Keywords
Last Name

Tsuneya Ikezu, MD, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 414-2658
ORCID ORCID Icon0000-0002-3979-8596
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentNeurology

 Research Expertise & Professional Interests
My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

 NIH RePORTER Grants
 Self-Described Keywords
  • Adeno-associated virus
  • Adenovirus
  • Alzheimer's disease
  • Amyloid precursor protein
  • Frontotemporal Dementia
  • HIV-1
  • Lentivirus
  • Macrophage
  • Microglia
  • Neural stem cells
  • Neurogenesis
  • Neuroimmunology
  • Neuroinflammation
  • Protein kinase
  • Spatial learning
  • synuclein
  • tau
  • Transgenic mice
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017 Jan 09. PMID: 28070672.
    View in: PubMed
  2. Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332. PMID: 26755131.
    View in: PubMed
  3. Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD. Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy. J Alzheimers Dis. 2016; 51(4):1099-109. PMID: 26890775.
    View in: PubMed
  4. Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia. J Pharmacol Exp Ther. 2016 Mar; 356(3):702-11. PMID: 26675679.
    View in: PubMed
  5. Wolozin B, Ikezu T. Syk and Yea Shall Find. EBioMedicine. 2015 Nov; 2(11):1590-1. PMID: 26870779.
    View in: PubMed
  6. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93. PMID: 26436904.
    View in: PubMed
  7. Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease. Neurobiol Aging. 2015 Nov; 36(11):2995-3007. PMID: 26315370.
    View in: PubMed
  8. Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack F, Ikezu T. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. J Neurosci. 2015 Jul 1; 35(26):9764-81. PMID: 26134658.
    View in: PubMed
  9. Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92. PMID: 25043464.
    View in: PubMed
  10. Ikezu S, Ikezu T. Tau-tubulin kinase. Front Mol Neurosci. 2014; 7:33. PMID: 24808823.
    View in: PubMed
  11. Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. Am J Pathol. 2014 Mar; 184(3):808-18. PMID: 24418258.
    View in: PubMed
  12. Freilich RW, Woodbury ME, Ikezu T. Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. PLoS One. 2013; 8(11):e79416. PMID: 24244499.
    View in: PubMed
  13. Woodbury ME, Ikezu T. Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration. J Neuroimmune Pharmacol. 2014 Mar; 9(2):92-101. PMID: 24057103.
    View in: PubMed
  14. Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. PMID: 23747948.
    View in: PubMed
  15. McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan; 136(Pt 1):43-64. PMID: 23208308.
    View in: PubMed
  16. Varnum MM, Ikezu T. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz). 2012 Aug; 60(4):251-66. PMID: 22710659.
    View in: PubMed
  17. Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. J Neurosci. 2012 Jun 13; 32(24):8270-83. PMID: 22699908.
    View in: PubMed
  18. Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16; 4(134):134ra60. PMID: 22593173.
    View in: PubMed
  19. Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer's disease? J Alzheimers Dis. 2012; 29(2):329-40. PMID: 22232014.
    View in: PubMed
  20. Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. Proc Natl Acad Sci U S A. 2011 Dec 6; 108(49):E1339-48. PMID: 22042871.
    View in: PubMed
  21. Kiyota T, Ingraham KL, Swan RJ, Jacobsen MT, Andrews SJ, Ikezu T. AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice. Gene Ther. 2012 Jul; 19(7):724-33. PMID: 21918553.
    View in: PubMed
  22. Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. The effect of HIV protease inhibitors on amyloid-ß peptide degradation and synthesis in human cells and Alzheimer's disease animal model. J Neuroimmune Pharmacol. 2012 Jun; 7(2):412-23. PMID: 21826404.
    View in: PubMed
  23. Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. J Immunol. 2011 Jun 15; 186(12):6925-32. PMID: 21551363.
    View in: PubMed
  24. Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga S, Ikezu T. Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. J Neurochem. 2011 Jan; 116(2):192-204. PMID: 20492361.
    View in: PubMed
  25. Freilich RW, Ikezu T. Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum. J Neuroimmune Pharmacol. 2011 Mar; 6(1):41-56. PMID: 21103946.
    View in: PubMed
  26. Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic bis-styrylbenzenes as ß-amyloid binding ligands and free radical scavengers. J Med Chem. 2010 Nov 25; 53(22):7992-9. PMID: 21038854.
    View in: PubMed
  27. Tokuraku K, Okuyama S, Matsushima K, Ikezu T, Kotani S. Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain. Neurosci Lett. 2010 Oct 29; 484(2):143-7. PMID: 20727942.
    View in: PubMed
  28. Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T. CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice. FASEB J. 2010 Aug; 24(8):3093-102. PMID: 20371618.
    View in: PubMed
  29. Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB J. 2010 Aug; 24(8):2904-15. PMID: 20354135.
