Keywords
Last Name

Mark W. Logue, PhD

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentPsychiatry
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-5937
ORCID ORCID Icon0000-0001-9347-7892
Other Positions
TitleResearch Assistant Professor
InstitutionBoston University School of Public Health
DepartmentBiostatistics

InstitutionVA Boston Healthcare System

 Research Expertise & Professional Interests
My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.



 Self-Described Keywords
  • GENETICS
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Hall KS, Kamboh MI, Kukull WA, Larson EB, Manly JJ. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement. 2016 Oct 20. PMID: 27770636.
    View in: PubMed
  2. Miller MW, Sperbeck E, Robinson ME, Sadeh N, Wolf EJ, Hayes JP, Logue M, Schichman SA, Stone A, Milberg W, McGlinchey R. 5-HT2A Gene Variants Moderate the Association between PTSD and Reduced Default Mode Network Connectivity. Front Neurosci. 2016; 10:299. PMID: 27445670.
    View in: PubMed
  3. Sadeh N, Wolf EJ, Logue MW, Hayes JP, Stone A, Griffin LM, Schichman SA, Miller MW. EPIGENETIC VARIATION AT SKA2 PREDICTS SUICIDE PHENOTYPES AND INTERNALIZING PSYCHOPATHOLOGY. Depress Anxiety. 2016 Apr; 33(4):308-15. PMID: 27038412.
    View in: PubMed
  4. Sadeh N, Spielberg JM, Logue MW, Wolf EJ, Smith AK, Lusk J, Hayes JP, Sperbeck E, Milberg WP, McGlinchey RE, Salat DH, Carter WC, Stone A, Schichman SA, Humphries DE, Miller MW. SKA2 methylation predicts reduced cortical thickness in prefrontal cortex. Mol Psychiatry. 2016 Mar; 21(3):299. PMID: 26887336.
    View in: PubMed
  5. Sadeh N, Wolf EJ, Logue MW, Lusk J, Hayes JP, McGlinchey RE, Milberg WP, Stone A, Schichman SA, Miller MW. Polygenic Risk for Externalizing Psychopathology and Executive Dysfunction in Trauma-Exposed Veterans. Clin Psychol Sci. 2016 May; 4(3):545-558. PMID: 27453802.
    View in: PubMed
  6. Wolf EJ, Sadeh N, Leritz EC, Logue MW, Stoop TB, McGlinchey R, Milberg W, Miller MW. Posttraumatic Stress Disorder as a Catalyst for the Association Between Metabolic Syndrome and Reduced Cortical Thickness. Biol Psychiatry. 2016 Sep 1; 80(5):363-71. PMID: 26826875.
    View in: PubMed
  7. Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith PA, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Lee JH, Schellenberg GD, St George-Hyslop P, Mayeux R, Rogaeva E. Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. JAMA Neurol. 2015 Nov; 72(11):1313-23. PMID: 26366463.
    View in: PubMed
  8. Wolf EJ, Logue MW, Hayes JP, Sadeh N, Schichman SA, Stone A, Salat DH, Milberg W, McGlinchey R, Miller MW. Accelerated DNA methylation age: Associations with PTSD and neural integrity. Psychoneuroendocrinology. 2016 Jan; 63:155-62. PMID: 26447678.
    View in: PubMed
  9. Miller MW, Wolf EJ, Sadeh N, Logue M, Spielberg JM, Hayes JP, Sperbeck E, Schichman SA, Stone A, Carter WC, Humphries DE, Milberg W, McGlinchey R. A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex. Psychoneuroendocrinology. 2015 Dec; 62:359-65. PMID: 26372769.
    View in: PubMed
  10. Sadeh N, Spielberg JM, Logue MW, Wolf EJ, Smith AK, Lusk J, Hayes JP, Sperbeck E, Milberg WP, McGlinchey RE, Salat DH, Carter WC, Stone A, Schichman SA, Humphries DE, Miller MW. SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans. Mol Psychiatry. 2016 Mar; 21(3):357-63. PMID: 26324104.
    View in: PubMed
  11. Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM, Lang R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement. 2016 Mar; 12(3):233-43. PMID: 26092349.
    View in: PubMed
  12. Logue MW, Amstadter AB, Baker DG, Duncan L, Koenen KC, Liberzon I, Miller MW, Morey RA, Nievergelt CM, Ressler KJ, Smith AK, Smoller JW, Stein MB, Sumner JA, Uddin M. The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration. Neuropsychopharmacology. 2015 Sep; 40(10):2287-97. PMID: 25904361.
