Keywords
Last Name

Jennifer I. Luebke, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology
Address85 E. Newton St Fuller Building
Boston MA 02118
Phone(617) 638-5995
ORCID ORCID Icon0000-0003-1399-6073
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.

 Self-Described Keywords
  • morphological analyses
  • neuroanatomy
  • Neurophysiology
  • whole-cell patch-clamping
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Rumbell TH, Draguljic D, Yadav A, Hof PR, Luebke JI, Weaver CM. Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. J Comput Neurosci. 2016 Aug; 41(1):65-90. PMID: 27106692.
    View in: PubMed
  2. Gilman JP, Medalla M, Luebke JI. Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2016 Mar 10. PMID: 26965903.
    View in: PubMed
  3. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93. PMID: 26436904.
    View in: PubMed
  4. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52. PMID: 25878286.
    View in: PubMed
  5. Medalla M, Luebke JI. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015 Jan 7; 35(1):112-27. PMID: 25568107.
    View in: PubMed
  6. Coskren PJ, Luebke JI, Kabaso D, Wearne SL, Yadav A, Rumbell T, Hof PR, Weaver CM. Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex. J Comput Neurosci. 2015 Apr; 38(2):263-83. PMID: 25527184.
    View in: PubMed
  7. Luebke JI, Medalla M, Amatrudo JM, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A. Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cereb Cortex. 2015 Jun; 25(6):1454-68. PMID: 24323499.
    View in: PubMed
  8. Crimins JL, Pooler A, Polydoro M, Luebke JI, Spires-Jones TL. The intersection of amyloid ß and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease. Ageing Res Rev. 2013 Jun; 12(3):757-63. PMID: 23528367.
    View in: PubMed
  9. Biasini E, Unterberger U, Solomon IH, Massignan T, Senatore A, Bian H, Voigtlaender T, Bowman FP, Bonetto V, Chiesa R, Luebke J, Toselli P, Harris DA. A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity. J Neurosci. 2013 Feb 6; 33(6):2408-18. PMID: 23392670.
    View in: PubMed
  10. Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39. PMID: 23365232.
    View in: PubMed
  11. Dickstein DL, Weaver CM, Luebke JI, Hof PR. Dendritic spine changes associated with normal aging. Neuroscience. 2013 Oct 22; 251:21-32. PMID: 23069756.
    View in: PubMed
  12. Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. J Neurosci. 2012 Oct 3; 32(40):13644-60. PMID: 23035077.
    View in: PubMed
  13. Crimins JL, Rocher AB, Luebke JI. Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy. Acta Neuropathol. 2012 Dec; 124(6):777-95. PMID: 22976049.
    View in: PubMed
  14. Yadav A, Gao YZ, Rodriguez A, Dickstein DL, Wearne SL, Luebke JI, Hof PR, Weaver CM. Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells. J Comp Neurol. 2012 Sep 1; 520(13):2888-902. PMID: 22315181.
    View in: PubMed
  15. Crimins JL, Rocher AB, Peters A, Shultz P, Lewis J, Luebke JI. Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy. Acta Neuropathol. 2011 Nov; 122(5):551-64. PMID: 21968531.
    View in: PubMed
  16. Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol. 2011 Oct; 179(4):2071-82. PMID: 21854751.
    View in: PubMed
  17. Ludvigson AE, Luebke JI, Lewis J, Peters A. Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study. Brain Struct Funct. 2011 Mar; 216(1):31-42. PMID: 21152933.
    View in: PubMed
  18. Luebke JI, Amatrudo JM. Age-related increase of sI(AHP) in prefrontal pyramidal cells of monkeys: relationship to cognition. Neurobiol Aging. 2012 Jun; 33(6):1085-95. PMID: 20727620.
    View in: PubMed
  19. Luebke JI, Weaver CM, Rocher AB, Rodriguez A, Crimins JL, Dickstein DL, Wearne SL, Hof PR. Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models. Brain Struct Funct. 2010 Mar; 214(2-3):181-99. PMID: 20177698.
    View in: PubMed
  20. Luebke J, Barbas H, Peters A. Effects of normal aging on prefrontal area 46 in the rhesus monkey. Brain Res Rev. 2010 Mar; 62(2):212-32. PMID: 20005254.
    View in: PubMed
  21. Rocher AB, Crimins JL, Amatrudo JM, Kinson MS, Todd-Brown MA, Lewis J, Luebke JI. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp Neurol. 2010 Jun; 223(2):385-93. PMID: 19665462.
    View in: PubMed
  22. Rocher AB, Kinson MS, Luebke JI. Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice. Neurobiol Dis. 2008 Nov; 32(2):309-18. PMID: 18721884.
    View in: PubMed
  23. Luebke JI, Chang YM. Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortex. Neuroscience. 2007 Dec 12; 150(3):556-62. PMID: 17981400.
    View in: PubMed
  24. Chang YM, Luebke JI. Electrophysiological diversity of layer 5 pyramidal cells in the prefrontal cortex of the rhesus monkey: in vitro slice studies. J Neurophysiol. 2007 Nov; 98(5):2622-32. PMID: 17804579.
    View in: PubMed
  25. Peters A, Sethares C, Luebke JI. Synapses are lost during aging in the primate prefrontal cortex. Neuroscience. 2008 Apr 9; 152(4):970-81. PMID: 18329176.