    View in: PubMed
  30. Tokuraku K, Marquardt M, Ikezu T. Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes. PLoS One. 2009; 4(12):e8492. PMID: 20041162.
    View in: PubMed
  31. Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. PLoS One. 2009; 4(7):e6197. PMID: 19593388.
    View in: PubMed
  32. Ikezu T. The aging of human-immunodeficiency-virus-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2009 Jun; 4(2):161-2. PMID: 19415503.
    View in: PubMed
  33. Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Mol Ther. 2009 May; 17(5):803-9. PMID: 19277012.
    View in: PubMed
  34. Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J Neurosci. 2008 Dec 31; 28(53):14511-21. PMID: 19118186.
    View in: PubMed
  35. Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. J Neuroimmune Pharmacol. 2009 Mar; 4(1):116-28. PMID: 19034669.
    View in: PubMed
  36. Buescher JL, Martinez LB, Sato S, Okuyama S, Ikezu T. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. J Neuroimmune Pharmacol. 2009 Mar; 4(1):103-15. PMID: 19034670.
    View in: PubMed
  37. Xu J, Ikezu T. The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era. J Neuroimmune Pharmacol. 2009 Jun; 4(2):200-12. PMID: 19016329.
    View in: PubMed
  38. Yamamoto M, Kiyota T, Walsh SM, Liu J, Kipnis J, Ikezu T. Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. J Immunol. 2008 Sep 15; 181(6):3877-86. PMID: 18768842.
    View in: PubMed
  39. Buescher JL, Duan F, Sun J, Price RW, Ikezu T. OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients. J Neuroimmune Pharmacol. 2008 Dec; 3(4):230-5. PMID: 18773297.
    View in: PubMed
  40. Yamamoto M, Ramirez SH, Sato S, Kiyota T, Cerny RL, Kaibuchi K, Persidsky Y, Ikezu T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol. 2008 Feb; 172(2):521-33. PMID: 18187566.
    View in: PubMed
  41. Ikezu T. Alzheimer’s Disease. Neuroimmune Pharmacology. Springer. New York, NY. 2008.
  42. Gendelman S, Gendelman HE, Ikezu T. Huntington’s Disease. Neuroimmune Pharmacology. Springer. New York, NY. 2008.
  43. Ikezu T. Glial regulation of beta-amyloid deposition in transgenic animal models of Alzheimer's disease. New Immunology Research Developments (G. V. Müller Ed.). Nova Science Publishers, Inc. Hauppauge, NY. 2008.
  44. Ikezu T, Gendelman HE. Neurobiology and Neural Systems. Neuroimmune Pharmacology. Springer. New York, NY. 2008.
  45. Gorantla S, Liu J, Sneller H, Dou H, Holguin A, Smith L, Ikezu T, Volsky DJ, Poluektova L, Gendelman HE. Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis. J Immunol. 2007 Oct 1; 179(7):4345-56. PMID: 17878329.
    View in: PubMed
  46. Flaherty DP, Walsh SM, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands. J Med Chem. 2007 Oct 4; 50(20):4986-92. PMID: 17845017.
    View in: PubMed
  47. Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol. 2007 Feb; 170(2):680-92. PMID: 17255335.
    View in: PubMed
  48. Buescher JB, Gross S, Gendelman HE, Ikezu T. Neuropathogenesis of HIV. Handbook of Clinical Neurology (J. R. Berger Ed.). Elsevier Science Pub Co. 2007.
  49. Horiba M, Martinez LB, Buescher JL, Sato S, Limoges J, Jiang Y, Jones C, Ikezu T. OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions. J Gen Virol. 2007 Jan; 88(Pt 1):236-41. PMID: 17170456.
    View in: PubMed
  50. Buescher JL, Gross S, Gendelman HE, Ikezu T. The neuropathogenesis of HIV-1 infection. Handb Clin Neurol. 2007; 85:45-67. PMID: 18808975.
    View in: PubMed
  51. Yamamoto M, Kiyota T, Walsh SM, Ikezu T. Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice. J Neuroimmune Pharmacol. 2007 Jun; 2(2):213-21. PMID: 18040846.
    View in: PubMed
  52. Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep; 98(5):1573-84. PMID: 16923168.
    View in: PubMed
  53. Huang Y, Erdmann N, Peng H, Herek S, Davis JS, Luo X, Ikezu T, Zheng J. TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation. J Immunol. 2006 Aug 15; 177(4):2304-13. PMID: 16887991.
    View in: PubMed
  54. Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood. 2006 Jun 15; 107(12):4770-80. PMID: 16478881.
    View in: PubMed
  55. Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. Am J Pathol. 2005 May; 166(5):1475-85. PMID: 15855647.
