Keywords
Last Name

Pietro Cottone, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-5662
ORCID ORCID Icon0000-0003-1320-1672
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPsychiatry

 Awards and Honors

Start-EndDescription
2010-2014National Institutes of Health/National Institute of Mental Health: Biobehavioral Research Awards for Innovative New Scientists (BRAINS)
2010-2014Boston University School of Medicine: Peter Paul Career Development Professorship
2007-2011National Institute on Drug Abuse (NIDA): NIH Pathway to Independence Award (K99/R00)
2008of Modena and Reggio Emilia, Italy: Paolo Guidetti Award, CINSPAN
2003-2007University of Rome La Sapienza, Rome, Italy: Merit Predoctoral Fellowship for Graduate Studies
2003University of Palermo, Palermo, Italy: Undergraduate Merit Fellowship
 Research Expertise & Professional Interests
Dr. Cottone is co-director of the Laboratory of Addictive Disorders. Dr. Cottone’s research interests focus on the neurobiological substrates of motivated behaviors including feeding and addiction. The major goal of Dr. Cottone’s research is identifying the biological bases of and potential treatments for eating disorders and obesity. Current studies concern the role of stress in compulsive eating and palatable food dependence. Areas of focused research include the investigation of the neurobiological bases of stress-related disorders such as anxiety and depression. Dr. Cottone’s studies are carried out on environmental and genetic animal models, using behavioral, biochemical, and molecular approaches.

Dr. Cottone co-directs a graduate course in neuropsychopharmacology offered for the first time in Fall 2010 which examines the interaction between behavior and classes of drugs that affect the central nervous system.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moore CF, Sabino V, Koob GF, Cottone P. Pathological Overeating: Emerging Evidence for a Compulsivity Construct. Neuropsychopharmacology. 2017 Jan 04. PMID: 27922596.
    View in: PubMed
  2. Sabino V, Cottone P. Sigma Receptors and Alcohol Use Disorders. Handb Exp Pharmacol. 2016 Dec 31. PMID: 28039543.
    View in: PubMed
  3. Ferragud A, Howell AD, Moore CF, Ta TL, Hoener MC, Sabino V, Cottone P. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2016 Nov 02. PMID: 27711047.
    View in: PubMed
  4. Kirkpatrick SL, Goldberg LR, Yazdani N, Babbs RK, Wu J, Reed ER, Jenkins DF, Bolgioni AF, Landaverde KI, Luttik KP, Mitchell KS, Kumar V, Johnson WE, Mulligan MK, Cottone P, Bryant CD. Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating. Biol Psychiatry. 2016 Oct 25. PMID: 27914629.
    View in: PubMed
  5. Iemolo A, Seiglie M, Blasio A, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nucleus of the amygdala induces anxiety via melanocortin receptors. Psychopharmacology (Berl). 2016 Sep; 233(17):3269-77. PMID: 27376948.
    View in: PubMed
  6. Giuliano C, Cottone P. The role of the opioid system in binge eating disorder. CNS Spectr. 2015 Dec; 20(6):537-45. PMID: 26499083.
    View in: PubMed
  7. Valenza M, DiLeo A, Steardo L, Cottone P, Sabino V. Ethanol-related behaviors in mice lacking the sigma-1 receptor. Behav Brain Res. 2016 Jan 15; 297:196-203. PMID: 26462569.
    View in: PubMed
  8. Seiglie MP, Smith KL, Blasio A, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide induces a depressive-like phenotype in rats. Psychopharmacology (Berl). 2015 Oct; 232(20):3821-31. PMID: 26264905.
    View in: PubMed
  9. Valenza M, Steardo L, Cottone P, Sabino V. Diet-induced obesity and diet-resistant rats: differences in the rewarding and anorectic effects of D-amphetamine. Psychopharmacology (Berl). 2015 Sep; 232(17):3215-26. PMID: 26047964.
    View in: PubMed
  10. Blasio A, Valenza M, Iyer MR, Rice KC, Steardo L, Hayashi T, Cottone P, Sabino V. Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats. Behav Brain Res. 2015; 287:315-22. PMID: 25848705.
    View in: PubMed
  11. Velázquez-Sánchez C, Santos JW, Smith KL, Ferragud A, Sabino V, Cottone P. Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food. Behav Neurosci. 2015 Apr; 129(2):219-24. PMID: 25798634.
