Wendy Qiu | Profiles RNS

Wendy Wei Qiao Qiu, MD, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Psychiatry

General Psychiatry

MD, Beijing Medical University
PhD, Cornell University Medical College

Websites

	Pharmacology & Experimental Therapeutics Faculty
	LinkedIn
	ResearchGate
	Boston University Alzheimer's Disease Research Center

ORCID : 0000-0002-2082-2410

Dr. Qiu is both a physician and a scientist. She is a Board Certified Psychiatrist who was trained at Tufts Medical Center and at the Payne Whitney Clinic, New York Presbyterian Hospital, Cornell Medical Center. She currently spends 50% of her time caring for patients with dementia and other psychiatric illnesses, including late life depression, and seeing patients in the ADC for the clinical trials. Many of her patients seek care at BU because they are frustrated with their deteriorating cognitive function and their behavior or mood symptoms are causing tremendous burdens for their caregivers. Motivated by her desire to help patients with devastating diseases in geriatric psychiatry, especially dementia which frequently lacks diagnostic tools and effective therapies, Dr. Qiu devotes the other 50% of her time to researching the fundamental causational mechanisms of these diseases, and to translate her findings to seeking biomarkers for the diagnoses and treatment of psychiatric illnesses.

Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Investigator
Framingham Heart Study

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Co-director of Biomarker Core
Boston University Chobanian & Avedisian School of Medicine
Alzheimer's Disease Research Center

BU Research
NIH RePORTER Research

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-03

Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
12/15/2022 - 11/30/2025 (Multi-PI)
PI: Wendy Wei Qiao Qiu, MD, PhD
NIH/National Institute on Aging
1RF1AG075832-01A1

Multi-center development of a novel diagnostic test for Alzheimer's disease
09/01/2018 - 05/31/2024 (Multi-PI)
PI: Wendy Wei Qiao Qiu, MD, PhD
NIH/National Institute on Aging
5R01AG059424-05

Metformin in Alzheimer's dementia Prevention (MAP)
05/01/2021 - 04/30/2024 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA
5R01AG062624-03

Metformin in Alzheimers dementia Prevention (MAP)
08/15/2019 - 04/30/2024 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA
5R01AG062624-04

Metformin in Alzheimer's dementia Prevention (MAP)
09/15/2020 - 04/30/2023 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NIA
5R01AG062624-03

Midcareer Investigator Award in Amylin, Cognition, and Alzheimer's Disease
09/01/2015 - 05/31/2022 (PI)
NIH/National Institute on Aging
5K24AG050842-05

Plasma Amylin Impact on Cognitive Function and Brain Morphology in the Framingham Heart Study
05/01/2015 - 01/31/2021 (Multi-PI)
PI: Wendy Wei Qiao Qiu, MD, PhD
NIH/National Institute on Aging
5R01AG049899-05

Quantitative systems pharmacology and translational study of pramlintide for Alzheimer's disease
09/30/2018 - 08/31/2020 (PI)
NIH/National Institute on Aging
1R56AG059805-01

Setting up a Challenge Diagnostic Test for Alzheimer's Disease
12/01/2013 - 11/30/2017 (PI)
Alzheimer's Association

Showing 10 of 13 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.	1RF1AG075832-01A1
2023	Characterizing the interaction of genetic vulnerabilities and chronic peripheral inflammation for AD risk	5U19AG068753-04-8063
2022	Characterizing the interaction of genetic vulnerabilities and chronic peripheral inflammation for AD risk	5U19AG068753-03-8040
2022	Multi-center development of a novel diagnostic test for Alzheimer's disease	5R01AG059424-05
2021	Characterizing the interaction of genetic vulnerabilities and chronic peripheral inflammation for AD risk	5U19AG068753-02-8040
2021	Multi-center development of a novel diagnostic test for Alzheimer's disease	5R01AG059424-04	2
2020	Characterizing the interaction of genetic vulnerabilities and chronic peripheral inflammation for AD risk	1U19AG068753-01-8040
2020	Multi-center development of a novel diagnostic test for Alzheimer's disease	5R01AG059424-03	2
2019	Multi-center development of a novel diagnostic test for Alzheimer's disease	5R01AG059424-02	2
2019	Midcareer Investigator Award in Amylin, Cognition, and Alzheimer's Disease	5K24AG050842-05	13

