Weiwei Lin | Profiles RNS

Weiwei Lin, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmcology, Physiology & Biophysics

Websites

My research aims to use the power of precision mass spectrometry towards functional multi-omics-based systems biology to uncover the molecular networks altered in Alzheimer’s disease and other brain pathologies.
A) Mapping protein-protein interactions linked to AD progression and other neurodegenerative diseases.
B) High-resolution LC-MS-based integrative metabolomic and proteomic platform development and application.
C) Brain disease-associated native protein complexes.

Other Research

Title

Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
12/15/2022 - 11/30/2025 (Co-Investigator)
PI: Wendy Wei Qiao Qiu, MD, PhD
NIH NIH
1 RF1 AG075832-01A1

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development. J Neurosci. 2024 Oct 16; 44(42).View Related Profiles.

Ho, Angela
Beffert, Uwe
Lin, Weiwei

PMID: 39227156

Zhang Z, Lin W, Gan Q, Lei M, Gong B, Zhang C, Henrique JS, Han J, Tian H, Tao Q, Potempa LA, Stein TD, Emili A, Qiu WQ. The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP. Angiogenesis. 2024 Sep 14.View Related Profiles.

Henrique, Jessica
Tao, Qiushan
Stein, Thor
Lin, Weiwei

PMID: 39276310; DOI: 10.1007/s10456-024-09946-4;

Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, Guo H, McComb M, Emili A. PANAMA-enabled high-sensitivity dual nanoflow LC-MS metabolomics and proteomics analysis. Cell Rep Methods. 2024 Jul 15; 4(7):100803.View Related Profiles.

Blum, Benjamin
Lin, Weiwei

PMID: 38959888; PMCID: PMC11294829; DOI: 10.1016/j.crmeth.2024.100803;

Lagani GD, Lin W, Natarajan S, Lampl N, Harper ER, Emili A, Beffert U, Ho A. Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development. bioRxiv. 2024 Jan 12.View Related Profiles.

Ho, Angela
Beffert, Uwe
Lin, Weiwei

PMID: 38260505; PMCID: PMC10802565; DOI: 10.1101/2024.01.12.575269;

Lin W, Mousavi F, Blum BC, Heckendorf CF, Moore J, Lampl N, McComb M, Kotelnikov S, Yin W, Rabhi N, Layne MD, Kozakov D, Chitalia VC, Emili A. Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease. Front Pharmacol. 2023; 14:1243505.View Related Profiles.

Blum, Benjamin
Layne, Matthew
Rabhi, Nabil
Chitalia, Vipul
Lin, Weiwei

PMID: 38089059; PMCID: PMC10715419; DOI: 10.3389/fphar.2023.1243505;

Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. Int J Mol Sci. 2023 Mar 01; 24(5).View Related Profiles.

Luptak, Ivan
Moore, Jarrod
Goel, Raghuveera
Perissi, Valentina
Lin, Weiwei

PMID: 36902152; PMCID: PMC10002553; DOI: 10.3390/ijms24054724;

Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, Denis GV, Kozakov D, Raught B, Siggers T, Wuchty S, Muthuswamy SK, Emili A. Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Nat Commun. 2023 Feb 08; 14(1):688.View Related Profiles.

Chen, Christopher
Denis, Gerald
Lin, Weiwei

PMID: 36755019; PMCID: PMC9908882; DOI: 10.1038/s41467-023-36122-x;

Heckendorf C, Blum BC, Lin W, Lawton ML, Emili A. Integration of Metabolomic and Proteomic Data to Uncover Actionable Metabolic Pathways. Methods Mol Biol. 2023; 2660:137-148.View Related Profiles.

Blum, Benjamin
Lin, Weiwei

PMID: 37191795

Liu Y, Zhang X, Lin W, Kehriman N, Kuang W, Ling X. Multi-factor combined biomarker screening strategy to rapidly diagnose Alzheimer's disease and evaluate drug effect based on a rat model. J Pharm Anal. 2022 Aug; 12(4):627-636. PMID: 36105160; PMCID: PMC9463486; DOI: 10.1016/j.jpha.2022.04.003;

Blum BC, Lin W, Lawton ML, Liu Q, Kwan J, Turcinovic I, Hekman R, Hu P, Emili A. Multiomic Metabolic Enrichment Network Analysis Reveals Metabolite-Protein Physical Interaction Subnetworks Altered in Cancer. Mol Cell Proteomics. 2022 01; 21(1):100189.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Lin, Weiwei

PMID: 34933084; PMCID: PMC8761777; DOI: 10.1016/j.mcpro.2021.100189;

Showing 10 of 20 results. Show More

Muraoka S, Lin W, Takamatsu-Yukawa K, Hu J, Ikezu S, DeTure MA, Dickson DW, Emili A, Ikezu T. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging Dis. 2021 Sep; 12(6):1376-1388.View Related Profiles.

