Pietro Cottone, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, University of Rome
PharmD, University of Palermo
MS, University of Palermo
BS, University of Palermo



Dr. Cottone is co-director of the Laboratory of Addictive Disorders. Dr. Cottone’s research interests focus on the neurobiological substrates of motivated behaviors including feeding and addiction. The major goal of Dr. Cottone’s research is identifying the biological bases of and potential treatments for eating disorders and obesity. Current studies concern the role of stress in compulsive eating and palatable food dependence. Areas of focused research include the investigation of the neurobiological bases of stress-related disorders such as anxiety and depression. Dr. Cottone’s studies are carried out on environmental and genetic animal models, using behavioral, biochemical, and molecular approaches.

Dr. Cottone co-directs a graduate course in neuropsychopharmacology offered for the first time in Fall 2010 which examines the interaction between behavior and classes of drugs that affect the central nervous system.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Psychiatry


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Alpha2 adrenergic receptors as a target for alcohol addiction
02/01/2022 - 01/31/2025 (Multi-PI)
PI: Pietro Cottone, PhD
NIH/National Institute on Alcohol Abuse and Alcoholism
5R21AA029495-02

Determining the role of PACAP neuronal populations in alcohol drinking using PACAP-Cre mice
04/20/2018 - 03/31/2021 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5R21AA026051-02

Effects of Samidorphan on olanzapine-induced overeating
12/13/2019 - 12/13/2020 (PI)
ALKERMES, Inc


CRF Modulation of reward function in compulsive eating
09/01/2017 - 05/17/2019 (Key Person / Mentor)
PI: Catherine Moore, PhD
NIH/National Institute on Drug Abuse
5F31DA044664-02

Neurobiology of Compulsive Eating
03/01/2011 - 02/28/2017 (PI)
NIH/National Institute on Drug Abuse
5R01DA030425-05

Role of the Endocannabinoid System in Compulsive Eating
07/15/2010 - 03/31/2016 (PI)
NIH/National Institute of Mental Health
5R01MH091945-05



Title


Yr Title Project-Sub Proj Pubs
2023 Alpha2 adrenergic receptors as a target for alcohol addiction 5R21AA029495-02
2022 Alpha2 adrenergic receptors as a target for alcohol addiction 1R21AA029495-01A1
2019 Determining the role of PACAP neuronal populations in alcohol drinking using PACAP-Cre mice 5R21AA026051-02
2018 Determining the role of PACAP neuronal populations in alcohol drinking using PACAP-Cre mice 1R21AA026051-01A1
2015 Neurobiology of compulsive eating. 5R01DA030425-05 33
2014 Neurobiology of compulsive eating. 5R01DA030425-04 33
2014 Role of the Endocannabinoid System in Compulsive Eating 5R01MH091945-05 25
2013 Neurobiology of compulsive eating. 5R01DA030425-03 33
2013 Role of the Endocannabinoid System in Compulsive Eating 5R01MH091945-04 25
2012 Neurobiology of compulsive eating. 5R01DA030425-02 33
Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Lepeak L, Miracle S, Ferragud A, Seiglie MP, Shafique S, Ozturk Z, Minnig MA, Medeiros G, Cottone P, Sabino V. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) of the Bed Nucleus of the Stria Terminalis Mediates Heavy Alcohol Drinking in Mice. eNeuro. 2023 Dec; 10(12).View Related Profiles. PMID: 38053471; PMCID: PMC10755645; DOI: 10.1523/ENEURO.0424-23.2023;
     
  2. Seiglie MP, Lepeak L, Miracle S, Cottone P, Sabino V. Stimulation of lateral parabrachial (LPB) to central amygdala (CeA) pituitary adenylate cyclase-activating polypeptide (PACAP) neurons induces anxiety-like behavior and mechanical allodynia. Pharmacol Biochem Behav. 2023 Sep; 230:173605.View Related Profiles. PMID: 37499765
     
  3. Seiglie MP, Lepeak L, Velázquez-Sanchez C, Ferragud A, Le T, Cottone P, Sabino V. The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro. 2022; 9(5).View Related Profiles. PMID: 36566434; PMCID: PMC9506682; DOI: 10.1523/ENEURO.0260-22.2022;
     
