-904.View Related Profiles. PMID: 32677044
     
  3. Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles. PMID: 32301581
     
  4. LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 2020; 14:285.View Related Profiles. PMID: 32327969
     
  5. Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, Moore TL. Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci. 2020 04 22; 40(17):3385-3407.View Related Profiles. PMID: 32241837
     
  6. Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2020 Feb 18.View Related Profiles. PMID: 32071385
     
  7. Go V, Bowley BGE, Pessina MA, Zhang ZG, Chopp M, Finklestein SP, Rosene DL, Medalla M, Buller B, Moore TL. Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys. Geroscience. 2020 02; 42(1):1-17.View Related Profiles. PMID: 31691891
     
  8. Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2019 03 01; 29(3):1121-1138.View Related Profiles. PMID: 29415216
     
  9. Moore TL, Bowley BGE, Pessina MA, Calderazzo SM, Medalla M, Go V, Zhang ZG, Chopp M, Finklestein S, Harbaugh AG, Rosene DL, Buller B. Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury. Restor Neurol Neurosci. 2019; 37(4):347-362.View Related Profiles. PMID: 31282441
     
  10. Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One. 2018; 13(8):e0200626.View Related Profiles. PMID: 30118496
     
Showing 10 of 26 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 26 publications over 13 distinct years, with a maximum of 6 publications in 2020

YearPublications
20051
20061
20071
20091
20101
20121
20132
20141
20153
20174
20181
20193
20206

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72 E. Concord St Housman (R)
Boston MA 02118
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