Keywords
Last Name

Ji Yi, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGastroenterology
Address650 Albany St Evans Biomed Research Ctr
Boston MA
 Awards and Honors

Start-EndDescription
2014-2015Juvenile Diabetes Research Foundation International (JDRF) postdoctoral fellowship
2013-2014Illinois society of the prevention of blindness (ISPB) seed grant
2013Baxter Young Investigator Award
 Research Expertise & Professional Interests
Our focus is to develop novel optical techniques for fundamental research and clinical applications. The research includes the development of inverse spectroscopic optical coherence tomography (ISOCT) and metabolic optical coherence tomography applicable in vivo, with ISOCT being sensitive to nanoscale tissue structural changes and metabolic OCT being able to quantify tissue oxygen metabolism. In addition, we also develop methods for label-free optical angiography on live animals. We are also interested in novel optical endoscopy, super resolution microscopy for fundamental science, biosensing and computational optics. The clinical applications encompass cancer early detection, eye diseases such as glaucoma, and aging diseases etc.

 Self-Described Keywords
  • Biophotonics, Optical coherence tomography, Biosensing, Detection of ultrastructural change in diseases, Oxygen metabolism, Ophthalmic imaging
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 1; 109(11):2218-26. PMID: 26636933.
    View in: PubMed
  2. Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Amani A. Fawzi, Robert A. Linsenmeier, and Hao F. Zhang. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation. Light: Science & Applications. 2015; e334(4).
    View in: External Website
  3. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. In vivo capture and label-free detection of early metastatic cells. Nat Commun. 2015; 6:8094. PMID: 26348915.
    View in: PubMed
  4. Liu W, Yi J, Chen S, Jiao S, Zhang HF. Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length. Med Phys. 2015 Sep; 42(9):5356-62. PMID: 26328984.
    View in: PubMed
  5. Ji Yi, Siyu Chen, Xiao Shu, Amani A. Fawzi, and Hao F. Zhang. Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy. Biomed. Opt. Express. 2015; 6(10):3701-3713.
    View in: External Website
  6. Chen S, Yi J, Zhang HF. Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography. Biomed Opt Express. 2015 Aug 1; 6(8):2840-53. PMID: 26309748.
    View in: PubMed
  7. Urban BE, Yi J, Chen S, Dong B, Zhu Y, DeVries SH, Backman V, Zhang HF. Super-resolution two-photon microscopy via scanning patterned illumination. Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Apr; 91(4):042703. PMID: 25974523.
    View in: PubMed
  8. Chen H, Zhao Y, Liu M, Feng L, Puyang Z, Yi J, Liang P, Zhang HF, Cang J, Troy JB, Liu X. Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1971-84. PMID: 25722210.
    View in: PubMed
  9. Chen S, Yi J, Dong B, Sun C, Kiser PF, Hope TJ, Zhang HF. Imaging endocervical mucus anatomy and dynamics in macaque female reproductive track using optical coherence tomography. Quant Imaging Med Surg. 2015 Feb; 5(1):40-5. PMID: 25694952.
    View in: PubMed
  10. Song W, Wei Q, Liu W, Liu T, Yi J, Sheibani N, Fawzi AA, Linsenmeier RA, Jiao S, Zhang HF. A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography. Sci Rep. 2014; 4:6525. PMID: 25283870.
    View in: PubMed
  11. Yi J, Chen S, Backman V, Zhang HF. In vivo functional microangiography by visible-light optical coherence tomography. Biomed Opt Express. 2014 Oct 1; 5(10):3603-12. PMID: 25360376.
    View in: PubMed
