Gustavo Mostoslavsky | Profiles RNS

Gustavo Mostoslavsky, MD, PhD Hear my name

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Gastroenterology

MD, Universidad Nacional de Tucumán
PhD, The Hebrew University of Jerusalem

Websites

	Mostoslavsky Lab
	Department of Medicine Faculty
	Microbiology Faculty
	Center for Regenerative Medicine
	Gastroenterology Research Activities
	Immunology Training Program Faculty

ORCID : 0000-0002-0784-2169

Expertise includes: Stem cells; Induced Pluripotent Stem cells (iPSC); Gene transfer and Gene editing; Lentiviruses; Disease modeling; Intestinal organoids; Neural differentiation; Immune relevant cell differentiation.

Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

Member
Boston University
Pulmonary Center

Co-Director
Boston University
Center for Regenerative Medicine

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Member
Boston University
Genome Science Institute

Boston Medical Center
Gastroenterology

An iPSC-derived human organoid based model of intestinal filovirus infection
03/01/2024 - 02/28/2025 (Key Person / Mentor)
NIH/National Institute of Allergy & Infectious Diseases
1F31AI183803-01

Functional T cells from iPSCs Using Chimeric Antigen Receptors
06/01/2019 - 05/31/2021 (Key Person / Mentor)
PI: Dar M. Heinze, PhD
NIH/National Heart, Lung, and Blood Institute
5F32HL149605-02

Modeling prion diseases using human iPSC-derived neurons
03/15/2019 - 02/28/2021 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111499-01

A National Resource for Lung disease-specific IPS cells
08/15/2014 - 04/30/2020 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Heart, Lung, and Blood Institute
5R24HL123828-05

Antiviral responses in iPSC-derived human primary cells to Ebola virus infection
06/30/2016 - 05/31/2019 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R21AI126457-02

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: Gustavo Mostoslavsky, MD, PhD
NIH/National Heart, Lung, and Blood Institute
5U01HL107443-05

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (Co-Investigator)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
1U01HL107443-01

Reverse genetic tools and novel models of henipavirus infection
10/28/2022 - 09/30/2025 (Subcontract PI)
PI: Gustavo Mostoslavsky, MD, PhD
Trustees of Boston University, BUMC Bill & Melinda Gates

Uncovering the RNA regulatory mechanisms driving pathogenicity of mass-casualty viruses: Merging the technologies of RNA biology and enhanced biosafety to create the next generation of broad spectrum, RNA-based antiviral therapies
10/01/2022 - 09/30/2025 (PI)
Howard Hughes Medical Institute

Pre notification Epigenetic Scars: Understanding DSB repair from pathway choice to long term effects and their consequences.
07/01/2023 - 07/31/2025 (Subcontract PI)
PI: Gustavo Mostoslavsky, MD, PhD
Ben Gurion University of the Negev Euro Research Coun

Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids
07/05/2022 - 06/30/2025 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
1R21AI167369-01A1

Synergistic Mechanisms of Inflammasome Activation in Microglia by Opiates and Chronic HIV infection
07/15/2020 - 04/30/2025 (Subcontract PI)
PI: Gustavo Mostoslavsky, MD, PhD
Trustees of Boston University, BUMC NIH NIAID

T cell function by targeting HER2 positive cancer cells in vitro
01/01/2021 - 12/31/2023 (PI)
Clade Therapeutics

Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids
07/05/2022 - 07/04/2023 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
1R21AI167369-01A1

Modeling Prion Diseases Using Human iPSC-derived Neurons
03/15/2020 - 02/28/2021 (Subcontract PI)
PI: Gustavo Mostoslavsky, MD, PhD
Trustees of Boston University, BUMC NIH NINDS

Modeling Creutzfeldt-Jakob Disease Using Human iPSC-derived Neurons
01/15/2020 - 01/14/2021 (PI)
Creutzfeldt-Jakob Disease Foundation, Inc.

Distinct Functional Outcomes or BCR/TLR7 and BCR/TLR9 Co-engagement
03/12/2015 - 02/29/2020 (PI)
UMASS Worcester NIH-NIAMS

Showing 10 of 17 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection	5R01DA051889-05
2023	Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids	5R21AI167369-02
2023	Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection	5R01DA051889-04
2022	Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoids	1R21AI167369-01A1
2022	Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection	5R01DA051889-03
2021	Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection	5R01DA051889-02
2020	Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection	1R01DA051889-01
2019	Modeling prion diseases using human iPSC-derived neurons	1R21NS111499-01
2018	A National Resource for Lung disease-specific iPS cells	5R24HL123828-05	12
2018	The Role of SIRT6 and Metabolism in APC Mediated Tumorigenesis	5R01CA175727-05	20

Showing 10 of 32 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs AB, Murphy GJ. De novo hematopoiesis from the fetal lung. Blood Adv. 2023 Nov 28; 7(22):6898-6912.View Related Profiles.

