Keywords
Last Name

Markus Bachschmid, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionVascular Biology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-2797
ORCID ORCID Icon0000-0002-0748-5528
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Biochemistry, Pharmacology and Toxicology.

Redox regulation of metabolism by Sirtuin-1 and glutaredoxin-1 in the cardiovascular system and liver.

 Self-Described Keywords
  • cardiovascular
  • imaging
  • mitochondria
  • oxidative stress
  • proteomics
  • metabolism
  • sirtuin-1
  • glutaredoxin-1
  • HRas
  • diabetes
  • non-alcoholic fatty liver disease
  • obesity
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nat Med. 2017 Mar; 23(3):361-367. PMID: 28191886.
    View in: PubMed
  2. Kumar S, Kim YR, Vikram A, Naqvi A, Li Q, Kassan M, Kumar V, Bachschmid MM, Jacobs JS, Kumar A, Irani K. Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):1714-1719. PMID: 28137876.
    View in: PubMed
  3. Shao D, Han J, Hou X, Fry JL, Behring JB, Seta F, Long M, Roy H, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 deficiency causes fatty liver and dyslipidemia by inhibiting sirtuin-1. Antioxid Redox Signal. 2016 Dec 13. PMID: 27958883.
    View in: PubMed
  4. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YM, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319. PMID: 27693992.
    View in: PubMed
  5. Fry JL, Al Sayah L, Weisbrod RM, Van Roy I, Weng X, Cohen RA, Bachschmid MM, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness. Hypertension. 2016 Sep; 68(3):775-84. PMID: 27432859.
    View in: PubMed
  6. Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ. Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. Antioxid Redox Signal. 2016 Dec 20; 25(18):967-982. PMID: 27224303.
    View in: PubMed
  7. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64. PMID: 26927696.
    View in: PubMed
  8. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1a and improve limb revascularization. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6011-6. PMID: 27162359.
    View in: PubMed
  9. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1). PMID: 26755553.
    View in: PubMed
  10. Ji Y, Bachschmid MM, Costello CE, Lin C. S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom. 2016 Apr; 27(4):677-85. PMID: 26729453.
    View in: PubMed
  11. Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015 Dec 31; 5(1). PMID: 26722122.
    View in: PubMed
  12. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025. PMID: 26642319.
    View in: PubMed
  13. Peskin AV, Pace PE, Behring JB, Paton LN, Soethoudt M, Bachschmid MM, Winterbourn CC. Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin. J Biol Chem. 2016 Feb 5; 291(6):3053-62. PMID: 26601956.
    View in: PubMed
  14. Fry JL, Shiraishi Y, Turcotte R, Yu X, Gao YZ, Akiki R, Bachschmid M, Zhang Y, Morgan KG, Cohen RA, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc. 2015 Sep; 4(9):e002384. PMID: 26376991.
    View in: PubMed
  15. Ji Y, Liu M, Bachschmid MM, Costello CE, Lin C. Surfactant-Induced Artifacts during Proteomic Sample Preparation. Anal Chem. 2015 Jun 2; 87(11):5500-4. PMID: 25945600.
    View in: PubMed
  16. Murdoch CE, Bachschmid MM, Matsui R. Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway. Biochem Soc Trans. 2014 Dec; 42(6):1665-70. PMID: 25399587.
    View in: PubMed
  17. Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol. 2015 Jan; 78:165-73. PMID: 25109264.
    View in: PubMed
  18. Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization. J Biol Chem. 2014 Mar 21; 289(12):8633-44. PMID: 24482236.
    View in: PubMed
  19. Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87. PMID: 24469991.
    View in: PubMed
  20. Shao D, Fry JL, Han J, Hou X, Pimentel DR, Matsui R, Cohen RA, Bachschmid MM. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem. 2014 Mar 14; 289(11):7293-306. PMID: 24451382.
    View in: PubMed
  21. Ji Y, Leymarie N, Haeussler DJ, Bachschmid MM, Costello CE, Lin C. Direct detection of S-palmitoylation by mass spectrometry. Anal Chem. 2013 Dec 17; 85(24):11952-9. PMID: 24279456.
