Reiko Matsui, MD
|Institution||Boston University School of Medicine|
|Division||Cardiovascular Medicine (Vascular Biology Unit)|
|Address||650 Albany St Evans Biomed Research Ctr|
Boston MA 02118
|Institution||Boston Medical Center|
Oxidants mediate cellular redox signaling through post-translational modification of protein thiols. My group studies the role of an enzyme glutaredoxin which controls S-glutathionylation (glutathione adducts) in cardiovascular disease, inflammation, and glucose metabolism.
Recently I focus on angiogenesis and hypoxia-induced factor (HIF-1) regulation by glutaredoxin using mouse models. My goal is to develop our study into therapeutic strategy for clinical problems including diabetic ischemic limbs.
- redox signaling
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