Keywords
Last Name

Hemant K. Roy, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGastroenterology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-8345
ORCID ORCID Icon0000-0001-7613-5575
Other Positions
TitleSection Chief of Medicine in Gastroenterology
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGastroenterology

 Research Expertise & Professional Interests
Dr. Roy joined the faculty in 2013. He completed his medical degree from Northwestern University with distinction and completed internal medicine residency at Beth Isreal followed by GI Fellowship at University of Chicago.

Dr. Roy’s research interests center on GI cancer risk stratification using intermediate biomarkers of field carcinogenesis. He has been involved in the development and clinical implementation of a variety of biophotonic techniques for risk stratification encompassing both fiberoptic probes and cytological based techniques and these are complemented by a variety of molecular markers including microRNAs.

This has served as a platform for assessing risk modification via chemoprevention and applied to a number of non-GI malignancies including lung and ovarian cancer. Dr. Roy is a fellow of the American Gastroenterological Association and member of the Early Detection Research Network and the Cancer Biomarkers Study Section of the NCI,

More clinically, his interests are in high risk colon cancer syndromes and role of gender in colorectal cancer screening. Throughout his career he has also been involved in teaching receiving numerous awards in this regard.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Chowdhury S, Roy HK. The genetics and molecular biology of colonic neoplasia: practical implications for the clinician. Curr Opin Gastroenterol. 2017 Jan; 33(1):47-52. PMID: 27798442.
    View in: PubMed
  2. Calderwood AH, Lasser KE, Roy HK. Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer. World J Gastrointest Oncol. 2016 Dec 15; 8(12):826-834. PMID: 28035253.
    View in: PubMed
  3. Wu W, Radosevich AJ, Eshein A, Nguyen TQ, Yi J, Cherkezyan L, Roy HK, Szleifer I, Backman V. Using electron microscopy to calculate optical properties of biological samples. Biomed Opt Express. 2016 Nov 01; 7(11):4749-4762. PMID: 27896013.
    View in: PubMed
  4. Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, Weinberg S, Zhang D, Thusgaard Ruhoff P, Roy HK, Subramanian H, Chandel NS, Szleifer I, Backman V. Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy. Proc Natl Acad Sci U S A. 2016 Oct 18; 113(42):E6372-E6381. PMID: 27702891.
    View in: PubMed
  5. Krishn SR, Kaur S, Sheinin YM, Smith LM, Gautam SK, Patel A, Jain M, Juvvigunta V, Pai P, Lazenby AJ, Roy HK, Batra SK. Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance. Oncotarget. 2016 Sep 29. PMID: 27705923.
    View in: PubMed
  6. Subramanian H, Viswanathan P, Cherkezyan L, Iyengar R, Rozhok S, Verleye M, Derbas J, Czarnecki J, Roy HK, Backman V. Procedures for risk-stratification of lung cancer using buccal nanocytology. Biomed Opt Express. 2016 Sep 01; 7(9):3795-3810. PMID: 27699138.
    View in: PubMed
  7. Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Szleifer I, Roy HK, Backman V. The Greater Genomic Landscape: The Heterogeneous Evolution of Cancer. Cancer Res. 2016 Oct 01; 76(19):5605-5609. PMID: 27550448.
    View in: PubMed
  8. Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 1; 109(11):2218-26. PMID: 26636933.
    View in: PubMed
  9. Roy HK, Turzhitsky V, Wali R, Radosevich AJ, Jovanovic B, Della'Zanna G, Umar A, Rubin DT, Goldberg MJ, Bianchi L, De La Cruz M, Bogojevic A, Helenowski IB, Rodriguez L, Chatterton R, Skripkauskas S, Page K, Weber CR, Huang X, Richmond E, Bergan RC, Backman V. Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. Gut. 2017 Feb; 66(2):285-292. PMID: 26503631.
    View in: PubMed
  10. Momi N, Backman V, Brendler CB, Roy HK. Harnessing novel modalities: field carcinogenesis detection for personalizing prostate cancer management. Future Oncol. 2015; 11(20):2737-41. PMID: 26374598.
    View in: PubMed
  11. Das S, Rachagani S, Sheinin Y, Smith LM, Gurumurthy CB, Roy HK, Batra SK. Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer. Oncogene. 2016 May 19; 35(20):2645-54. PMID: 26364605.
    View in: PubMed
  12. Tiwari AK, Roy HK, Lynch HT. Lynch syndrome in the 21st century: clinical perspectives. QJM. 2016 Mar; 109(3):151-8. PMID: 26224055.