Belkina, Anna
Murphy, George
Mostoslavsky, Gustavo
Vanuytsel, Kim

PMID: 37729429; PMCID: PMC10685174; DOI: 10.1182/bloodadvances.2022008347;

Heinze D, Park S, McCracken A, Haratianfar M, Lindstrom J, Villacorta-Martin C, Mithal A, Wang F, Yang MW, Murphy G, Mostoslavsky G. Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs. Stem Cell Reports. 2022 Dec 13; 17(12):2610-2628.View Related Profiles.

Murphy, George
Mostoslavsky, Gustavo

PMID: 36332629; PMCID: PMC9768581; DOI: 10.1016/j.stemcr.2022.10.007;

Scoon WA, Mancio-Silva L, Suder EL, Villacorta-Martin C, Lindstrom-Vautrin J, Bernbaum JG, Mazur S, Johnson RF, Olejnik J, Flores EY, Mithal A, Wang F, Hume AJ, Kaserman JE, March-Riera S, Wilson AA, Bhatia SN, Mühlberger E, Mostoslavsky G. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem Cell Reports. 2022 Oct 11; 17(10):2286-2302.View Related Profiles.

Hume, Adam
Wilson, Andrew
Muhlberger, Elke
Mostoslavsky, Gustavo
Kaserman, Joseph
Olejnik, Judith

PMID: 36084636; PMCID: PMC9561183; DOI: 10.1016/j.stemcr.2022.08.003;

Berical A, Lee RE, Lu J, Beermann ML, Le Suer JA, Mithal A, Thomas D, Ranallo N, Peasley M, Stuffer A, Bukis K, Seymour R, Harrington J, Coote K, Valley H, Hurley K, McNally P, Mostoslavsky G, Mahoney J, Randell SH, Hawkins FJ. A multimodal iPSC platform for cystic fibrosis drug testing. Nat Commun. 2022 Jul 29; 13(1):4270.View Related Profiles.

Berical, Andrew
Hawkins, Finn
Mostoslavsky, Gustavo

PMID: 35906215; PMCID: PMC9338271; DOI: 10.1038/s41467-022-31854-8;

Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103.View Related Profiles.

Belkina, Anna
Murphy, George
Mostoslavsky, Gustavo
Campbell, Joshua
Vanuytsel, Kim
Dries, Ruben
Matte, Taylor

PMID: 35232959; PMCID: PMC8888592; DOI: 10.1038/s41467-022-28616-x;

Wang Q, Feng L, Zhang H, Gao J, Mao C, Landesman-Bollag E, Mostoslavsky G, Lunderberg JM, Zheng W, Hao S, Gao W. Longitudinal waning of mRNA vaccine-induced neutralizing antibodies against SARS-CoV-2 detected by an LFIA rapid test. Antib Ther. 2022 Jan; 5(1):55-62. PMID: 35146332; PMCID: PMC8807222; DOI: 10.1093/abt/tbac004;

Casalia ML, Casabona JC, García C, Cavaliere Candedo V, Quintá HR, Farías MI, Gonzalez J, Gonzalez Morón D, Córdoba M, Consalvo D, Mostoslavsky G, Urbano FJ, Pasquini J, Murer MG, Rela L, Kauffman MA, Pitossi FJ. A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels. Stem Cell Res Ther. 2021 11 25; 12(1):590. PMID: 34823607; PMCID: PMC8620942; DOI: 10.1186/s13287-021-02658-2;

Chahla RE, Tomas-Grau RH, Cazorla SI, Ploper D, Vera Pingitore E, López MA, Aznar P, Alcorta ME, Vélez EMDM, Stagnetto A, Ávila CL, Maldonado-Galdeano C, Socias SB, Heinze D, Navarro SA, Llapur CJ, Costa D, Flores I, Edelstein A, Kowdle S, Perandones C, Lee B, Apfelbaum G, Mostoslavsky R, Mostoslavsky G, Perdigón G, Chehín RN. Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina. Lancet Reg Health Am. 2022 Feb; 6:100123. PMID: 34841388; PMCID: PMC8604626; DOI: 10.1016/j.lana.2021.100123;

Tomas-Grau RH, Ploper D, Ávila CL, Vera Pingitore E, Maldonado Galdeano C, Chaves S, Socias SB, Stagnetto A, Navarro SA, Chahla RE, Aguilar López M, Llapur CJ, Aznar P, Alcorta ME, Costas D, Flores I, Heinze D, Apfelbaum G, Mostoslavsky R, Mostoslavsky G, Cazorla SI, Perdigón GDV, Chehín R. Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD "In-House" ELISA. Front Med (Lausanne). 2021; 8:720988. PMID: 34722566; PMCID: PMC8551828; DOI: 10.3389/fmed.2021.720988;

Mithal A, Hume AJ, Lindstrom-Vautrin J, Villacorta-Martin C, Olejnik J, Bullitt E, Hinds A, Mühlberger E, Mostoslavsky G. Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response. Stem Cell Reports. 2021 04 13; 16(4):940-953.View Related Profiles.

