Mark W. Logue, PhD
Associate Professor
Boston University School of Medicine
Dept of Psychiatry

PhD, University of Iowa
MS, University of Iowa



My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.


Associate Professor
Boston University School of Public Health
Biostatistics


VA Boston Healthcare System




The impact of traumatic stress on the methylome: implications for PTSD
08/18/2016 - 05/31/2018 (PI)
Emory University NIH NIMH
1R01MH108826-01

A Linkage Study of Panic Disorder and Related Phenotypes
08/27/2007 - 07/31/2013 (PI)
NIH/National Institute of Mental Health
5K01MH076100-05



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Hayes JP, Hayes S, Miller DR, Lafleche G, Logue MW, Verfaellie M. Automated measurement of hippocampal subfields in PTSD: Evidence for smaller dentate gyrus volume. J Psychiatr Res. 2017 Dec; 95:247-252.View Related Profiles. PMID: 28923718.
  2. Logue MW, Smith AK, Wolf EJ, Maniates H, Stone A, Schichman SA, McGlinchey RE, Milberg W, Miller MW. The correlation of methylation levels measured using Illumina 450K and EPIC BeadChips in blood samples. Epigenomics. 2017 Nov; 9(11):1363-1371.View Related Profiles. PMID: 28809127.
  3. Hayes JP, Reagan A, Logue MW, Hayes SM, Sadeh N, Miller DR, Verfaellie M, Wolf EJ, McGlinchey RE, Milberg WP, Stone A, Schichman SA, Miller MW. BDNF genotype is associated with hippocampal volume in mild traumatic brain injury. Genes Brain Behav. 2017 Jul 28.View Related Profiles. PMID: 28755387.
  4. Wolf EJ, Logue MW, Stoop TB, Schichman SA, Stone A, Sadeh N, Hayes JP, Miller MW. Accelerated DNA Methylation Age: Associations with PTSD and Mortality. Psychosom Med. 2017 Jul 20.View Related Profiles. PMID: 28731985.
  5. Ratanatharathorn A, Boks MP, Maihofer AX, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bromet E, Dennis M, Garrett ME, Geuze E, Guffanti G, Hauser MA, Kilaru V, Kimbrel NA, Koenen KC, Kuan PF, Logue MW, Luft BJ, Miller MW, Mitchell C, Nugent NR, Ressler KJ, Rutten BPF, Stein MB, Vermetten E, Vinkers CH, Youssef NA, Uddin M, Nievergelt CM, Smith AK. Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. Am J Med Genet B Neuropsychiatr Genet. 2017 Sep; 174(6):619-630. PMID: 28691784.
  6. Hayes JP, Logue MW, Reagan A, Salat D, Wolf EJ, Sadeh N, Spielberg JM, Sperbeck E, Hayes SM, McGlinchey RE, Milberg WP, Verfaellie M, Stone A, Schichman SA, Miller MW. COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume. J Psychiatry Neurosci. 2017 Mar; 42(2):95-102.View Related Profiles. PMID: 28234210.
  7. Hayes JP, Logue MW, Sadeh N, Spielberg JM, Verfaellie M, Hayes SM, Reagan A, Salat DH, Wolf EJ, McGlinchey RE, Milberg WP, Stone A, Schichman SA, Miller MW. Mild traumatic brain injury is associated with reduced cortical thickness in those at risk for Alzheimer''s disease. Brain. 2017 Mar 01; 140(3):813-825.View Related Profiles. PMID: 28077398; DOI: 10.1093/brain/aww344;.
  8. Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer''s disease loci. Alzheimers Dement. 2017 Jul; 13(7):727-738.View Related Profiles. PMID: 28183528; DOI: 10.1016/j.jalz.2016.12.012;.
  9. Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Hall KS, Kamboh MI, Kukull WA, Larson EB, Manly JJ, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA. Two novel loci, COBL and SLC10A2, for Alzheimer''s disease in African Americans. Alzheimers Dement. 2017 Feb; 13(2):119-129.View Related Profiles. PMID: 27770636; DOI: 10.1016/j.jalz.2016.09.002;.
  10. Miller MW, Sperbeck E, Robinson ME, Sadeh N, Wolf EJ, Hayes JP, Logue M, Schichman SA, Stone A, Milberg W, McGlinchey R. 5-HT2A Gene Variants Moderate the Association between PTSD and Reduced Default Mode Network Connectivity. Front Neurosci. 2016; 10:299.View Related Profiles. PMID: 27445670; DOI: 10.3389/fnins.2016.00299;.
Showing 10 of 63 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 18 distinct years, with a maximum of 9 publications in 2015

YearPublications
19981
20011
20022
20032
20042
20053
20062
20071
20081
20091
20101
20114
20127
20138
20146
20159
20164
20178
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

GENETICS
Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
Google Map


Logue's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department