    View in: PubMed
  13. Mutyal NN, Radosevich AJ, Bajaj S, Konda V, Siddiqui UD, Waxman I, Goldberg MJ, Rogers JD, Gould B, Eshein A, Upadhye S, Koons A, Gonzalez-Haba Ruiz M, Roy HK, Backman V. In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa. Pancreas. 2015 Jul; 44(5):735-41. PMID: 25906443.
    View in: PubMed
  14. Radosevich AJ, Mutyal NN, Eshein A, Nguyen TQ, Gould B, Rogers JD, Goldberg MJ, Bianchi LK, Yen EF, Konda V, Rex DK, Van Dam J, Backman V, Roy HK. Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions. Clin Cancer Res. 2015 Oct 1; 21(19):4347-55. PMID: 25991816.
    View in: PubMed
  15. Jovanovic BD, Subramanian H, Helenowski IB, Roy HK, Backman V. Clinical Trial Laboratory Data Nested With in Subject: Components of Variance, Sample Size and Cost. Biom Biostat Int J. 2015; 2(3). PMID: 26457336.
    View in: PubMed
  16. Roy HK, Brendler CB, Subramanian H, Zhang D, Maneval C, Chandler J, Bowen L, Kaul KL, Helfand BT, Wang CH, Quinn M, Petkewicz J, Paterakos M, Backman V. Nanocytological field carcinogenesis detection to mitigate overdiagnosis of prostate cancer: a proof of concept study. PLoS One. 2015; 10(2):e0115999. PMID: 25706755.
    View in: PubMed
  17. Radosevich AJ, Mutyal NN, Rogers JD, Gould B, Hensing TA, Ray D, Backman V, Roy HK. Buccal spectral markers for lung cancer risk stratification. PLoS One. 2014; 9(10):e110157. PMID: 25299667.
    View in: PubMed
  18. Cruz MD, Wali RK, Bianchi LK, Radosevich AJ, Crawford SE, Jepeal L, Goldberg MJ, Weinstein J, Momi N, Roy P, Calderwood AH, Backman V, Roy HK. Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender. Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2413-21. PMID: 25155760.
    View in: PubMed
  19. Wali RK, Hensing TA, Ray DW, Dela Cruz M, Tiwari AK, Radosevich A, Jepeal L, Fernando HC, Litle VR, Charlot M, Momi N, Backman V, Roy HK. Buccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications. Int J Oncol. 2014 Sep; 45(3):1209-15. PMID: 24919547.
    View in: PubMed
  20. Khunger M, Kumar U, Roy HK, Tiwari AK. Dysplasia and cancer screening in 21st century. APMIS. 2014 Aug; 122(8):674-82. PMID: 24910362.
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  21. Patel M, Gomes A, Ruderman S, Hardee D, Crespo S, Raimondo M, Woodward T, Backman V, Roy H, Wallace M. Polarization gating spectroscopy of normal-appearing duodenal mucosa to detect pancreatic cancer. Gastrointest Endosc. 2014 Nov; 80(5):786-93.e1-2. PMID: 24861243.
    View in: PubMed
  22. Cherkezyan L, Stypula-Cyrus Y, Subramanian H, White C, Dela Cruz M, Wali RK, Goldberg MJ, Bianchi LK, Roy HK, Backman V. Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study. BMC Cancer. 2014; 14:189. PMID: 24629088.
    View in: PubMed
  23. Yi J, Radosevich AJ, Stypula-Cyrus Y, Mutyal NN, Azarin SM, Horcher E, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography. J Biomed Opt. 2014 Mar; 19(3):36013. PMID: 24643530.
    View in: PubMed
  24. Stypula-Cyrus Y, Mutyal NN, Dela Cruz M, Kunte DP, Radosevich AJ, Wali R, Roy HK, Backman V. End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis. FEBS Lett. 2014 Mar 3; 588(5):829-35. PMID: 24492008.
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  25. Radosevich AJ, Mutyal NN, Yi J, Stypula-Cyrus Y, Rogers JD, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy. J Biomed Opt. 2013 Sep; 18(9):097002. PMID: 24008865.
    View in: PubMed
  26. Roy HK, Damania DP, DelaCruz M, Kunte DP, Subramanian H, Crawford SE, Tiwari AK, Wali RK, Backman V. Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening. Cancer Prev Res (Phila). 2013 Oct; 6(10):1111-9. PMID: 23983085.
    View in: PubMed
  27. Stypula-Cyrus Y, Damania D, Kunte DP, Cruz MD, Subramanian H, Roy HK, Backman V. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. PLoS One. 2013; 8(5):e64600. PMID: 23724067.
    View in: PubMed
  28. Qi W, Fitchev PS, Cornwell ML, Greenberg J, Cabe M, Weber CR, Roy HK, Crawford SE, Savkovic SD. FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. J Biol Chem. 2013 Jun 7; 288(23):16274-81. PMID: 23603907.