Hume, Adam
Muhlberger, Elke
Bullitt, Esther
Mostoslavsky, Gustavo
Olejnik, Judith

PMID: 33852884; PMCID: PMC8042780; DOI: 10.1016/j.stemcr.2021.02.019;

Showing 10 of 91 results. Show More

Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles.

Olson, Alex
Belkina, Anna
Steiner, Dylan
Korkmaz, Filiz
Mostoslavsky, Gustavo
Rifkin, Ian
Snyder-Cappione , Jennifer
Quillen, Karen
Sagar, Manish
Bhadelia, Nahid
Lin, Nina
Pihl, Riley
Corley, Ronald
Gummuluru, Suryaram
Kataria, Yachana

PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;

Mostoslavsky G. Lentiviral Transduction for Optimal LSC/HSC Manipulation. Methods Mol Biol. 2021; 2185:299-306. PMID: 33165856

Akiyama H, Jalloh S, Park S, Lei M, Mostoslavsky G, Gummuluru S. Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses. J Virol. 2021 Mar 01; 95(5).View Related Profiles.

Mostoslavsky, Gustavo
Akiyama, Hisashi
Gummuluru, Suryaram

PMID: 33298546; PMCID: PMC8092841; DOI: 10.1128/JVI.01386-20;

Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF. Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell Stem Cell. 2020 10 01; 27(4):663-678.e8.View Related Profiles.

Emili, Andrew
Blum, Benjamin
Kotton, Darrell
Mostoslavsky, Gustavo

PMID: 32891189; PMCID: PMC7541765; DOI: 10.1016/j.stem.2020.07.022;

Abo KM, Ma L, Matte T, Huang J, Alysandratos KD, Werder RB, Mithal A, Beermann ML, Lindstrom-Vautrin J, Mostoslavsky G, Ikonomou L, Kotton DN, Hawkins F, Wilson A, Villacorta-Martin C. Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv. 2020 Jun 04.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Hawkins, Finn
Mostoslavsky, Gustavo
Huang, Jessie
Werder, Rhiannon Bree
Matte, Taylor

PMID: 32577635; PMCID: PMC7302183; DOI: 10.1101/2020.06.03.132639;

Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, Murphy G, Rabinovitch M, Rader DJ, Steinberg MH, Topol E, Yang W, Knowles JW, Jaquish CE, Ruczinski I, Mathias RA. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Res. 2020 07; 46:101803.View Related Profiles.

Murphy, George
Mostoslavsky, Gustavo
Steinberg, Martin

PMID: 32442913; PMCID: PMC7575060; DOI: 10.1016/j.scr.2020.101803;

Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell. 2020 04 02; 26(4):593-608.e8.View Related Profiles.

Wilson, Andrew
Jacob, Anjali
Kotton, Darrell
Mostoslavsky, Gustavo
Huang, Jessie
Herriges, Michael
Werder, Rhiannon Bree
Sun, Yuliang

PMID: 32004478; PMCID: PMC7469703; DOI: 10.1016/j.stem.2019.12.009;

Mithal A, Capilla A, Heinze D, Berical A, Villacorta-Martin C, Vedaie M, Jacob A, Abo K, Szymaniak A, Peasley M, Stuffer A, Mahoney J, Kotton DN, Hawkins F, Mostoslavsky G. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020 01 10; 11(1):215.View Related Profiles.

Szymaniak, Aleksander
Berical, Andrew
Jacob, Anjali
Heinze, Dar
Kotton, Darrell
Hawkins, Finn
Mostoslavsky, Gustavo

PMID: 31924806; PMCID: PMC6954238; DOI: 10.1038/s41467-019-13916-6;

Engler AE, Mostoslavsky G, Miller L, Rock JR. Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque. Methods Protoc. 2019 Oct 01; 2(4).View Related Profiles.