  12. Urban BE, Yi J, Yakovlev V, Zhang HF. Investigating femtosecond-laser-induced two-photon photoacoustic generation. J Biomed Opt. 2014 Aug; 19(8):085001. PMID: 25084119.
    View in: PubMed
  13. Yi J, Radosevich AJ, Stypula-Cyrus Y, Mutyal NN, Azarin SM, Horcher E, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography. J Biomed Opt. 2014 Mar; 19(3):36013. PMID: 24643530.
    View in: PubMed
  14. Rogers JD, Radosevich AJ, Yi J, Backman V. Modeling Light Scattering in Tissue as Continuous Random Media Using a Versatile Refractive Index Correlation Function. IEEE J Sel Top Quantum Electron. 2013 Sep 06; 20(2):7000514. PMID: 25587211.
    View in: PubMed
  15. Radosevich AJ, Mutyal NN, Yi J, Stypula-Cyrus Y, Rogers JD, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy. J Biomed Opt. 2013 Sep; 18(9):097002. PMID: 24008865.
    View in: PubMed
  16. Black KC, Sileika TS, Yi J, Zhang R, Rivera JG, Messersmith PB. Bacterial killing by light-triggered release of silver from biomimetic metal nanorods. Small. 2014 Jan 15; 10(1):169-78. PMID: 23847147.
    View in: PubMed
  17. Yi J, Wei Q, Liu W, Backman V, Zhang HF. Visible-light optical coherence tomography for retinal oximetry. Opt Lett. 2013 Jun 1; 38(11):1796-8. PMID: 23722747.
    View in: PubMed
  18. Yi J, Radosevich AJ, Rogers JD, Norris SC, Çapoglu IR, Taflove A, Backman V. Can OCT be sensitive to nanoscale structural alterations in biological tissue? Opt Express. 2013 Apr 8; 21(7):9043-59. PMID: 23571994.
    View in: PubMed
  19. Liu W, Liu T, Song W, Yi J, Zhang HF. Automatic retinal vessel segmentation based on active contours method in Doppler spectral-domain optical coherence tomography. J Biomed Opt. 2013 Jan; 18(1):16002. PMID: 23292611.
    View in: PubMed
  20. Radosevich AJ, Yi J, Rogers JD, Backman V. Structural length-scale sensitivities of reflectance measurements in continuous random media under the Born approximation. Opt Lett. 2012 Dec 15; 37(24):5220-2. PMID: 23258058.
    View in: PubMed
  21. Yi J, Backman V. Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography. Opt Lett. 2012 Nov 1; 37(21):4443-5. PMID: 23114323.
    View in: PubMed
  22. Black KC, Yi J, Rivera JG, Zelasko-Leon DC, Messersmith PB. Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy. Nanomedicine (Lond). 2013 Jan; 8(1):17-28. PMID: 22891865.
    View in: PubMed
  23. Yi J, Wei Q, Zhang HF, Backman V. Structured interference optical coherence tomography. Opt Lett. 2012 Aug 1; 37(15):3048-50. PMID: 22859081.
    View in: PubMed
  24. Radosevich AJ, Rogers JD, Turzhitsky V, Mutyal NN, Yi J, Roy HK, Backman V. Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length-scales. IEEE J Sel Top Quantum Electron. 2012 Jul; 18(4):1313-1325. PMID: 24163574.
    View in: PubMed
  25. Radosevich AJ, Mutyal NN, Turzhitsky V, Rogers JD, Yi J, Taflove A, Backman V. Measurement of the spatial backscattering impulse-response at short length scales with polarized enhanced backscattering. Opt Lett. 2011 Dec 15; 36(24):4737-9. PMID: 22179867.
    View in: PubMed
  26. Yi J, Li X. Estimation of oxygen saturation from erythrocytes by high-resolution spectroscopic optical coherence tomography. Opt Lett. 2010 Jun 15; 35(12):2094-6. PMID: 20548397.
    View in: PubMed
  27. Yi J, Gong J, Li X. Analyzing absorption and scattering spectra of micro-scale structures with spectroscopic optical coherence tomography. Opt Express. 2009 Jul 20; 17(15):13157-67. PMID: 19654721.
    View in: PubMed
  28. Gong J, Yi J, Turzhitsky VM, Muro K, Li X. Characterization of malignant brain tumor using elastic light scattering spectroscopy. Dis Markers. 2008; 25(6):303-12. PMID: 19208948.
    View in: PubMed
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