Keywords
Last Name

Sayon Roy, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-4107
ORCID ORCID Icon0000-0002-9156-8085
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentOphthalmology

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
My expertise is in understanding the pathogenesis of diabetic microvascular complications. In particular, studying the effect of high glucose in retinal endothelial cells, pericytes, and Muller cell gene expression.

 Self-Described Keywords
  • Diabetic microangiopathy
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Roy S, Kern TS, Song B, Stuebe C. Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy. Am J Pathol. 2017 Jan; 187(1):9-19. PMID: 27846381.
    View in: PubMed
  2. Hymowitz MB, Chang D, Feinberg EB, Roy S. Increased Intraocular Pressure and Hyperglycemic Level in Diabetic Patients. PLoS One. 2016; 11(3):e0151833. PMID: 27002725.
    View in: PubMed
  3. Roy S, Amin S, Roy S. Retinal fibrosis in diabetic retinopathy. Exp Eye Res. 2016 Jan; 142:71-5. PMID: 26675403.
    View in: PubMed
  4. Tien T, Muto T, Zhang J, Sohn EH, Mullins RF, Roy S. Association of reduced Connexin 43 expression with retinal vascular lesions in human diabetic retinopathy. Exp Eye Res. 2016 May; 146:103-6. PMID: 26738943.
    View in: PubMed
  5. Roy S, Kim D, Hernández C, Simó R, Roy S. Beneficial effects of fenofibric acid on overexpression of extracellular matrix components, COX-2, and impairment of endothelial permeability associated with diabetic retinopathy. Exp Eye Res. 2015 Nov; 140:124-9. PMID: 26297615.
    View in: PubMed
  6. Roy S, Bae E, Amin S, Kim D. Extracellular matrix, gap junctions, and retinal vascular homeostasis in diabetic retinopathy. Exp Eye Res. 2015 Apr; 133:58-68. PMID: 25819455.
    View in: PubMed
  7. Chronopoulos A, Roy S, Beglova E, Mansfield K, Wachtman L, Roy S. Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy. Diabetes. 2015 Jul; 64(7):2603-8. PMID: 25732190.
    View in: PubMed
  8. Muto T, Tien T, Kim D, Sarthy VP, Roy S. High glucose alters Cx43 expression and gap junction intercellular communication in retinal Müller cells: promotes Müller cell and pericyte apoptosis. Invest Ophthalmol Vis Sci. 2014 Jul; 55(7):4327-37. PMID: 24938518.
    View in: PubMed
  9. Tien T, Muto T, Barrette K, Challyandra L, Roy S. Downregulation of Connexin 43 promotes vascular cell loss and excess permeability associated with the development of vascular lesions in the diabetic retina. Mol Vis. 2014; 20:732-41. PMID: 24940027.
    View in: PubMed
  10. Roy S, Trudeau K, Roy S, Tien T, Barrette KF. Mitochondrial dysfunction and endoplasmic reticulum stress in diabetic retinopathy: mechanistic insights into high glucose-induced retinal cell death. Curr Clin Pharmacol. 2013 Nov; 8(4):278-84. PMID: 23173958.
    View in: PubMed
  11. Tien T, Barrette KF, Chronopoulos A, Roy S. Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells. Invest Ophthalmol Vis Sci. 2013; 54(10):6518-25. PMID: 24008412.
    View in: PubMed
  12. Oshitari T, Yamamoto S, Roy S. Increased expression of c-Fos, c-Jun and c-Jun N-terminal kinase associated with neuronal cell death in retinas of diabetic patients. Curr Eye Res. 2014 May; 39(5):527-31. PMID: 24073601.
    View in: PubMed
  13. Traish AM, Stottrup C, van Renterghem K, Achten R, Roy S. Density and distribution of connexin 43 in corpus cavernosum tissue from diabetic and hypogonadal patients with erectile dysfunction. Horm Mol Biol Clin Investig. 2013 Jun; 13(1):7-12. PMID: 25436709.
    View in: PubMed
  14. Manasson J, Tien T, Moore C, Kumar NM, Roy S. High glucose-induced downregulation of connexin 30.2 promotes retinal vascular lesions: implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 2013 Mar; 54(3):2361-6. PMID: 23385797.
    View in: PubMed
  15. Traish Abdulmaged M., Stottrup Casey, Renterghem Koenraad van, Achten Ruthand Roy Sayon. Density and distribution of connexin 43 in corpus cavernosum tissue from diabetic and hypogonadal patients with erectile dysfunction. Horm Mol Biol Clin Invest. 2013; 13(1):7-12.
  16. Simó R, Roy S, Behar-Cohen F, Keech A, Mitchell P, Wong TY. Fenofibrate: a new treatment for diabetic retinopathy. Molecular mechanisms and future perspectives. Curr Med Chem. 2013; 20(26):3258-66. PMID: 23745548.
    View in: PubMed
  17. Trudeau K, Muto T, Roy S. Downregulation of mitochondrial connexin 43 by high glucose triggers mitochondrial shape change and cytochrome C release in retinal endothelial cells. Invest Ophthalmol Vis Sci. 2012; 53(10):6675-81. PMID: 22915032.
    View in: PubMed
  18. Roy S, Nasser S, Yee M, Graves DT, Roy S. A long-term siRNA strategy regulates fibronectin overexpression and improves vascular lesions in retinas of diabetic rats. Mol Vis. 2011; 17:3166-74. PMID: 22171163.
    View in: PubMed
