Weiming Xia | Profiles RNS

Weiming Xia, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, University of Texas Health Science Center at Houston
MS, University of Texas Health Science Center at Houston
BS, Fudan University

Websites

	BU ADC
	Cure Alzheimer's Fund
	LinkedIn
	ResearchGate
	BUMC
	Google Scholar

ORCID : 0000-0002-7463-3295

Dr. Xia completed his graduate studies at the University of Texas Medical School at Houston where he earned his MS and PhD degrees (Biochemistry and Molecular Biology). He completed his postdoctoral training in Alzheimer’s disease (AD) at Brigham and Women’s Hospital, Harvard Medical School. In 1999 he became Assistant Professor of Neurology at Harvard Medical School and established a NIH-funded research lab to study AD. In 2012 he joined Department of Veterans Affairs Bedford VA Medical Center, and he leads an independent lab to explore molecular mechanism and biomarkers for AD.

Dr. Xia’s research interests involve target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for AD. He has established multiple platforms to quantify pathological proteins like amyloid ß protein (Aß), Tau, neuroinflammatory factors, and related biomarkers. He also develops Mass Spectrometry-based analytic approaches to explore biomarkers for AD and other central nervous system disorders.

Bedford VA - Edith Nourse Rogers Memorial VA Hosp

BU Research
NIH RePORTER Research

Big data and small molecules for Alzheimer's disease
08/15/2019 - 03/31/2024 (Multi-PI)
PI: Weiming Xia, PhD
NIH/National Institute on Aging
3RF1AG063913-01S2

3DDS: Alzheimer's Disease Pharmacomics in 3D (Year 4)
11/01/2018 - 10/31/2023 (PI)
Cure Alzheimer's Fund

Personnel Agreement for Research Services of Joshua Daniel Jackson
09/30/2022 - 09/29/2023 (PI)
Department of Veterans Administration, Bedford

Personnel Agreement for Research Services of Joshua Jackson
10/01/2021 - 09/30/2022 (PI)
Department of Veterans Administration, Bedford

Personnel Agreement for Research Services of Jinhui Li
09/28/2021 - 09/27/2022 (PI)
Department of Veterans Administration, Bedford

Personnel Agreement for Research Services of Ryan O'Dea
09/28/2021 - 09/27/2022 (PI)
Department of Veterans Administration, Bedford

Alzheimer's disease burden of illness and care pathways in the real world clinical population served by the US Veterans Affairs Healthcare System
03/30/2020 - 03/30/2022 (PI)
Eisai, Inc.

Eye to Brain: Eye Biomarkers and Cognition
07/01/2019 - 02/28/2022 (Subcontract PI)
Boston Medical Center Corporation NIH NIA
5R03AG063255-02

Natural History, Care Pathways, and Resource Utilization in Alzheimer’s Disease from the Administrative and Unstructured Clinical Data of the Veterans Affairs Healthcare System
04/01/2021 - 12/31/2021 (PI)
Eisai, Inc.

Early and late-life metal exposures and Alzheimer's disease
07/01/2017 - 04/30/2021 (Subcontract PI)
President and Fellows of Harvard College dba Harvard T.H. Chan School of Public Health NIH NIEHS
5R01ES024165-05

Showing 10 of 14 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Exploring Alzheimer Therapeutics	5I01BX004730-04
2022	Exploring Alzheimer Therapeutics	5I01BX004730-03
2021	Exploring Alzheimer Therapeutics	5I01BX004730-02
2021	Big data and small molecules for Alzheimer's disease	3RF1AG063913-01S2
2021	Profiling Alzheimer's Biomarkers	5I01BX003527-04	4
2020	Exploring Alzheimer Therapeutics	1I01BX004730-01
2020	Big data and small molecules for Alzheimer's disease	3RF1AG063913-01S1
2020	Profiling Alzheimer's Biomarkers	5I01BX003527-03	4
2019	Big data and small molecules for Alzheimer's disease	1RF1AG063913-01
2019	ShEEP Request for Imaging Mass Spectrometry System	1IS1BX004390-01A1

Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Morin PJ, Zhang Q, Xia W, Miller D, Querfurth H, Tahami Monfared AA. Clinical and Scientific Challenges to Effectiveness Studies Under Coverage with Evidence Development in Alzheimer's Disease. Neurol Ther. 2023 Jun; 12(3):721-726.View Related Profiles.