    View in: PubMed
  13. Logue MW, Smith AK, Baldwin C, Wolf EJ, Guffanti G, Ratanatharathorn A, Stone A, Schichman SA, Humphries D, Binder EB, Arloth J, Menke A, Uddin M, Wildman D, Galea S, Aiello AE, Koenen KC, Miller MW. An analysis of gene expression in PTSD implicates genes involved in the glucocorticoid receptor pathway and neural responses to stress. Psychoneuroendocrinology. 2015 Jul; 57:1-13. PMID: 25867994.
    View in: PubMed
  14. Sikora JL, Logue MW, Chan GG, Spencer BH, Prokaeva TB, Baldwin CT, Seldin DC, Connors LH. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Hum Genet. 2015 Jan; 134(1):111-21. PMID: 25367359.
    View in: PubMed
  15. Nievergelt CM, Maihofer AX, Mustapic M, Yurgil KA, Schork NJ, Miller MW, Logue MW, Geyer MA, Risbrough VB, O'Connor DT, Baker DG. Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. Psychoneuroendocrinology. 2015 Jan; 51:459-71. PMID: 25456346.
    View in: PubMed
  16. Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T, Goate A, Graff-Radford NR, Kamboh MI, Kukull WA, Manly JJ. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimers Dement. 2014 Nov; 10(6):609-618.e11. PMID: 25172201.
    View in: PubMed
  17. Wolf EJ, Mitchell KS, Logue MW, Baldwin CT, Reardon AF, Aiello A, Galea S, Koenen KC, Uddin M, Wildman D, Miller MW. The dopamine D3 receptor gene and posttraumatic stress disorder. J Trauma Stress. 2014 Aug; 27(4):379-87. PMID: 25158632.
    View in: PubMed
  18. Hodges LM, Fyer AJ, Weissman MM, Logue MW, Haghighi F, Evgrafov O, Rotondo A, Knowles JA, Hamilton SP. Evidence for linkage and association of GABRB3 and GABRA5 to panic disorder. Neuropsychopharmacology. 2014 Sep; 39(10):2423-31. PMID: 24755890.
    View in: PubMed
  19. Wolf EJ, Rasmusson AM, Mitchell KS, Logue MW, Baldwin CT, Miller MW. A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample. Depress Anxiety. 2014 Apr; 31(4):352-60. PMID: 24677629.
    View in: PubMed
  20. Moore CS, Grant MD, Zink TA, Panizzon MS, Franz CE, Logue MW, Hauger RL, Kremen WS, Lyons MJ. Erectile dysfunction, vascular risk, and cognitive performance in late middle age. Psychol Aging. 2014 Mar; 29(1):163-72. PMID: 24660805.
    View in: PubMed
  21. Logue MW, Schu M, Vardarajan BN, Farrell J, Lunetta KL, Jun G, Baldwin CT, Deangelis MM, Farrer LA. Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways. Neurobiol Aging. 2014 Jun; 35(6):1510.e7-18. PMID: 24439028.
    View in: PubMed
  22. Wolf EJ, Mitchell KS, Logue MW, Baldwin CT, Reardon AF, Humphries DE, Miller MW. Corticotropin releasing hormone receptor 2 (CRHR-2) gene is associated with decreased risk and severity of posttraumatic stress disorder in women. Depress Anxiety. 2013 Dec; 30(12):1161-9. PMID: 24123648.
    View in: PubMed
  23. Lyons MJ, Genderson M, Grant MD, Logue M, Zink T, McKenzie R, Franz CE, Panizzon M, Lohr JB, Jerskey B, Kremen WS. Gene-environment interaction of ApoE genotype and combat exposure on PTSD. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):762-9. PMID: 24132908.
    View in: PubMed
  24. Miller MW, Wolf EJ, Logue MW, Baldwin CT. The retinoid-related orphan receptor alpha (RORA) gene and fear-related psychopathology. J Affect Disord. 2013 Nov; 151(2):702-8. PMID: 24007783.
    View in: PubMed
  25. Hendricks AE, Dupuis J, Logue MW, Myers RH, Lunetta KL. Correction for multiple testing in a gene region. Eur J Hum Genet. 2014 Mar; 22(3):414-8. PMID: 23838599.
    View in: PubMed
  26. Logue MW, Solovieff N, Leussis MP, Wolf EJ, Melista E, Baldwin C, Koenen KC, Petryshen TL, Miller MW. The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity. Psychoneuroendocrinology. 2013 Oct; 38(10):2249-57. PMID: 23796624.
