Keywords
Last Name

Wendy Q. Qiu, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPsychiatry
DivisionGeneral Psychiatry
Address85 E. Newton St Fuller Building
Boston MA 02118
Phone(617) 638-4336
ORCID ORCID Icon0000-0002-2082-2410
Other Positions
TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

 Awards and Honors

Start-EndDescription
2013Boston Unviersity: J&J Clinical Innovation Award
2012Boston University: Ignition Award
2003New England Medical Center, Tufts University School of Medicine: CREFF Award
2002New England Medical Center, Boston: Psychiatry Resident Award sponsored by Pfizer
2002Tufts University School of Medicine: Resident Recognized for Excellence in Teaching
1999Cornell Medical College, New York: Vincent du Vigneaud Prize for Excellent Research
 Research Expertise & Professional Interests
Wendy Qiu is an Associate Professor in the Psychiatry Department, Pharmacology & Experimental Therapeutics Department, Alzheimer’s disease Center (ADC) at Boston University School of Medicine. She is also a faculty member in the Neuroscience Program at Boston University.

Dr. Qiu is both a physician and a scientist. She is a Board Certified Psychiatrist who was trained at Tufts Medical Center and at the Payne Whitney Clinic, New York Presbyterian Hospital, Cornell Medical Center. She currently spends 50% of her time caring for patients with dementia and other psychiatric illnesses, including late life depression, and seeing patients in the ADC for the clinical trials. Many of her patients seek care at BU because they are frustrated with their deteriorating cognitive function and their behavior or mood symptoms are causing tremendous burdens for their caregivers. Motivated by her desire to help patients with devastating diseases in geriatric psychiatry, especially dementia which frequently lacks diagnostic tools and effective therapies, Dr. Qiu devotes the other 50% of her time to researching the fundamental causational mechanisms of these diseases, and to translate her findings to seeking biomarkers for the diagnoses and treatment of psychiatric illnesses.

Research Interests:

-Identifying and studying the modifiable and non-modifiable risk factors and their mechanisms in Alzheimer’s disease (AD): We have an established homebound elderly population in the Boston area, and we are performing longitudinal evaluations of their cognition, psychiatric, and neurological conditions. Some of the homebound elderly have also taken part in brain imaging. Our study focuses on the relationship between late life depression, type 2 diabetes, and AD. Investigating the brain’s regulation of emotion, obesity/diabetes, and cognition in AD pathogenesis will help to develop novel treatments for the intervention and early treatment of AD.

-Identifying and studying the communication between peripheral biomarkers and brain abnormalities in aging and the prodromal stage of AD: We are targeting biomarkers that could lead to an early diagnosis of AD, especially Aß peptides and cytopkines found in blood and cerebral spinal fluid. We are also using neuro-imaging such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), to study these biomarkers and brain composition.