Morin, Peter
Xia, Weiming

PMID: 36933140; PMCID: PMC10195925; DOI: 10.1007/s40120-023-00462-z;

Kirsch D, Shah A, Dixon E, Kelley H, Cherry JD, Xia W, Daley S, Aytan N, Cormier K, Kubilus C, Mathias R, Alvarez VE, Huber BR, McKee AC, Stein TD. Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2023 Jan 20; 82(2):127-139.View Related Profiles.

McKee, Ann
Huber, Bertrand
Cherry, Jonathan
Aytan, Nurgul
Stein, Thor
Alvarez, Victor
Xia, Weiming

PMID: 36617181; PMCID: PMC9852946; DOI: 10.1093/jnen/nlac122;

Prasad M, Xu J, Agranat JS, Xia W, Daley S, Ness S, Chen X, Siegel NH, Stein TD, Chung J, Subramanian ML. Upregulation of Neuroinflammatory Protein Biomarkers in Acute Rhegmatogenous Retinal Detachments. Life (Basel). 2022 Dec 31; 13(1).View Related Profiles.

Xu, Jia
Agranat, Joshua
Subramanian, Manju
Prasad, Minali
Siegel, Nicole
Ness, Steven
Stein, Thor
Xia, Weiming
Chen, Xuejing

PMID: 36676067; PMCID: PMC9862737; DOI: 10.3390/life13010118;

Morin P, Li M, Wang Y, Aguilar BJ, Berlowitz D, Tahami Monfared AA, Irizarry M, Zhang Q, Xia W. Clinical Staging of Alzheimer's Disease: Concordance of Subjective and Objective Assessments in the Veteran's Affairs Healthcare System. Neurol Ther. 2022 Sep; 11(3):1341-1352.View Related Profiles.

Morin, Peter
Xia, Weiming

PMID: 35778542; PMCID: PMC9338180; DOI: 10.1007/s40120-022-00379-z;

Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease. Alzheimers Dement. 2022 Nov; 18(11):2042-2054.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Au, Rhoda
Stein, Thor
Ikezu, Tsuneya
Xia, Weiming

PMID: 35142023; PMCID: PMC9360190; DOI: 10.1002/alz.12607;

Panitch R, Hu J, Xia W, Bennett DA, Stein TD, Farrer LA, Jun GR. Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):30.View Related Profiles.

Jun, Gyungah
Farrer, Lindsay
Stein, Thor
Xia, Weiming

PMID: 35139885; PMCID: PMC8830081; DOI: 10.1186/s13195-022-00975-z;

Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28.View Related Profiles.

Budson, Andrew
McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Katz, Douglas
Mez, Jesse
Cherry, Jonathan
Turk, Katherine
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Stern, Robert
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 35139894; PMCID: PMC8830027; DOI: 10.1186/s13195-022-00976-y;

Stathas S, Alvarez VE, Xia W, Nicks R, Meng G, Daley S, Pothast M, Shah A, Kelley H, Esnault C, McCormack R, Dixon E, Fishbein L, Cherry JD, Huber BR, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease. Alzheimers Dement. 2022 Aug; 18(8):1511-1522.View Related Profiles.

McKee, Ann
Huber, Bertrand
Mez, Jesse
Cherry, Jonathan
Alosco, Michael
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 34854540; PMCID: PMC9160206; DOI: 10.1002/alz.12502;

Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE e2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 10; 26(10):6054-6064.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Hu, Jun
Lunetta, Kathryn
Farrer, Lindsay
Au, Rhoda
Stein, Thor
Ikezu, Tsuneya
Xia, Weiming

PMID: 34480088; PMCID: PMC8758485; DOI: 10.1038/s41380-021-01266-z;

Ratner MH, Downing SS, Guo O, Odamah KE, Stewart TM, Kumaresan V, Robitsek RJ, Xia W, Farb DH. Prodromal dysfunction of a5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease. Heliyon. 2021 Sep; 7(9):e07895.View Related Profiles.

Farb, David
Ratner, Marcia
Downing, Scott
Stewart, Tara
Kumaresan, Vidhya
Xia, Weiming

PMID: 34568591; PMCID: PMC8449175; DOI: 10.1016/j.heliyon.2021.e07895;

Showing 10 of 123 results. Show More

Xia W, Li M, Wang Y, Kazis LE, Berlo K, Melikechi N, Chiklis GR. Longitudinal analysis of antibody decay in convalescent COVID-19 patients. Sci Rep. 2021 08 18; 11(1):16796.View Related Profiles.