Engler, Anna
Mostoslavsky, Gustavo
Rock, Jason

PMID: 31581513; PMCID: PMC6961120; DOI: 10.3390/mps2040079;

Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D'Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, Michelassi F. Challenges in IBD Research: Novel Technologies. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S24-S30. PMID: 31095703; PMCID: PMC6787667; DOI: 10.1093/ibd/izz077;

Sommer CA, Capilla A, Molina-Estevez FJ, Gianotti-Sommer A, Skvir N, Caballero I, Chowdhury S, Mostoslavsky G. Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells. PLoS One. 2018; 13(7):e0200657.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo
Chowdhury, Sanjib

PMID: 30024920; PMCID: PMC6053155; DOI: 10.1371/journal.pone.0200657;

Park S, Mostoslavsky G. Generation of Human Induced Pluripotent Stem Cells Using a Defined, Feeder-Free Reprogramming System. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e48. PMID: 30040234; PMCID: PMC6060628; DOI: 10.1002/cpsc.48;

Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018 03 01; 32(5-6):373-388. PMID: 29555651; PMCID: PMC5900711; DOI: 10.1101/gad.307330.117;

Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC. Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nat Commun. 2017 10 10; 8(1):765.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 29018244; PMCID: PMC5635127; DOI: 10.1038/s41467-017-00779-y;

Jamalpour M, Li X, Cavelier L, Gustafsson K, Mostoslavsky G, Höglund M, Welsh M. Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia. Tumour Biol. 2017 Oct; 39(10):1010428317720643. PMID: 28982308

Zhang L, Capilla A, Song W, Mostoslavsky G, Yi J. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan. Sci Rep. 2017 08 17; 7(1):8591.View Related Profiles.

Mostoslavsky, Gustavo
Yi, Ji
Song, Weiye

PMID: 28819250; PMCID: PMC5561209; DOI: 10.1038/s41598-017-08822-0;

Shaikho EM, Farrell JJ, Alsultan A, Qutub H, Al-Ali AK, Figueiredo MS, Chui DHK, Farrer LA, Murphy GJ, Mostoslavsky G, Sebastiani P, Steinberg MH. A phased SNP-based classification of sickle cell anemia HBB haplotypes. BMC Genomics. 2017 Aug 11; 18(1):608.View Related Profiles.

Chui, David
Murphy, George
Mostoslavsky, Gustavo
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola

PMID: 28800727; PMCID: PMC5553663; DOI: 10.1186/s12864-017-4013-y;

Guha P, Morgan JW, Mostoslavsky G, Rodrigues NP, Boyd AS. Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):144-148.View Related Profiles.

Mostoslavsky, Gustavo
Guha, Prajna

PMID: 28686864

Qiang L, Rao AN, Mostoslavsky G, James MF, Comfort N, Sullivan K, Baas PW. Reprogramming cells from Gulf War veterans into neurons to study Gulf War illness. Neurology. 2017 May 16; 88(20):1968-1975.View Related Profiles.

Mostoslavsky, Gustavo
Sullivan, Kimberly

PMID: 28507260; PMCID: PMC5444312; DOI: 10.1212/WNL.0000000000003938;

Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 11; 8(4):1076-1085.View Related Profiles.

Chui, David
Murphy, George
Mostoslavsky, Gustavo
Luo, Hong
Vanuytsel, Kim
Steinberg, Martin
Sebastiani, Paola
Jiang, Zhihua

PMID: 28111279; PMCID: PMC5390092; DOI: 10.1016/j.stemcr.2016.12.017;

Schlimgen R, Howard J, Wooley D, Thompson M, Baden LR, Yang OO, Christiani DC, Mostoslavsky G, Diamond DV, Duane EG, Byers K, Winters T, Gelfand JA, Fujimoto G, Hudson TW, Vyas JM. Risks Associated With Lentiviral Vector Exposures and Prevention Strategies. J Occup Environ Med. 2016 Dec; 58(12):1159-1166. PMID: 27930472; PMCID: PMC5152689; DOI: 10.1097/JOM.0000000000000879;

Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH. A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia. Am J Hematol. 2016 Nov; 91(11):1118-1122.View Related Profiles.

Chui, David
Murphy, George
Mostoslavsky, Gustavo
Luo, Hong
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola
Vathipadiekal, Vinod
Jiang, Zhihua

PMID: 27501013; PMCID: PMC5072989; DOI: 10.1002/ajh.24527;

Thomas DD, Sommer AG, Balazs AB, Beerman I, Murphy GJ, Rossi D, Mostoslavsky G. Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57. Exp Hematol. 2016 May; 44(5):422-433.e1.View Related Profiles.

Murphy, George
Mostoslavsky, Gustavo

PMID: 26872540; PMCID: PMC5555112; DOI: 10.1016/j.exphem.2016.01.010;

Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332.View Related Profiles.