  4. Minnig MA, Blasio A, Ferragud A, Sami YN, Erhard EE, Clark RH, DiLeo A, Giuliano C, Everitt BJ, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats. Neuropharmacology. 2022 Jul 01; 212:109063.View Related Profiles. PMID: 35460713; PMCID: PMC10342914; DOI: 10.1016/j.neuropharm.2022.109063;
     
  5. Minnig MA, Park T, Echeveste Sanchez M, Cottone P, Sabino V. Viral-Mediated Knockdown of Nucleus Accumbens Shell PAC1 Receptor Promotes Excessive Alcohol Drinking in Alcohol-Preferring Rats. Front Behav Neurosci. 2021; 15:787362.View Related Profiles. PMID: 34924973; PMCID: PMC8678417; DOI: 10.3389/fnbeh.2021.787362;
     
  6. Valentina S, Blasio A, Ferragud A, Quadir SG, Iyer MR, Rice KC, Cottone P. Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors. Neuropharmacology. 2021 12 01; 200:108786.View Related Profiles. PMID: 34516984; PMCID: PMC9869339; DOI: 10.1016/j.neuropharm.2021.108786;
     
  7. Quadir SG, Tanino SM, Sami YN, Minnig MA, Iyer MR, Rice KC, Cottone P, Sabino V. Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice. Alcohol Clin Exp Res. 2021 07; 45(7):1398-1407.View Related Profiles. PMID: 34060104; PMCID: PMC8295198; DOI: 10.1111/acer.14635;
     
  8. Quadir SG, Tanino SM, Rohl CD, Sahn JJ, Yao EJ, Cruz LDR, Cottone P, Martin SF, Sabino V. The Sigma-2 receptor / transmembrane protein 97 (s2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. Neuropharmacology. 2021 02 15; 184:108409.View Related Profiles. PMID: 33221481; PMCID: PMC7856185; DOI: 10.1016/j.neuropharm.2020.108409;
     
  9. Ferragud A, Velazquez-Sanchez C, Minnig MA, Sabino V, Cottone P. Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats. Neuropsychopharmacology. 2021 02; 46(3):509-518.View Related Profiles. PMID: 33191400; PMCID: PMC8027820; DOI: 10.1038/s41386-020-00904-4;
     
  10. Lee HS, Giunti E, Sabino V, Cottone P. Consummatory, Feeding Microstructural, and Metabolic Effects Induced by Limiting Access to Either a High-Sucrose or a High-Fat Diet. Nutrients. 2020 May 30; 12(6).View Related Profiles. PMID: 32486207; PMCID: PMC7352440; DOI: 10.3390/nu12061610;
     
Showing 10 of 75 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 74 publications over 18 distinct years, with a maximum of 8 publications in 2015

YearPublications
20062
20075
20085
20094
20102
20113
20125
20137
20144
20158
20164
20175
20183
20193
20207
20213
20222
20232


Brain peptide identified as key player in heavy alcohol drinking

News Medical 12/1/2023

Does Yo-Yo Dieting Drive Compulsive Eating?

Psyche Central 10/22/2019

BU Neuroscientist on Recording an Album Defending Immigrants and His Recent Journey to US Citizenship

BU Today 8/9/2019

Far from the Washington turmoil, nearly 200 immigrants become Americans

The Boston Globe 7/17/2019

2010-2014 National Institutes of Health/National Institute of Mental Health: Biobehavioral Research Awards for Innovative New Scientists (BRAINS)
2010-2014 Boston University School of Medicine: Peter Paul Career Development Professorship
2008 of Modena and Reggio Emilia, Italy: Paolo Guidetti Award, CINSPAN
2007-2011 National Institute on Drug Abuse (NIDA): NIH Pathway to Independence Award (K99/R00)
2003-2007 University of Rome La Sapienza, Rome, Italy: Merit Predoctoral Fellowship for Graduate Studies
2003 University of Palermo, Palermo, Italy: Undergraduate Merit Fellowship
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72 E. Concord St Housman (R)
Boston MA 02118
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