    View in: PubMed
  22. Oelze M, Kröller-Schön S, Steven S, Lubos E, Doppler C, Hausding M, Tobias S, Brochhausen C, Li H, Torzewski M, Wenzel P, Bachschmid M, Lackner KJ, Schulz E, Münzel T, Daiber A. Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging. Hypertension. 2014 Feb; 63(2):390-6. PMID: 24296279.
    View in: PubMed
  23. Daiber A, Daub S, Bachschmid M, Schildknecht S, Oelze M, Steven S, Schmidt P, Megner A, Wada M, Tanabe T, Münzel T, Bottari S, Ullrich V. Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications. Int J Mol Sci. 2013; 14(4):7542-70. PMID: 23567270.
    View in: PubMed
  24. Haeussler DJ, Pimentel DR, Hou X, Burgoyne JR, Cohen RA, Bachschmid MM. Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration. J Biol Chem. 2013 May 24; 288(21):15380-9. PMID: 23548900.
    View in: PubMed
  25. Kumar V, Calamaras TD, Haeussler D, Colucci WS, Cohen RA, McComb ME, Pimentel D, Bachschmid MM. Cardiovascular redox and ox stress proteomics. Antioxid Redox Signal. 2012 Dec 1; 17(11):1528-59. PMID: 22607061.
    View in: PubMed
  26. Schildknecht S, Karreman C, Daiber A, Zhao C, Hamacher J, Perlman D, Jung B, van der Loo B, O'Connor P, Leist M, Ullrich V, Bachschmid MM. Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages. Antioxid Redox Signal. 2012 Nov 15; 17(10):1393-406. PMID: 22578329.
    View in: PubMed
  27. Pimentel D, Haeussler DJ, Matsui R, Burgoyne JR, Cohen RA, Bachschmid MM. Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal. 2012 Mar 15; 16(6):524-42. PMID: 22010840.
    View in: PubMed
  28. Bachschmid MM, Schildknecht S, Matsui R, Zee R, Haeussler D, Cohen RA, Pimental D, Loo Bv. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med. 2013 Feb; 45(1):17-36. PMID: 22380696.
    View in: PubMed
  29. Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2012 Feb; 26(2):832-41. PMID: 22085642.
    View in: PubMed
  30. Xu S, Jiang B, Hou X, Shi C, Bachschmid MM, Zang M, Verbeuren TJ, Cohen RA. High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol. 2011 Sep; 58(3):263-71. PMID: 21654327.
    View in: PubMed
  31. Haeussler DJ, Evangelista AM, Burgoyne JR, Cohen RA, Bachschmid MM, Pimental DR. Checkpoints in adenoviral production: cross-contamination and E1A. PLoS One. 2011; 6(8):e23160. PMID: 21826235.
    View in: PubMed
  32. Lugus JJ, Ngoh GA, Bachschmid MM, Walsh K. Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells. J Mol Cell Cardiol. 2011 Dec; 51(6):885-93. PMID: 21839087.
    View in: PubMed
  33. Zee RS, Yoo CB, Pimentel DR, Perlman DH, Burgoyne JR, Hou X, McComb ME, Costello CE, Cohen RA, Bachschmid MM. Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal. 2010 Oct 1; 13(7):1023-32. PMID: 20392170.
    View in: PubMed
  34. Bachschmid MM, Xu S, Maitland-Toolan KA, Ho YS, Cohen RA, Matsui R. Attenuated cardiovascular hypertrophy and oxidant generation in response to angiotensin II infusion in glutaredoxin-1 knockout mice. Free Radic Biol Med. 2010 Oct 15; 49(7):1221-9. PMID: 20638471.
    View in: PubMed
  35. Daiber A, Schildknecht S, Müller J, Kamuf J, Bachschmid MM, Ullrich V. Chemical model systems for cellular nitros(yl)ation reactions. Free Radic Biol Med. 2009 Aug 15; 47(4):458-67. PMID: 19477267.