Yen, Allen
Wolozin, Benjamin
Trengrove, Chelsea
Mostoslavsky, Gustavo
Asai, Hirohide
Kirber, Michael
Aziz, Nadine
Zhou, Qingde
Ikezu, Tsuneya
Bolotina, Victoria

PMID: 26755131; PMCID: PMC4729940; DOI: 10.1038/ncomms10332;

Bar-Nur O, Verheul C, Sommer AG, Brumbaugh J, Schwarz BA, Lipchina I, Huebner AJ, Mostoslavsky G, Hochedlinger K. Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage. Nat Biotechnol. 2015 Jul; 33(7):761-8. PMID: 26098450; PMCID: PMC4840929; DOI: 10.1038/nbt.3247;

Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, Goren A, Rao A, Mostoslavsky R. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nat Cell Biol. 2015 May; 17(5):545-57.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 25915124; PMCID: PMC4593707; DOI: 10.1038/ncb3147;

Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.View Related Profiles.

Gower, Adam
Wilson, Andrew
Spira, Avrum
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo
Jean, Jyh-Chang
Ramirez, Maria
Shirihai, Orian

PMID: 25843048; PMCID: PMC4437473; DOI: 10.1016/j.stemcr.2015.02.021;

Alajem A, Biran A, Harikumar A, Sailaja BS, Aaronson Y, Livyatan I, Nissim-Rafinia M, Sommer AG, Mostoslavsky G, Gerbasi VR, Golden DE, Datta A, Sze SK, Meshorer E. Differential association of chromatin proteins identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation. Cell Rep. 2015 Mar 31; 10(12):2019-31. PMID: 25818293; DOI: 10.1016/j.celrep.2015.02.064;

Sommer CA, Mostoslavsky G. RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion. Mol Endocrinol. 2014 Nov; 28(11):1855-65.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 25268051; PMCID: PMC5414789; DOI: 10.1210/me.2014-1194;

Pipino C, Mukherjee S, David AL, Blundell MP, Shaw SW, Sung P, Shangaris P, Waters JJ, Ellershaw D, Cavazzana M, Mostoslavsky G, Pandolfi A, Pierro A, Guillot PV, Thrasher AJ, De Coppi P. Trisomy 21 mid-trimester amniotic fluid induced pluripotent stem cells maintain genetic signatures during reprogramming: implications for disease modeling and cryobanking. Cell Reprogram. 2014 Oct; 16(5):331-44. PMID: 25162836; DOI: 10.1089/cell.2013.0091;

Navarro S, Moleiro V, Molina-Estevez FJ, Lozano ML, Chinchon R, Almarza E, Quintana-Bustamante O, Mostoslavsky G, Maetzig T, Galla M, Heinz N, Schiedlmeier B, Torres Y, Modlich U, Samper E, Río P, Segovia JC, Raya A, Güenechea G, Izpisua-Belmonte JC, Bueren JA. Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy. Stem Cells. 2014 Feb; 32(2):436-46. PMID: 24420904; DOI: 10.1002/stem.1586;

Thomas D, Mostoslavsky G. Efficient transduction of hematopoietic stem cells and its potential for gene correction of hematopoietic diseases. Methods Mol Biol. 2014; 1114:441-50. PMID: 24557921; DOI: 10.1007/978-1-62703-761-7_29;

Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports. 2013; 1(5):451-63.View Related Profiles.

Leung, Amy
Ebata, Atsushi
Wolozin, Benjamin
Koch, Clarissa
Kotton, Darrell
Seldin, David
Murphy, George
Mostoslavsky, Gustavo
Berk, John
Connors, Lawreen
Monti, Stefano

PMID: 24286032; PMCID: PMC3841264; DOI: 10.1016/j.stemcr.2013.10.003;

Mills JA, Wang K, Paluru P, Ying L, Lu L, Galvão AM, Xu D, Yao Y, Sullivan SK, Sullivan LM, Mac H, Omari A, Jean JC, Shen S, Gower A, Spira A, Mostoslavsky G, Kotton DN, French DL, Weiss MJ, Gadue P. Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines. Blood. 2013 Sep 19; 122(12):2047-51.View Related Profiles.

Gower, Adam
Kotton, Darrell
Mostoslavsky, Gustavo
Jean, Jyh-Chang

PMID: 23940280; PMCID: PMC3778548; DOI: 10.1182/blood-2013-02-484444;

Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 2013 Jul 18; 122(3):376-85.View Related Profiles.

Leung, Amy
Costello, Catherine
Kotton, Darrell
Sherr, David
Chui, David
Murphy, George
Mostoslavsky, Gustavo
McComb, Mark
Steinberg, Martin
Theberge, Roger
Monti, Stefano

PMID: 23723449; PMCID: PMC3716202; DOI: 10.1182/blood-2012-11-466722;

Fragola G, Germain PL, Laise P, Cuomo A, Blasimme A, Gross F, Signaroldi E, Bucci G, Sommer C, Pruneri G, Mazzarol G, Bonaldi T, Mostoslavsky G, Casola S, Testa G. Cell reprogramming requires silencing of a core subset of polycomb targets. PLoS Genet. 2013; 9(2):e1003292.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 23468641; PMCID: PMC3585017; DOI: 10.1371/journal.pgen.1003292;

Grahn TH, Zhang Y, Lee MJ, Sommer AG, Mostoslavsky G, Fried SK, Greenberg AS, Puri V. FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. Biochem Biophys Res Commun. 2013 Mar 8; 432(2):296-301.View Related Profiles.

