Keywords
Last Name

Weiming Xia, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Instructional (L)
Boston MA
Other Positions
InstitutionBedford VA - Edith Nourse Rogers Memorial VA Hosp

 Research Expertise & Professional Interests
Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.

Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

 NIH RePORTER Grants
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, Xia W. Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. PLoS One. 2016; 11(9):e0163072. PMID: 27684569.
    View in: PubMed
  2. Lee HK, Morin P, Xia W. Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient. Stem Cell Res. 2016 Mar; 16(2):213-5. PMID: 27345971.
    View in: PubMed
  3. Xia W, Mo H. Potential of tocotrienols in the prevention and therapy of Alzheimer's disease. J Nutr Biochem. 2016 May; 31:1-9. PMID: 27133418.
    View in: PubMed
  4. Lee HK, Morin P, Wells J, Hanlon EB, Xia W. Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells. Stem Cell Res. 2015 Sep; 15(2):325-7. PMID: 26246272.
    View in: PubMed
  5. Kong R, Chang S, Xia W, Wong ST. Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1. J Struct Biol. 2015 Aug; 191(2):120-9. PMID: 26142917.
    View in: PubMed
  6. Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, Daneshvar DH, Mez J, Solomon T, Meng G, Kubilus CA, Cormier KA, Meng S, Babcock K, Kiernan P, Murphy L, Nowinski CJ, Martin B, Dixon D, Stern RA, Cantu RC, Kowall NW, McKee AC. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015 Jul; 130(1):21-34. PMID: 25943889.
    View in: PubMed
  7. Findeis MA, Schroeder FC, Creaser SP, McKee TD, Xia W. Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts. Medicines. 2015; (2):127-140.
    View in: External Website
  8. Zhang Y, Shao H, Dong Y, Swain CA, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice. Transl Neurodegener. 2014; 3(1):8. PMID: 24725331.
    View in: PubMed
  9. Cai H, Yang Z, Cao X, Xia W, Xu X. A new iterative triclass thresholding technique in image segmentation. IEEE Trans Image Process. 2014 Mar; 23(3):1038-46. PMID: 24474373.
    View in: PubMed
  10. Shao H, Zhang Y, Dong Y, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. J Alzheimers Dis. 2014; 41(2):499-513. PMID: 24643139.
    View in: PubMed
  11. Tate B, McKee TD, Loureiro RM, Dumin JA, Xia W, Pojasek K, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS. Modulation of gamma-secretase for the treatment of Alzheimer's disease. Int J Alzheimers Dis. 2012; 2012:210756. PMID: 23320246.
    View in: PubMed
  12. Xia S, Zhu Y, Xu X, Xia W. Computational techniques in zebrafish image processing and analysis. J Neurosci Methods. 2013 Feb 15; 213(1):6-13. PMID: 23219894.
    View in: PubMed
  13. Hubbs JL, Fuller NO, Austin WF, Shen R, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives J, Bronk BS. Optimization of a natural product-based class of ?-secretase modulators. J Med Chem. 2012 Nov 8; 55(21):9270-82. PMID: 23030762.
    View in: PubMed
  14. Fuller NO, Hubbs JL, Austin WF, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives JL, Findeis MA, Bronk BS. Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside. ACS Med Chem Lett. 2012 Nov 8; 3(11):908-13. PMID: 24900406.
    View in: PubMed
  15. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing. Transl Neurodegener. 2012; 1(1):8. PMID: 23211096.
    View in: PubMed
  16. Mazumdar M, Xia W, Hofmann O, Gregas M, Ho Sui S, Hide W, Yang T, Needleman HL, Bellinger DC. Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood. Environ Health Perspect. 2012 May; 120(5):702-7. PMID: 22313790.
    View in: PubMed
  17. Townsend MK, Okereke OI, Xia W, Yang T, Selkoe DJ, Grodstein F. Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study. Alzheimer Dis Assoc Disord. 2012 Jan-Mar; 26(1):50-4. PMID: 21502851.
    View in: PubMed
  18. Xia W, Wong ST, Hanlon E, Morin P. ?-Secretase modulator in Alzheimer's disease: shifting the end. J Alzheimers Dis. 2012; 31(4):685-96. PMID: 22710916.
