Joseph Burgoyne | Profiles RNS

Joseph Burgoyne, MD, PhD

Visiting Fellow (previously held)

Boston University Chobanian & Avedisian School of Medicine

Vascular Biology

Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Su J, Coleman P, Ntorla A, Anderson R, Shattock MJ, Burgoyne JR. Sensing Cytosolic DNA Lowers Blood Pressure by Direct cGAMP-Dependent PKGI Activation. Circulation. 2023 Sep 26; 148(13):1023-1034. PMID: 37548012; PMCID: PMC10516174; DOI: 10.1161/CIRCULATIONAHA.123.065547;

Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann T, Belousov VV, Katschinski DM. IDH3? functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart. Nat Commun. 2023 Apr 14; 14(1):2123. PMID: 37055412; PMCID: PMC10102218; DOI: 10.1038/s41467-023-37744-x;

Ntorla A, Burgoyne JR. The Regulation and Function of Histone Crotonylation. Front Cell Dev Biol. 2021; 9:624914. PMID: 33889571; PMCID: PMC8055951; DOI: 10.3389/fcell.2021.624914;

Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P. Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth. Redox Biol. 2020 01; 29:101405. PMID: 31926628; PMCID: PMC6928308; DOI: 10.1016/j.redox.2019.101405;

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P, Burgoyne JR. Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase". Circulation. 2019 11 26; 140(22):e810-e811. PMID: 31765257

Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P, Burgoyne JR. Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase. Circulation. 2019 07 09; 140(2):126-137. PMID: 31116951; PMCID: PMC6635045; DOI: 10.1161/CIRCULATIONAHA.118.037398;

Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J, Eaton P. PKG1a oxidation negatively regulates food seeking behaviour and reward. Redox Biol. 2019 02; 21:101077. PMID: 30593979; PMCID: PMC6306694; DOI: 10.1016/j.redox.2018.101077;

Burgoyne JR. Oxidative stress impairs autophagy through oxidation of ATG3 and ATG7. Autophagy. 2018; 14(6):1092-1093. PMID: 29746182; PMCID: PMC6103406; DOI: 10.1080/15548627.2018.1444311;

Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P. Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. Mol Cell. 2018 02 01; 69(3):438-450.e5. PMID: 29358077; PMCID: PMC5807093; DOI: 10.1016/j.molcel.2017.12.019;

Frudd K, Burgoyne T, Burgoyne JR. Oxidation of Atg3 and Atg7 mediates inhibition of autophagy. Nat Commun. 2018 01 08; 9(1):95. PMID: 29311554; PMCID: PMC5758830; DOI: 10.1038/s41467-017-02352-z;

Showing 10 of 42 results. Show More

Ranieri A, Kemp E, Burgoyne JR, Avkiran M. ß-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56d at S573. J Mol Cell Cardiol. 2018 02; 115:20-31. PMID: 29294329; PMCID: PMC5823843; DOI: 10.1016/j.yjmcc.2017.12.016;

Bassi R, Burgoyne JR, DeNicola GF, Rudyk O, DeSantis V, Charles RL, Eaton P, Marber MS. Redox-dependent dimerization of p38a mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3. J Biol Chem. 2017 Sep 29; 292(39):16161-16173. PMID: 28739872; PMCID: PMC5625047; DOI: 10.1074/jbc.M117.785410;

Burgoyne JR, Prysyazhna O, Richards DA, Eaton P. Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Ia (Protein Kinase G Ia). Hypertension. 2017 Sep; 70(3):577-586. PMID: 28716990; PMCID: PMC5548503; DOI: 10.1161/HYPERTENSIONAHA.117.09670;

Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P. Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Ia Oxidation. J Biol Chem. 2016 Aug 12; 291(33):17427-36. PMID: 27342776; PMCID: PMC5016139; DOI: 10.1074/jbc.M116.724070;

Fernandez-Caggiano M, Schröder E, Cho HJ, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P. Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2. J Biol Chem. 2016 May 06; 291(19):10399-410. PMID: 26945066; PMCID: PMC4858985; DOI: 10.1074/jbc.M115.699850;

Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T. Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation. Biochemistry. 2016 Feb 9; 55(5):751-61. PMID: 26784639; DOI: 10.1021/acs.biochem.5b00774;

Mistry RK, Murray TV, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM, Brewer AC. Transcriptional Regulation of Cystathionine-?-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling. J Biol Chem. 2016 Jan 22; 291(4):1774-88. PMID: 26620565; PMCID: PMC4722457; DOI: 10.1074/jbc.M115.685578;

Johnston AS, Lehnart SE, Burgoyne JR. Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII. Front Pharmacol. 2015; 6:166. PMID: 26321952; PMCID: PMC4530260; DOI: 10.3389/fphar.2015.00166;

Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P. Protein kinase G Ia oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide. Hypertension. 2014 Dec; 64(6):1344-51. PMID: 25267801; DOI: 10.1161/HYPERTENSIONAHA.114.04281;

Burgoyne JR, Oviosu O, Eaton P. The PEG-switch assay: a fast semi-quantitative method to determine protein reversible cysteine oxidation. J Pharmacol Toxicol Methods. 2013 Nov-Dec; 68(3):297-301. PMID: 23856010; DOI: 10.1016/j.vascn.2013.07.001;

Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P. Protein kinase G oxidation is a major cause of injury during sepsis. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9909-13.View Related Profiles.

Phinikaridou, Alkystis
Burgoyne, Joseph

PMID: 23716652; PMCID: PMC3683714; DOI: 10.1073/pnas.1301026110;

Haeussler DJ, Pimentel DR, Hou X, Burgoyne JR, Cohen RA, Bachschmid MM. Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration. J Biol Chem. 2013 May 24; 288(21):15380-9.View Related Profiles.

Haeussler, Dagmar
Pimentel, David
Burgoyne, Joseph
Bachschmid, Markus
Cohen, Richard

PMID: 23548900; PMCID: PMC3663556; DOI: 10.1074/jbc.M112.427765;

Burgoyne JR, Din HM, Eaton P, Shah AM. Response to "Detailed aspects of redox signaling in cardiac physiology and pathology". Circ Res. 2013 Jan 4; 112(1):e2. PMID: 23409289

Burgoyne JR, Eaton P. Detecting disulfide-bound complexes and the oxidative regulation of cyclic nucleotide-dependent protein kinases by H2O2. Methods Enzymol. 2013; 528:111-28. PMID: 23849862; DOI: 10.1016/B978-0-12-405881-1.00007-0;

Burgoyne JR, Eaton P. Approaches for monitoring PKG1a oxidative activation. Methods Mol Biol. 2013; 1020:163-73. PMID: 23709032; DOI: 10.1007/978-1-62703-459-3_10;

Burgoyne JR, Mongue-Din H, Eaton P, Shah AM. Redox signaling in cardiac physiology and pathology. Circ Res. 2012 Sep 28; 111(8):1091-106. PMID: 23023511

Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P. cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control. Hypertension. 2012 Nov; 60(5):1301-8. PMID: 23006734

Burgoyne JR, Oka S, Ale-Agha N, Eaton P. Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system. Antioxid Redox Signal. 2013 Mar 20; 18(9):1042-52. PMID: 22867279; PMCID: PMC3567777; DOI: 10.1089/ars.2012.4817;

Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P. Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1a knock-in mouse. Circulation. 2012 Jul 17; 126(3):287-95. PMID: 22685118; PMCID: PMC3617728; DOI: 10.1161/CIRCULATIONAHA.112.101287;

Pimentel D, Haeussler DJ, Matsui R, Burgoyne JR, Cohen RA, Bachschmid MM. Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal. 2012 Mar 15; 16(6):524-42.View Related Profiles.

Haeussler, Dagmar
Pimentel, David
Burgoyne, Joseph
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard

PMID: 22010840; PMCID: PMC3270052; DOI: 10.1089/ars.2011.4336;

Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2012 Feb; 26(2):832-41.View Related Profiles.