Mostoslavsky, Gustavo
Fried, Susan
Puri, Vishwajeet

PMID: 23399566; PMCID: PMC3595328; DOI: 10.1016/j.bbrc.2013.01.113;

Sommer CA, Mostoslavsky G. The evolving field of induced pluripotency: recent progress and future challenges. J Cell Physiol. 2013 Feb; 228(2):267-75.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 22767332; DOI: 10.1002/jcp.24155;

Guha P, Morgan JW, Mostoslavsky G, Rodrigues NP, Boyd AS. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell. 2013 Apr 4; 12(4):407-12.View Related Profiles.

Mostoslavsky, Gustavo
Guha, Prajna

PMID: 23352605; DOI: 10.1016/j.stem.2013.01.006;

Sommer CA, Christodoulou C, Gianotti-Sommer A, Shen SS, Sailaja BS, Hezroni H, Spira A, Meshorer E, Kotton DN, Mostoslavsky G. Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells. PLoS One. 2012; 7(12):e51711.View Related Profiles.

Spira, Avrum
Sommer, Cesar
Kotton, Darrell
Mostoslavsky, Gustavo

PMID: 23272148; PMCID: PMC3522693; DOI: 10.1371/journal.pone.0051711;

Sommer AG, Rozelle SS, Sullivan S, Mills JA, Park SM, Smith BW, Iyer AM, French DL, Kotton DN, Gadue P, Murphy GJ, Mostoslavsky G. Generation of human induced pluripotent stem cells from peripheral blood using the STEMCCA lentiviral vector. J Vis Exp. 2012; (68).View Related Profiles.

Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo

PMID: 23149977; PMCID: PMC3499070; DOI: 10.3791/4327;

Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G, Ordovas-Montanes J, Jouanguy E, Plancoulaine S, Tu E, Elkabetz Y, Al-Muhsen S, Tardieu M, Schlaeger TM, Daley GQ, Abel L, Casanova JL, Studer L, Notarangelo LD. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature. 2012 Nov 29; 491(7426):769-73. PMID: 23103873; PMCID: PMC3527075; DOI: 10.1038/nature11583;

Farago M, Rosenbluh C, Tevlin M, Fraenkel S, Schlesinger S, Masika H, Gouzman M, Teng G, Schatz D, Rais Y, Hanna JH, Mildner A, Jung S, Mostoslavsky G, Cedar H, Bergman Y. Clonal allelic predetermination of immunoglobulin-? rearrangement. Nature. 2012 Oct 25; 490(7421):561-5. PMID: 23023124; DOI: 10.1038/nature11496;

Stroncek DF, Berger C, Cheever MA, Childs RW, Dudley ME, Flynn P, Gattinoni L, Heath JR, Kalos M, Marincola FM, Miller JS, Mostoslavsky G, Powell DJ, Rao M, Restifo NP, Rosenberg SA, O'Shea J, Melief CJ. New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer. J Transl Med. 2012; 10:48. PMID: 22420641; PMCID: PMC3362772; DOI: 10.1186/1479-5876-10-48;

Mostoslavsky G. Concise review: The magic act of generating induced pluripotent stem cells: many rabbits in the hat. Stem Cells. 2012 Jan; 30(1):28-32. PMID: 21948613; DOI: 10.1002/stem.742;

Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. J Clin Invest. 2011 Jun; 121(6):2313-25.View Related Profiles.

Spira, Avrum
Sommer, Cesar
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo
Gouon-Evans, Valerie

PMID: 21537085; PMCID: PMC3104741; DOI: 10.1172/JCI43853;

Ye JH, Xu YJ, Gao J, Yan SG, Zhao J, Tu Q, Zhang J, Duan XJ, Sommer CA, Mostoslavsky G, Kaplan DL, Wu YN, Zhang CP, Wang L, Chen J. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials. 2011 Aug; 32(22):5065-76.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 21492931; PMCID: PMC3100415; DOI: 10.1016/j.biomaterials.2011.03.053;

Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011 Feb 4; 8(2):200-13.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 21295276; PMCID: PMC3134318; DOI: 10.1016/j.stem.2011.01.008;

Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal. 2011 Jun; 23(6):1030-40.View Related Profiles.