    View in: PubMed
  36. Kienhöfer J, Häussler DJ, Ruckelshausen F, Muessig E, Weber K, Pimentel D, Ullrich V, Bürkle A, Bachschmid MM. Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents. FASEB J. 2009 Jul; 23(7):2034-44. PMID: 19228881.
    View in: PubMed
  37. van der Loo B, Schildknecht S, Zee R, Bachschmid MM. Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans. Exp Physiol. 2009 Mar; 94(3):305-10. PMID: 18996949.
    View in: PubMed
  38. Osto E, Matter CM, Kouroedov A, Malinski T, Bachschmid M, Camici GG, Kilic U, Stallmach T, Boren J, Iliceto S, Lüscher TF, Cosentino F. c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress. Circulation. 2008 Nov 11; 118(20):2073-80. PMID: 18955669.
    View in: PubMed
  39. Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol. 2008 Oct; 10(10):1208-16. PMID: 18806787.
    View in: PubMed
  40. Wenzel P, Schuhmacher S, Kienhöfer J, Müller J, Hortmann M, Oelze M, Schulz E, Treiber N, Kawamoto T, Scharffetter-Kochanek K, Münzel T, Bürkle A, Bachschmid MM, Daiber A. Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc Res. 2008 Nov 1; 80(2):280-9. PMID: 18596060.
    View in: PubMed
  41. Schildknecht S, van der Loo B, Weber K, Tiefenthaler K, Daiber A, Bachschmid MM. Endogenous peroxynitrite modulates PGHS-1-dependent thromboxane A2 formation and aggregation in human platelets. Free Radic Biol Med. 2008 Aug 15; 45(4):512-20. PMID: 18514074.
    View in: PubMed
  42. Schildknecht S, Daiber A, Ghisla S, Cohen RA, Bachschmid MM. Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite. FASEB J. 2008 Jan; 22(1):215-24. PMID: 17724253.
    View in: PubMed
  43. Tanner FC, van der Loo B, Shaw S, Greutert H, Bachschmid MM, Berrozpe M, Rozenberg I, Blau N, Siebenmann R, Schmidli J, Meyer P, Lüscher TF. Inactivity of nitric oxide synthase gene in the atherosclerotic human carotid artery. Basic Res Cardiol. 2007 Jul; 102(4):308-17. PMID: 17356797.
    View in: PubMed
  44. Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F. Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5217-22. PMID: 17360381.
    View in: PubMed
  45. Griffoni C, Spisni E, Strillacci A, Toni M, Bachschmid MM, Tomasi V. Selective inhibition of prostacyclin synthase activity by rofecoxib. J Cell Mol Med. 2007 Mar-Apr; 11(2):327-38. PMID: 17488481.
    View in: PubMed
  46. Wenzel P, Hink U, Oelze M, Schuppan S, Schaeuble K, Schildknecht S, Ho KK, Weiner H, Bachschmid M, Münzel T, Daiber A. Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance. J Biol Chem. 2007 Jan 5; 282(1):792-9. PMID: 17102135.
    View in: PubMed
  47. Clavreul N, Bachschmid MM, Hou X, Shi C, Idrizovic A, Ido Y, Pimentel D, Cohen RA. S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2454-61. PMID: 16931794.
    View in: PubMed
  48. van der Loo B, Bachschmid M, Skepper JN, Labugger R, Schildknecht S, Hahn R, Müssig E, Gygi D, Lüscher TF. Age-associated cellular relocation of Sod 1 as a self-defense is a futile mechanism to prevent vascular aging. Biochem Biophys Res Commun. 2006 Jun 9; 344(3):972-80. PMID: 16631605.
    View in: PubMed
  49. Schildknecht S, Heinz K, Daiber A, Hamacher J, Kavaklí C, Ullrich V, Bachschmid M. Autocatalytic tyrosine nitration of prostaglandin endoperoxide synthase-2 in LPS-stimulated RAW 264.7 macrophages. Biochem Biophys Res Commun. 2006 Feb 3; 340(1):318-25. PMID: 16375865.