    View in: PubMed
  19. Chen S, Zhu Y, Xia W, Xia S, Xu X. Automated analysis of zebrafish images for phenotypic changes in drug discovery. J Neurosci Methods. 2011 Sep 15; 200(2):229-36. PMID: 21767568.
    View in: PubMed
  20. Lifshitz V, Weiss R, Benromano T, Kfir E, Blumenfeld-Katzir T, Tempel-Brami C, Assaf Y, Xia W, Wyss-Coray T, Weiner HL, Frenkel D. Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model. Neurobiol Aging. 2012 Feb; 33(2):432.e1-432.e13. PMID: 21371785.
    View in: PubMed
  21. Liu ZP, Wang Y, Zhang XS, Xia W, Chen L. Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients. Mol Biosyst. 2011 May; 7(5):1441-52. PMID: 21336338.
    View in: PubMed
  22. Xu X, Xu X, Huang X, Xia W, Xia S. A high-throughput analysis method to detect regions of interest and quantify zebrafish embryo images. J Biomol Screen. 2010 Oct; 15(9):1152-9. PMID: 20930217.
    View in: PubMed
  23. Xia W. Brain amyloid ß protein and memory disruption in Alzheimer's disease. Neuropsychiatr Dis Treat. 2010; 6:605-11. PMID: 20856923.
    View in: PubMed
  24. Huttunen HJ, Havas D, Peach C, Barren C, Duller S, Xia W, Frosch MP, Hutter-Paier B, Windisch M, Kovacs DM. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice. J Neuropathol Exp Neurol. 2010 Aug; 69(8):777-88. PMID: 20613640.
    View in: PubMed
  25. Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J Neurosci. 2010 Jun 16; 30(24):8180-9. PMID: 20554868.
    View in: PubMed
  26. Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem. 2010 Jul 16; 285(29):22350-9. PMID: 20460383.
    View in: PubMed
  27. Arslanova D, Yang T, Xu X, Wong ST, Augelli-Szafran CE, Xia W. Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors. BMC Biotechnol. 2010; 10:24. PMID: 20307292.
    View in: PubMed
  28. Yang T, Arslanova D, Xu X, Li YM, Xia W. In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors. J Neurochem. 2010 Jun; 113(5):1200-9. PMID: 20345767.
    View in: PubMed
  29. Lu Q, Ding K, Frosch MP, Jones S, Wolfe M, Xia W, Lanford GW. Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution. J Alzheimers Dis. 2010; 22(1):235-45. PMID: 20847418.
    View in: PubMed
  30. Xia W. Exploring Alzheimer's disease in zebrafish. J Alzheimers Dis. 2010; 20(4):981-90. PMID: 20182049.
    View in: PubMed
  31. Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Arch Neurol. 2009 Oct; 66(10):1247-53. PMID: 19822780.
    View in: PubMed
  32. Zhong Z, Nural H, He P, Civarella G, Beach T, Sue L, Adler C, Shill H, Caviness J, Xia W, Shen Y. Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients. Mol Neurodegener. 2009; 4:30. PMID: 19604362.
    View in: PubMed
  33. Nural H, He P, Beach T, Sue L, Xia W, Shen Y. Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients. Mol Neurodegener. 2009; 4:23. PMID: 19497122.
    View in: PubMed
  34. Zhao H, Zhu J, Cui K, Xu X, O'Brien M, Wong KK, Kesari S, Xia W, Wong ST. Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid beta protein. Cancer Cell Int. 2009; 9:15. PMID: 19480719.
    View in: PubMed
  35. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 2009 May; 66(5):620-31. PMID: 19433662.
    View in: PubMed
  36. Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Mol Neurodegener. 2009; 4:12. PMID: 19243613.
    View in: PubMed
  37. Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol. 2009 Feb; 66(2):190-9. PMID: 19204155.
    View in: PubMed
  38. Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis. 2009; 16(2):277-85. PMID: 19221417.
    View in: PubMed
  39. Yang T, Arslanova D, Gu Y, Augelli-Szafran C, Xia W. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein. Mol Brain. 2008; 1:15. PMID: 18983676.