Kazis, Lewis
Xia, Weiming

PMID: 34408200; PMCID: PMC8373894; DOI: 10.1038/s41598-021-96171-4;

Loporchio DF, Tam EK, Cho J, Chung J, Jun GR, Xia W, Fiorello MG, Siegel NH, Ness S, Stein TD, Subramanian ML. Cytokine Levels in Human Vitreous in Proliferative Diabetic Retinopathy. Cells. 2021 04 30; 10(5).View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Subramanian, Manju
Siegel, Nicole
Ness, Steven
Stein, Thor
Xia, Weiming

PMID: 33946446; PMCID: PMC8147162; DOI: 10.3390/cells10051069;

Cherry JD, Meng G, Daley S, Xia W, Svirsky S, Alvarez VE, Nicks R, Pothast M, Kelley H, Huber B, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy. J Neuroinflammation. 2020 Dec 05; 17(1):370.View Related Profiles.

McKee, Ann
Huber, Bertrand
Mez, Jesse
Cherry, Jonathan
Alosco, Michael
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 33278887; PMCID: PMC7718711; DOI: 10.1186/s12974-020-02036-4;

Subramanian ML, Vig V, Chung J, Fiorello MG, Xia W, Zetterberg H, Blennow K, Zetterberg M, Shareef F, Siegel NH, Ness S, Jun GR, Stein TD. Neurofilament light chain in the vitreous humor of the eye. Alzheimers Res Ther. 2020 09 17; 12(1):111.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Subramanian, Manju
Siegel, Nicole
Ness, Steven
Stein, Thor
Xia, Weiming

PMID: 32943089; PMCID: PMC7500015; DOI: 10.1186/s13195-020-00677-4;

Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles.

Zaia, Joseph
Sethi, Manveen
Medalla, Maria
Ikezu, Seiko
Ikezu, Tsuneya
Xia, Weiming
You, Yang
Ruan, Zhi

PMID: 32301581; PMCID: PMC7293582; DOI: 10.1002/alz.12089;

Friedberg JS, Aytan N, Cherry JD, Xia W, Standring OJ, Alvarez VE, Nicks R, Svirsky S, Meng G, Jun G, Ryu H, Au R, Stein TD. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype. Sci Rep. 2020 02 19; 10(1):2924.View Related Profiles.

Jun, Gyungah
Ryu, Hoon
Friedberg, Jacob
Cherry, Jonathan
Aytan, Nurgul
Au, Rhoda
Stein, Thor
Alvarez, Victor
Xia, Weiming

PMID: 32076055; PMCID: PMC7031423; DOI: 10.1038/s41598-020-59869-5;

Muraoka S, Lin W, Chen M, Hersh SW, Emili A, Xia W, Ikezu T. Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids. Methods. 2020 05 01; 177:35-49.View Related Profiles.

Emili, Andrew
Ikezu, Tsuneya
Xia, Weiming
Lin, Weiwei

PMID: 32035230; PMCID: PMC7667497; DOI: 10.1016/j.ymeth.2020.02.002;

Chen M, Xia W. Proteomic Profiling of Plasma and Brain Tissue from Alzheimer's Disease Patients Reveals Candidate Network of Plasma Biomarkers. J Alzheimers Dis. 2020; 76(1):349-368. PMID: 32474469; PMCID: PMC7457324; DOI: 10.3233/JAD-200110;

Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 09; 138(3):401-413.View Related Profiles.

McKee, Ann
Huber, Bertrand
Dwyer, Brigid
Katz, Douglas
Mahar, Ian
Friedberg, Jacob
Mez, Jesse
Cherry, Jonathan
Goldstein, Lee
Alosco, Michael
Kowall, Neil
Stern, Robert
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 31183671; PMCID: PMC6689453; DOI: 10.1007/s00401-019-02031-x;

Xia W. ?-Secretase and its modulators: Twenty years and beyond. Neurosci Lett. 2019 05 14; 701:162-169. PMID: 30763650; PMCID: PMC7008970; DOI: 10.1016/j.neulet.2019.02.011;

Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Porco, John
Brown, Lauren
Xia, Weiming

PMID: 30776010; PMCID: PMC6474660; DOI: 10.3233/JAD-180923;

Wright LM, Stein TD, Jun G, Chung J, McConnell K, Fiorello M, Siegel N, Ness S, Xia W, Turner KL, Subramanian ML. Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor. J Alzheimers Dis. 2019; 68(4):1429-1438.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Subramanian, Manju
Siegel, Nicole
Ness, Steven
Stein, Thor
Xia, Weiming

PMID: 30856114; PMCID: PMC6850770; DOI: 10.3233/JAD-181104;

Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics. 2018 06 30; 182:21-33.View Related Profiles.