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  50. Aleksandrov DA, Zagryagskaya AN, Pushkareva MA, Bachschmid M, Peters-Golden M, Werz O, Steinhilber D, Sud'ina GF. Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells. FEBS J. 2006 Feb; 273(3):548-57. PMID: 16420478.
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  51. Daiber A, Oelze M, Coldewey M, Kaiser K, Huth C, Schildknecht S, Bachschmid M, Nazirisadeh Y, Ullrich V, Mülsch A, Münzel T, Tsilimingas N. Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure. Biochem Biophys Res Commun. 2005 Dec 30; 338(4):1865-74. PMID: 16289107.
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  52. Frein D, Schildknecht S, Bachschmid M, Ullrich V. Redox regulation: a new challenge for pharmacology. Biochem Pharmacol. 2005 Sep 15; 70(6):811-23. PMID: 15899473.
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  53. Bachschmid M, Schildknecht S, Ullrich V. Redox regulation of vascular prostanoid synthesis by the nitric oxide-superoxide system. Biochem Biophys Res Commun. 2005 Dec 9; 338(1):536-42. PMID: 16153593.
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  54. Schildknecht S, Bachschmid M, Ullrich V. Peroxynitrite provides the peroxide tone for PGHS-2-dependent prostacyclin synthesis in vascular smooth muscle cells. FASEB J. 2005 Jul; 19(9):1169-71. PMID: 15878931.
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  55. Bachschmid MM, van der Loo B. A new "sunshine" in the vasculature? Circulation. 2005 Apr 5; 111(13):1571-3. PMID: 15811866.
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  56. Schildknecht S, Bachschmid M, Weber K, Maass D, Ullrich V. Endotoxin elicits nitric oxide release in rat but prostacyclin synthesis in human and bovine vascular smooth muscle cells. Biochem Biophys Res Commun. 2005 Feb 4; 327(1):43-8. PMID: 15629427.
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  57. Klumpp G, Schildknecht S, Nastainczyk W, Ullrich V, Bachschmid M. Prostacyclin in the cardiovascular system: new aspects and open questions. Pharmacol Rep. 2005; 57 Suppl:120-6. PMID: 16415492.
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  58. van der Loo B, Bachschmid M, Labugger R, Schildknecht S, Kilo J, Hahn R, Palacios-Callender M, Lüscher TF. Expression and activity patterns of nitric oxide synthases and antioxidant enzymes reveal a substantial heterogeneity between cardiac and vascular aging in the rat. Biogerontology. 2005; 6(5):325-34. PMID: 16463109.
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  59. Francia P, delli Gatti C, Bachschmid M, Martin-Padura I, Savoia C, Migliaccio E, Pelicci PG, Schiavoni M, Lüscher TF, Volpe M, Cosentino F. Deletion of p66shc gene protects against age-related endothelial dysfunction. Circulation. 2004 Nov 2; 110(18):2889-95. PMID: 15505103.
    View in: PubMed
  60. Daiber A, Oelze M, Coldewey M, Bachschmid M, Wenzel P, Sydow K, Wendt M, Kleschyov AL, Stalleicken D, Ullrich V, Mülsch A, Münzel T. Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates. Mol Pharmacol. 2004 Dec; 66(6):1372-82. PMID: 15331769.
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  61. Galkina SI, Dormeneva EV, Bachschmid M, Pushkareva MA, Sud'ina GF, Ullrich V. Endothelium-leukocyte interactions under the influence of the superoxide-nitrogen monoxide system. Med Sci Monit. 2004 Sep; 10(9):BR307-16. PMID: 15328475.
    View in: PubMed
  62. Daiber A, Bachschmid M, Beckman JS, Munzel T, Ullrich V. The impact of metal catalysis on protein tyrosine nitration by peroxynitrite. Biochem Biophys Res Commun. 2004 May 7; 317(3):873-81. PMID: 15081421.
    View in: PubMed
  63. Bachschmid M, van der Loo B, Schüler K, Labugger R, Thurau S, Eto M, Kilo J, Hölz R, Lüscher TF, Ullrich V. Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway. Arch Gerontol Geriatr. 2004 Mar-Apr; 38(2):181-90. PMID: 14698497.