    View in: PubMed
  27. Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013 Apr 10; 309(14):1483-92. PMID: 23571587.
    View in: PubMed
  28. Vardarajan B, Vergote D, Tissir F, Logue M, Yang J, Daude N, Ando K, Rogaeva E, Lee J, Cheng R, Brion JP, Ghani M, Shi B, Baldwin CT, Kar S, Mayeux R, Fraser P, Goffinet AM, George-Hyslop PS, Farrer LA, Westaway D. Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts. Mol Neurodegener. 2013; 8:10. PMID: 23414597.
    View in: PubMed
  29. Logue MW, Baldwin C, Guffanti G, Melista E, Wolf EJ, Reardon AF, Uddin M, Wildman D, Galea S, Koenen KC, Miller MW. A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol Psychiatry. 2013 Aug; 18(8):937-42. PMID: 22869035.
    View in: PubMed
  30. Hendricks AE, Dupuis J, Gupta M, Logue MW, Lunetta KL. A comparison of gene region simulation methods. PLoS One. 2012; 7(7):e40925. PMID: 22815869.
    View in: PubMed
  31. Melville SA, Buros J, Parrado AR, Vardarajan B, Logue MW, Shen L, Risacher SL, Kim S, Jun G, DeCarli C, Lunetta KL, Baldwin CT, Saykin AJ, Farrer LA. Multiple loci influencing hippocampal degeneration identified by genome scan. Ann Neurol. 2012 Jul; 72(1):65-75. PMID: 22745009.
    View in: PubMed
  32. Fyer AJ, Costa R, Haghighi F, Logue MW, Knowles JA, Weissman MM, Hodge SE, Hamilton SP. Linkage analysis of alternative anxiety phenotypes in multiply affected panic disorder families. Psychiatr Genet. 2012 Jun; 22(3):123-9. PMID: 22525237.
    View in: PubMed
  33. Kamboh MI, Demirci FY, Wang X, Minster RL, Carrasquillo MM, Pankratz VS, Younkin SG, Saykin AJ. Genome-wide association study of Alzheimer's disease. Transl Psychiatry. 2012; 2:e117. PMID: 22832961.
    View in: PubMed
  34. Logue MW, Bauver SR, Knowles JA, Gameroff MJ, Weissman MM, Crowe RR, Fyer AJ, Hamilton SP. Multivariate analysis of anxiety disorders yields further evidence of linkage to chromosomes 4q21 and 7p in panic disorder families. Am J Med Genet B Neuropsychiatr Genet. 2012 Apr; 159B(3):274-80. PMID: 22253211.
    View in: PubMed
  35. Farrer L, Logue M. Collection of clinical and epidemiological data for genetic linkage and association studies. Curr Protoc Hum Genet. 2012 Jan; Chapter 1:Unit1.1. PMID: 22241654.
    View in: PubMed
  36. Logue MW, Schu M, Vardarajan BN, Buros J, Green RC, Go RC, Griffith P, Obisesan TO, Shatz R, Borenstein A, Cupples LA, Lunetta KL, Fallin MD, Baldwin CT, Farrer LA. A comprehensive genetic association study of Alzheimer disease in African Americans. Arch Neurol. 2011 Dec; 68(12):1569-79. PMID: 22159054.
    View in: PubMed
  37. Choi SH, Liu C, Dupuis J, Logue MW, Jun G. Using linkage analysis of large pedigrees to guide association analyses. BMC Proc. 2011; 5 Suppl 9:S79. PMID: 22373287.
    View in: PubMed
  38. Logue MW, Posner H, Green RC, Moline M, Cupples LA, Lunetta KL, Zou H, Hurt SW, Farrer LA, Decarli C. Magnetic resonance imaging-measured atrophy and its relationship to cognitive functioning in vascular dementia and Alzheimer's disease patients. Alzheimers Dement. 2011 Sep; 7(5):493-500. PMID: 21723205.
    View in: PubMed
  39. Logue MW, Bauver SR, Kremen WS, Franz CE, Eisen SA, Tsuang MT, Grant MD, Lyons MJ. Evidence of overlapping genetic diathesis of panic attacks and gastrointestinal disorders in a sample of male twin pairs. Twin Res Hum Genet. 2011 Feb; 14(1):16-24. PMID: 21314252.
    View in: PubMed
  40. Sherva R, Kranzler HR, Yu Y, Logue MW, Poling J, Arias AJ, Anton RF, Oslin D, Farrer LA, Gelernter J. Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology. 2010 Aug; 35(9):1921-31. PMID: 20485328.