Showing 10 of 36 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Chen J, Doyle MF, Fang Y, Mez J, Crane PK, Scollard P, Satizabal CL, Alosco ML, Qiu WQ, Murabito JM, Lunetta KL. Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort. Aging Cell. 2023 Oct; 22(10):e13955.View Related Profiles.

Satizabal, Claudia
Mez, Jesse
Murabito, Joanne
Lunetta, Kathryn
Alosco, Michael
Qiu, Wendy
Fang, Yuan

PMID: 37584418; PMCID: PMC10577533; DOI: 10.1111/acel.13955;

Zhang Z, Gan Q, Han J, Tao Q, Qiu WQ, Madri JA. CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer's disease. J Cereb Blood Flow Metab. 2023 Jul; 43(7):1027-1041.View Related Profiles.

Han, Jingyan
Tao, Qiushan
Qiu, Wendy

PMID: 37051650; PMCID: PMC10291450; DOI: 10.1177/0271678X231170041;

Groechel RC, Tripodis Y, Alosco ML, Mez J, Qiu WQ, Mercier G, Goldstein L, Budson AE, Kowall NW, Killiany RJ. Annualized changes in rate of amyloid deposition and neurodegeneration are greater in participants who become amyloid positive than those who remain amyloid negative. Neurobiol Aging. 2023 Jul; 127:33-42.View Related Profiles.

Budson, Andrew
Mercier, Gustavo
Mez, Jesse
Alosco, Michael
Kowall, Neil
Qiu, Wendy
Tripodis, Yorghos

PMID: 37043881

Na H, Yang JB, Zhang Z, Gan Q, Tian H, Rajab IM, Potempa LA, Tao Q, Qiu WQ. Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation. Neurobiol Aging. 2023 Jul; 127:54-69.View Related Profiles.

Tao, Qiushan
Qiu, Wendy

PMID: 37060729; PMCID: PMC10198819; DOI: 10.1016/j.neurobiolaging.2023.02.013;

Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. Circulating Endothelial Progenitor Cells Reduce the Risk of Alzheimer's Disease. medRxiv. 2023 Jan 18.View Related Profiles.

Belkina, Anna
Gurnani, Ashita
Denis, Gerald
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Alosco, Michael
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy

PMID: 36711847; PMCID: PMC9882408; DOI: 10.1101/2023.01.16.23284571;

Bei J, Miranda-Morales EG, Gan Q, Qiu Y, Husseinzadeh S, Liew JY, Chang Q, Krishnan B, Gaitas A, Yuan S, Felicella M, Qiu WQ, Fang X, Gong B. Circulating Exosomes from Alzheimer's Disease Suppress Vascular Endothelial-Cadherin Expression and Induce Barrier Dysfunction in Recipient Brain Microvascular Endothelial Cell. J Alzheimers Dis. 2023; 95(3):869-885. PMID: 37661885; DOI: 10.3233/JAD-230347;

Huang J, Tao Q, Ang TFA, Farrell J, Zhu C, Wang Y, Stein TD, Lunetta KL, Massaro J, Mez J, Au R, Farrer LA, Qiu WQ, Zhang X. The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease. Transl Psychiatry. 2022 Dec 22; 12(1):523.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy

PMID: 36550123; PMCID: PMC9780312; DOI: 10.1038/s41398-022-02281-6;

Huang J, Stein TD, Wang Y, Ang TFA, Tao Q, Lunetta KL, Massaro J, Akhter-Khan SC, Mez J, Au R, Farrer LA, Zhang X, Qiu WQ. Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease. Alzheimers Dement. 2023 May; 19(5):1925-1937.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy

PMID: 36396603; PMCID: PMC10182187; DOI: 10.1002/alz.12851;

Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 Oct 21; 145(10):3546-3557.View Related Profiles.