Stein, Thor
Xia, Weiming

PMID: 29709615; PMCID: PMC7457321; DOI: 10.1016/j.jprot.2018.04.032;

Chen M, Song H, Cui J, Johnson CE, Hubler GK, DePalma RG, Gu Z, Xia W. Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau. J Alzheimers Dis. 2018; 66(2):751-773. PMID: 30347620; PMCID: PMC6827339; DOI: 10.3233/JAD-180726;

Zhu H, Stern RA, Tao Q, Bourlas A, Essis MD, Chivukula M, Rosenzweig J, Steenkamp D, Xia W, Mercier GA, Tripodis Y, Farlow M, Kowall N, Qiu WQ. An amylin analog used as a challenge test for Alzheimer's disease. Alzheimers Dement (N Y). 2017 Jan; 3(1):33-43.View Related Profiles.

Steenkamp, Devin
Mercier, Gustavo
Zhu, Haihao
Kowall, Neil
Tao, Qiushan
Stern, Robert
Xia, Weiming
Tripodis, Yorghos

PMID: 28503657; PMCID: PMC5424531; DOI: 10.1016/j.trci.2016.12.002;

Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, Xia W. Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. PLoS One. 2016; 11(9):e0163072.View Related Profiles.

Morin, Peter
Xia, Weiming

PMID: 27684569; PMCID: PMC5042502; DOI: 10.1371/journal.pone.0163072;

Lee HK, Morin P, Xia W. Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient. Stem Cell Res. 2016 Mar; 16(2):213-5.View Related Profiles.

Morin, Peter
Xia, Weiming

PMID: 27345971; PMCID: PMC7008971; DOI: 10.1016/j.scr.2015.12.050;

Xia W, Mo H. Potential of tocotrienols in the prevention and therapy of Alzheimer's disease. J Nutr Biochem. 2016 May; 31:1-9. PMID: 27133418; DOI: 10.1016/j.jnutbio.2015.10.011;

Lee HK, Morin P, Wells J, Hanlon EB, Xia W. Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells. Stem Cell Res. 2015 Sep; 15(2):325-7.View Related Profiles.

Morin, Peter
Xia, Weiming

PMID: 26246272; DOI: 10.1016/j.scr.2015.07.004;

Kong R, Chang S, Xia W, Wong ST. Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1. J Struct Biol. 2015 Aug; 191(2):120-9. PMID: 26142917; DOI: 10.1016/j.jsb.2015.07.001;

Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, Daneshvar DH, Mez J, Solomon T, Meng G, Kubilus CA, Cormier KA, Meng S, Babcock K, Kiernan P, Murphy L, Nowinski CJ, Martin B, Dixon D, Stern RA, Cantu RC, Kowall NW, McKee AC. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015 Jul; 130(1):21-34.View Related Profiles.

McKee, Ann
Nowinski, Christopher
Daneshvar, Daniel
Mez, Jesse
Babcock, Katharine
Kowall, Neil
Montenigro, Philip
Stern, Robert
Cantu, Robert
Stein, Thor
Alvarez, Victor
Xia, Weiming
Tripodis, Yorghos

PMID: 25943889; PMCID: PMC4529056; DOI: 10.1007/s00401-015-1435-y;

Findeis MA, Schroeder FC, Creaser SP, McKee TD, Xia W. Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts. Medicines. 2015; (2):127-140. View Publication

Zhang Y, Shao H, Dong Y, Swain CA, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice. Transl Neurodegener. 2014; 3(1):8. PMID: 24725331; PMCID: PMC3989795; DOI: 10.1186/2047-9158-3-8;

Cai H, Yang Z, Cao X, Xia W, Xu X. A new iterative triclass thresholding technique in image segmentation. IEEE Trans Image Process. 2014 Mar; 23(3):1038-46. PMID: 24474373; DOI: 10.1109/TIP.2014.2298981;

