Richard A. Cohen, MD
Emeritus Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine (Vascular Biology Unit) Section

MD, Johns Hopkins University



A professor of Medicine, Physiology, and Pharmacology and Experimental Therapeutics, Dr. Cohen is the Jay and Louise Coffman Professor of Medicine and Director of the Vascular Biology Unit. Dr. Cohen is also the Co-principal Investigator of the Boston University Cardiovascular Proteomics Center. Dr. Cohen is also a recipient of an R37 MERIT award from the NHLBI and is currently the PI or Co-PI of 6 NIH investigator initiated research studies. In 2008 he was named to a 5 year Robert Dawson Evans Scholar Award by the Department of Medicine. He is a former recipient of the American Heart Association Clinician Investigator and the Established Investigator awards. He is past president of the American Federation for Medical Research and founding president of the American Federation for Medical Research Foundation. Dr. Cohen is distinguished by his elections to the American Society for Clinical Investigation and the Association of American Physicians. He is an elected Fellow of the Cardiovascular Section of the American Physiological Society. He is a member of the editorial boards of the American Journal of Physiology: Heart and Circulatory Physiology and Arteriosclerosis, Thrombosis, and Vascular Biology, and Free Radical Biology and Medicine. Dr. Cohen is a past member of the NIH Experimental Cardiovascular Study Section and currently serves as an ad hoc reviewer for several NIH review groups. The research in the Vascular Biology Unit which Dr. Cohen directs focuses on the effect of vascular and metabolic disease on the function of blood vessels with special emphasis on the role of endothelium-derived nitric oxide and reactive oxygen species. The roles of redox-mediated post-translational protein modifications of cardiovascular proteins including the sarcoplasmic reticulum calcium ATPase, sirtuin-1, and p21ras in cell signaling and disease are a current focus. Applications of these basic areas are currently bein g pursued in funded programs with respect to clinical areas problems of atherosclerosis, impaired ischemia-induced angiogenesis, arterial stiffness, hypertension, and failure of hemodialysis fistulae.

The Vascular Biology Unit led by Dr. Richard Cohen seeks to understand mechanisms of abnormal vascular function and disease in order to better develop therapies. The role of reactive oxygen and nitrogen species is of key importance to that understanding. His group has found that in diabetes, hypertension, and atherosclerosis, the vasodilator, nitric oxide, reacts with superoxide anion, an oxidant produced in diseased blood vessels. As a result of this reaction even more potent oxidants, including peroxynitrite, are formed. Low levels of oxidants form protein cysteine thiol adducts with the low molecular weight antioxidant glutathione. Targeted proteins include the sarcoplasmic reticulum calcium ATPase, p21ras, and sirtuin-1, whose function is thereby altered, consequently modulating cell calcium and signaling. High levels of peroxynitrite can be blamed for inactivating these and other important proteins, such as endothelial nitric oxide synthase and manganese superoxide dismutase. As part of the BU Cardiovascular Proteomics Center, Dr. Cohen and his group are identifying chemical modifications of proteins formed by oxidants with mass spectrometric and protein tagging strategies. These modifications may serve as biomarkers for abnormal tissue and cell signaling as well as abnormal cell function in disease. Such markers have been discovered in diseased human arteries and platelets. A new program focuses on arterial stiffness and hypertension associated with obesity and metabolic disease.

Boston Medical Center



2010-2015 NIH: MERIT Award R37 HL104017
2007 American Diabetes Association: Takeda Mentorship Award
1987-1992 American Heart Association: Established Investigator Award
1982-1987 American Heart Association: Clinician Scientist Award
1980-1981 Greater Boston Massachusetts Affiliate AHA: Research Fellow


Aortic Stiffness and Hypertension in Obese Mice
09/30/2010 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL105287-04

Redox Regulation of p21ras in Angiogenesis
07/15/2010 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R37HL104017-05

Redox Regulation of SERCA by Nitric Oxide
02/01/2010 - 01/31/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL031607-29

Proteins Targeted by Oxidants in Diabetic Blood Vessels
01/01/2008 - 12/31/2009 (PI)
American Diabetes Association

Cardiovascular Proteomics Center Symposia Series
09/30/2005 - 12/31/2008 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R13 HL78317 02


Servier Research Agreement-Amendment 5
11/01/2002 - 09/01/2016 (PI)
Servier

Proteomic Centers: Modification of cardiovascular proteins by metabolic disease
08/15/2010 - 08/14/2015 (PI)
Trustees of Boston University NIH-NHLBI