Budson, Andrew
McKee, Ann
Frank, Brandon
Steinberg, Eric
Jun, Gyungah
Aparicio, Hugo
Mez, Jesse
Turk, Katherine
Goldstein, Lee
Morrison, Madeline
Alosco, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Qiu, Wendy
Tripodis, Yorghos

PMID: 35554506; PMCID: PMC10233293; DOI: 10.1093/brain/awac175;

Potempa LA, Qiu WQ, Stefanski A, Rajab IM. Relevance of lipoproteins, membranes, and extracellular vesicles in understanding C-reactive protein biochemical structure and biological activities. Front Cardiovasc Med. 2022; 9:979461. PMID: 36158829; PMCID: PMC9493015; DOI: 10.3389/fcvm.2022.979461;

Showing 10 of 67 results. Show More

Tao Q, Akhter-Khan SC, Ang TFA, DeCarli C, Alosco ML, Mez J, Killiany R, Devine S, Rokach A, Itchapurapu IS, Zhang X, Lunetta KL, Steffens DC, Farrer LA, Greve DN, Au R, Qiu WQ. Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study. EClinicalMedicine. 2022 Nov; 53:101643.View Related Profiles.

Itchapurapu, Indira Swetha
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Alosco, Michael
Tao, Qiushan
Au, Rhoda
Killiany, Ronald
Devine, Sherral
Ang, Ting Fang Alvin
Qiu, Wendy

PMID: 36105871; PMCID: PMC9465265; DOI: 10.1016/j.eclinm.2022.101643;

Gan Q, Wong A, Zhang Z, Na H, Tian H, Tao Q, Rajab IM, Potempa LA, Qiu WQ. Monomeric C-reactive protein induces the cellular pathology of Alzheimer's disease. Alzheimers Dement (N Y). 2022; 8(1):e12319.View Related Profiles.

Tao, Qiushan
Qiu, Wendy

PMID: 35846159; PMCID: PMC9270638; DOI: 10.1002/trc2.12319;

Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, Yan Z, Yang JB, Tian H, Zhu S, Li Q, Rajab IM, Blusztajn JK, Wolozin B, Emili A, Zhang X, Stein T, Potempa LA, Qiu WQ. Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? Aging Cell. 2021 11; 20(11):e13501.View Related Profiles.

Emili, Andrew
Wolozin, Benjamin
Blusztajn, Jan
Tao, Qiushan
Stein, Thor
Qiu, Wendy
Zhang, Xiaoling
Alekseyev, Yuriy

PMID: 34687487; PMCID: PMC8590103; DOI: 10.1111/acel.13501;

Tao Q, Alvin Ang TF, Akhter-Khan SC, Itchapurapu IS, Killiany R, Zhang X, Budson AE, Turk KW, Goldstein L, Mez J, Alosco ML, Qiu WQ. Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous APOE ?4 Carriers. Neurology. 2021 Sep 20; 97(12):e1243-e1252.View Related Profiles.

Budson, Andrew
Itchapurapu, Indira Swetha
Mez, Jesse
Turk, Katherine
Goldstein, Lee
Alosco, Michael
Tao, Qiushan
Killiany, Ronald
Qiu, Wendy
Zhang, Xiaoling

PMID: 34266923; PMCID: PMC8480484; DOI: 10.1212/WNL.0000000000012512;

Akhter-Khan SC, Tao Q, Ang TFA, Itchapurapu IS, Alosco ML, Mez J, Piers RJ, Steffens DC, Au R, Qiu WQ. Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study. Alzheimers Dement. 2021 10; 17(10):1619-1627.View Related Profiles.