Costello, Catherine
Lin, Cheng
Haeussler, Dagmar
Burgoyne, Joseph
McComb, Mark
Bachschmid, Markus
Cohen, Richard
Kumar, Vikas

PMID: 22085642; PMCID: PMC3290434; DOI: 10.1096/fj.11-189415;

Burgoyne JR, Eaton P. Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation. Biochem Soc Trans. 2011 Oct; 39(5):1260-7. PMID: 21936799; DOI: 10.1042/BST0391260;

Haeussler DJ, Evangelista AM, Burgoyne JR, Cohen RA, Bachschmid MM, Pimental DR. Checkpoints in adenoviral production: cross-contamination and E1A. PLoS One. 2011; 6(8):e23160.View Related Profiles.

Haeussler, Dagmar
Pimentel, David
Burgoyne, Joseph
Bachschmid, Markus
Cohen, Richard

PMID: 21826235; PMCID: PMC3149638; DOI: 10.1371/journal.pone.0023160;

Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ Res. 2011 Feb 4; 108(3):324-34. PMID: 21164107; PMCID: PMC3259859; DOI: 10.1161/CIRCRESAHA.110.235879;

Burgoyne JR, Rudyk O, Mayr M, Eaton P. Nitrosative protein oxidation is modulated during early endotoxemia. Nitric Oxide. 2011 Aug 1; 25(2):118-24. PMID: 21130178; PMCID: PMC3600856; DOI: 10.1016/j.niox.2010.11.005;

Zee RS, Yoo CB, Pimentel DR, Perlman DH, Burgoyne JR, Hou X, McComb ME, Costello CE, Cohen RA, Bachschmid MM. Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal. 2010 Oct 1; 13(7):1023-32.View Related Profiles.

Costello, Catherine
Pimentel, David
Burgoyne, Joseph
McComb, Mark
Bachschmid, Markus
Cohen, Richard

PMID: 20392170; PMCID: PMC2959181; DOI: 10.1089/ars.2010.3251;

Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ, Eaton P. Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H827-36. PMID: 20543084; PMCID: PMC2944484; DOI: 10.1152/ajpheart.00129.2010;

Burgoyne JR, Eaton P. Oxidant sensing by protein kinases a and g enables integration of cell redox state with phosphoregulation. Sensors (Basel). 2010; 10(4):2731-51. PMID: 22319269; PMCID: PMC3274199; DOI: 10.3390/s100402731;

Burgoyne JR, Eaton P. A rapid approach for the detection, quantification, and discovery of novel sulfenic acid or S-nitrosothiol modified proteins using a biotin-switch method. Methods Enzymol. 2010; 473:281-303. PMID: 20513484; DOI: 10.1016/S0076-6879(10)73015-9;

Burgoyne JR, Eaton P. Transnitrosylating nitric oxide species directly activate type I protein kinase A, providing a novel adenylate cyclase-independent cross-talk to beta-adrenergic-like signaling. J Biol Chem. 2009 Oct 23; 284(43):29260-8. PMID: 19726669; PMCID: PMC2785556; DOI: 10.1074/jbc.M109.046722;

Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P. Cysteine redox sensor in PKGIa enables oxidant-induced activation. Science. 2007 Sep 7; 317(5843):1393-7. PMID: 17717153

Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schröder E, Wait R, Begum S, Kentish JC, Eaton P. Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. J Biol Chem. 2006 Aug 4; 281(31):21827-36. PMID: 16754666

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 42 publications over 15 distinct years, with a maximum of 6 publications in 2010 and 2013

Bar chart showing 42 publications over 15 distinct years, with a maximum of 6 publications in 2010 and 2013

Year	Publications
2006	1
2007	1
2009	1
2010	6
2011	3
2012	5
2013	6
2014	1
2015	2
2016	3
2017	3
2018	4
2019	3
2021	1
2023	2

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Boston MA 02118
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