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  29. Damania D, Roy HK, Kunte D, Hurteau JA, Subramanian H, Cherkezyan L, Krosnjar N, Shah M, Backman V. Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells. Int J Cancer. 2013 Sep 1; 133(5):1143-52. PMID: 23436651.
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  30. Backman V, Roy HK. Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification. J Cancer. 2013; 4(3):251-61. PMID: 23459690.
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  31. Mutyal NN, Radosevich A, Tiwari AK, Stypula Y, Wali R, Kunte D, Roy HK, Backman V. Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with low-coherence enhanced backscattering (LEBS) spectroscopy. PLoS One. 2013; 8(2):e57206. PMID: 23431406.
    View in: PubMed
  32. Calderwood AH, Roy HK. Increasing colorectal cancer screening adherence: comment on "A randomized comparison of print and web communication on colorectal cancer screening". JAMA Intern Med. 2013 Jan 28; 173(2):129-31. PMID: 23247843.
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  33. Roy HK. NIH: Drop re-review for big grant holders. Nature. 2012 Oct 11; 490(7419):176. PMID: 23060177.
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  34. Roy HK, Backman V. Spectroscopic applications in gastrointestinal endoscopy. Clin Gastroenterol Hepatol. 2012 Dec; 10(12):1335-41. PMID: 23059052.
    View in: PubMed
  35. Kunte DP, DelaCruz M, Wali RK, Menon A, Du H, Stypula Y, Patel A, Backman V, Roy HK. Dysregulation of microRNAs in colonic field carcinogenesis: implications for screening. PLoS One. 2012; 7(9):e45591. PMID: 23049818.
    View in: PubMed
  36. Tiwari AK, Laird-Fick HS, Wali RK, Roy HK. Surveillance for gastrointestinal malignancies. World J Gastroenterol. 2012 Sep 7; 18(33):4507-16. PMID: 22969223.
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  37. Roy HK, Khandekar JD. APC gene testing for familial adenomatosis polyposis. JAMA. 2012 Aug 1; 308(5):514-5. PMID: 22851119.
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  38. Radosevich AJ, Rogers JD, Turzhitsky V, Mutyal NN, Yi J, Roy HK, Backman V. Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length-scales. IEEE J Sel Top Quantum Electron. 2012 Jul; 18(4):1313-1325. PMID: 24163574.
    View in: PubMed
  39. Wali RK, Kunte DP, De La Cruz M, Tiwari AK, Brasky J, Weber CR, Gibson TP, Patel A, Savkovic SD, Brockstein BE, Roy HK. Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response. PLoS One. 2012; 7(6):e38047. PMID: 22675506.
    View in: PubMed
  40. Damania D, Roy HK, Subramanian H, Weinberg DS, Rex DK, Goldberg MJ, Muldoon J, Cherkezyan L, Zhu Y, Bianchi LK, Shah D, Pradhan P, Borkar M, Lynch H, Backman V. Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization. Cancer Res. 2012 Jun 1; 72(11):2720-7. PMID: 22491589.
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  41. Marsh Rde W, Alonzo M, Bajaj S, Baker M, Elton E, Farrell TA, Gore RM, Hall C, Nowak J, Roy H, Shaikh A, Talamonti MS. Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. Part II: multidisciplinary management. J Surg Oncol. 2012 Sep 1; 106(3):339-45. PMID: 22488601.
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  42. Marsh Rde W, Alonzo M, Bajaj S, Baker M, Elton E, Farrell TA, Gore RM, Hall C, Nowak J, Roy H, Shaikh A, Talamonti MS. Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. Part I: diagnosis-clinical staging and pathology. J Surg Oncol. 2012 Sep 1; 106(3):332-8. PMID: 22488652.
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  43. Gomes AJ, Ruderman S, DelaCruz M, Wali RK, Roy HK, Backman V. In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesis. J Biomed Opt. 2012 Apr; 17(4):047005. PMID: 22559696.
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  44. Roy HK, Bianchi LK. Sex-specific prevalence of adenomas and colorectal cancer. JAMA. 2012 Jan 11; 307(2):142; author reply 143-4. PMID: 22235076.
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  45. Simon MS, Rosenberg CA, Rodabough RJ, Greenland P, Ockene I, Roy HK, Lane DS, Cauley JA, Khandekar J. Prospective analysis of association between use of statins or other lipid-lowering agents and colorectal cancer risk. Ann Epidemiol. 2012 Jan; 22(1):17-27. PMID: 22056480.