    View in: PubMed
  40. Li G, Liu T, Nie J, Guo L, Chen J, Zhu J, Xia W, Mara A, Holley S, Wong ST. Segmentation of touching cell nuclei using gradient flow tracking. J Microsc. 2008 Jul; 231(Pt 1):47-58. PMID: 18638189.
    View in: PubMed
  41. Li F, Zhou X, Zhu J, Xia W, Ma J, Wong ST. Workflow and methods of high-content time-lapse analysis for quantifying intracellular calcium signals. Neuroinformatics. 2008; 6(2):97-108. PMID: 18506641.
    View in: PubMed
  42. Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, Dembinsky-Vaknin A, Shen J, Plante M, Burt DS, Weiner HL. A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008 May; 63(5):591-601. PMID: 18360829.
    View in: PubMed
  43. Xia W. From presenilinase to gamma-secretase, cleave to capacitate. Curr Alzheimer Res. 2008 Apr; 5(2):172-8. PMID: 18393802.
    View in: PubMed
  44. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 2; 283(18):11866-75. PMID: 18326038.
    View in: PubMed
  45. Liu T, Li G, Nie J, Tarokh A, Zhou X, Guo L, Malicki J, Xia W, Wong ST. An automated method for cell detection in zebrafish. Neuroinformatics. 2008; 6(1):5-21. PMID: 18288618.
    View in: PubMed
  46. Li G, Liu T, Nie J, Guo L, Malicki J, Mara A, Holley SA, Xia W, Wong ST. Detection of blob objects in microscopic zebrafish images based on gradient vector diffusion. Cytometry A. 2007 Oct; 71(10):835-45. PMID: 17654652.
    View in: PubMed
  47. Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007 Sep 21; 282(38):28285-95. PMID: 17684015.
    View in: PubMed
  48. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci. 2007 Feb 7; 27(6):1247-54. PMID: 17287498.
    View in: PubMed
  49. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem. 2007 Feb 16; 282(7):4318-25. PMID: 17170108.
    View in: PubMed
  50. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 6; 51(1):29-42. PMID: 16815330.
    View in: PubMed
  51. Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 2006 Mar 23; 440(7083):528-34. PMID: 16554819.
    View in: PubMed
  52. Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic. 2006 Mar; 7(3):354-64. PMID: 16497228.
    View in: PubMed
  53. Zetterberg H, Campbell WA, Yang HW, Xia W. The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis. J Biol Chem. 2006 Apr 28; 281(17):11933-9. PMID: 16507571.
    View in: PubMed
  54. Campbell WA, Yang H, Zetterberg H, Baulac S, Sears JA, Liu T, Wong ST, Zhong TP, Xia W. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem. 2006 Mar; 96(5):1423-40. PMID: 16464238.
    View in: PubMed
  55. Liu T, Lu J, Wang Y, Campbell WA, Huang L, Zhu J, Xia W, Wong ST. Computerized image analysis for quantitative neuronal phenotyping in zebrafish. J Neurosci Methods. 2006 Jun 15; 153(2):190-202. PMID: 16364449.
    View in: PubMed
  56. Baulac S, LaVoie MJ, Strahle J, Schlossmacher MG, Xia W. Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain. Mol Cell Neurosci. 2004 Nov; 27(3):236-46. PMID: 15519239.
    View in: PubMed
  57. Harnasch M, Grau S, Behrends C, Dove SL, Hochschild A, Iskandar MK, Xia W, Ehrmann M. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins. Mol Membr Biol. 2004 Nov-Dec; 21(6):373-83. PMID: 15764367.
    View in: PubMed
  58. Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis. 2003 Nov; 14(2):194-204. PMID: 14572442.
    View in: PubMed
  59. Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH. APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol. 2003 Oct 13; 163(1):83-95. PMID: 14557249.
    View in: PubMed
  60. Réchards M, Xia W, Oorschot VM, Selkoe DJ, Klumperman J. Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes. Traffic. 2003 Aug; 4(8):553-65. PMID: 12839498.
    View in: PubMed
  61. Xia W, Wolfe MS. Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci. 2003 Jul 15; 116(Pt 14):2839-44. PMID: 12808018.