  19. Trudeau K, Molina AJ, Roy S. High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest Ophthalmol Vis Sci. 2011 Nov; 52(12):8657-64. PMID: 21979999.
    View in: PubMed
  20. Trudeau K, Roy S, Guo W, Hernández C, Villarroel M, Simó R, Roy S. Fenofibric acid reduces fibronectin and collagen type IV overexpression in human retinal pigment epithelial cells grown in conditions mimicking the diabetic milieu: functional implications in retinal permeability. Invest Ophthalmol Vis Sci. 2011 Aug; 52(9):6348-54. PMID: 21715349.
    View in: PubMed
  21. Chronopoulos A, Trudeau K, Roy S, Huang H, Vinores SA, Roy S. High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: implications for diabetic retinopathy. Curr Eye Res. 2011 Aug; 36(8):747-53. PMID: 21780924.
    View in: PubMed
  22. Roy S, Ha J, Trudeau K, Beglova E. Vascular basement membrane thickening in diabetic retinopathy. Curr Eye Res. 2010 Dec; 35(12):1045-56. PMID: 20929292.
    View in: PubMed
  23. Chronopoulos A, Tang A, Beglova E, Trackman PC, Roy S. High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function. Diabetes. 2010 Dec; 59(12):3159-66. PMID: 20823103.
    View in: PubMed
  24. Trudeau K, Molina AJ, Guo W, Roy S. High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am J Pathol. 2010 Jul; 177(1):447-55. PMID: 20522647.
    View in: PubMed
  25. Alikhani M, Roy S, Graves DT. FOXO1 plays an essential role in apoptosis of retinal pericytes. Mol Vis. 2010; 16:408-15. PMID: 20300563.
    View in: PubMed
  26. Bobbie MW, Roy S, Trudeau K, Munger SJ, Simon AM, Roy S. Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3758-63. PMID: 20130277.
    View in: PubMed
  27. Roy S, Tonkiss J, Roy S. Aging increases retinal vascular lesions characteristic of early diabetic retinopathy. Biogerontology. 2010 Aug; 11(4):447-55. PMID: 20119717.
    View in: PubMed
  28. Roy S, Trudeau K, Roy S, Behl Y, Dhar S, Chronopoulos A. New insights into hyperglycemia-induced molecular changes in microvascular cells. J Dent Res. 2010 Feb; 89(2):116-27. PMID: 20042738.
    View in: PubMed
  29. Behl Y, Krothapalli P, Desta T, Roy S, Graves DT. FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes. 2009 Apr; 58(4):917-25. PMID: 19168598.
    View in: PubMed
  30. Li AF, Roy S. High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1400-7. PMID: 19029021.
    View in: PubMed
  31. Cherian S, Roy S, Pinheiro A, Roy S. Tight glycemic control regulates fibronectin expression and basement membrane thickening in retinal and glomerular capillaries of diabetic rats. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):943-9. PMID: 18775856.
    View in: PubMed
  32. Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, Graves DT. Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol. 2008 May; 172(5):1411-8. PMID: 18403591.
    View in: PubMed
  33. Tane N, Dhar S, Roy S, Pinheiro A, Ohira A, Roy S. Effect of excess synthesis of extracellular matrix components by trabecular meshwork cells: possible consequence on aqueous outflow. Exp Eye Res. 2007 May; 84(5):832-42. PMID: 17350618.
    View in: PubMed
  34. Oshitari T, Polewski P, Chadda M, Li AF, Sato T, Roy S. Effect of combined antisense oligonucleotides against high-glucose- and diabetes-induced overexpression of extracellular matrix components and increased vascular permeability. Diabetes. 2006 Jan; 55(1):86-92. PMID: 16380480.
    View in: PubMed
  35. Oshitari T, Roy S. Diabetes: a potential enhancer of retinal injury in rat retinas. Neurosci Lett. 2005 Dec 16; 390(1):25-30. PMID: 16154273.
    View in: PubMed
  36. Oshitari T, Brown D, Roy S. SiRNA strategy against overexpression of extracellular matrix in diabetic retinopathy. Exp Eye Res. 2005 Jul; 81(1):32-7. PMID: 15978252.
    View in: PubMed
  37. Li AF, Tane N, Roy S. Fibronectin overexpression inhibits trabecular meshwork cell monolayer permeability. Mol Vis. 2004 Oct 7; 10:750-7. PMID: 15496827.
    View in: PubMed
  38. Li AF, Sato T, Haimovici R, Okamoto T, Roy S. High glucose alters connexin 43 expression and gap junction intercellular communication activity in retinal pericytes. Invest Ophthalmol Vis Sci. 2003 Dec; 44(12):5376-82. PMID: 14638741.
    View in: PubMed
  39. Roy S, Sato T, Paryani G, Kao R. Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats. Diabetes. 2003 May; 52(5):1229-34. PMID: 12716757.
    View in: PubMed
  40. Roy S, Rothschild JG, Chen A. Vascular complications and gene therapy. Expert Opin Biol Ther. 2003 Feb; 3(1):71-83. PMID: 12718732.
    View in: PubMed
  41. Sato T, Haimovici R, Kao R, Li AF, Roy S. Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells. Diabetes. 2002 May; 51(5):1565-71. PMID: 11978657.
    View in: PubMed
  42. Sato T, Roy S. Effect of high glucose on fibronectin expression and cell proliferation in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2002 Jan; 43(1):170-5. PMID: 11773028.
    View in: PubMed
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