Itchapurapu, Indira Swetha
Mez, Jesse
Alosco, Michael
Tao, Qiushan
Au, Rhoda
Ang, Ting Fang Alvin
Qiu, Wendy

PMID: 33760348; PMCID: PMC8460688; DOI: 10.1002/alz.12327;

Na H, Tian H, Zhang Z, Li Q, Yang JB, Mcparland L, Gan Q, Qiu WQ. Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model. Am J Alzheimers Dis Other Demen. 2021; 36:15333175211012867. PMID: 34137273; PMCID: PMC10623958; DOI: 10.1177/15333175211012867;

Piers RJ, Liu Y, Ang TFA, Tao Q, Au R, Qiu WQ. Association Between Elevated Depressive Symptoms and Cognitive Function Moderated by APOE4 Status: Framingham Offspring Study. J Alzheimers Dis. 2021; 80(3):1269-1279.View Related Profiles.

Tao, Qiushan
Au, Rhoda
Ang, Ting Fang Alvin
Qiu, Wendy

PMID: 33646152; PMCID: PMC8172078; DOI: 10.3233/JAD-200998;

Sugarman MA, Zetterberg H, Blennow K, Tripodis Y, McKee AC, Stein TD, Martin B, Palmisano JN, Steinberg EG, Simkin I, Budson AE, Killiany R, O'Connor MK, Au R, Qiu WWQ, Goldstein LE, Kowall NW, Mez J, Stern RA, Alosco ML. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease. Neurobiol Aging. 2020 10; 94:60-70.View Related Profiles.

Budson, Andrew
McKee, Ann
Steinberg, Eric
Mez, Jesse
Goldstein, Lee
O'Connor, Maureen
Alosco, Michael
Kowall, Neil
Au, Rhoda
Stern, Robert
Killiany, Ronald
Stein, Thor
Qiu, Wendy
Tripodis, Yorghos

PMID: 32585491; PMCID: PMC7484086; DOI: 10.1016/j.neurobiolaging.2020.05.011;

Na H, Gan Q, Mcparland L, Yang JB, Yao H, Tian H, Zhang Z, Qiu WQ. Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer's disease. Neuropharmacology. 2020 May 15; 168:108017. PMID: 32113968; PMCID: PMC7199095; DOI: 10.1016/j.neuropharm.2020.108017;

Zhu H, Tao Q, Ang TFA, Massaro J, Gan Q, Salim S, Zhu RY, Kolachalama VB, Zhang X, Devine S, Auerbach SH, DeCarli C, Au R, Qiu WQ. Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults. JAMA Netw Open. 2019 08 02; 2(8):e199826.View Related Profiles.

Zhu, Haihao
Massaro, Joseph
Tao, Qiushan
Au, Rhoda
Auerbach, Sanford
Ang, Ting Fang Alvin
Kolachalama, Vijaya
Qiu, Wendy
Zhang, Xiaoling

PMID: 31433485; PMCID: PMC6707010; DOI: 10.1001/jamanetworkopen.2019.9826;

Gan Q, Yao H, Na H, Ballance H, Tao Q, Leung L, Tian H, Zhu H, Wolozin B, Qiu WQ. Effects of Amylin Against Amyloid-ß-Induced Tauopathy and Synapse Loss in Primary Neurons. J Alzheimers Dis. 2019; 70(4):1025-1040.View Related Profiles.

Wolozin, Benjamin
Zhu, Haihao
Tao, Qiushan
Qiu, Wendy

PMID: 31306122; PMCID: PMC6833957; DOI: 10.3233/JAD-190161;

Tao Q, Ang TFA, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au R, Qiu WQ. Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers. JAMA Netw Open. 2018 10 05; 1(6):e183597.View Related Profiles.

Massaro, Joseph
Tao, Qiushan
Au, Rhoda
Auerbach, Sanford
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 30646251; PMCID: PMC6324596; DOI: 10.1001/jamanetworkopen.2018.3597;

Qiu WQ. Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease. Neuroscience. 2017 Jul 25; 356:44-51. PMID: 28528968; PMCID: PMC5536977; DOI: 10.1016/j.neuroscience.2017.05.024;

Zhu H, Wang X, Wallack M, Li H, Carreras I, Dedeoglu A, Hur JY, Zheng H, Li H, Fine R, Mwamburi M, Sun X, Kowall N, Stern RA, Qiu WQ. Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease. Mol Psychiatry. 2015 Feb; 20(2):252-62.View Related Profiles.