    View in: PubMed
  56. Xiong H, McCabe L, Costello J, Anderson E, Weber G, Ikezu T. Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease. Neurobiol Aging. 2004 Aug; 25(7):905-11. PMID: 15212844.
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  57. Carlson KA, Limoges J, Pohlman GD, Poluektova LY, Langford D, Masliah E, Ikezu T, Gendelman HE. OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. J Neuroimmunol. 2004 May; 150(1-2):186-98. PMID: 15081264.
    View in: PubMed
  58. Li X, Ikezu T, Hexum TD. Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation. Peptides. 2004 Feb; 25(2):267-74. PMID: 15063008.
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  59. Carlson KA, Leisman G, Limoges J, Pohlman GD, Horiba M, Buescher J, Gendelman HE, Ikezu T. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. J Immunol. 2004 Jan 1; 172(1):381-91. PMID: 14688346.
    View in: PubMed
  60. Ikezu T, Luo X, Weber GA, Zhao J, McCabe L, Buescher JL, Ghorpade A, Zheng J, Xiong H. Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity. J Neurochem. 2003 May; 85(4):925-34. PMID: 12716424.
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  61. Luo X, Weber GA, Zheng J, Gendelman HE, Ikezu T. C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease. J Neuroimmunol. 2003 Feb; 135(1-2):62-71. PMID: 12576225.
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  62. Li X, Drakulich DA, Zhang P, Shen M, Weber GA, Ikezu T, Hexum TD. Transduction of bovine adrenal chromaffin cells using a recombinant adenovirus expressing GFP. J Neurosci Methods. 2002 Dec 31; 122(1):91-6. PMID: 12535768.
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  63. Parolini I, Sargiacomo M, Galbiati F, Rizzo G, Grignani F, Engelman JA, Okamoto T, Ikezu T, Scherer PE, Mora R, Rodriguez-Boulan E, Peschle C, Lisanti MP. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. J Biol Chem. 1999 Sep 3; 274(36):25718-25. PMID: 10464309.
    View in: PubMed
  64. Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA. A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury. Am J Physiol. 1999 Aug; 277(2 Pt 1):E316-24. PMID: 10444428.
    View in: PubMed
  65. Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease. J Neurosci. 1999 Aug 1; 19(15):6538-48. PMID: 10414982.
    View in: PubMed
  66. Ikezu T, Ueda H, Trapp BD, Nishiyama K, Sha JF, Volonte D, Galbiati F, Byrd AL, Bassell G, Serizawa H, Lane WS, Lisanti MP, Okamoto T. Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types. Brain Res. 1998 Sep 7; 804(2):177-92. PMID: 9841091.
    View in: PubMed
  67. Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett. 1998 May 29; 428(3):205-11. PMID: 9654135.
    View in: PubMed
  68. Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T. Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein. J Biol Chem. 1998 Apr 24; 273(17):10485-95. PMID: 9553108.
    View in: PubMed
  69. Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA. Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem. 1997 Oct 3; 272(40):25289-95. PMID: 9312146.
    View in: PubMed
  70. Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I. G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 1997 Aug 15; 16(16):4897-907. PMID: 9305632.
    View in: PubMed
  71. Giambarella U, Murayama Y, Ikezu T, Fujita T, Nishimoto I. Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation. FEBS Lett. 1997 Jul 21; 412(1):97-101. PMID: 9257698.
    View in: PubMed
  72. Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem. 1997 Mar 7; 272(10):6525-33. PMID: 9045678.
    View in: PubMed
  73. Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Martyn JA, Nishimoto I. Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP. EMBO J. 1996 May 15; 15(10):2468-75. PMID: 8665854.
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  74. Ikezu T, Okamoto T, Giambarella U, Yokota T, Nishimoto I. In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor. J Biol Chem. 1995 Dec 8; 270(49):29224-8. PMID: 7493951.
    View in: PubMed
  75. Ikezu T, Okamoto T, Murayama Y, Okamoto T, Homma Y, Ogata E, Nishimoto I. Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product. J Biol Chem. 1994 Dec 16; 269(50):31955-61. PMID: 7989371.
    View in: PubMed
  76. Takahashi K, Murayama Y, Okamoto T, Yokota T, Ikezu T, Takahashi S, Giambarella U, Ogata E, Nishimoto I. Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11772-6. PMID: 8265625.
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  77. Ikezu T, Okamoto T, Ogata E, Nishimoto I. Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif. FEBS Lett. 1992 Oct 12; 311(1):29-32. PMID: 1327875.
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  78. Okamoto T, Ikezu T, Murayama Y, Ogata E, Nishimoto I. Measurement of GTP gamma S binding to specific G proteins in membranes using G-protein antibodies. FEBS Lett. 1992 Jun 29; 305(2):125-8. PMID: 1618340.
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