Shao H, Zhang Y, Dong Y, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. J Alzheimers Dis. 2014; 41(2):499-513. PMID: 24643139; PMCID: PMC4071129; DOI: 10.3233/JAD-132792;

Tate B, McKee TD, Loureiro RM, Dumin JA, Xia W, Pojasek K, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS. Modulation of gamma-secretase for the treatment of Alzheimer's disease. Int J Alzheimers Dis. 2012; 2012:210756. PMID: 23320246; PMCID: PMC3536039; DOI: 10.1155/2012/210756;

Xia S, Zhu Y, Xu X, Xia W. Computational techniques in zebrafish image processing and analysis. J Neurosci Methods. 2013 Feb 15; 213(1):6-13. PMID: 23219894; DOI: 10.1016/j.jneumeth.2012.11.009;

Hubbs JL, Fuller NO, Austin WF, Shen R, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives J, Bronk BS. Optimization of a natural product-based class of ?-secretase modulators. J Med Chem. 2012 Nov 8; 55(21):9270-82. PMID: 23030762; DOI: 10.1021/jm300976b;

Fuller NO, Hubbs JL, Austin WF, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives JL, Findeis MA, Bronk BS. Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside. ACS Med Chem Lett. 2012 Nov 8; 3(11):908-13. PMID: 24900406; PMCID: PMC4025870; DOI: 10.1021/ml300256p;

Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing. Transl Neurodegener. 2012; 1(1):8. PMID: 23211096; PMCID: PMC3514095; DOI: 10.1186/2047-9158-1-8;

Mazumdar M, Xia W, Hofmann O, Gregas M, Ho Sui S, Hide W, Yang T, Needleman HL, Bellinger DC. Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood. Environ Health Perspect. 2012 May; 120(5):702-7. PMID: 22313790; PMCID: PMC3346789; DOI: 10.1289/ehp.1104474;

Xia W, Wong ST, Hanlon E, Morin P. ?-Secretase modulator in Alzheimer's disease: shifting the end. J Alzheimers Dis. 2012; 31(4):685-96.View Related Profiles.

Morin, Peter
Xia, Weiming

PMID: 22710916; DOI: 10.3233/JAD-2012-120751;

Townsend MK, Okereke OI, Xia W, Yang T, Selkoe DJ, Grodstein F. Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study. Alzheimer Dis Assoc Disord. 2012 Jan-Mar; 26(1):50-4. PMID: 21502851; PMCID: PMC3140548; DOI: 10.1097/WAD.0b013e31821764ce;

Chen S, Zhu Y, Xia W, Xia S, Xu X. Automated analysis of zebrafish images for phenotypic changes in drug discovery. J Neurosci Methods. 2011 Sep 15; 200(2):229-36. PMID: 21767568; DOI: 10.1016/j.jneumeth.2011.06.015;

Lifshitz V, Weiss R, Benromano T, Kfir E, Blumenfeld-Katzir T, Tempel-Brami C, Assaf Y, Xia W, Wyss-Coray T, Weiner HL, Frenkel D. Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model. Neurobiol Aging. 2012 Feb; 33(2):432.e1-432.e13. PMID: 21371785; PMCID: PMC3136542; DOI: 10.1016/j.neurobiolaging.2011.01.006;

Liu ZP, Wang Y, Zhang XS, Xia W, Chen L. Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients. Mol Biosyst. 2011 May; 7(5):1441-52. PMID: 21336338; DOI: 10.1039/c0mb00325e;

Xu X, Xu X, Huang X, Xia W, Xia S. A high-throughput analysis method to detect regions of interest and quantify zebrafish embryo images. J Biomol Screen. 2010 Oct; 15(9):1152-9. PMID: 20930217; DOI: 10.1177/1087057110379155;

Xia W. Brain amyloid ß protein and memory disruption in Alzheimer's disease. Neuropsychiatr Dis Treat. 2010; 6:605-11. PMID: 20856923; PMCID: PMC2938309; DOI: 10.2147/NDT.S7460;

Huttunen HJ, Havas D, Peach C, Barren C, Duller S, Xia W, Frosch MP, Hutter-Paier B, Windisch M, Kovacs DM. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice. J Neuropathol Exp Neurol. 2010 Aug; 69(8):777-88. PMID: 20613640; PMCID: PMC2918281; DOI: 10.1097/NEN.0b013e3181e77ed9;

Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J Neurosci. 2010 Jun 16; 30(24):8180-9. PMID: 20554868; PMCID: PMC6634596; DOI: 10.1523/JNEUROSCI.0340-10.2010;

Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem. 2010 Jul 16; 285(29):22350-9. PMID: 20460383; PMCID: PMC2903357; DOI: 10.1074/jbc.M110.116962;

Arslanova D, Yang T, Xu X, Wong ST, Augelli-Szafran CE, Xia W. Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors. BMC Biotechnol. 2010; 10:24. PMID: 20307292; PMCID: PMC2851663; DOI: 10.1186/1472-6750-10-24;

Yang T, Arslanova D, Xu X, Li YM, Xia W. In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors. J Neurochem. 2010 Jun; 113(5):1200-9. PMID: 20345767; PMCID: PMC4539131; DOI: 10.1111/j.1471-4159.2010.06681.x;

Xia W. Exploring Alzheimer's disease in zebrafish. J Alzheimers Dis. 2010; 20(4):981-90. PMID: 20182049; DOI: 10.3233/JAD-2010-1412;

Lu Q, Ding K, Frosch MP, Jones S, Wolfe M, Xia W, Lanford GW. Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution. J Alzheimers Dis. 2010; 22(1):235-45. PMID: 20847418; PMCID: PMC3813954; DOI: 10.3233/JAD-2010-100585;

Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Arch Neurol. 2009 Oct; 66(10):1247-53. PMID: 19822780; PMCID: PMC2761951; DOI: 10.1001/archneurol.2009.207;

Zhong Z, Nural H, He P, Civarella G, Beach T, Sue L, Adler C, Shill H, Caviness J, Xia W, Shen Y. Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients. Mol Neurodegener. 2009; 4:30. PMID: 19604362; PMCID: PMC2722623; DOI: 10.1186/1750-1326-4-30;

Nural H, He P, Beach T, Sue L, Xia W, Shen Y. Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients. Mol Neurodegener. 2009; 4:23. PMID: 19497122; PMCID: PMC2704189; DOI: 10.1186/1750-1326-4-23;

Zhao H, Zhu J, Cui K, Xu X, O'Brien M, Wong KK, Kesari S, Xia W, Wong ST. Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid beta protein. Cancer Cell Int. 2009; 9:15. PMID: 19480719; PMCID: PMC2701410; DOI: 10.1186/1475-2867-9-15;

Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 2009 May; 66(5):620-31. PMID: 19433662; PMCID: PMC2748878; DOI: 10.1001/archneurol.2009.48;

Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Mol Neurodegener. 2009; 4:12. PMID: 19243613; PMCID: PMC2654450; DOI: 10.1186/1750-1326-4-12;

Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol. 2009 Feb; 66(2):190-9. PMID: 19204155; PMCID: PMC3618974; DOI: 10.1001/archneurol.2008.565;

Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis. 2009; 16(2):277-85.View Related Profiles.

Xia, Weiming
Qiu, Wendy

PMID: 19221417; PMCID: PMC2737811; DOI: 10.3233/JAD-2009-0948;

Yang T, Arslanova D, Gu Y, Augelli-Szafran C, Xia W. Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein. Mol Brain. 2008; 1:15. PMID: 18983676; PMCID: PMC2637266; DOI: 10.1186/1756-6606-1-15;

Li G, Liu T, Nie J, Guo L, Chen J, Zhu J, Xia W, Mara A, Holley S, Wong ST. Segmentation of touching cell nuclei using gradient flow tracking. J Microsc. 2008 Jul; 231(Pt 1):47-58. PMID: 18638189; DOI: 10.1111/j.1365-2818.2008.02016.x;

Li F, Zhou X, Zhu J, Xia W, Ma J, Wong ST. Workflow and methods of high-content time-lapse analysis for quantifying intracellular calcium signals. Neuroinformatics. 2008; 6(2):97-108. PMID: 18506641; PMCID: PMC2853186; DOI: 10.1007/s12021-008-9016-z;

Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, Dembinsky-Vaknin A, Shen J, Plante M, Burt DS, Weiner HL. A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008 May; 63(5):591-601. PMID: 18360829; PMCID: PMC2747093; DOI: 10.1002/ana.21340;

