Keywords
Last Name

Jingyan Han, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentVascular Biology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7116
 Awards and Honors

Start-EndDescription
2014-2018AHA: Role of glutaredoxin-1 in endothelial barrier dysfunction and atherosclerosis
2015-2016CTSI, Boston Univeristy: Protein S-glutathionylation: the potential therapeutic target for cardiovascular disease
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YM, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319. PMID: 27693992.
    View in: PubMed
  2. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64. PMID: 26927696.
    View in: PubMed
  3. Luo T, Nocon A, Fry J, Sherban A, Rui X, Jiang B, Xu XJ, Han J, Yan Y, Yang Q, Li Q, Zang M. AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity. Diabetes. 2016 Aug; 65(8):2295-310. PMID: 27207538.
    View in: PubMed
  4. Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M, Eckmann DM, Davies PF, Muzykantov VR. Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS Nano. 2015 Jul 28; 9(7):6785-93. PMID: 26153796.
    View in: PubMed
  5. Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Control Release. 2015 Jul 28; 210:39-47. PMID: 25966362.
    View in: PubMed
  6. Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization. J Biol Chem. 2014 Mar 21; 289(12):8633-44. PMID: 24482236.
    View in: PubMed
  7. Shao D, Fry JL, Han J, Hou X, Pimentel DR, Matsui R, Cohen RA, Bachschmid MM. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem. 2014 Mar 14; 289(11):7293-306. PMID: 24451382.
    View in: PubMed
  8. Greineder CF, Chacko AM, Zaytsev S, Zern BJ, Carnemolla R, Hood ED, Han J, Ding BS, Esmon CT, Muzykantov VR. Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. PLoS One. 2013; 8(11):e80110. PMID: 24244621.
    View in: PubMed
  9. Shuvaev VV, Han J, Tliba S, Arguiri E, Christofidou-Solomidou M, Ramirez SH, Dykstra H, Persidsky Y, Atochin DN, Huang PL, Muzykantov VR. Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo. PLoS One. 2013; 8(10):e77002. PMID: 24146950.
    View in: PubMed
  10. Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood. 2013 Dec 12; 122(25):4140-9. PMID: 24108461.
    View in: PubMed
  11. Han J, Zern BJ, Shuvaev VV, Davies PF, Muro S, Muzykantov V. Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1. ACS Nano. 2012 Oct 23; 6(10):8824-36. PMID: 22957767.
    View in: PubMed
  12. Hood ED, Greineder CF, Dodia C, Han J, Mesaros C, Shuvaev VV, Blair IA, Fisher AB, Muzykantov VR. Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo. J Control Release. 2012 Oct 28; 163(2):161-9. PMID: 22974832.
    View in: PubMed
  13. Han J, Shuvaev VV, Muzykantov VR. Targeted interception of signaling reactive oxygen species in the vascular endothelium. Ther Deliv. 2012 Feb; 3(2):263-76. PMID: 22834201.
    View in: PubMed
  14. Profirovic J, Han J, Andreeva AV, Neamu RF, Pavlovic S, Vogel SM, Walter U, Voyno-Yasenetskaya TA. Vasodilator-stimulated phosphoprotein deficiency potentiates PAR-1-induced increase in endothelial permeability in mouse lungs. J Cell Physiol. 2011 May; 226(5):1255-64. PMID: 20945373.
    View in: PubMed
  15. Han J, Shuvaev VV, Muzykantov VR. Catalase and superoxide dismutase conjugated with platelet-endothelial cell adhesion molecule antibody distinctly alleviate abnormal endothelial permeability caused by exogenous reactive oxygen species and vascular endothelial growth factor. J Pharmacol Exp Ther. 2011 Jul; 338(1):82-91. PMID: 21474567.
    View in: PubMed
  16. Shuvaev VV, Han J, Yu KJ, Huang S, Hawkins BJ, Madesh M, Nakada M, Muzykantov VR. PECAM-targeted delivery of SOD inhibits endothelial inflammatory response. FASEB J. 2011 Jan; 25(1):348-57. PMID: 20876216.
    View in: PubMed
  17. Feng H, Guo L, Song Z, Gao H, Wang D, Fu W, Han J, Li Z, Huang B, Li XA. Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis. J Biol Chem. 2010 Aug 13; 285(33):25154-60. PMID: 20534584.
    View in: PubMed
  18. Andreeva AV, Han J, Kutuzov MA, Profirovic J, Tkachuk VA, Voyno-Yasenetskaya TA. T-cadherin modulates endothelial barrier function. J Cell Physiol. 2010 Apr; 223(1):94-102. PMID: 20039275.
    View in: PubMed
  19. Han J, Liu G, Profirovic J, Niu J, Voyno-Yasenetskaya T. Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor. FASEB J. 2009 Dec; 23(12):4193-206. PMID: 19690217.
    View in: PubMed
  20. Gorovoy M, Han J, Pan H, Welch E, Neamu R, Jia Z, Predescu D, Vogel S, Minshall RD, Ye RD, Malik AB, Voyno-Yasenetskaya T. LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs. Circ Res. 2009 Sep 11; 105(6):549-56. PMID: 19679840.
    View in: PubMed
  21. Zhang G, Han J, Welch EJ, Ye RD, Voyno-Yasenetskaya TA, Malik AB, Du X, Li Z. Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol. 2009 Jun 15; 182(12):7997-8004. PMID: 19494325.
    View in: PubMed
  22. Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA. Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis. Angiogenesis. 2009; 12(1):1-15. PMID: 19093215.
    View in: PubMed
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