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  46. Tiwari AK, Roy HK. Progress against cancer (1971-2011): how far have we come? J Intern Med. 2012 Apr; 271(4):392-9. PMID: 21950375.
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  47. Qi W, Joshi S, Weber CR, Wali RK, Roy HK, Savkovic SD. Polyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epithelia. Gut Microbes. 2011 Sep 1; 2(5):267-73. PMID: 22067938.
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  48. Yen EF, Pokhrel B, Bianchi LK, Roy HK, Du H, Patel A, Hall CR, Witt BL. Decreased colorectal cancer and adenoma risk in patients with microscopic colitis. Dig Dis Sci. 2012 Jan; 57(1):161-9. PMID: 21847567.
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  49. Gandhi SR, Tiwari AK, Kunte DP, De la Cruz MA, Stypula Y, Gibson T, Brasky J, Backman V, Wali RK, Roy HK. Association of stem-like cells in gender-specific chemoprevention against intestinal neoplasia in MIN mouse. Oncol Rep. 2011 Nov; 26(5):1127-32. PMID: 21769438.
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  50. Roy HK, Goldberg MJ, Bajaj S, Backman V. Colonoscopy and optical biopsy: bridging technological advances to clinical practice. Gastroenterology. 2011 Jun; 140(7):1863-7. PMID: 21521641.
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  51. Tiwari AK, Crawford SE, Radosevich A, Wali RK, Stypula Y, Kunte DP, Mutyal N, Ruderman S, Gomes A, Cornwell ML, De La Cruz M, Brasky J, Gibson TP, Backman V, Roy HK. Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. Cancer Lett. 2011 Jul 28; 306(2):205-13. PMID: 21493000.
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  52. Pradhan P, Damania D, Joshi HM, Turzhitsky V, Subramanian H, Roy HK, Taflove A, Dravid VP, Backman V. Quantification of nanoscale density fluctuations by electron microscopy: probing cellular alterations in early carcinogenesis. Phys Biol. 2011 Apr; 8(2):026012. PMID: 21441647.
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  53. Roy HK, Hensing T, Backman V. Nanocytology for field carcinogenesis detection: novel paradigm for lung cancer risk stratification. Future Oncol. 2011 Jan; 7(1):1-3. PMID: 21174531.
    View in: PubMed
  54. Roy HK, Koetsier JL, Tiwari AK, Joshi S, Kunte DP, Ward TP, Gandhi SR, Wali RK. Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesis. Int J Oncol. 2011 Feb; 38(2):529-36. PMID: 21170505.
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  55. Pradhan P, Damania D, Joshi HM, Turzhitsky V, Subramanian H, Roy HK, Taflove A, Dravid VP, Backman V. Quantification of nanoscale density fluctuations using electron microscopy: Light-localization properties of biological cells. Appl Phys Lett. 2010 Dec 13; 97(24):243704. PMID: 21221251.
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  56. Qi W, Weber CR, Wasland K, Roy H, Wali R, Joshi S, Savkovic SD. Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300(2):G264-72. PMID: 21109589.
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  57. Backman V, Roy HK. Light-scattering technologies for field carcinogenesis detection: a modality for endoscopic prescreening. Gastroenterology. 2011 Jan; 140(1):35-41. PMID: 21078318.
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  58. Radosevich AJ, Turzhitsky VM, Mutyal NN, Rogers JD, Stoyneva V, Tiwari AK, De La Cruz M, Kunte DP, Wali RK, Roy HK, Backman V. Depth-resolved measurement of mucosal microvascular blood content using ?low-coherence enhanced backscattering spectroscopy. Biomed Opt Express. 2010 Oct 20; 1(4):1196-1208. PMID: 21258541.
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  59. Roy HK, Subramanian H, Damania D, Hensing TA, Rom WN, Pass HI, Ray D, Rogers JD, Bogojevic A, Shah M, Kuzniar T, Pradhan P, Backman V. Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening. Cancer Res. 2010 Oct 15; 70(20):7748-54. PMID: 20924114.
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  60. Damania D, Subramanian H, Tiwari AK, Stypula Y, Kunte D, Pradhan P, Roy HK, Backman V. Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architecture. Biophys J. 2010 Aug 4; 99(3):989-96. PMID: 20682278.
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  61. Roy HK, Bianchi LK. Moving toward personalization of colorectal cancer screening: Comment on "Influence of race and sex on prevalence and recurrence of colon polyps". Arch Intern Med. 2010 Jul 12; 170(13):1132-4. PMID: 20625019.
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  62. Roy HK, Gomes AJ, Ruderman S, Bianchi LK, Goldberg MJ, Stoyneva V, Rogers JD, Turzhitsky V, Kim Y, Yen E, Jameel M, Bogojevic A, Backman V. Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications. Cancer Prev Res (Phila). 2010 Jul; 3(7):844-51. PMID: 20570881.