Emili, Andrew
Ikezu, Seiko
Ikezu, Tsuneya
Lin, Weiwei

PMID: 34527416; PMCID: PMC8407888; DOI: 10.14336/AD.2020.1007;

Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, Abisambra JF, Kuo MH, Kanaan N, Murray ME, Crary JF, Zhao J, Cheng JX, Petrucelli L, Li H, Emili A, Wolozin B. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell. 2021 10 21; 81(20):4209-4227.e12.View Related Profiles.

Emili, Andrew
Wolozin, Benjamin
Cheng, Ji-Xin
Jiang, Lulu
Verma, Mamta
Ash, Peter
Alvarez, Victor
Lin, Weiwei
Yang, Zhuo

PMID: 34453888; PMCID: PMC8541906; DOI: 10.1016/j.molcel.2021.07.038;

Deehan M, Lin W, Blum B, Emili A, Frydman H. Intracellular Density of Wolbachia Is Mediated by Host Autophagy and the Bacterial Cytoplasmic Incompatibility Gene cifB in a Cell Type-Dependent Manner in Drosophila melanogaster. mBio. 2021 01 12; 12(1).View Related Profiles.

Emili, Andrew
Blum, Benjamin
Frydman, Horacio
Lin, Weiwei

PMID: 33436431; PMCID: PMC7844536; DOI: 10.1128/mBio.02205-20;

Muraoka S, Lin W, Chen M, Hersh SW, Emili A, Xia W, Ikezu T. Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids. Methods. 2020 05 01; 177:35-49.View Related Profiles.

Emili, Andrew
Ikezu, Tsuneya
Xia, Weiming
Lin, Weiwei

PMID: 32035230; PMCID: PMC7667497; DOI: 10.1016/j.ymeth.2020.02.002;

Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 01 02; 40(1):107-130.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Wolozin, Benjamin
Bryant, Camron
Apicco, Daniel
Rosene, Douglas
Mortazavi, Farzad
Beierle, Jacob
Yazdani, Neema
Ash, Peter
Lin, Weiwei

PMID: 31704785; PMCID: PMC6939476; DOI: 10.1523/JNEUROSCI.1808-19.2019;

Zhang J, Lin W, Wu R, Liu Y, Zhu K, Ren J, Zhang S, Ling X. Mechanisms of the active components from Korean pine nut preventing and treating d-galactose-induced aging rats. Biomed Pharmacother. 2018 Jul; 103:680-690. PMID: 29679909; DOI: 10.1016/j.biopha.2018.04.063;

Lin W, Zhang J, Liu Y, Wu R, Yang H, Hu X, Ling X. Studies on diagnostic biomarkers and therapeutic mechanism of Alzheimer's disease through metabolomics and hippocampal proteomics. Eur J Pharm Sci. 2017 Jul 15; 105:119-126. PMID: 28495476; DOI: 10.1016/j.ejps.2017.05.003;

Li Z, Zhao Y, Lin W, Ye M, Ling X. Rapid screening and identification of active ingredients in licorice extract interacting with V3 loop region of HIV-1 gp120 using ACE and CE-MS. J Pharm Biomed Anal. 2015; 111:28-35. PMID: 25854854; DOI: 10.1016/j.jpba.2015.02.021;

Li J, Lin W, Lin W, Xu P, Zhang J, Yang H, Ling X. Metabolic profiling study on potential toxicity and immunotoxicity-biomarker discovery in rats treated with cyclophosphamide using HPLC-ESI-IT-TOF-MS. Biomed Chromatogr. 2015 May; 29(5):768-76. PMID: 25322901; DOI: 10.1002/bmc.3355;

Yang H, Lin W, Zhang J, Lin W, Xu P, Li J, Ling X. Metabonomic analysis of the toxic effects of TM208 in rat urine by HPLC-ESI-IT-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 15; 959:49-54. PMID: 24747524; DOI: 10.1016/j.jchromb.2014.03.036;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 10 distinct years, with a maximum of 4 publications in 2021 and 2023 and 2024

Bar chart showing 20 publications over 10 distinct years, with a maximum of 4 publications in 2021 and 2023 and 2024

Year	Publications
2014	2
2015	1
2017	1
2018	1
2019	1
2020	1
2021	4
2022	1
2023	4
2024	4

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

LC-MS/MS
Proteomics
Phosphoproteomics
Metabolomics
Mass Spectrometry
Protein Protein Interaction
Protein-metabolite interaction
Protein Complexes
Alzheimer Disease
Tauopathies
ApoE

Contact for Mentoring:

71 East Concord St.
Boston MA 02118
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617.358.0565

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