    View in: PubMed
  26. Dickstein DL, Kabaso D, Rocher AB, Luebke JI, Wearne SL, Hof PR. Changes in the structural complexity of the aged brain. Aging Cell. 2007 Jun; 6(3):275-84. PMID: 17465981.
    View in: PubMed
  27. Chang YM, Rosene DL, Killiany RJ, Mangiamele LA, Luebke JI. Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys. Cereb Cortex. 2005 Apr; 15(4):409-18. PMID: 15749985.
    View in: PubMed
  28. Moore TL, Schettler SP, Killiany RJ, Herndon JG, Luebke JI, Moss MB, Rosene DL. Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex. Behav Brain Res. 2005 May 28; 160(2):208-21. PMID: 15863218.
    View in: PubMed
  29. Turner TJ, Mokler DJ, Luebke JI. Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies. Neuroscience. 2004; 129(3):703-18. PMID: 15541891.
    View in: PubMed
  30. Luebke JI, Chang YM, Moore TL, Rosene DL. Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex. Neuroscience. 2004; 125(1):277-88. PMID: 15051166.
    View in: PubMed
  31. O'Brien S, Rosene DL, Luebke JI. GABAA receptor-mediated neurotransmission in the dentate gyrus of the rhesus monkey: comparison with the rat. Synapse. 2003 Sep 15; 49(4):287-9. PMID: 12827648.
    View in: PubMed
  32. Chang YM, Galler JR, Luebke JI. Prenatal protein malnutrition results in increased frequency of miniature inhibitory postsynaptic currents in rat CA3 interneurons. Nutr Neurosci. 2003 Aug; 6(4):263-7. PMID: 12887143.
    View in: PubMed
  33. Luebke JI, Rosene DL. Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey. J Comp Neurol. 2003 Jun 9; 460(4):573-84. PMID: 12717715.
    View in: PubMed
  34. Mokler DJ, Galler JR, Luebke JI. Development and modulation of GABA(A) receptor-mediated neurotransmission in the CA1 region of prenatally protein malnourished rats. Nutr Neurosci. 2001; 4(2):109-19. PMID: 11842879.
    View in: PubMed
  35. Luebke J, St John J, Galler JR. Prenatal protein malnutrition results in increased frequency of miniature inhibitory synaptic currents in rat CA1 pyramidal cells. Synapse. 2000 Jul; 37(1):23-31. PMID: 10842348.
    View in: PubMed
  36. Rushmore J, Luebke J, Galler JR. Electrophysiological properties of rat hippocampal principal cells are unaltered by prenatal protein malnutrition. Hippocampus. 1998; 8(4):380-9. PMID: 9744423.
    View in: PubMed
  37. St John JL, Rosene DL, Luebke JI. Morphology and electrophysiology of dentate granule cells in the rhesus monkey: comparison with the rat. J Comp Neurol. 1997 Oct 13; 387(1):136-47. PMID: 9331177.
    View in: PubMed
  38. Dunlap K, Luebke JI, Turner TJ. Exocytotic Ca2+ channels in mammalian central neurons. Trends Neurosci. 1995 Feb; 18(2):89-98. PMID: 7537420.
    View in: PubMed
  39. Dunlap K, Luebke JI, Turner TJ. Identification of calcium channels that control neurosecretion. Science. 1994 Nov 4; 266(5186):828-31. PMID: 7973643.
    View in: PubMed
  40. Luebke JI, Dunlap K. Sensory neuron N-type calcium currents are inhibited by both voltage-dependent and -independent mechanisms. Pflugers Arch. 1994 Oct; 428(5-6):499-507. PMID: 7838672.
    View in: PubMed
  41. Luebke JI, McCarley RW, Greene RW. Inhibitory action of muscarinic agonists on neurons in the rat laterodorsal tegmental nucleus in vitro. J Neurophysiol. 1993 Nov; 70(5):2128-35. PMID: 8294974.
    View in: PubMed
  42. Luebke JI, Dunlap K, Turner TJ. Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus. Neuron. 1993 Nov; 11(5):895-902. PMID: 7902110.
    View in: PubMed
  43. Luebke JI, Weider JM, McCarley RW, Greene RW. Distribution of NADPH-diaphorase positive somata in the brainstem of the monitor lizard Varanus exanthematicus. Neurosci Lett. 1992 Dec 14; 148(1-2):129-32. PMID: 1300484.
    View in: PubMed
  44. Luebke JI, Wright LL. Characterization of superior cervical ganglion neurons that project to the submandibular glands, the eyes, and the pineal gland in rats. Brain Res. 1992 Aug 28; 589(1):1-14. PMID: 1358399.
    View in: PubMed
  45. Luebke JI, Weight FF, Aguayo LG. Labelling and recording from dissociated target-specific rat superior cervical ganglion neurons. Neurosci Lett. 1992 Feb 3; 135(2):210-4. PMID: 1378213.
    View in: PubMed
  46. Luebke JI, Greene RW, Semba K, Kamondi A, McCarley RW, Reiner PB. Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro. Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):743-7. PMID: 1731349.
    View in: PubMed
  47. Wright LL, Luebke JI. Somatostatin-, vasoactive intestinal polypeptide- and neuropeptide Y-like immunoreactivity in eye- and submandibular gland-projecting sympathetic neurons. Brain Res. 1989 Aug 14; 494(2):267-75. PMID: 2570622.
    View in: PubMed
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