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  63. Turzhitsky V, Rogers JD, Mutyal NN, Roy HK, Backman V. Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering. IEEE J Sel Top Quantum Electron. 2010; 16(3):619-626. PMID: 21037980.
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  64. Roy HK, Bianchi LK. Differences in colon adenomas and carcinomas among women and men: potential clinical implications. JAMA. 2009 Oct 21; 302(15):1696-7. PMID: 19843905.
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  65. Brand RE, Greer JB, Zolotarevsky E, Brand R, Du H, Simeone D, Zisman A, Gorchow A, Lee SY, Roy HK, Anderson MA. Pancreatic cancer patients who smoke and drink are diagnosed at younger ages. Clin Gastroenterol Hepatol. 2009 Sep; 7(9):1007-12. PMID: 19560558.
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  66. Subramanian H, Roy HK, Pradhan P, Goldberg MJ, Muldoon J, Brand RE, Sturgis C, Hensing T, Ray D, Bogojevic A, Mohammed J, Chang JS, Backman V. Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy. Cancer Res. 2009 Jul 1; 69(13):5357-63. PMID: 19549915.
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  67. Huo D, Hetzel JT, Roy H, Rubin DT. Association of colorectal cancer and prostate cancer and impact of radiation therapy. Cancer Epidemiol Biomarkers Prev. 2009 Jul; 18(7):1979-85. PMID: 19531678.
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  68. Roy HK, Turzhitsky V, Kim Y, Goldberg MJ, Watson P, Rogers JD, Gomes AJ, Kromine A, Brand RE, Jameel M, Bogovejic A, Pradhan P, Backman V. Association between rectal optical signatures and colonic neoplasia: potential applications for screening. Cancer Res. 2009 May 15; 69(10):4476-83. PMID: 19417131.
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  69. Gomes AJ, Roy HK, Turzhitsky V, Kim Y, Rogers JD, Ruderman S, Stoyneva V, Goldberg MJ, Bianchi LK, Yen E, Kromine A, Jameel M, Backman V. Rectal mucosal microvascular blood supply increase is associated with colonic neoplasia. Clin Cancer Res. 2009 May 1; 15(9):3110-7. PMID: 19383816.
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  70. Subramanian H, Pradhan P, Liu Y, Capoglu IR, Rogers JD, Roy HK, Brand RE, Backman V. Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: an application to cancer diagnosis. Opt Lett. 2009 Feb 15; 34(4):518-20. PMID: 19373360.
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  71. Backman V, Subramanian H, Pradhan P, Liu Y, Capoglu I, Rogers JD, Roy HK, Taflove A. Detecting alterations in cell ultrastructure with optical imaging. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6325-6. PMID: 19964153.
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  72. Walker SL, Nicholls PG, Butlin CR, Nery JA, Roy HK, Rangel E, Sales AM, Lockwood DN. Development and validation of a severity scale for leprosy type 1 reactions. PLoS Negl Trop Dis. 2008; 2(12):e351. PMID: 19104651.
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  73. Subramanian H, Pradhan P, Liu Y, Capoglu IR, Li X, Rogers JD, Heifetz A, Kunte D, Roy HK, Taflove A, Backman V. Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20118-23. PMID: 19073935.
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  74. Senapati S, Sharma P, Bafna S, Roy HK, Batra SK. The MUC gene family: their role in the diagnosis and prognosis of gastric cancer. Histol Histopathol. 2008 Dec; 23(12):1541-52. PMID: 18830939.
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  75. Turzhitsky VM, Gomes AJ, Kim YL, Liu Y, Kromine A, Rogers JD, Jameel M, Roy HK, Backman V. Measuring mucosal blood supply in vivo with a polarization-gating probe. Appl Opt. 2008 Nov 10; 47(32):6046-57. PMID: 19002229.
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  76. Roy HK, Bianchi LK. Colorectal cancer risk: black, white, or shades of gray? JAMA. 2008 Sep 24; 300(12):1459-61. PMID: 18812539.
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  77. Senapati S, Chaturvedi P, Sharma P, Venkatraman G, Meza JL, El-Rifai W, Roy HK, Batra SK. Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer. Br J Cancer. 2008 Sep 16; 99(6):949-56. PMID: 18781152.
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  78. Wali RK, Kunte DP, Koetsier JL, Bissonnette M, Roy HK. Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail. Mol Cancer Ther. 2008 Sep; 7(9):3103-11. PMID: 18790788.
    View in: PubMed
  79. Kunte DP, Wali RK, Koetsier JL, Roy HK. Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase. Mol Cancer Ther. 2008 Jul; 7(7):1797-806. PMID: 18644992.
