Sayon Roy, PhD, FARVO
Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

PhD, Boston University
MS, University of Kalyani




My expertise is in understanding the pathogenesis of diabetic microvascular complications. In particular, studying the effect of high glucose in retinal endothelial cells, pericytes, and Muller cell gene expression.

Professor
Boston University School of Medicine
Ophthalmology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Boston Medical Center




Thickening of Basement Membrane in Diabetic Retinopathy
01/01/2004 - 12/31/2009 (PI)
NIH/National Eye Institute
3 R01 EY14702 04S1

Towards Development of a Primate Model of Diabetic Retinopathy
03/31/2006 - 03/31/2008 (PI)
Pearl Vision Foundation

Role of Basement Membrane Thickening in Vascular Complications of Diabetes
07/01/2002 - 06/30/2006 (PI)
American Diabetes Association

Basement Membrane Thickening in Diabetic Retinopathy
04/01/1999 - 06/30/2004 (PI)
NIH/National Eye Institute
5 R29 EY11990 06

Gene Delivery and Regulation of Abnormal Gene Expression in Diabetes
02/01/2000 - 02/28/2002 (PI)
National Medical Technology Testbed

Role of Extracellular Matrix Accumulation in the Vascular Complications of Diabetes
04/01/1999 - 12/31/2001 (PI)
American Diabetes Association


Mitochondrial fragmentation and dysfunction in diabetic retinopathy
02/01/2018 - 01/31/2023 (PI)
NIH-NEI
1R01EY027082-01A1

Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy
04/01/2016 - 03/31/2021 (PI)
NIH-NEI
5R01EY025528-05

Novel Therapies to inhibit diabetic retinopathy
04/01/2019 - 03/31/2020 (PI)
University of California, Irvine NIH-NEI

Novel Therapies to inhibit diabetic retinopathy
04/01/2015 - 03/31/2020 (PI)
Case Western Reserve University NIH-NEI
5R24EY024864-04

Assessment of Therapeutic Potential of Danegaptide/Rotigaptide in Diabetic Retinopathy
08/29/2014 - 04/30/2018 (PI)
Zealand Pharma

Role of Intercellular Communication in Pathogenesis of Diabetic Retinopathy
01/01/2009 - 12/31/2014 (PI)
NIH-NEI
5R01 EY018218-05

Diabetic mamoset, a potential non-human primate model of diabetic retinopathy
03/01/2008 - 02/28/2010 (PI)
Juvenile Diab Fdtn

Effect of Insulin against High Glucose-induced apoptosis in retinal vascular cells
06/01/2006 - 08/31/2006 (PI)
Fight for Sight


Title


Yr Title Project-Sub Proj Pubs
2020 Mitochondrial fragmentation and dysfunction in diabetic retinopathy 5R01EY027082-03 2
2020 Role of intercellular communication in pathogenesis of diabetic retinopathy 2R01EY018218-06 17
2019 Mitochondrial fragmentation and dysfunction in diabetic retinopathy 5R01EY027082-02 2
2019 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 5R01EY025528-05 8
2018 Mitochondrial fragmentation and dysfunction in diabetic retinopathy 1R01EY027082-01A1 2
2018 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 5R01EY025528-04 8
2017 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 5R01EY025528-03 8
2016 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 5R01EY025528-02 8
2015 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 1R01EY025528-01 8
2013 Role of intercellular communication in pathogenesis of diabetic retinopathy 5R01EY018218-05 17
Showing 10 of 32 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Roy S, Kim D. Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy. Prog Retin Eye Res. 2020 Sep 17; 100903. PMID: 32950677
     
  2. Kim D, Roy S. Effects of Diabetes on Mitochondrial Morphology and Its Implications in Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2020 08 03; 61(10):10. PMID: 32756920
     
  3. Kim D, Sankaramoorthy A, Roy S. Downregulation of Drp1 and Fis1 Inhibits Mitochondrial Fission and Prevents High Glucose-Induced Apoptosis in Retinal Endothelial Cells. Cells. 2020 Jul 10; 9(7). PMID: 32664237
     
  4. Nguyen NH, Kim D, Roy S. High Glucose Increases Binding of Lysyl Oxidase to Extracellular Matrix Proteins: Implications for Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2020 04 09; 61(4):40. PMID: 32340032
     
  5. Subramanian ML, Stein TD, Siegel N, Ness S, Fiorello MG, Kim D, Roy S. Upregulation of Lysyl Oxidase Expression in Vitreous of Diabetic Subjects: Implications for Diabetic Retinopathy. Cells. 2019 09 21; 8(10).View Related Profiles. PMID: 31546618
     
  6. Kim D, Lee D, Trackman PC, Roy S. Effects of High Glucose-Induced Lysyl Oxidase Propeptide on Retinal Endothelial Cell Survival: Implications for Diabetic Retinopathy. Am J Pathol. 2019 10; 189(10):1945-1952.View Related Profiles. PMID: 31537300
     
  7. Roy S, Kim D, Sankaramoorthy A. Mitochondrial Structural Changes in the Pathogenesis of Diabetic Retinopathy. J Clin Med. 2019 Sep 01; 8(9). PMID: 31480638
     
  8. Daley EJ, Pajevic PD, Roy S, Trackman PC. Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus. JBMR Plus. 2019 Oct; 3(10):e10212.View Related Profiles. PMID: 31687648
     
  9. Kim D, Mecham RP, Nguyen NH, Roy S. Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy. Exp Eye Res. 2019 07; 184:221-226. PMID: 31022398
     
  10. Song B, Kim D, Nguyen NH, Roy S. Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2018 12 03; 59(15):5965-5972. PMID: 30550614
     
Showing 10 of 59 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 59 publications over 19 distinct years, with a maximum of 7 publications in 2013

YearPublications
20022
20033
20041
20052
20061
20071
20083
20092
20106
20114
20121
20137
20142
20154
20163
20175
20183
20195
20204
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Diabetic microangiopathy
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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