Dedeoglu, Alpaslan
Zhu, Haihao
Carreras, Isabel
Kowall, Neil
Fine, Richard
Stern, Robert
Qiu, Wendy

PMID: 24614496; PMCID: PMC4161670; DOI: 10.1038/mp.2014.17;

Qiu WQ, Wallack M, Dean M, Liebson E, Mwamburi M, Zhu H. Association between amylin and amyloid-ß peptides in plasma in the context of apolipoprotein E4 allele. PLoS One. 2014; 9(2):e88063.View Related Profiles.

Zhu, Haihao
Qiu, Wendy

PMID: 24520345; PMCID: PMC3919737; DOI: 10.1371/journal.pone.0088063;

Qiu WQ, Au R, Zhu H, Wallack M, Liebson E, Li H, Rosenzweig J, Mwamburi M, Stern RA. Positive association between plasma amylin and cognition in a homebound elderly population. J Alzheimers Dis. 2014; 42(2):555-63.View Related Profiles.

Zhu, Haihao
Rosenzweig, James
Au, Rhoda
Stern, Robert
Qiu, Wendy

PMID: 24898659; PMCID: PMC4834912; DOI: 10.3233/JAD-140210;

Vu LN, Dean MJ, Mwamburi M, Au R, Qiu WQ. Executive function and mortality in homebound elderly adults. J Am Geriatr Soc. 2013 Dec; 61(12):2128-34.View Related Profiles.

Au, Rhoda
Qiu, Wendy

PMID: 24479144; PMCID: PMC3919053

Qiu WW, Lai A, Mon T, Mwamburi M, Taylor W, Rosenzweig J, Kowall N, Stern R, Zhu H, Steffens DC. Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele. Am J Geriatr Psychiatry. 2014 Feb; 22(2):177-85.View Related Profiles.

Zhu, Haihao
Rosenzweig, James
Kowall, Neil
Stern, Robert
Qiu, Wendy

PMID: 23567418; PMCID: PMC3873370; DOI: 10.1016/j.jagp.2012.08.017;

Brodoefel H, Ramachandran R, Pantol G, Bergethon P, Qiu WQ, Scott T, Rojas R, Horger M, Rosenberg I, Bhadelia RA. Association between linear measurements of corpus callosum and gait in the elderly. Eur Radiol. 2013 Aug; 23(8):2252-7. PMID: 23512195; PMCID: PMC4429761; DOI: 10.1007/s00330-013-2818-x;

Qiu WQ, Mwamburi M, Besser LM, Zhu H, Li H, Wallack M, Phillips L, Qiao L, Budson AE, Stern R, Kowall N. Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer's disease in the absence of apolipoprotein E4 allele. J Alzheimers Dis. 2013; 37(2):421-8.View Related Profiles.

Budson, Andrew
Zhu, Haihao
Kowall, Neil
Stern, Robert
Qiu, Wendy

PMID: 23948883; PMCID: PMC3972060; DOI: 10.3233/JAD-130716;

Ma XY, Qiu WQ, Smith CE, Parnell LD, Jiang ZY, Ordovas JM, Tucker KL, Lai CQ. Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study. J Obes. 2012; 2012:102942. PMID: 23326649; PMCID: PMC3543800; DOI: 10.1155/2012/102942;

Zhu H, Bhadelia RA, Liu Z, Vu L, Li H, Scott T, Bergethon P, Mwamburi M, Rosenzweig JL, Rosenberg I, Qiu WQ. The association between small vessel infarcts and the activities of amyloid-ß peptide degrading proteases in apolipoprotein E4 allele carriers. Angiology. 2013 Nov; 64(8):614-20.View Related Profiles.