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  80. Roy HK, Gomes A, Turzhitsky V, Goldberg MJ, Rogers J, Ruderman S, Young KL, Kromine A, Brand RE, Jameel M, Vakil P, Hasabou N, Backman V. Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk. Gastroenterology. 2008 Oct; 135(4):1069-78. PMID: 18722372.
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  81. Roy HK, Turzhitsky V, Kim YL, Goldberg MJ, Muldoon JP, Liu Y, Brand RE, Hall C, Hasabou N, Jameel M, Backman V. Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study. Dis Colon Rectum. 2008 Sep; 51(9):1381-6. PMID: 18536963.
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  82. Roy HK, Bianchi LK. Purging the colon while preserving the kidneys. Arch Intern Med. 2008 Mar 24; 168(6):565-7. PMID: 18362246.
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  83. Backman V, Roy HK. Optical spectroscopic markers of cancer. Dis Markers. 2008; 25(6):279. PMID: 19208945.
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  84. Turzhitsky V, Liu Y, Hasabou N, Goldberg M, Roy HK, Backman V, Brand R. Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa. Dis Markers. 2008; 25(6):313-21. PMID: 19208949.
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  85. Roy HK, Khandekar JD. Biomarkers for the early detection of cancer: an inflammatory concept. Arch Intern Med. 2007 Sep 24; 167(17):1822-4. PMID: 17893302.
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  86. Liu Y, Brand RE, Turzhitsky V, Kim YL, Roy HK, Hasabou N, Sturgis C, Shah D, Hall C, Backman V. Optical markers in duodenal mucosa predict the presence of pancreatic cancer. Clin Cancer Res. 2007 Aug 1; 13(15 Pt 1):4392-9. PMID: 17671121.
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  87. Roy HK, Wali RK, Kim Y, Liu Y, Hart J, Kunte DP, Koetsier JL, Goldberg MJ, Backman V. Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett. 2007 Aug 7; 581(20):3857-62. PMID: 17658518.
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  88. Backman V, Kim Y, Liu Y, Turzhitsky V, Subramanian H, Pradhan P, Roy H, Goldberg M. Low-coherence enhanced backscattering and its applications. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:521-3. PMID: 18002007.
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  89. Kelloff GJ, Sullivan DC, Baker H, Clarke LP, Nordstrom R, Tatum JL, Dorfman GS, Jacobs P, Berg CD, Pomper MG, Birrer MJ, Tempero M, Higley HR, Petty BG, Sigman CC, Maley C, Sharma P, Wax A, Ginsberg GG, Dannenberg AJ, Hawk ET, Messing EM, Grossman HB, Harisinghani M, Bigio IJ, Griebel D, Henson DE, Fabian CJ, Ferrara K, Fantini S, Schnall MD, Zujewski JA, Hayes W, Klein EA, DeMarzo A, Ocak I, Ketterling JA, Tempany C, Shtern F, Parnes HL, Gomez J, Srivastava S, Szabo E, Lam S, Seibel EJ, Massion P, McLennan G, Cleary K, Suh R, Burt RW, Pfeiffer RM, Hoffman JM, Roy HK, Wang T, Limburg PJ, El-Deiry WS, Papadimitrakopoulou V, Hittelman WN, MacAulay C, Veltri RW, Solomon D, Jeronimo J, Richards-Kortum R, Johnson KA, Viner JL, Stratton SP, Rajadhyaksha M, Dhawan A. Workshop on imaging science development for cancer prevention and preemption. Cancer Biomark. 2007; 3(1):1-33. PMID: 17655039.
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  90. Roy HK, Backman V, Goldberg MJ. Colon cancer screening: the good, the bad, and the ugly. Arch Intern Med. 2006 Nov 13; 166(20):2177-9. PMID: 17101934.
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  91. Roy HK, Kunte DP, Koetsier JL, Hart J, Kim YL, Liu Y, Bissonnette M, Goldberg M, Backman V, Wali RK. Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling. Mol Cancer Ther. 2006 Aug; 5(8):2060-9. PMID: 16928827.
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  92. Brand RM, Jones DD, Lynch HT, Brand RE, Watson P, Ashwathnayaran R, Roy HK. Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. World J Gastroenterol. 2006 Jul 28; 12(28):4485-91. PMID: 16874859.
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  93. Allison M, Garland C, Chlebowski R, Criqui M, Langer R, Wu L, Roy H, McTiernan A, Kuller L. The association between aspirin use and the incidence of colorectal cancer in women. Am J Epidemiol. 2006 Sep 15; 164(6):567-75. PMID: 16847042.