    View in: PubMed
  62. Campbell WA, Reed ML, Strahle J, Wolfe MS, Xia W. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem. 2003 Jun; 85(6):1563-74. PMID: 12787075.
    View in: PubMed
  63. Xia W. Relationship between presenilinase and gamma-secretase. Drug News Perspect. 2003 Mar; 16(2):69-74. PMID: 12792666.
    View in: PubMed
  64. Xia W. Amyloid inhibitors and Alzheimer's disease. Curr Opin Investig Drugs. 2003 Jan; 4(1):55-9. PMID: 12625030.
    View in: PubMed
  65. Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y. Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med. 2003 Jan; 9(1):3-4. PMID: 12514700.
    View in: PubMed
  66. Tsai JY, Wolfe MS, Xia W. The search for gamma-secretase and development of inhibitors. Curr Med Chem. 2002 Jun; 9(11):1087-106. PMID: 12052174.
    View in: PubMed
  67. Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nat Cell Biol. 2002 May; 4(5):E110-1; author reply E111-2. PMID: 11988746.
    View in: PubMed
  68. Campbell WA, Iskandar MK, Reed ML, Xia W. Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors. Biochemistry. 2002 Mar 12; 41(10):3372-9. PMID: 11876645.
    View in: PubMed
  69. Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy SA, Takashima A. Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging. 2002 Mar-Apr; 23(2):195-203. PMID: 11804703.
    View in: PubMed
  70. Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):14-20. PMID: 11731004.
    View in: PubMed
  71. Xia W. Amyloid metabolism and secretases in Alzheimer's disease. Curr Neurol Neurosci Rep. 2001 Sep; 1(5):422-7. PMID: 11898552.
    View in: PubMed
  72. Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol Dis. 2000 Dec; 7(6 Pt B):673-81. PMID: 11114265.
    View in: PubMed
  73. Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 2000 Sep; 27(3):561-72. PMID: 11055438.
    View in: PubMed
  74. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem. 2000 Aug; 75(2):583-93. PMID: 10899933.
    View in: PubMed
  75. Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):9299-304. PMID: 10922078.
    View in: PubMed
  76. Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol. 2000 Jul; 2(7):428-34. PMID: 10878808.
    View in: PubMed
  77. Xia W. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein. Exp Gerontol. 2000 Jul; 35(4):453-60. PMID: 10959033.
    View in: PubMed
  78. Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem. 2000 Feb 4; 275(5):3173-8. PMID: 10652302.
    View in: PubMed
  79. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Ann N Y Acad Sci. 2000; 920:223-6. PMID: 11193154.
    View in: PubMed
  80. Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry. 1999 Aug 31; 38(35):11223-30. PMID: 10471271.
    View in: PubMed
  81. Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem. 1999 Jul 2; 274(27):18851-6. PMID: 10383380.
    View in: PubMed
  82. Querfurth HW, Jiang J, Xia W, Selkoe DJ. Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter. Gene. 1999 May 17; 232(1):125-41. PMID: 10333529.
    View in: PubMed
  83. Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 1999 Apr 13; 38(15):4720-7. PMID: 10200159.
    View in: PubMed
  84. Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999 Apr 8; 398(6727):513-7. PMID: 10206644.
    View in: PubMed
  85. Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 1998 Nov 24; 37(47):16465-71. PMID: 9843412.
    View in: PubMed
  86. Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiol Dis. 1998 Aug; 5(2):107-16. PMID: 9746908.
    View in: PubMed
  87. Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT, Kosik KS. A detergent-insoluble membrane compartment contains A beta in vivo. Nat Med. 1998 Jun; 4(6):730-4. PMID: 9623986.
    View in: PubMed
  88. Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. J Biol Chem. 1998 May 15; 273(20):12436-42. PMID: 9575200.
    View in: PubMed
  89. Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J Med Chem. 1998 Jan 1; 41(1):6-9. PMID: 9438016.
    View in: PubMed
  90. Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8208-13. PMID: 9223340.
    View in: PubMed
  91. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 1997 May 16; 89(4):629-39. PMID: 9160754.
    View in: PubMed
  92. Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem. 1997 Mar 21; 272(12):7977-82. PMID: 9065468.
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  93. Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis. 1997; 3(4):325-37. PMID: 9173929.
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