    View in: PubMed
  41. Logue MW, Durner M, Heiman GA, Hodge SE, Hamilton SP, Knowles JA, Fyer AJ, Weissman MM. A linkage search for joint panic disorder/bipolar genes. Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5; 150B(8):1139-46. PMID: 19308964.
    View in: PubMed
  42. Logue MW, Li Y. Computation of the posterior probability of linkage using 'high effect' genetic model priors. Hum Hered. 2008; 66(1):25-34. PMID: 18223315.
    View in: PubMed
  43. Swartz MD, Thomas DC, Daw EW, Albers K, Charlesworth JC, Dyer TC, Fridley BL, Govil M, Kraft P, Kwon S, Logue MW, Oh C, Pique-Regi R, Saba L, Schumacher FR, Uh HW. Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15. Genet Epidemiol. 2007; 31 Suppl 1:S96-102. PMID: 18046760.
    View in: PubMed
  44. Logue MW, Brzustowicz LM, Bassett AS, Chow EW, Vieland VJ. A posterior probability of linkage-based re-analysis of schizophrenia data yields evidence of linkage to chromosomes 1 and 17. Hum Hered. 2006; 62(1):47-54. PMID: 17019084.
    View in: PubMed
  45. Logue MW, Vieland VJ. The incorporation of prior genomic information does not necessarily improve the performance of Bayesian linkage methods: an example involving sex-specific recombination and the two-point PPL. Hum Hered. 2005; 60(4):196-205. PMID: 16397399.
    View in: PubMed
  46. George AW, Mangin LA, Bartlett CW, Logue MW, Segre AM, Vieland VJ. Calculation of multipoint likelihoods using flanking marker data: a simulation study. BMC Genet. 2005; 6 Suppl 1:S44. PMID: 16451655.
    View in: PubMed
  47. Logue MW, George AW, Spence MA, Vieland VJ. Performance comparison of two-point linkage methods using microsatellite markers flanking known disease locations. BMC Genet. 2005; 6 Suppl 1:S141. PMID: 16451601.
    View in: PubMed
  48. Yang X, Huang J, Logue MW, Vieland VJ. The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker. Hum Hered. 2005; 59(4):210-9. PMID: 16015031.
    View in: PubMed
  49. Logue MW, Vieland VJ. A new method for computing the multipoint posterior probability of linkage. Hum Hered. 2004; 57(2):90-9. PMID: 15192281.
    View in: PubMed
  50. Bartlett CW, Flax JF, Logue MW, Smith BJ, Vieland VJ, Tallal P, Brzustowicz LM. Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment. Hum Hered. 2004; 57(1):10-20. PMID: 15133308.
    View in: PubMed
  51. Logue MW, Goedken RJ, Vieland VJ. A model-integrated multipoint Bayesian analysis of hypertension in the Framingham Heart Study data finds little evidence of linkage. BMC Genet. 2003; 4 Suppl 1:S75. PMID: 14975143.
    View in: PubMed
  52. Logue MW, Vieland VJ, Goedken RJ, Crowe RR. Bayesian analysis of a previously published genome screen for panic disorder reveals new and compelling evidence for linkage to chromosome 7. Am J Med Genet B Neuropsychiatr Genet. 2003 Aug 15; 121B(1):95-9. PMID: 12898582.
    View in: PubMed
  53. Bartlett CW, Flax JF, Logue MW, Vieland VJ, Bassett AS, Tallal P, Brzustowicz LM. A major susceptibility locus for specific language impairment is located on 13q21. Am J Hum Genet. 2002 Jul; 71(1):45-55. PMID: 12048648.
    View in: PubMed
  54. Vieland VJ, Logue M. HLODs, trait models, and ascertainment: implications of admixture for parameter estimation and linkage detection. Hum Hered. 2002; 53(1):23-35. PMID: 11901268.
    View in: PubMed
  55. Wang K, Huang J, Logue M, Vieland V. Combined multipoint analysis of multiple asthma data sets based on the posterior probability of linkage. Genet Epidemiol. 2001; 21 Suppl 1:S73-8. PMID: 11793769.
    View in: PubMed
  56. Leslie LR, Southard TE, Southard KA, Casko JS, Jakobsen JR, Tolley EA, Hillis SL, Carolan C, Logue M. Prediction of mandibular growth rotation: assessment of the Skieller, Björk, and Linde-Hansen method. Am J Orthod Dentofacial Orthop. 1998 Dec; 114(6):659-67. PMID: 9844205.
    View in: PubMed
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