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  94. Kim YL, Turzhitsky VM, Liu Y, Roy HK, Wali RK, Subramanian H, Pradhan P, Backman V. Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening. J Biomed Opt. 2006 Jul-Aug; 11(4):041125. PMID: 16965153.
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  95. Zisman AL, Nickolov A, Brand RE, Gorchow A, Roy HK. Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening. Arch Intern Med. 2006 Mar 27; 166(6):629-34. PMID: 16567601.
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  96. Roy HK, Kim YL, Liu Y, Wali RK, Goldberg MJ, Turzhitsky V, Horwitz J, Backman V. Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa. Clin Cancer Res. 2006 Feb 1; 12(3 Pt 1):961-8. PMID: 16467111.
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  97. Siegel MP, Kim YL, Roy HK, Wali RK, Backman V. Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy. Appl Opt. 2006 Jan 10; 45(2):335-42. PMID: 16422163.
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  98. Au A, Li B, Wang W, Roy H, Koehler K, Birt D. Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models. Nutr Cancer. 2006; 54(2):243-51. PMID: 16898869.
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  99. Rubinstein WS, Roy HK. Practicing medicine at the front lines of the genomic revolution. Arch Intern Med. 2005 Sep 12; 165(16):1815-7. PMID: 16157823.
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  100. Kunte DP, Wali RK, Koetsier JL, Hart J, Kostjukova MN, Kilimnik AY, Pyatkin IG, Strelnikova SR, Roy HK. Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. FEBS Lett. 2005 Jul 4; 579(17):3497-502. PMID: 15961079.
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  101. Roy HK, Kim YL, Wali RK, Liu Y, Koetsier J, Kunte DP, Goldberg MJ, Backman V. Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse. Cancer Epidemiol Biomarkers Prev. 2005 Jul; 14(7):1639-45. PMID: 16030095.
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  102. Wali RK, Roy HK, Kim YL, Liu Y, Koetsier JL, Kunte DP, Goldberg MJ, Turzhitsky V, Backman V. Increased microvascular blood content is an early event in colon carcinogenesis. Gut. 2005 May; 54(5):654-60. PMID: 15831911.
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  103. Kim YL, Liu Y, Turzhitsky VM, Wali RK, Roy HK, Backman V. Depth-resolved low-coherence enhanced backscattering. Opt Lett. 2005 Apr 1; 30(7):741-3. PMID: 15832924.
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  104. Kim YL, Liu Y, Wali RK, Roy HK, Backman V. Low-coherent backscattering spectroscopy for tissue characterization. Appl Opt. 2005 Jan 20; 44(3):366-77. PMID: 15717826.
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  105. Roy HK, Karolski WJ, Wali RK, Ratashak A, Hart J, Smyrk TC. The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis. Cancer Lett. 2005 Jan 20; 217(2):161-9. PMID: 15617833.
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  106. Roy HK, Smyrk TC, Koetsier J, Victor TA, Wali RK. The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig Dis Sci. 2005 Jan; 50(1):42-6. PMID: 15712635.
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  107. Watson P, Ashwathnarayan R, Lynch HT, Roy HK. Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome). Arch Intern Med. 2004 Dec 13-27; 164(22):2429-31. PMID: 15596632.
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  108. Roy HK, Gulizia J, DiBaise JK, Karolski WJ, Ansari S, Madugula M, Hart J, Bissonnette M, Wali RK. Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) mice. Cancer Lett. 2004 Nov 8; 215(1):35-42. PMID: 15374630.
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  109. Roy HK, Iversen P, Hart J, Liu Y, Koetsier JL, Kim Y, Kunte DP, Madugula M, Backman V, Wali RK. Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther. 2004 Sep; 3(9):1159-65. PMID: 15367710.
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  110. Kim YL, Liu Y, Turzhitsky VM, Roy HK, Wali RK, Backman V. Coherent backscattering spectroscopy. Opt Lett. 2004 Aug 15; 29(16):1906-8. PMID: 15357355.
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  111. Roy HK, Liu Y, Wali RK, Kim YL, Kromine AK, Goldberg MJ, Backman V. Four-dimensional elastic light-scattering fingerprints as preneoplastic markers in the rat model of colon carcinogenesis. Gastroenterology. 2004 Apr; 126(4):1071-81; discussion 948. PMID: 15057746.
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  112. Roy HK, Lynch HT. Diagnosing Lynch syndrome: is the answer in the mouth? Gut. 2003 Dec; 52(12):1665-7. PMID: 14633939.
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  113. Sanjeevi A, Roy HK. Necrobiotic nodules: a rare pulmonary manifestion of Crohn's disease. Am J Gastroenterol. 2003 Apr; 98(4):941-3. PMID: 12738489.