    View in: PubMed
  12. Smith KL, Rao RR, Velázquez-Sánchez C, Valenza M, Giuliano C, Everitt BJ, Sabino V, Cottone P. The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus accumbens shell. Neuropsychopharmacology. 2015 Apr; 40(5):1163-71. PMID: 25381776.
    View in: PubMed
  13. Iemolo A, Ferragud A, Cottone P, Sabino V. Pituitary Adenylate Cyclase-Activating Peptide in the Central Amygdala Causes Anorexia and Body Weight Loss via the Melanocortin and the TrkB Systems. Neuropsychopharmacology. 2015 Jul; 40(8):1846-55. PMID: 25649277.
    View in: PubMed
  14. Blasio A, Rice KC, Sabino V, Cottone P. Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior. Behav Pharmacol. 2014 Oct; 25(7):609-17. PMID: 25011007.
    View in: PubMed
  15. Velázquez-Sánchez C, Ferragud A, Moore CF, Everitt BJ, Sabino V, Cottone P. High trait impulsivity predicts food addiction-like behavior in the rat. Neuropsychopharmacology. 2014 Sep; 39(10):2463-72. PMID: 24776685.
    View in: PubMed
  16. Velázquez-Sánchez C, Ferragud T, Moore CF, Everitt BJ, Sabino V, Cottone P. High trait impulsivity predicts food Addiction-like behavior in the rat. Neuropsychopharmacol. 2014.
  17. Blasio A, Rice KC, Sabino V, Cottone P. Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior. Behav Pharmacol “Special Issue on Behavioural Pharmacology of Stress". 2014.
  18. Blasio A, Iemolo A, Sabino V, Petrosino S, Steardo L, Rice KC, Orlando P, Iannotti FA, Di Marzo V, Zorrilla EP, Cottone P. Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. Neuropsychopharmacology. 2013 Nov; 38(12):2498-507. PMID: 23793355.
    View in: PubMed
  19. Iemolo A, Blasio A, St Cyr SA, Jiang F, Rice KC, Sabino V, Cottone P. CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food. Neuropsychopharmacology. 2013 Nov; 38(12):2456-66. PMID: 23748225.
    View in: PubMed
  20. Dore R, Iemolo A, Smith KL, Wang X, Cottone P, Sabino V. CRF mediates the anxiogenic and anti-rewarding, but not the anorectic effects of PACAP. Neuropsychopharmacology. 2013 Oct; 38(11):2160-9. PMID: 23657440.
    View in: PubMed
  21. Dore R, Valenza M, Wang X, Rice KC, Sabino V, Cottone P. The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food. Addict Biol. 2014 Sep; 19(5):849-61. PMID: 23587012.
    View in: PubMed
  22. Cottone P, Sabino V, Nagy TR, Coscina DV, Levin BE, Zorrilla EP. Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats. Int J Obes (Lond). 2013 Dec; 37(12):1515-23. PMID: 23478425.
    View in: PubMed
  23. Sabino V, Narayan AR, Zeric T, Steardo L, Cottone P. mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. Behav Brain Res. 2013 Jun 15; 247:9-16. PMID: 23466691.
    View in: PubMed
  24. Blasio A, Steardo L, Sabino V, Cottone P. Opioid system in the medial prefrontal cortex mediates binge-like eating. Addict Biol. 2014 Jul; 19(4):652-62. PMID: 23346966.
    View in: PubMed
  25. Sabino V, Kwak J, Rice KC, Cottone P. Pharmacological characterization of the 20% alcohol intermittent access model in Sardinian alcohol-preferring rats: a model of binge-like drinking. Alcohol Clin Exp Res. 2013 Apr; 37(4):635-43. PMID: 23126554.
    View in: PubMed
  26. Cottone P, Iemolo A, Narayan AR, Kwak J, Momaney D, Sabino V. The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats. Psychopharmacology (Berl). 2013 Mar; 226(1):127-38. PMID: 23104264.
    View in: PubMed
  27. Iemolo A, Valenza M, Tozier L, Knapp CM, Kornetsky C, Steardo L, Sabino V, Cottone P. Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats. Behav Pharmacol. 2012 Sep; 23(5-6):593-602. PMID: 22854309.
    View in: PubMed
  28. Parylak SL, Cottone P, Sabino V, Rice KC, Zorrilla EP. Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses. Physiol Behav. 2012 Sep 10; 107(2):231-42. PMID: 22776620.