    View in: PubMed
  64. Schildknecht S, Bachschmid M, Baumann A, Ullrich V. COX-2 inhibitors selectively block prostacyclin synthesis in endotoxin-exposed vascular smooth muscle cells. FASEB J. 2004 Apr; 18(6):757-9. PMID: 14977876.
    View in: PubMed
  65. van der Loo B, Labugger R, Aebischer CP, Bachschmid M, Spitzer V, Kilo J, Altwegg L, Ullrich V, Lüscher TF. Age-related changes of vitamin A status. J Cardiovasc Pharmacol. 2004 Jan; 43(1):26-30. PMID: 14668564.
    View in: PubMed
  66. Hink U, Oelze M, Kolb P, Bachschmid M, Zou MH, Daiber A, Mollnau H, August M, Baldus S, Tsilimingas N, Walter U, Ullrich V, Münzel T. Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance. J Am Coll Cardiol. 2003 Nov 19; 42(10):1826-34. PMID: 14642695.
    View in: PubMed
  67. Daiber A, Bachschmid M, Kavaklí C, Frein D, Wendt M, Ullrich V, Munzel T. A new pitfall in detecting biological end products of nitric oxide-nitration, nitros(yl)ation and nitrite/nitrate artefacts during freezing. Nitric Oxide. 2003 Aug; 9(1):44-52. PMID: 14559431.
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  68. van der Loo B, Bachschmid M, Spitzer V, Brey L, Ullrich V, Lüscher TF. Decreased plasma and tissue levels of vitamin C in a rat model of aging: implications for antioxidative defense. Biochem Biophys Res Commun. 2003 Apr 4; 303(2):483-7. PMID: 12659843.
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  69. Bachschmid M, Thurau S, Zou MH, Ullrich V. Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation. FASEB J. 2003 May; 17(8):914-6. PMID: 12670882.
    View in: PubMed
  70. Cosentino F, Eto M, De Paolis P, van der Loo B, Bachschmid M, Ullrich V, Kouroedov A, Delli Gatti C, Joch H, Volpe M, Lüscher TF. High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation. 2003 Feb 25; 107(7):1017-23. PMID: 12600916.
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  71. Schmidt P, Youhnovski N, Daiber A, Balan A, Arsic M, Bachschmid M, Przybylski M, Ullrich V. Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase. J Biol Chem. 2003 Apr 11; 278(15):12813-9. PMID: 12562775.
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  72. van der Loo B, Labugger R, Aebischer CP, Skepper JN, Bachschmid M, Spitzer V, Kilo J, Altwegg L, Ullrich V, Lüscher TF. Cardiovascular aging is associated with vitamin E increase. Circulation. 2002 Apr 9; 105(14):1635-8. PMID: 11940539.
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  73. Ullrich V, Zou MH, Bachschmid M. New physiological and pathophysiological aspects on the thromboxane A(2)-prostacyclin regulatory system. Biochim Biophys Acta. 2001 May 31; 1532(1-2):1-14. PMID: 11420169.
    View in: PubMed
  74. van der Loo B, Labugger R, Skepper JN, Bachschmid M, Kilo J, Powell JM, Palacios-Callender M, Erusalimsky JD, Quaschning T, Malinski T, Gygi D, Ullrich V, Lüscher TF. Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med. 2000 Dec 18; 192(12):1731-44. PMID: 11120770.
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  75. Ullrich V, Bachschmid M. Superoxide as a messenger of endothelial function. Biochem Biophys Res Commun. 2000 Nov 11; 278(1):1-8. PMID: 11071846.
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  76. Daiber A, Zou MH, Bachschmid M, Ullrich V. Ebselen as a peroxynitrite scavenger in vitro and ex vivo. Biochem Pharmacol. 2000 Jan 15; 59(2):153-60. PMID: 10810449.
    View in: PubMed
  77. Zou MH, Bachschmid M. Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase. J Exp Med. 1999 Jul 5; 190(1):135-9. PMID: 10429677.
    View in: PubMed
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