-Investigating the Insulin Degrading Enzyme: Our study and others have identified that the insulin-degrading enzyme (IDE) plays a key role in the clearance of amyloid beta peptides (Aß), a major component in AD pathology. IDE also degrades insulin and amylin, and it might be a key component in type 2 diabetes. Our research goal is to further investigate whether defects of IDE activity and its regulation accelerates AD pathology in the elderly who suffer from type 2 diabetes.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhu H, Wang X, Wallack M, Li H, Carreras I, Dedeoglu A, Hur JY, Zheng H, Li H, Fine R, Mwamburi M, Sun X, Kowall N, Stern RA, Qiu WQ. Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease. Mol Psychiatry. 2015 Feb; 20(2):252-62. PMID: 24614496.
    View in: PubMed
  2. Qiu WQ, Wallack M, Dean M, Liebson E, Mwamburi M, Zhu H. Association between amylin and amyloid-ß peptides in plasma in the context of apolipoprotein E4 allele. PLoS One. 2014; 9(2):e88063. PMID: 24520345.
    View in: PubMed
  3. Qiu WQ, Au R, Zhu H, Wallack M, Liebson E, Li H, Rosenzweig J, Mwamburi M, Stern RA. Positive association between plasma amylin and cognition in a homebound elderly population. J Alzheimers Dis. 2014; 42(2):555-63. PMID: 24898659.
    View in: PubMed
  4. Vu LN, Dean MJ, Mwamburi M, Au R, Qiu WQ. Executive function and mortality in homebound elderly adults. J Am Geriatr Soc. 2013 Dec; 61(12):2128-34. PMID: 24479144.
    View in: PubMed
  5. Qiu WW, Lai A, Mon T, Mwamburi M, Taylor W, Rosenzweig J, Kowall N, Stern R, Zhu H, Steffens DC. Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele. Am J Geriatr Psychiatry. 2014 Feb; 22(2):177-85. PMID: 23567418.
    View in: PubMed
  6. Brodoefel H, Ramachandran R, Pantol G, Bergethon P, Qiu WQ, Scott T, Rojas R, Horger M, Rosenberg I, Bhadelia RA. Association between linear measurements of corpus callosum and gait in the elderly. Eur Radiol. 2013 Aug; 23(8):2252-7. PMID: 23512195.
    View in: PubMed
  7. Qiu WQ, Mwamburi M, Besser LM, Zhu H, Li H, Wallack M, Phillips L, Qiao L, Budson AE, Stern R, Kowall N. Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer's disease in the absence of apolipoprotein E4 allele. J Alzheimers Dis. 2013; 37(2):421-8. PMID: 23948883.
    View in: PubMed
  8. Ma XY, Qiu WQ, Smith CE, Parnell LD, Jiang ZY, Ordovas JM, Tucker KL, Lai CQ. Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study. J Obes. 2012; 2012:102942. PMID: 23326649.
    View in: PubMed
  9. Zhu H, Bhadelia RA, Liu Z, Vu L, Li H, Scott T, Bergethon P, Mwamburi M, Rosenzweig JL, Rosenberg I, Qiu WQ. The association between small vessel infarcts and the activities of amyloid-ß peptide degrading proteases in apolipoprotein E4 allele carriers. Angiology. 2013 Nov; 64(8):614-20. PMID: 23076436.
    View in: PubMed
  10. Koo BB, Bergethon P, Qiu WQ, Scott T, Hussain M, Rosenberg I, Caplan LR, Bhadelia RA. Clinical prediction of fall risk and white matter abnormalities: a diffusion tensor imaging study. Arch Neurol. 2012 Jun; 69(6):733-8. PMID: 22332181.
    View in: PubMed
  11. Claunch JD, Chan ST, Nixon EE, Qiu WQ, Sporko T, Dunn JP, Kwong KK, Hui KK. Commonality and specificity of acupuncture action at three acupoints as evidenced by FMRI. Am J Chin Med. 2012; 40(4):695-712. PMID: 22809025.
    View in: PubMed
  12. Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer's disease? J Alzheimers Dis. 2012; 29(2):329-40. PMID: 22232014.
    View in: PubMed
  13. Mwamburi DM, Liebson E, Folstein M, Bungay K, Tucker KL, Qiu WQ. Depression and glycemic intake in the homebound elderly. J Affect Disord. 2011 Jul; 132(1-2):94-8. PMID: 21396718.
    View in: PubMed
  14. Sun X, Bhadelia R, Liebson E, Bergethon P, Folstein M, Zhu JJ, Mwamburi DM, Patz S, Qiu WQ. The relationship between plasma amyloid-ß peptides and the medial temporal lobe in the homebound elderly. Int J Geriatr Psychiatry. 2011 Jun; 26(6):593-601. PMID: 21480376.
    View in: PubMed
  15. Sun X, Bhadelia R, Liebson E, Bergethon P, Folstein M, Zhu JJ, Mwamburi DM, Patz S, Qiu WQ. The relationship between plasma amyloid-ß peptides and the medial temporal lobe in the homebound elderly. Int J Geriatr Psychiatry. 2010 Dec 9. PMID: 21154622.
    View in: PubMed
  16. Qiu WQ, Dean M, Liu T, George L, Gann M, Cohen J, Bruce ML. Physical and mental health of homebound older adults: an overlooked population. J Am Geriatr Soc. 2010 Dec; 58(12):2423-8. PMID: 21070195.
    View in: PubMed
  17. Qiu WQ, Claunch J, Kong J, Nixon EE, Fang J, Li M, Vangel M, Hui KK. The effects of acupuncture on the brain networks for emotion and cognition: an observation of gender differences. Brain Res. 2010 Nov 29; 1362:56-67. PMID: 20851113.
    View in: PubMed
  18. Qiu WQ, Sun X, Mwamburi DM, Haker J, Lisle D, Rizal A, Lin YM, Qiao L, Summergrad P, Folstein M, Rosenberg I. Plasma Amyloid-ß Peptides and Homocysteine in Depression in the Homebound Elderly. N Am J Med Sci (Boston). 2010 Apr; 3(2):61-67. PMID: 23766866.
    View in: PubMed