Zhu, Haihao
Rosenzweig, James
Qiu, Wendy

PMID: 23076436; PMCID: PMC3788834; DOI: 10.1177/0003319712462125;

Koo BB, Bergethon P, Qiu WQ, Scott T, Hussain M, Rosenberg I, Caplan LR, Bhadelia RA. Clinical prediction of fall risk and white matter abnormalities: a diffusion tensor imaging study. Arch Neurol. 2012 Jun; 69(6):733-8.View Related Profiles.

Koo, Bang-bon
Qiu, Wendy

PMID: 22332181; PMCID: PMC4443844; DOI: 10.1001/archneurol.2011.2272;

Claunch JD, Chan ST, Nixon EE, Qiu WQ, Sporko T, Dunn JP, Kwong KK, Hui KK. Commonality and specificity of acupuncture action at three acupoints as evidenced by FMRI. Am J Chin Med. 2012; 40(4):695-712. PMID: 22809025; PMCID: PMC3754829; DOI: 10.1142/S0192415X12500528;

Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer's disease? J Alzheimers Dis. 2012; 29(2):329-40.View Related Profiles.

Wolozin, Benjamin
Zhu, Haihao
Ikezu, Tsuneya
Qiu, Wendy

PMID: 22232014; PMCID: PMC3784270; DOI: 10.3233/JAD-2011-111472;

Mwamburi DM, Liebson E, Folstein M, Bungay K, Tucker KL, Qiu WQ. Depression and glycemic intake in the homebound elderly. J Affect Disord. 2011 Jul; 132(1-2):94-8. PMID: 21396718; PMCID: PMC3109136; DOI: 10.1016/j.jad.2011.02.002;

Sun X, Bhadelia R, Liebson E, Bergethon P, Folstein M, Zhu JJ, Mwamburi DM, Patz S, Qiu WQ. The relationship between plasma amyloid-ß peptides and the medial temporal lobe in the homebound elderly. Int J Geriatr Psychiatry. 2010 Dec 9. PMID: 21154622; DOI: 10.1002/gps.2568;

Qiu WQ, Dean M, Liu T, George L, Gann M, Cohen J, Bruce ML. Physical and mental health of homebound older adults: an overlooked population. J Am Geriatr Soc. 2010 Dec; 58(12):2423-8. PMID: 21070195; PMCID: PMC3044592; DOI: 10.1111/j.1532-5415.2010.03161.x;

Qiu WQ, Claunch J, Kong J, Nixon EE, Fang J, Li M, Vangel M, Hui KK. The effects of acupuncture on the brain networks for emotion and cognition: an observation of gender differences. Brain Res. 2010 Nov 29; 1362:56-67. PMID: 20851113; PMCID: PMC3784241; DOI: 10.1016/j.brainres.2010.09.040;

Qiu WQ, Sun X, Mwamburi DM, Haker J, Lisle D, Rizal A, Lin YM, Qiao L, Summergrad P, Folstein M, Rosenberg I. Plasma Amyloid-ß Peptides and Homocysteine in Depression in the Homebound Elderly. N Am J Med Sci (Boston). 2010 Apr; 3(2):61-67. PMID: 23766866; PMCID: PMC3678954

Lai CQ, Parnell LD, Troen AM, Shen J, Caouette H, Warodomwichit D, Lee YC, Crott JW, Qiu WQ, Rosenberg IH, Tucker KL, Ordovás JM. MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. Am J Clin Nutr. 2010 May; 91(5):1377-86.View Related Profiles.

