Valentina Sabino, PhD
Associate Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, Univ of Rome
MS, University of Palermo
PharmD, University of Palermo



Dr. Sabino is co-director of the Laboratory of Addictive Disorders, and is currently researching the neurobiology of addiction and stress-related disorders. Studies on addiction aim to understand the neurobiological substrates of alcohol abuse and dependence by exploring the role of neurochemical systems in excessive alcohol drinking.

Dr. Sabino is working toward the development of new therapeutic agents to alleviate alcohol addiction. Animal models for excessive drinking are studied in order to identify compounds for potential clinical development. Research is also conducted on the neurobiology of stress-related disorders such as anxiety and depression.

The approach of the laboratory is interdisciplinary, involving behavioral neuroscience, neuropharmacology, neuroanatomy, biochemistry and molecular biology.

Dr. Sabino co-directs a graduate course in Behavioral Pharmacology which examines the interaction between behavior and classes of drugs that affect the central nervous system giving emphasis on how behavioral studies can assist in our understanding of mental disorders.

Associate Professor
Boston University School of Medicine
Psychiatry
General Psychiatry Section

Co-Director
Boston University School of Medicine
Pharmacology & Experimental Therapeutics
Laboratory of Addictive Disorders Section

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



2014 Peter McManus Trust Award for alcohol and drug abuse research
2011 Peter McManus Trust Award for alcohol and drug abuse research
2008 CINSPAN, University of Modena and Reggio Emilia, Italy: Award Paolo Guidetti
2008 RSA Student Merit/Junior Investigator Award for the 2008 RSA/ISBRA Meeting
2006-2013 NIAAA/NIH: NIH Pathway to Independence Award (K99/R00)


Prefrontal cortex In excessive alcohol drinking: role of sigma receptors
08/01/2016 - 04/30/2018 (PI)
NIH/National Institute on Alcohol Abuse
5R01AA024439-02

Role of Neuropeptides in Anxiety
01/01/2016 - 12/31/2017 (PI)
NIH/National Institute of Mental Health
4R01MH093650-05

Role of Neuropeptides in Anxiety
01/12/2012 - 12/31/2015 (PI)
NIH/National Institute of Mental Health
5R01MH093650-04

Neurobiological Bases of Alcohol Addiction
01/01/2014 - 12/31/2014 (PI)
Peter F. McManus Charitable Trust




Yr Title Project-Sub Proj Pubs
2017 Prefrontal cortex in excessive alcohol drinking: role of sigma receptors 5R01AA024439-02
2016 Prefrontal cortex in excessive alcohol drinking: role of sigma receptors 1R01AA024439-01A1
2016 Role of Neuropeptides in Anxiety 4R01MH093650-05 17
2015 Role of Neuropeptides in Anxiety 5R01MH093650-04 17
2014 Role of Neuropeptides in Anxiety 5R01MH093650-03 17
2013 Role of Neuropeptides in Anxiety 5R01MH093650-02 17
2012 Role of Neuropeptides in Anxiety 1R01MH093650-01A1 17
2011 Role of sigma receptors in ethanol reinforcement 5R00AA016731-05 14
2010 Role of sigma receptors in ethanol reinforcement 5R00AA016731-04 14
2009 Role of sigma receptors in ethanol reinforcement 4R00AA016731-03 14
Showing 10 of 12 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Sabino V, Hicks C, Cottone P. Sigma Receptors and Substance Use Disorders. Adv Exp Med Biol. 2017; 964:177-199.View Related Profiles. PMID: 28315272; DOI: 10.1007/978-3-319-50174-1_13;.
  2. Sabino V, Cottone P. Sigma Receptors and Alcohol Use Disorders. Handb Exp Pharmacol. 2016 Dec 31.View Related Profiles. PMID: 28039543; DOI: 10.1007/164_2016_97;.
  3. Iemolo A, Seiglie M, Blasio A, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nucleus of the amygdala induces anxiety via melanocortin receptors. Psychopharmacology (Berl). 2016 Sep; 233(17):3269-77.View Related Profiles. PMID: 27376948; PMCID: PMC4982769; DOI: 10.1007/s00213-016-4366-y;.
  4. Valenza M, DiLeo A, Steardo L, Cottone P, Sabino V. Ethanol-related behaviors in mice lacking the sigma-1 receptor. Behav Brain Res. 2016 Jan 15; 297:196-203.View Related Profiles. PMID: 26462569; DOI: 10.1016/j.bbr.2015.10.013;.
  5. Seiglie MP, Smith KL, Blasio A, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide induces a depressive-like phenotype in rats. Psychopharmacology (Berl). 2015 Oct; 232(20):3821-31.View Related Profiles. PMID: 26264905; PMCID: PMC4565740; DOI: 10.1007/s00213-015-4045-4;.
  6. Valenza M, Steardo L, Cottone P, Sabino V. Diet-induced obesity and diet-resistant rats: differences in the rewarding and anorectic effects of D-amphetamine. Psychopharmacology (Berl). 2015 Sep; 232(17):3215-26.View Related Profiles. PMID: 26047964; PMCID: PMC4536171; DOI: 10.1007/s00213-015-3981-3;.
  7. Blasio A, Valenza M, Iyer MR, Rice KC, Steardo L, Hayashi T, Cottone P, Sabino V. Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats. Behav Brain Res. 2015; 287:315-22.View Related Profiles. PMID: 25848705; PMCID: PMC4424067; DOI: 10.1016/j.bbr.2015.03.065;.
  8. Velázquez-Sánchez C, Santos JW, Smith KL, Ferragud A, Sabino V, Cottone P. Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food. Behav Neurosci. 2015 Apr; 129(2):219-24.View Related Profiles. PMID: 25798634; PMCID: PMC4456453; DOI: 10.1037/bne0000042;.
  9. Smith KL, Rao RR, Velázquez-Sánchez C, Valenza M, Giuliano C, Everitt BJ, Sabino V, Cottone P. The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus accumbens shell. Neuropsychopharmacology. 2015 Apr; 40(5):1163-71.View Related Profiles. PMID: 25381776; PMCID: PMC4367459; DOI: 10.1038/npp.2014.299;.
  10. Iemolo A, Ferragud A, Cottone P, Sabino V. Pituitary Adenylate Cyclase-Activating Peptide in the Central Amygdala Causes Anorexia and Body Weight Loss via the Melanocortin and the TrkB Systems. Neuropsychopharmacology. 2015 Jul; 40(8):1846-55.View Related Profiles. PMID: 25649277; PMCID: PMC4839508; DOI: 10.1038/npp.2015.34;.
Showing 10 of 43 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 43 publications over 14 distinct years, with a maximum of 8 publications in 2013

YearPublications
20031
20041
20062
20073
20084
20093
20102
20112
20125
20138
20142
20157
20162
20171
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72 E. Concord St Housman (R)
Boston MA 02118
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