Keywords
Last Name

Reiko Matsui, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine (Vascular Biology Unit)
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7134
ORCID ORCID Icon0000-0002-8132-2823
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Oxidants mediate cellular redox signaling through post-translational modification of protein thiols. My group studies the role of an enzyme glutaredoxin which controls S-glutathionylation (glutathione adducts) in cardiovascular disease, inflammation, and glucose metabolism.

Recently I focus on angiogenesis and hypoxia-induced factor (HIF-1) regulation by glutaredoxin using mouse models. My goal is to develop our study into therapeutic strategy for clinical problems including diabetic ischemic limbs.

 Self-Described Keywords
  • G6PD
  • glutaredoxin
  • angiogenesis
  • redox signaling
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Shao D, Han J, Hou X, Fry JL, Behring JB, Seta F, Long M, Roy H, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 deficiency causes fatty liver and dyslipidemia by inhibiting sirtuin-1. Antioxid Redox Signal. 2016 Dec 13. PMID: 27958883.
    View in: PubMed
  2. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YM, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319. PMID: 27693992.
    View in: PubMed
  3. Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ. Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. Antioxid Redox Signal. 2016 Dec 20; 25(18):967-982. PMID: 27224303.
    View in: PubMed
  4. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64. PMID: 26927696.
    View in: PubMed
  5. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1a and improve limb revascularization. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6011-6. PMID: 27162359.
    View in: PubMed
  6. Watanabe Y, Cohen RA, Matsui R. Redox Regulation of Ischemic Angiogenesis - Another Aspect of Reactive Oxygen Species. Circ J. 2016 May 25; 80(6):1278-84. PMID: 27151566.
    View in: PubMed
  7. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025. PMID: 26642319.
    View in: PubMed
  8. Murdoch CE, Bachschmid MM, Matsui R. Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway. Biochem Soc Trans. 2014 Dec; 42(6):1665-70. PMID: 25399587.
    View in: PubMed
  9. Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization. J Biol Chem. 2014 Mar 21; 289(12):8633-44. PMID: 24482236.
    View in: PubMed
  10. Shao D, Fry JL, Han J, Hou X, Pimentel DR, Matsui R, Cohen RA, Bachschmid MM. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem. 2014 Mar 14; 289(11):7293-306. PMID: 24451382.
    View in: PubMed
  11. Pimentel D, Haeussler DJ, Matsui R, Burgoyne JR, Cohen RA, Bachschmid MM. Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal. 2012 Mar 15; 16(6):524-42. PMID: 22010840.
    View in: PubMed
  12. Bachschmid MM, Schildknecht S, Matsui R, Zee R, Haeussler D, Cohen RA, Pimental D, Loo Bv. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med. 2013 Feb; 45(1):17-36. PMID: 22380696.
    View in: PubMed
  13. Bachschmid MM, Xu S, Maitland-Toolan KA, Ho YS, Cohen RA, Matsui R. Attenuated cardiovascular hypertrophy and oxidant generation in response to angiotensin II infusion in glutaredoxin-1 knockout mice. Free Radic Biol Med. 2010 Oct 15; 49(7):1221-9. PMID: 20638471.
    View in: PubMed
  14. Matsui R, Xu S, Maitland KA, Mastroianni R, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):910-6. PMID: 16439706.
    View in: PubMed
  15. Matsui R, Xu S, Maitland KA, Hayes A, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005 Jul 12; 112(2):257-63. PMID: 15998684.
    View in: PubMed
  16. Guo W, Adachi T, Matsui R, Xu S, Jiang B, Zou MH, Kirber M, Lieberthal W, Cohen RA. Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney. Am J Physiol Heart Circ Physiol. 2003 Oct; 285(4):H1396-403. PMID: 12791589.
    View in: PubMed
  17. Adachi T, Matsui R, Xu S, Kirber M, Lazar HL, Sharov VS, Schöneich C, Cohen RA. Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation. Circ Res. 2002 May 31; 90(10):1114-21. PMID: 12039802.
    View in: PubMed
  18. Adachi T, Matsui R, Weisbrod RM, Najibi S, Cohen RA. Reduced sarco/endoplasmic reticulum Ca(2+) uptake activity can account for the reduced response to NO, but not sodium nitroprusside, in hypercholesterolemic rabbit aorta. Circulation. 2001 Aug 28; 104(9):1040-5. PMID: 11524399.
    View in: PubMed
  19. Matsui R, Brody JS, Yu Q. FGF-2 induces surfactant protein gene expression in foetal rat lung epithelial cells through a MAPK-independent pathway. Cell Signal. 1999 Mar; 11(3):221-8. PMID: 10353697.
    View in: PubMed
  20. Matsui R, Goldstein RH, Mihal K, Brody JS, Steele MP, Fine A. Type I collagen formation in rat type II alveolar cells immortalised by viral gene products. Thorax. 1994 Mar; 49(3):201-6. PMID: 8202874.
    View in: PubMed
  21. Fine A, Matsui R, Zhan X, Poliks CF, Smith BD, Goldstein RH. Discordant regulation of human type I collagen genes by prostaglandin E2. Biochim Biophys Acta. 1992 Apr 30; 1135(1):67-72. PMID: 1375511.
    View in: PubMed
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