Xia W. From presenilinase to gamma-secretase, cleave to capacitate. Curr Alzheimer Res. 2008 Apr; 5(2):172-8. PMID: 18393802

Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 2; 283(18):11866-75. PMID: 18326038; PMCID: PMC2335348; DOI: 10.1074/jbc.M800199200;

Liu T, Li G, Nie J, Tarokh A, Zhou X, Guo L, Malicki J, Xia W, Wong ST. An automated method for cell detection in zebrafish. Neuroinformatics. 2008; 6(1):5-21. PMID: 18288618; DOI: 10.1007/s12021-007-9005-7;

Li G, Liu T, Nie J, Guo L, Malicki J, Mara A, Holley SA, Xia W, Wong ST. Detection of blob objects in microscopic zebrafish images based on gradient vector diffusion. Cytometry A. 2007 Oct; 71(10):835-45. PMID: 17654652

Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007 Sep 21; 282(38):28285-95. PMID: 17684015; DOI: 10.1074/jbc.M702951200;

Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci. 2007 Feb 7; 27(6):1247-54. PMID: 17287498; PMCID: PMC6673586; DOI: 10.1523/JNEUROSCI.5320-06.2007;

Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem. 2007 Feb 16; 282(7):4318-25. PMID: 17170108

Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 6; 51(1):29-42. PMID: 16815330; DOI: 10.1016/j.neuron.2006.05.022;

Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 2006 Mar 23; 440(7083):528-34. PMID: 16554819; DOI: 10.1038/nature04543;

Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic. 2006 Mar; 7(3):354-64. PMID: 16497228; DOI: 10.1111/j.1600-0854.2006.00388.x;

Zetterberg H, Campbell WA, Yang HW, Xia W. The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis. J Biol Chem. 2006 Apr 28; 281(17):11933-9. PMID: 16507571; DOI: 10.1074/jbc.M512521200;

Campbell WA, Yang H, Zetterberg H, Baulac S, Sears JA, Liu T, Wong ST, Zhong TP, Xia W. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem. 2006 Mar; 96(5):1423-40. PMID: 16464238

Liu T, Lu J, Wang Y, Campbell WA, Huang L, Zhu J, Xia W, Wong ST. Computerized image analysis for quantitative neuronal phenotyping in zebrafish. J Neurosci Methods. 2006 Jun 15; 153(2):190-202. PMID: 16364449

Baulac S, LaVoie MJ, Strahle J, Schlossmacher MG, Xia W. Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain. Mol Cell Neurosci. 2004 Nov; 27(3):236-46. PMID: 15519239; DOI: 10.1016/j.mcn.2004.06.014;

Harnasch M, Grau S, Behrends C, Dove SL, Hochschild A, Iskandar MK, Xia W, Ehrmann M. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins. Mol Membr Biol. 2004 Nov-Dec; 21(6):373-83. PMID: 15764367; DOI: 10.1080/09687860400008429;

Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis. 2003 Nov; 14(2):194-204. PMID: 14572442

Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH. APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol. 2003 Oct 13; 163(1):83-95. PMID: 14557249; PMCID: PMC2173445; DOI: 10.1083/jcb.200301115;

Réchards M, Xia W, Oorschot VM, Selkoe DJ, Klumperman J. Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes. Traffic. 2003 Aug; 4(8):553-65. PMID: 12839498

Xia W, Wolfe MS. Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci. 2003 Jul 15; 116(Pt 14):2839-44. PMID: 12808018; DOI: 10.1242/jcs.00651;

Campbell WA, Reed ML, Strahle J, Wolfe MS, Xia W. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem. 2003 Jun; 85(6):1563-74. PMID: 12787075

Xia W. Relationship between presenilinase and gamma-secretase. Drug News Perspect. 2003 Mar; 16(2):69-74. PMID: 12792666

Xia W. Amyloid inhibitors and Alzheimer's disease. Curr Opin Investig Drugs. 2003 Jan; 4(1):55-9. PMID: 12625030

Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y. Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med. 2003 Jan; 9(1):3-4. PMID: 12514700; DOI: 10.1038/nm0103-3;

Tsai JY, Wolfe MS, Xia W. The search for gamma-secretase and development of inhibitors. Curr Med Chem. 2002 Jun; 9(11):1087-106. PMID: 12052174

Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nat Cell Biol. 2002 May; 4(5):E110-1; author reply E111-2. PMID: 11988746; DOI: 10.1038/ncb0502-e110b;