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  114. Ozden N, Saruc M, Smith LM, Sanjeevi A, Roy HK. Increased cumulative incidence of prostate malignancies in colorectal cancer patients. Int J Gastrointest Cancer. 2003; 34(1):49-54. PMID: 15235135.
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  115. Roy HK, Gulizia JM, Karolski WJ, Ratashak A, Sorrell MF, Tuma D. Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia. Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1499-502. PMID: 12433735.
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  116. Roy HK, Olusola BF, Clemens DL, Karolski WJ, Ratashak A, Lynch HT, Smyrk TC. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis. 2002 Jan; 23(1):201-5. PMID: 11756242.
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  117. Zack DL, DiBaise JK, Quigley EM, Roy HK. Colorectal cancer screening compliance by medicine residents: perceived and actual. Am J Gastroenterol. 2001 Oct; 96(10):3004-8. PMID: 11693339.
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  118. Roy HK, Karoski WJ, Ratashak A, Smyrk TC. Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. Br J Cancer. 2001 May 18; 84(10):1412-6. PMID: 11355956.
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  119. Roy HK, Karolski WJ, Ratashak A. Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone. Int J Cancer. 2001 May 15; 92(4):609-15. PMID: 11304699.
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  120. Roy HK, DiBaise JK, Black J, Karolski WJ, Ratashak A, Ansari S. Polyethylene glycol induces apoptosis in HT-29 cells: potential mechanism for chemoprevention of colon cancer. FEBS Lett. 2001 May 11; 496(2-3):143-6. PMID: 11356199.
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  121. Smith SR, de Jonge L, Zachwieja JJ, Roy H, Nguyen T, Rood J, Windhauser M, Volaufova J, Bray GA. Concurrent physical activity increases fat oxidation during the shift to a high-fat diet. Am J Clin Nutr. 2000 Jul; 72(1):131-8. PMID: 10871571.
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  122. Smith SR, de Jonge L, Zachwieja JJ, Roy H, Nguyen T, Rood JC, Windhauser MM, Bray GA. Fat and carbohydrate balances during adaptation to a high-fat. Am J Clin Nutr. 2000 Feb; 71(2):450-7. PMID: 10648257.
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  123. Roy HK. Colon cancer after gynecological cancer: guilt by association? Am J Gastroenterol. 1999 Dec; 94(12):3405. PMID: 10606294.
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  124. Khare S, Bolt MJ, Wali RK, Skarosi SF, Roy HK, Niedziela S, Scaglione-Sewell B, Aquino B, Abraham C, Sitrin MD, Brasitus TA, Bissonnette M. 1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation. J Clin Invest. 1997 Apr 15; 99(8):1831-41. PMID: 9109427.
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  125. Wali RK, Frawley BP, Hartmann S, Roy HK, Khare S, Scaglione-Sewell BA, Earnest DL, Sitrin MD, Brasitus TA, Bissonnette M. Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta. Cancer Res. 1995 Nov 15; 55(22):5257-64. PMID: 7585585.
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  126. Roy HK, Bissonnette M, Frawley BP, Wali RK, Niedziela SM, Earnest D, Brasitus TA. Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam. FEBS Lett. 1995 Jun 12; 366(2-3):143-5. PMID: 7789532.
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  127. Bissonnette M, Wali RK, Hartmann SC, Niedziela SM, Roy HK, Tien XY, Sitrin MD, Brasitus TA. 1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes. J Clin Invest. 1995 May; 95(5):2215-21. PMID: 7738187.
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  128. Wali RK, Bissonnette M, Jiang K, Niedziela SM, Khare S, Roy HK, Sitrin MD, Brasitus TA. 1,25-Dihydroxyvitamin D3 stimulates the phosphorylation of two acidic membrane proteins of 42,000 and 48,000 daltons in rat colonocytes: an effect modulated by vitamin D status. J Cell Physiol. 1995 Feb; 162(2):172-80. PMID: 7822428.
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  129. Earnest DL, Holubec H, Wali RK, Jolley CS, Bissonette M, Bhattacharyya AK, Roy H, Khare S, Brasitus TA. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res. 1994 Oct 1; 54(19):5071-4. PMID: 7923119.
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  130. Bissonnette M, Tien XY, Niedziela SM, Hartmann SC, Frawley BP, Roy HK, Sitrin MD, Perlman RL, Brasitus TA. 1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i. Am J Physiol. 1994 Sep; 267(3 Pt 1):G465-75. PMID: 7943245.
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  131. Roy H. Cigarette smoking and risk of cataracts. JAMA. 1993 Feb 10; 269(6):748. PMID: 8423655.
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