Jennifer I. Luebke, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University



The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Neural Substrates of cognitive decline and curcumin intervention in aging monkeys
09/30/2016 - 08/31/2018 (PI)
NIH/National Institute on Aging
1R56AG049870-01A1

RNA binding proteins as novel targets in Alzheimer's disease
09/15/2015 - 04/30/2018 (SP Co-PI of Sub-Project / SP)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging
5R01AG050471-02

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (PI)
NIH/National Institute of Neurological D
5R21NS089340-02

Empirical and Computational Analyses of Striatal MSN's and FSI's and of L5 CPN's in the Q175 and DN17 Models
04/01/2016 - 03/31/2017 (PI)
CHDI Foundation, Inc.


Modeling Cellular Determinants of Cognitive Decline in Aging
09/30/2010 - 05/31/2015 (PI)
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG035071-05

Intraneuronal Beta Amyloid and Synaptic Plasticity in the Prefrontal Cortex
09/01/2013 - 08/30/2014 (PI)
Rhode Island Hospital


Functional Consequences of Cholinergic Degeneration in Aged Rhesus Monkeys
07/01/2000 - 06/30/2002 (PI)
American Federation for Aging Research

Inhibitory Roles of Layer I Neurons in Rat Barrel Cortex
03/01/2000 - 02/28/2002 (PI)
National Science Foundation
IOS-9982184



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Medalla M, Gilman JP, Wang JY, Luebke JI. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017 May 03; 37(18):4717-4734.View Related Profiles. PMID: 28381592; DOI: 10.1523/JNEUROSCI.3757-16.2017;.
  2. Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15; 525(9):2175-2191.View Related Profiles. PMID: 28256708; DOI: 10.1002/cne.24196;.
  3. Luebke JI. Pyramidal Neurons Are Not Generalizable Building Blocks of Cortical Networks. Front Neuroanat. 2017; 11:11. PMID: 28326020; DOI: 10.3389/fnana.2017.00011;.
  4. Gilman JP, Medalla M, Luebke JI. Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2017 Mar 01; 27(3):2078-2094.View Related Profiles. PMID: 26965903; DOI: 10.1093/cercor/bhw062;.
  5. Rumbell TH, Draguljic D, Yadav A, Hof PR, Luebke JI, Weaver CM. Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. J Comput Neurosci. 2016 08; 41(1):65-90. PMID: 27106692; DOI: 10.1007/s10827-016-0605-9;.
  6. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles. PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.
  7. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52.View Related Profiles. PMID: 25878286; PMCID: PMC4397608; DOI: 10.1523/JNEUROSCI.0335-15.2015;.
  8. Medalla M, Luebke JI. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015 Jan 7; 35(1):112-27.View Related Profiles. PMID: 25568107; PMCID: PMC4287137; DOI: 10.1523/JNEUROSCI.3426-14.2015;.
  9. Coskren PJ, Luebke JI, Kabaso D, Wearne SL, Yadav A, Rumbell T, Hof PR, Weaver CM. Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. J Comput Neurosci. 2015 Apr; 38(2):263-83. PMID: 25527184; PMCID: PMC4352129; DOI: 10.1007/s10827-014-0541-5;.
  10. Luebke JI, Medalla M, Amatrudo JM, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A. Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cereb Cortex. 2015 Jun; 25(6):1454-68.View Related Profiles. PMID: 24323499; PMCID: PMC4428297; DOI: 10.1093/cercor/bht336;.
Showing 10 of 47 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 47 publications over 22 distinct years, with a maximum of 4 publications in 2007 and 2012 and 2013 and 2017

YearPublications
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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

morphological analyses
neuroanatomy
Neurophysiology
whole-cell patch-clamping
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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