    View in: PubMed
  29. Cottone P, Wang X, Park JW, Valenza M, Blasio A, Kwak J, Iyer MR, Steardo L, Rice KC, Hayashi T, Sabino V. Antagonism of sigma-1 receptors blocks compulsive-like eating. Neuropsychopharmacology. 2012 Nov; 37(12):2593-604. PMID: 22713906.
    View in: PubMed
  30. Fekete EM, Zhao Y, Szücs A, Sabino V, Cottone P, Rivier J, Vale WW, Koob GF, Zorrilla EP. Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. Br J Pharmacol. 2011 Dec; 164(8):1959-75. PMID: 21627635.
    View in: PubMed
  31. Blasio A, Narayan AR, Kaminski BJ, Steardo L, Sabino V, Cottone P. A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT2A/C and 5-HT1A receptor agonists. Psychopharmacology (Berl). 2012 Jan; 219(2):377-86. PMID: 21989803.
    View in: PubMed
  32. Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of s-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology. 2011 May; 36(6):1207-18. PMID: 21346735.
    View in: PubMed
  33. Repunte-Canonigo V, Berton F, Cottone P, Reifel-Miller A, Roberts AJ, Morales M, Francesconi W, Sanna PP. A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake. Brain Res. 2010 Jun 21; 1339:11-7. PMID: 20380822.
    View in: PubMed
  34. Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biol Psychiatry. 2010 May 1; 67(9):831-9. PMID: 20060104.
    View in: PubMed
  35. Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):20016-20. PMID: 19901333.
    View in: PubMed
  36. Fonareva I, Spangler E, Cannella N, Sabino V, Cottone P, Ciccocioppo R, Zorrilla EP, Ryabinin AE. Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats. Alcohol Clin Exp Res. 2009 Nov; 33(11):1956-65. PMID: 19673740.
    View in: PubMed
  37. Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology (Berl). 2009 Aug; 205(2):327-35. PMID: 19440699.
    View in: PubMed
  38. Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addict Biol. 2009 Apr; 14(2):130-43. PMID: 19291009.
    View in: PubMed
  39. Sabino V, Cottone P, Parylak SL, Steardo L, Zorrilla EP. Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res. 2009 Mar 17; 198(2):472-6. PMID: 19100292.
    View in: PubMed
  40. Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology. 2009 May; 34(6):1482-93. PMID: 18946467.
    View in: PubMed
  41. Cottone P, Sabino V, Steardo L, Zorrilla EP. Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food. Psychoneuroendocrinology. 2009 Jan; 34(1):38-49. PMID: 18842344.
    View in: PubMed
  42. Cottone P, Sabino V, Steardo L, Zorrilla EP. Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats. Am J Physiol Regul Integr Comp Physiol. 2008 Oct; 295(4):R1066-76. PMID: 18667718.
    View in: PubMed
  43. Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacol Biochem Behav. 2009 Jan; 91(3):295-302. PMID: 18703080.
    View in: PubMed
  44. George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17198-203. PMID: 17921249.
    View in: PubMed
  45. Cottone P, Sabino V, Nagy TR, Coscina DV, Zorrilla EP. Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2. J Physiol. 2007 Sep 1; 583(Pt 2):487-504. PMID: 17627984.
    View in: PubMed
  46. Esposito G, Scuderi C, Savani C, Steardo L, De Filippis D, Cottone P, Iuvone T, Cuomo V, Steardo L. Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol. 2007 Aug; 151(8):1272-9. PMID: 17592514.
    View in: PubMed
  47. Cottone P, Sabino V, Steardo L, Zorrilla EP. Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. Neuropsychopharmacology. 2008 Feb; 33(3):524-35. PMID: 17443124.
    View in: PubMed
  48. Sabino V, Cottone P, Steardo L, Schmidhammer H, Zorrilla EP. 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2007 Jul; 192(4):537-46. PMID: 17345066.
    View in: PubMed
  49. Cottone P, Sabino V, Steardo L, Zorrilla EP. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology. 2007 May; 32(5):1069-81. PMID: 17077811.
    View in: PubMed
  50. Sabino V, Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2006 Dec; 189(2):175-86. PMID: 17047935.
    View in: PubMed
  51. Parylak SL, Cottone P, Zorrilla EP. Encyclopedia of Psychopharmacology. Eating disorders: animal models. Springer. New York.
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