Lerner, Adam
Mostoslavsky, Gustavo
Near, Richard

PMID: 21262352; PMCID: PMC3062698; DOI: 10.1016/j.cellsig.2011.01.018;

Gustafsson K, Calounova G, Hjelm F, Kriz V, Heyman B, Grönvik KO, Mostoslavsky G, Welsh M. Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells. BMC Immunol. 2011; 12:3. PMID: 21223549; PMCID: PMC3024994; DOI: 10.1186/1471-2172-12-3;

Duan X, Tu Q, Zhang J, Ye J, Sommer C, Mostoslavsky G, Kaplan D, Yang P, Chen J. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. J Cell Physiol. 2011 Jan; 226(1):150-7.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 20658533; PMCID: PMC4137963; DOI: 10.1002/jcp.22316;

Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V. An ES-like pluripotent state in FGF-dependent murine iPS cells. PLoS One. 2010; 5(12):e16092. PMID: 21209851; PMCID: PMC3012723; DOI: 10.1371/journal.pone.0016092;

Pessach IM, Ordovas-Montanes J, Zhang SY, Casanova JL, Giliani S, Gennery AR, Al-Herz W, Manos PD, Schlaeger TM, Park IH, Rucci F, Agarwal S, Mostoslavsky G, Daley GQ, Notarangelo LD. Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies. J Allergy Clin Immunol. 2011 Jun; 127(6):1400-7.e4. PMID: 21185069; PMCID: PMC3081993; DOI: 10.1016/j.jaci.2010.11.008;

Novak A, Shtrichman R, Germanguz I, Segev H, Zeevi-Levin N, Fishman B, Mandel YE, Barad L, Domev H, Kotton D, Mostoslavsky G, Binah O, Itskovitz-Eldor J. Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus. Cell Reprogram. 2010 Dec; 12(6):665-78.View Related Profiles.

Kotton, Darrell
Mostoslavsky, Gustavo

PMID: 20964482; DOI: 10.1089/cell.2010.0027;

Ellis J, Baum C, Benvenisty N, Mostoslavsky G, Okano H, Stanford WL, Porteus M, Sadelain M. Benefits of utilizing gene-modified iPSCs for clinical applications. Cell Stem Cell. 2010 Oct 8; 7(4):429-30. PMID: 20887948; DOI: 10.1016/j.stem.2010.09.010;

Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells. 2010 Oct; 28(10):1728-40.View Related Profiles.

Somers, Aba
Sommer, Cesar
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo
Jean, Jyh-Chang
Lafyatis, Robert

PMID: 20715179; PMCID: PMC3422663; DOI: 10.1002/stem.495;

Sommer CA, Mostoslavsky G. Experimental approaches for the generation of induced pluripotent stem cells. Stem Cell Res Ther. 2010; 1(3):26.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 20699015; PMCID: PMC2941118; DOI: 10.1186/scrt26;

Staerk J, Dawlaty MM, Gao Q, Maetzel D, Hanna J, Sommer CA, Mostoslavsky G, Jaenisch R. Reprogramming of human peripheral blood cells to induced pluripotent stem cells. Cell Stem Cell. 2010 Jul 2; 7(1):20-4.View Related Profiles.

Sommer, Cesar
Mostoslavsky, Gustavo

PMID: 20621045; PMCID: PMC2917234; DOI: 10.1016/j.stem.2010.06.002;

Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells. 2010 Jan; 28(1):64-74.View Related Profiles.

Sommer, Cesar
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo

PMID: 19904830; PMCID: PMC4848036; DOI: 10.1002/stem.255;

Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet. 2009 Sep; 41(9):968-76. PMID: 19668214; PMCID: PMC3987895; DOI: 10.1038/ng.428;

Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells. 2009 Mar; 27(3):543-9.View Related Profiles.

Sommer, Cesar
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo

PMID: 19096035; PMCID: PMC4848035; DOI: 10.1634/stemcells.2008-1075;

Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8. PMID: 19242469; PMCID: PMC2708674; DOI: 10.1038/nature07765;

Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J Clin Invest. 2008 Apr; 118(4):1511-8. PMID: 18324336; PMCID: PMC2263145; DOI: 10.1172/JCI33764;

Pan H, Mostoslavsky G, Eruslanov E, Kotton DN, Kramnik I. Dual-promoter lentiviral system allows inducible expression of noxious proteins in macrophages. J Immunol Methods. 2008 Jan 1; 329(1-2):31-44.View Related Profiles.