AMPK Project 2
04/15/2009 - 01/31/2015 (PI)
NIH-NHLBI
5P01 HL068758-10

Angiotensin - Induced Oxidants and Vascular Cell Phenotype
03/01/2005 - 02/28/2010 (PI)
NIH-NIA
1 R01 AG27080-02

Nitric Oxide In Atherogenisis
05/01/2004 - 06/30/2009 (PI)
NIH-NHLBI
5 R01 HL31607-23

Project 3--Oxidative Stress, AMPK, and Diabetic Cardiovascular Disease
05/01/2003 - 01/30/2009 (PI)
NIH-NHLBI
5 P01 HL068758-05(A)

Nitric Oxide In Atherogenisis
05/01/1998 - 10/31/2005 (PI)
NIH-NHLBI
5 R01 HL31607-20 (F)

Angiotensin Ii, Oxidative Stre
09/01/1998 - 08/31/2005 (PI)
NIH-NHLBI
5 R01 HL055620-09 (C)

Oxidative Stress, AMPK, and Diabetic
03/01/2003 - 02/28/2005 (PI)
Juvenile Diab Fdtn

Oxidative Stress, AMPK, and Diabetic
03/01/2002 - 02/28/2005 (PI)
Juvenile Diab Fdtn

Showing 10 of 18 results. Show All Results


Yr Title Project-Sub Proj Pubs
2014 Redox Regulation of p21ras in Angiogenesis 5R37HL104017-05 25
2013 Aortic Stiffness and Hypertension in Obese Mice 5R01HL105287-04 7
2013 Redox Regulation of p21ras in Angiogenesis 5R37HL104017-04 25
2013 Redox Regulation of SERCA by Nitric Oxide 5R01HL031607-29 102
2013 SIRT1, Polyphenols, and Endothelial Oxidants 5P01HL068758-10-5224 93
2012 Aortic Stiffness and Hypertension in Obese Mice 5R01HL105287-03 7
2012 Redox Regulation of p21ras in Angiogenesis 5R37HL104017-03 25
2012 Redox Regulation of SERCA by Nitric Oxide 5R01HL031607-28 102
2012 SIRT1, Polyphenols, and Endothelial Oxidants 5P01HL068758-09-5224 93
2011 ID OF OXIDANT SENSITIVE CYSTEINE CONTAINING PROTEINS BY MASS SPECTROMETRY 5P41RR010888-15-5083 236
Showing 10 of 97 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Feb 16.View Related Profiles. PMID: 27958883; DOI: 10.1089/ars.2016.6716;.
  2. Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KSS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochim Biophys Acta. 2017 Jun; 1863(6):1382-1391.View Related Profiles. PMID: 28185955; DOI: 10.1016/j.bbadis.2017.02.004;.
  3. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YM, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles. PMID: 27693992; DOI: 10.1016/j.redox.2016.09.003;.
  4. Fry JL, Al Sayah L, Weisbrod RM, Van Roy I, Weng X, Cohen RA, Bachschmid MM, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness. Hypertension. 2016 Sep; 68(3):775-84.View Related Profiles. PMID: 27432859; PMCID: PMC4982825; DOI: 10.1161/HYPERTENSIONAHA.116.07622;.
  5. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;.
  6. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1a and improve limb revascularization. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6011-6.View Related Profiles. PMID: 27162359; PMCID: PMC4889374; DOI: 10.1073/pnas.1524198113;.
  7. Watanabe Y, Cohen RA, Matsui R. Redox Regulation of Ischemic Angiogenesis - Another Aspect of Reactive Oxygen Species. Circ J. 2016 May 25; 80(6):1278-84.View Related Profiles. PMID: 27151566; DOI: 10.1253/circj.CJ-16-0317;.
  8. Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016 Mar; 92:30-40.View Related Profiles. PMID: 26812119; PMCID: PMC5008453; DOI: 10.1016/j.yjmcc.2016.01.020;.
  9. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1).View Related Profiles. PMID: 26755553; PMCID: PMC4859372; DOI: 10.1161/JAHA.115.002555;.
  10. Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015 Dec 31; 5(1).View Related Profiles. PMID: 26722122; PMCID: PMC4859355; DOI: 10.1161/JAHA.115.002277;.
Showing 10 of 252 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 250 publications over 38 distinct years, with a maximum of 14 publications in 1992

YearPublications
19801
19813
19821
19836
19848
19853
19864
19877
198811
19897
19908
19912
199214
19939
19945
19959
19967
19976
19985
199913
20009
20017
20027
20035
200410
20056
200613
20077
20082
20091
20108
20117
20128
20137
201411
20154
20167
20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cardiovascular disease
Vascular Biology

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650 Albany St Evans Biomed Research Ctr
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