Campbell WA, Iskandar MK, Reed ML, Xia W. Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors. Biochemistry. 2002 Mar 12; 41(10):3372-9. PMID: 11876645

Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy SA, Takashima A. Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging. 2002 Mar-Apr; 23(2):195-203. PMID: 11804703

Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):14-20. PMID: 11731004

Xia W. Amyloid metabolism and secretases in Alzheimer's disease. Curr Neurol Neurosci Rep. 2001 Sep; 1(5):422-7. PMID: 11898552

Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol Dis. 2000 Dec; 7(6 Pt B):673-81. PMID: 11114265; DOI: 10.1006/nbdi.2000.0322;

Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 2000 Sep; 27(3):561-72. PMID: 11055438

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem. 2000 Aug; 75(2):583-93. PMID: 10899933

Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):9299-304. PMID: 10922078; PMCID: PMC16862

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol. 2000 Jul; 2(7):428-34. PMID: 10878808; DOI: 10.1038/35017062;

Xia W. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein. Exp Gerontol. 2000 Jul; 35(4):453-60. PMID: 10959033

Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem. 2000 Feb 4; 275(5):3173-8. PMID: 10652302

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Ann N Y Acad Sci. 2000; 920:223-6. PMID: 11193154

Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry. 1999 Aug 31; 38(35):11223-30. PMID: 10471271; DOI: 10.1021/bi991080q;

Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem. 1999 Jul 2; 274(27):18851-6. PMID: 10383380

Querfurth HW, Jiang J, Xia W, Selkoe DJ. Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter. Gene. 1999 May 17; 232(1):125-41. PMID: 10333529

Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 1999 Apr 13; 38(15):4720-7. PMID: 10200159; DOI: 10.1021/bi982562p;

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999 Apr 8; 398(6727):513-7. PMID: 10206644; DOI: 10.1038/19077;

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 1998 Nov 24; 37(47):16465-71. PMID: 9843412; DOI: 10.1021/bi9816195;

Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiol Dis. 1998 Aug; 5(2):107-16. PMID: 9746908; DOI: 10.1006/nbdi.1998.0183;

Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT, Kosik KS. A detergent-insoluble membrane compartment contains A beta in vivo. Nat Med. 1998 Jun; 4(6):730-4. PMID: 9623986

Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. J Biol Chem. 1998 May 15; 273(20):12436-42. PMID: 9575200

Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J Med Chem. 1998 Jan 1; 41(1):6-9. PMID: 9438016; DOI: 10.1021/jm970621b;

Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8208-13. PMID: 9223340; PMCID: PMC21582

Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 1997 May 16; 89(4):629-39. PMID: 9160754

Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem. 1997 Mar 21; 272(12):7977-82. PMID: 9065468

Xia W. Investigational Drugs Research Alerts. Drug Evaluation: Nefiracetam. 1997; (2):425-430.

Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis. 1997; 3(4):325-37. PMID: 9173929; DOI: 10.1006/nbdi.1997.0129;

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med. 1997 Jan; 3(1):67-72. PMID: 8986743

Tropp BE, Ragolia L, Xia W, Dowhan W, Milkman R, Rudd KE, Ivanisevic R, Savic DJ. Identity of the Escherichia coli cls and nov genes. J Bacteriol. 1995 Sep; 177(17):5155-7. PMID: 7665497; PMCID: PMC177298

Xia W, Dowhan W. Phosphatidylinositol cannot substitute for phosphatidylglycerol in supporting cell growth of Escherichia coli. J Bacteriol. 1995 May; 177(10):2926-8. PMID: 7751309; PMCID: PMC176971

Xia W, Dowhan W. In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):783-7. PMID: 7846051; PMCID: PMC42704

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 123 publications over 27 distinct years, with a maximum of 9 publications in 2010

Bar chart showing 123 publications over 27 distinct years, with a maximum of 9 publications in 2010

Year	Publications
1995	3
1997	6
1998	5
1999	5
2000	8
2001	2
2002	4
2003	8
2004	2
2005	1
2006	6
2007	3
2008	7
2009	8
2010	9
2011	3
2012	8
2014	3
2015	5
2016	2
2017	1
2018	2
2019	4
2020	6
2021	5
2022	5
2023	2

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1998 Alzheimer's Association International Conference: Travel Award

1994 Travel Award

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