Jennifer I. Luebke, PhD
|Institution||Boston University School of Medicine|
|Department||Anatomy & Neurobiology|
|Address||85 E. Newton St Fuller Building|
Boston MA 02118
|Title||Graduate Faculty (Primary Mentor of Grad Students)|
|Institution||Boston University School of Medicine, Division of Graduate Medical Sciences|
The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.
- morphological analyses
- whole-cell patch-clamping
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