Kotton, Darrell
Mostoslavsky, Gustavo
Kramnik, Igor

PMID: 17967462; PMCID: PMC2244810; DOI: 10.1016/j.jim.2007.09.009;

Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug; 21(8):1723-32. PMID: 17568820

Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007 Aug 17; 282(33):23910-8. PMID: 17562701

Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D. PPARalpha deficiency in inflammatory cells suppresses tumor growth. PLoS One. 2007; 2(2):e260. PMID: 17327920; PMCID: PMC1800345; DOI: 10.1371/journal.pone.0000260;

De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007 Jan; 25(1):100-6. PMID: 17206138

Hägerkvist R, Mokhtari D, Lindholm C, Farnebo F, Mostoslavsky G, Mulligan RC, Welsh N, Welsh M. Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli. Exp Cell Res. 2007 Jan 15; 313(2):284-91. PMID: 17112510

Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC. Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16406-11. PMID: 17062750; PMCID: PMC1637595; DOI: 10.1073/pnas.0608130103;

Murphy GJ, Mostoslavsky G, Kotton DN, Mulligan RC. Exogenous control of mammalian gene expression via modulation of translational termination. Nat Med. 2006 Sep; 12(9):1093-9.View Related Profiles.

Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo

PMID: 16892063

Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 9; 103(19):7378-83. PMID: 16670198; PMCID: PMC1464348; DOI: 10.1073/pnas.0601938103;

Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27; 124(2):315-29. PMID: 16439206

Amital H, Heilweil M, Ulmansky R, Szafer F, Bar-Tana R, Morel L, Foster MH, Mostoslavsky G, Eilat D, Pizov G, Naparstek Y. Treatment with a laminin-derived peptide suppresses lupus nephritis. J Immunol. 2005 Oct 15; 175(8):5516-23. PMID: 16210660

Mostoslavsky G, Kotton DN, Fabian AJ, Gray JT, Lee JS, Mulligan RC. Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation. Mol Ther. 2005 Jun; 11(6):932-40.View Related Profiles.

Kotton, Darrell
Mostoslavsky, Gustavo

PMID: 15922964

Kong D, Melo LG, Gnecchi M, Zhang L, Mostoslavsky G, Liew CC, Pratt RE, Dzau VJ. Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. Circulation. 2004 Oct 5; 110(14):2039-46. PMID: 15451799

Podar K, Mostoslavsky G, Sattler M, Tai YT, Hayashi T, Catley LP, Hideshima T, Mulligan RC, Chauhan D, Anderson KC. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. J Biol Chem. 2004 May 14; 279(20):21658-65. PMID: 15010462

Yachimovich N, Mostoslavsky G, Yarkoni Y, Verbovetski I, Eilat D. The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status. Eur J Immunol. 2002 Apr; 32(4):1164-74. PMID: 11932924

Mostoslavsky G, Fischel R, Yachimovich N, Yarkoni Y, Rosenmann E, Monestier M, Baniyash M, Eilat D. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur J Immunol. 2001 Apr; 31(4):1221-7. PMID: 11298348

Friedmann D, Yachimovich N, Mostoslavsky G, Pewzner-Jung Y, Ben-Yehuda A, Rajewsky K, Eilat D. Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain. J Immunol. 1999 Apr 15; 162(8):4406-16. PMID: 10201976

Jovelin F, Mostoslavsky G, Amoura Z, Chabre H, Gilbert D, Eilat D, Bach JF, Koutouzov S. Early anti-nucleosome autoantibodies from a single MRL+/+ mouse: fine specificity, V gene structure and pathogenicity. Eur J Immunol. 1998 Nov; 28(11):3411-22. PMID: 9842884

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 91 publications over 24 distinct years, with a maximum of 8 publications in 2010

Bar chart showing 91 publications over 24 distinct years, with a maximum of 8 publications in 2010

Year	Publications
1998	1
1999	1
2001	1
2002	1
2004	2
2005	2
2006	5
2007	5
2008	1
2009	3
2010	8
2011	6
2012	6
2013	7
2014	4
2015	4
2016	4
2017	7
2018	3
2019	2
2020	6
2021	6
2022	5
2023	1

Media Mentions

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Researchers harness stem cells to study how Ebola virus infects and damages the liver

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Drug Target Review 4/14/2021

Intestinal Organoids Developed to Test New Drugs for COVID-19

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After a decade of squabbles, BU’s biolab is in business

The Boston Globe 8/20/2018

2019 CJD Foundation: CJD Foundation Research Awardee

2019 ASRM: Ky Cha Award in Stem Cell Technologies

2019 DOM BUSM: Evans Outstanding Citizenship Award

2017 Boston University: Innovator of the Year

2015-2020 World Learning The Fulbright Specialist Program: Fulbright Senior Specialist Scholar

2009 NIH RC2 Challenge Award: Role Co-PI

2002-2004 Postdoctoral Award from the Lady Tata Memorial Trust

2000 Travel Allowance Fellowship from Boehringer Ingelheim Fonds

1999-2000 Hebrew University: The Excellency Award as Teaching Assistant at the Department of Microbiology, Faculty of Medicine

1995-1996 The Hebrew University of Jerusalem: Golda Meir Award

1994 Ministry of Science and the Arts of Israel: Ph.D. Fellowship

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

stem cells, iPSC, disease modeling

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