Crott, Jimmy
Qiu, Wendy

PMID: 20335551; PMCID: PMC2854908; DOI: 10.3945/ajcn.2009.28923;

Bhadelia RA, Price LL, Tedesco KL, Scott T, Qiu WQ, Patz S, Folstein M, Rosenberg I, Caplan LR, Bergethon P. Diffusion tensor imaging, white matter lesions, the corpus callosum, and gait in the elderly. Stroke. 2009 Dec; 40(12):3816-20. PMID: 19797696; PMCID: PMC3401013; DOI: 10.1161/STROKEAHA.109.564765;

Sun X, Chiu CC, Liebson E, Crivello NA, Wang L, Claunch J, Folstein M, Rosenberg I, Mwamburi DM, Peter I, Qiu WQ. Depression and plasma amyloid beta peptides in the elderly with and without the apolipoprotein E4 allele. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):238-44. PMID: 19812466; PMCID: PMC2919337; DOI: 10.1097/WAD.0b013e31819cb3ac;

Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis. 2009; 16(2):277-85.View Related Profiles.

Xia, Weiming
Qiu, Wendy

PMID: 19221417; PMCID: PMC2737811; DOI: 10.3233/JAD-2009-0948;

Sun X, Steffens DC, Au R, Folstein M, Summergrad P, Yee J, Rosenberg I, Mwamburi DM, Qiu WQ. Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psychiatry. 2008 May; 65(5):542-50.View Related Profiles.

Au, Rhoda
Qiu, Wendy

PMID: 18458206; PMCID: PMC3042807; DOI: 10.1001/archpsyc.65.5.542;

Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul; 171(1):241-51. PMID: 17591969; PMCID: PMC1941603; DOI: 10.2353/ajpath.2007.070105;

Sun X, Mwamburi DM, Bungay K, Prasad J, Yee J, Lin YM, Liu TC, Summergrad P, Folstein M, Qiu WQ. Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease. Biol Psychiatry. 2007 Dec 15; 62(12):1413-7. PMID: 17544381

Folstein M, Liu T, Peter I, Buell J, Buel J, Arsenault L, Scott T, Qiu WW. The homocysteine hypothesis of depression. Am J Psychiatry. 2007 Jun; 164(6):861-7. PMID: 17541043; DOI: 10.1176/appi.ajp.164.6.861;

Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, Bhadela R, Bergethon P, Scott TM, Summergrad P, Wang L, Rosenberg I, Folstein M. Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. Int J Geriatr Psychiatry. 2007 Jun; 22(6):536-42. PMID: 17096467

Scott TM, Peter I, Tucker KL, Arsenault L, Bergethon P, Bhadelia R, Buell J, Collins L, Dashe JF, Griffith J, Hibberd P, Leins D, Liu T, Ordovas JM, Patz S, Price LL, Qiu WQ, Sarnak M, Selhub J, Smaldone L, Wagner C, Wang L, Weiner D, Yee J, Rosenberg I, Folstein M. The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly population. Int J Geriatr Psychiatry. 2006 Jun; 21(6):519-28.View Related Profiles.

Dashe, John
Hibberd, Patricia
Qiu, Wendy

PMID: 16645938

Qiu WQ, Price LL, Hibberd P, Buell J, Collins L, Leins D, Mwamburi DM, Rosenberg I, Smaldone L, Scott TM, Siegel RD, Summergrad P, Sun X, Wagner C, Wang L, Yee J, Tucker KL, Folstein M. Executive dysfunction in homebound older people with diabetes mellitus. J Am Geriatr Soc. 2006 Mar; 54(3):496-501.View Related Profiles.

Hibberd, Patricia
Qiu, Wendy

PMID: 16551319

Qiu WQ, Folstein MF. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol Aging. 2006 Feb; 27(2):190-8. PMID: 16399206

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1; 20(5):1657-65. PMID: 10684867

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 4; 273(49):32730-8. PMID: 9830016

Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ. Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem. 1997 Mar 7; 272(10):6641-6. PMID: 9045694

Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. J Biol Chem. 1996 Apr 5; 271(14):8443-51. PMID: 8626544

Kosik KS, Qiu WQ, Greenberg S. Cellular signaling pathways and cytoskeletal organization. Ann N Y Acad Sci. 1996 Jan 17; 777:114-20. PMID: 8624073

Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett. 1995 Sep 22; 198(1):52-6. PMID: 8570096

Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci. 1995 Mar; 15(3 Pt 2):2157-67. PMID: 7891158

Feinman R, Qiu WQ, Pearse RN, Nikolajczyk BS, Sen R, Sheffery M, Ravetch JV. PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter. EMBO J. 1994 Aug 15; 13(16):3852-60.View Related Profiles.