  19. Lai CQ, Parnell LD, Troen AM, Shen J, Caouette H, Warodomwichit D, Lee YC, Crott JW, Qiu WQ, Rosenberg IH, Tucker KL, Ordovás JM. MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. Am J Clin Nutr. 2010 May; 91(5):1377-86. PMID: 20335551.
    View in: PubMed
  20. Bhadelia RA, Price LL, Tedesco KL, Scott T, Qiu WQ, Patz S, Folstein M, Rosenberg I, Caplan LR, Bergethon P. Diffusion tensor imaging, white matter lesions, the corpus callosum, and gait in the elderly. Stroke. 2009 Dec; 40(12):3816-20. PMID: 19797696.
    View in: PubMed
  21. Sun X, Chiu CC, Liebson E, Crivello NA, Wang L, Claunch J, Folstein M, Rosenberg I, Mwamburi DM, Peter I, Qiu WQ. Depression and plasma amyloid beta peptides in the elderly with and without the apolipoprotein E4 allele. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):238-44. PMID: 19812466.
    View in: PubMed
  22. Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis. 2009; 16(2):277-85. PMID: 19221417.
    View in: PubMed
  23. Sun X, Steffens DC, Au R, Folstein M, Summergrad P, Yee J, Rosenberg I, Mwamburi DM, Qiu WQ. Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psychiatry. 2008 May; 65(5):542-50. PMID: 18458206.
    View in: PubMed
  24. Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul; 171(1):241-51. PMID: 17591969.
    View in: PubMed
  25. Sun X, Mwamburi DM, Bungay K, Prasad J, Yee J, Lin YM, Liu TC, Summergrad P, Folstein M, Qiu WQ. Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease. Biol Psychiatry. 2007 Dec 15; 62(12):1413-7. PMID: 17544381.
    View in: PubMed
  26. Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, Bhadela R, Bergethon P, Scott TM, Summergrad P, Wang L, Rosenberg I, Folstein M. Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. Int J Geriatr Psychiatry. 2007 Jun; 22(6):536-42. PMID: 17096467.
    View in: PubMed
  27. Folstein M, Liu T, Peter I, Buell J, Buel J, Arsenault L, Scott T, Qiu WW. The homocysteine hypothesis of depression. Am J Psychiatry. 2007 Jun; 164(6):861-7. PMID: 17541043.
    View in: PubMed
  28. Scott TM, Peter I, Tucker KL, Arsenault L, Bergethon P, Bhadelia R, Buell J, Collins L, Dashe JF, Griffith J, Hibberd P, Leins D, Liu T, Ordovas JM, Patz S, Price LL, Qiu WQ, Sarnak M, Selhub J, Smaldone L, Wagner C, Wang L, Weiner D, Yee J, Rosenberg I, Folstein M. The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. Int J Geriatr Psychiatry. 2006 Jun; 21(6):519-28. PMID: 16645938.
    View in: PubMed
  29. Qiu WQ, Price LL, Hibberd P, Buell J, Collins L, Leins D, Mwamburi DM, Rosenberg I, Smaldone L, Scott TM, Siegel RD, Summergrad P, Sun X, Wagner C, Wang L, Yee J, Tucker KL, Folstein M. Executive dysfunction in homebound older people with diabetes mellitus. J Am Geriatr Soc. 2006 Mar; 54(3):496-501. PMID: 16551319.
    View in: PubMed
  30. Qiu WQ, Folstein MF. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol Aging. 2006 Feb; 27(2):190-8. PMID: 16399206.
    View in: PubMed
  31. Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1; 20(5):1657-65. PMID: 10684867.
    View in: PubMed
  32. Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 4; 273(49):32730-8. PMID: 9830016.
    View in: PubMed
  33. Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ. Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem. 1997 Mar 7; 272(10):6641-6. PMID: 9045694.
    View in: PubMed
  34. Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. J Biol Chem. 1996 Apr 5; 271(14):8443-51. PMID: 8626544.
    View in: PubMed
  35. Kosik KS, Qiu WQ, Greenberg S. Cellular signaling pathways and cytoskeletal organization. Ann N Y Acad Sci. 1996 Jan 17; 777:114-20. PMID: 8624073.
    View in: PubMed
  36. Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett. 1995 Sep 22; 198(1):52-6. PMID: 8570096.
    View in: PubMed
  37. Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci. 1995 Mar; 15(3 Pt 2):2157-67. PMID: 7891158.
    View in: PubMed
  38. Feinman R, Qiu WQ, Pearse RN, Nikolajczyk BS, Sen R, Sheffery M, Ravetch JV. PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter. EMBO J. 1994 Aug 15; 13(16):3852-60. PMID: 8070412.
    View in: PubMed
  39. Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7104-8. PMID: 8041753.
    View in: PubMed
  40. Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem. 1993 Nov 5; 268(31):22959-62. PMID: 8226807.
    View in: PubMed
  41. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV. Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science. 1990 May 11; 248(4956):732-5. PMID: 2139735.
    View in: PubMed
  42. Brooks DG, Qiu WQ, Luster AD, Ravetch JV. Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med. 1989 Oct 1; 170(4):1369-85. PMID: 2529342.
    View in: PubMed
  43. Perussia B, Tutt MM, Qiu WQ, Kuziel WA, Tucker PW, Trinchieri G, Bennett M, Ravetch JV, Kumar V. Murine natural killer cells express functional Fc gamma receptor II encoded by the Fc gamma R alpha gene. J Exp Med. 1989 Jul 1; 170(1):73-86. PMID: 2526196.
    View in: PubMed
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