Valentina Sabino, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, University of Palermo
PharmD, University of Palermo
MS, University of Palermo
BS, University of Palermo

Pronouns: she/her/hers



Dr. Sabino co-directs the Laboratory of Addictive Disorders with Dr. Cottone, and she is Professor in the Pharmacology, Physiology & Biophysics Department and in the Psychiatry Department.
Her lab investigates the neurobiological substrates of addiction by exploring the role of neuropeptide systems in excessive alcohol drinking. Research is also aimed to shed light on the neural substrates of stress-related and mood disorders, such as anxiety and depression.

Dr. Sabino is working toward the development of new therapeutic agents to alleviate these highly prevalent psychiatric conditions. The approach of the laboratory is interdisciplinary, involving behavioral neuroscience, neuropharmacology, neuroanatomy, biochemistry, and molecular biology.

Dr. Sabino is highly involved in teaching, as she directs and lectures in several graduate level courses (MD students, Dental students, PhD students, Master's students).

Professor
Boston University Chobanian & Avedisian School of Medicine
Psychiatry
General Psychiatry

Co-Director of Laboratory of Addictive Disorders
Boston University Chobanian & Avedisian School of Medicine
Dean’s Office
Laboratory of Addictive Disorders

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Graduate Program for Neuroscience




The role of prefrontostriatal Pituitary Adenylate Cyclase Activating Polypeptide in excessive and compulsive ethanol drinking
08/11/2020 - 08/10/2024 (Key Person / Mentor)
NIH/National Institute on Alcohol Abuse and Alcoholism
5F30AA028184-04

Alpha2 adrenergic receptors as a target for alcohol addiction
02/01/2022 - 01/31/2024 (Multi-PI)
PI: Valentina Sabino, PhD
NIH/National Institute on Alcohol Abuse and Alcoholism
5R21AA029495-02

Involvement of neuropeptide systems in excessive alcohol drinking
09/20/2017 - 08/31/2023 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5R01AA025038-05

Prefrontal cortex In excessive alcohol drinking: role of sigma receptors
08/01/2016 - 04/30/2022 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5R01AA024439-05

Involvement of prelimbic cortex Pituitary Adenylate Cyclase Activating Polypeptide in alcohol consumption
07/01/2020 - 12/31/2021 (Key Person / Mentor)
Research Society on Alcoholism


Does REST make you resilient?
05/07/2018 - 03/31/2021 (Multi-PI)
PI: Valentina Sabino, PhD
NIH/National Institute of Mental Health
5R21MH113128-02

Investigating the role of the Sigma-1 receptors in alcohol addiction and associated cognitive deficits and pain states
07/21/2020 - 11/13/2020 (Key Person / Mentor)
PI: Sema Quadir
NIH/National Institute on Alcohol Abuse and Alcoholism
1F31AA028191-01A1

Role of Neuropeptides in Anxiety
01/01/2016 - 12/31/2017 (PI)
NIH/National Institute of Mental Health
4R01MH093650-05

Role of Neuropeptides in Anxiety
01/12/2012 - 12/31/2015 (PI)
NIH/National Institute of Mental Health
5R01MH093650-04

Neurobiological Bases of Alcohol Addiction
01/01/2014 - 12/31/2014 (PI)
Peter F. McManus Charitable Trust




Title


Yr Title Project-Sub Proj Pubs
2023 Alpha2 adrenergic receptors as a target for alcohol addiction 5R21AA029495-02
2022 Alpha2 adrenergic receptors as a target for alcohol addiction 1R21AA029495-01A1
2021 Involvement of neuropeptide systems in excessive alcohol drinking 5R01AA025038-05 1
2020 Involvement of neuropeptide systems in excessive alcohol drinking 5R01AA025038-04 1
2020 Prefrontal cortex in excessive alcohol drinking: role of sigma receptors 5R01AA024439-05 1
2019 Does REST make you resilient? 5R21MH113128-02 1
2019 Involvement of neuropeptide systems in excessive alcohol drinking 5R01AA025038-03 1
2019 Prefrontal cortex in excessive alcohol drinking: role of sigma receptors 5R01AA024439-04 1
2018 Does REST make you resilient? 1R21MH113128-01A1 1
2018 Involvement of neuropeptide systems in excessive alcohol drinking 5R01AA025038-02 1
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Lepeak L, Miracle S, Ferragud A, Seiglie MP, Shafique S, Ozturk Z, Minnig MA, Medeiros G, Cottone P, Sabino V. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) of the Bed Nucleus of the Stria Terminalis Mediates Heavy Alcohol Drinking in Mice. eNeuro. 2023 Dec; 10(12).View Related Profiles. PMID: 38053471; PMCID: PMC10755645; DOI: 10.1523/ENEURO.0424-23.2023;
     
