Reiko Matsui, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine (Vascular Biology Unit) Section

MD, Kanazawa University



Oxidants mediate cellular redox signaling through post-translational modification of protein thiols. My group studies the role of an enzyme glutaredoxin which controls S-glutathionylation (glutathione adducts) in cardiovascular disease, inflammation, and glucose metabolism.

Recently I focus on angiogenesis and hypoxia-induced factor (HIF-1) regulation by glutaredoxin using mouse models. My goal is to develop our study into therapeutic strategy for clinical problems including diabetic ischemic limbs.

Boston Medical Center




Regulation of Hypoxia-incucable factor-1 and angiogenesis by glutaredoxin-1
08/01/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R03AG051857-02

Hindlimb Ischemia Model
02/02/2017 - 02/02/2018 (PI)
VL39, Inc.

Regulation of ischemic limb vascularization by glutaredoxin-1
07/01/2016 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL133013-01


Protein Modification By Nitrat
07/01/2001 - 06/30/2002 (PI)
NIH
1RO3 AG19078-01 (A)


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kracun D, Krause KH, Kren V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milkovic L, Miranda-Vizuete A, Mojovic M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavicevic A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanic V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçin AS, Yelisyeyeva O, Žarkovic N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 2017 May 18; 13:94-162.View Related Profiles. PMID: 28577489.
  2. Matsui R, Watanabe Y, Murdoch CE. Redox regulation of ischemic limb neovascularization - What we have learned from animal studies. Redox Biol. 2017 Aug; 12:1011-1019. PMID: 28505880.
  3. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Feb 16.View Related Profiles. PMID: 27958883; DOI: 10.1089/ars.2016.6716;.
  4. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YM, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles. PMID: 27693992; DOI: 10.1016/j.redox.2016.09.003;.
  5. Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ. Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson''s Disease. Antioxid Redox Signal. 2016 Dec 20; 25(18):967-982.View Related Profiles. PMID: 27224303.
  6. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;.
  7. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1a and improve limb revascularization. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6011-6.View Related Profiles. PMID: 27162359; PMCID: PMC4889374; DOI: 10.1073/pnas.1524198113;.
  8. Watanabe Y, Cohen RA, Matsui R. Redox Regulation of Ischemic Angiogenesis - Another Aspect of Reactive Oxygen Species. Circ J. 2016 May 25; 80(6):1278-84.View Related Profiles. PMID: 27151566; DOI: 10.1253/circj.CJ-16-0317;.
  9. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025.View Related Profiles. PMID: 26642319; PMCID: PMC4671598; DOI: 10.1371/journal.pone.0144025;.
  10. Murdoch CE, Bachschmid MM, Matsui R. Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway. Biochem Soc Trans. 2014 Dec; 42(6):1665-70.View Related Profiles. PMID: 25399587; DOI: 10.1042/BST20140213;.
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 14 distinct years, with a maximum of 5 publications in 2016

YearPublications
19921
19941
19991
20011
20021
20031
20051
20061
20101
20122
20143
20151
20165
20173
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

angiogenesis
G6PD
glutaredoxin
redox signaling
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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