Nikolajczyk, Barbara
Qiu, Wendy

PMID: 8070412; PMCID: PMC395298

Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7104-8. PMID: 8041753; PMCID: PMC44347

Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem. 1993 Nov 5; 268(31):22959-62. PMID: 8226807

Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV. Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science. 1990 May 11; 248(4956):732-5. PMID: 2139735

Brooks DG, Qiu WQ, Luster AD, Ravetch JV. Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med. 1989 Oct 1; 170(4):1369-85. PMID: 2529342; PMCID: PMC2189488

Perussia B, Tutt MM, Qiu WQ, Kuziel WA, Tucker PW, Trinchieri G, Bennett M, Ravetch JV, Kumar V. Murine natural killer cells express functional Fc gamma receptor II encoded by the Fc gamma R alpha gene. J Exp Med. 1989 Jul 1; 170(1):73-86. PMID: 2526196; PMCID: PMC2189375

Yiannikas C, Shahani BT. Painful sequelae of injuries to peripheral nerves. Am J Phys Med. 1984 Apr; 63(2):53-83. PMID: 6324596

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 27 distinct years, with a maximum of 6 publications in 2010 and 2022 and 2023

Bar chart showing 67 publications over 27 distinct years, with a maximum of 6 publications in 2010 and 2022 and 2023

Year	Publications
1984	1
1989	2
1990	1
1993	1
1994	2
1995	2
1996	2
1997	1
1998	1
2000	1
2005	1
2006	2
2007	4
2008	1
2009	3
2010	6
2011	1
2012	5
2013	4
2014	3
2017	1
2018	1
2019	2
2020	2
2021	5
2022	6
2023	6

Media Mentions

Recent (within 3 months)

Can We Find a Cure for Alzheimer’s Disease?

The Brink 2/21/2024

Older

Loneliness in Mid-Life Linked to Higher Odds for Alzheimer's

Health Day 3/29/2021

Loneliness in Mid-Life Linked to Higher Odds for Alzheimer's

U.S. News & World Report 3/29/2021

Middle-Age Loneliness Linked to Alzheimer's Disease

Medpage Today 3/25/2021

Being LONELY during midlife can increase your risk of dementia and Alzheimer's later in life, study warns

Daily Mail 3/24/2021

Relation Between Immune Factors Leads To Cancer-Promoting Inflammation

NewsPrimo 2/13/2019

Why Some With The 'Alzheimer's Gene' Do NOT Develop The Disease

Centre Daily Times 10/22/2018

Why Some With The 'Alzheimer's Gene' Do NOT Develop The Disease: Study Finds Inflammation Aggravates The Gene - And Those Who Keep Their Blood Pressure In Check Lower Their Risk

The Daily Mail 10/19/2018

Chronic Inflammation May Boost Alzheimer's Risk for APOE4 Carriers

MedPage Today 10/19/2018

BU Researchers Examine Role Of Inflammation In Alzheimer’s Disease

The Boston Globe 10/19/2018

2013 Boston Unviersity: J&J Clinical Innovation Award

2012 Boston University: Ignition Award

2003 New England Medical Center, Tufts University School of Medicine: CREFF Award

2002 New England Medical Center, Boston: Psychiatry Resident Award sponsored by Pfizer

2002 Tufts University School of Medicine: Resident Recognized for Excellence in Teaching

1999 Cornell Medical College, New York: Vincent du Vigneaud Prize for Excellent Research

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Alzheimer Dementia (AD)
Biomarkers for alzheimer's disease
Drug discovery
Peripheral inflammatory factors on brain aging
Brain endothelia pathology
Loneliness, depression and Alzheimer's disease
amylin and its receptor for Alzheimer's disease

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