  2. Seiglie MP, Lepeak L, Miracle S, Cottone P, Sabino V. Stimulation of lateral parabrachial (LPB) to central amygdala (CeA) pituitary adenylate cyclase-activating polypeptide (PACAP) neurons induces anxiety-like behavior and mechanical allodynia. Pharmacol Biochem Behav. 2023 Sep; 230:173605.View Related Profiles. PMID: 37499765
     
  3. Seiglie MP, Lepeak L, Velázquez-Sanchez C, Ferragud A, Le T, Cottone P, Sabino V. The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro. 2022; 9(5).View Related Profiles. PMID: 36566434; PMCID: PMC9506682; DOI: 10.1523/ENEURO.0260-22.2022;
     
  4. Minnig MA, Blasio A, Ferragud A, Sami YN, Erhard EE, Clark RH, DiLeo A, Giuliano C, Everitt BJ, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats. Neuropharmacology. 2022 Jul 01; 212:109063.View Related Profiles. PMID: 35460713; PMCID: PMC10342914; DOI: 10.1016/j.neuropharm.2022.109063;
     
  5. Minnig MA, Park T, Echeveste Sanchez M, Cottone P, Sabino V. Viral-Mediated Knockdown of Nucleus Accumbens Shell PAC1 Receptor Promotes Excessive Alcohol Drinking in Alcohol-Preferring Rats. Front Behav Neurosci. 2021; 15:787362.View Related Profiles. PMID: 34924973; PMCID: PMC8678417; DOI: 10.3389/fnbeh.2021.787362;
     
  6. Valentina S, Blasio A, Ferragud A, Quadir SG, Iyer MR, Rice KC, Cottone P. Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors. Neuropharmacology. 2021 12 01; 200:108786.View Related Profiles. PMID: 34516984; PMCID: PMC9869339; DOI: 10.1016/j.neuropharm.2021.108786;
     
  7. Quadir SG, Tanino SM, Sami YN, Minnig MA, Iyer MR, Rice KC, Cottone P, Sabino V. Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice. Alcohol Clin Exp Res. 2021 07; 45(7):1398-1407.View Related Profiles. PMID: 34060104; PMCID: PMC8295198; DOI: 10.1111/acer.14635;
     
  8. Quadir SG, Tanino SM, Rohl CD, Sahn JJ, Yao EJ, Cruz LDR, Cottone P, Martin SF, Sabino V. The Sigma-2 receptor / transmembrane protein 97 (s2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. Neuropharmacology. 2021 02 15; 184:108409.View Related Profiles. PMID: 33221481; PMCID: PMC7856185; DOI: 10.1016/j.neuropharm.2020.108409;
     
  9. Ferragud A, Velazquez-Sanchez C, Minnig MA, Sabino V, Cottone P. Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats. Neuropsychopharmacology. 2021 02; 46(3):509-518.View Related Profiles. PMID: 33191400; PMCID: PMC8027820; DOI: 10.1038/s41386-020-00904-4;
     
  10. Lee HS, Giunti E, Sabino V, Cottone P. Consummatory, Feeding Microstructural, and Metabolic Effects Induced by Limiting Access to Either a High-Sucrose or a High-Fat Diet. Nutrients. 2020 May 30; 12(6).View Related Profiles. PMID: 32486207; PMCID: PMC7352440; DOI: 10.3390/nu12061610;
     
Showing 10 of 74 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 74 publications over 20 distinct years, with a maximum of 8 publications in 2013

YearPublications
20031
20042
20062
20074
20084
20094
20102
20113
20125
20138
20142
20157
20163
20174
20185
20194
20207
20213
20222
20232


Alcohol Use Disorder Linked to Pituitary Adenylate Cyclase Activating Polypeptide

Inside Precision Medicine 12/6/2023

Peptide PACAP’s Key Role in Alcohol Addiction

Neuroscience News 12/1/2023

2014 Peter McManus Trust Award for alcohol and drug abuse research
2011 Peter McManus Trust Award for alcohol and drug abuse research
2008 CINSPAN, University of Modena and Reggio Emilia, Italy: Award Paolo Guidetti
2008 RSA Student Merit/Junior Investigator Award for the 2008 RSA/ISBRA Meeting
2006-2013 NIAAA/NIH: NIH Pathway to Independence Award (K99/R00)
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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617.358.1311
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