Keywords
Last Name

Richard A. Cohen, MD

TitleEmeritus Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine (Vascular Biology Unit)
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7115
ORCID ORCID Icon0000-0002-1070-6408
Other Positions
InstitutionBoston Medical Center

 Awards and Honors

Start-EndDescription
1980-1981Greater Boston Massachusetts Affiliate AHA: Research Fellow
1982-1987American Heart Association: Clinician Scientist Award
1987-1992American Heart Association: Established Investigator Award
2007American Diabetes Association: Takeda Mentorship Award
2010-2015NIH: MERIT Award R37 HL104017
 Research Expertise & Professional Interests
A professor of Medicine, Physiology, and Pharmacology and Experimental Therapeutics, Dr. Cohen is the Jay and Louise Coffman Professor of Medicine and Director of the Vascular Biology Unit. Dr. Cohen is also the Co-principal Investigator of the Boston University Cardiovascular Proteomics Center. Dr. Cohen is also a recipient of an R37 MERIT award from the NHLBI and is currently the PI or Co-PI of 6 NIH investigator initiated research studies. In 2008 he was named to a 5 year Robert Dawson Evans Scholar Award by the Department of Medicine. He is a former recipient of the American Heart Association Clinician Investigator and the Established Investigator awards. He is past president of the American Federation for Medical Research and founding president of the American Federation for Medical Research Foundation. Dr. Cohen is distinguished by his elections to the American Society for Clinical Investigation and the Association of American Physicians. He is an elected Fellow of the Cardiovascular Section of the American Physiological Society. He is a member of the editorial boards of the American Journal of Physiology: Heart and Circulatory Physiology and Arteriosclerosis, Thrombosis, and Vascular Biology, and Free Radical Biology and Medicine. Dr. Cohen is a past member of the NIH Experimental Cardiovascular Study Section and currently serves as an ad hoc reviewer for several NIH review groups. The research in the Vascular Biology Unit which Dr. Cohen directs focuses on the effect of vascular and metabolic disease on the function of blood vessels with special emphasis on the role of endothelium-derived nitric oxide and reactive oxygen species. The roles of redox-mediated post-translational protein modifications of cardiovascular proteins including the sarcoplasmic reticulum calcium ATPase, sirtuin-1, and p21ras in cell signaling and disease are a current focus. Applications of these basic areas are currently bein g pursued in funded programs with respect to clinical areas problems of atherosclerosis, impaired ischemia-induced angiogenesis, arterial stiffness, hypertension, and failure of hemodialysis fistulae.

The Vascular Biology Unit led by Dr. Richard Cohen seeks to understand mechanisms of abnormal vascular function and disease in order to better develop therapies. The role of reactive oxygen and nitrogen species is of key importance to that understanding. His group has found that in diabetes, hypertension, and atherosclerosis, the vasodilator, nitric oxide, reacts with superoxide anion, an oxidant produced in diseased blood vessels. As a result of this reaction even more potent oxidants, including peroxynitrite, are formed. Low levels of oxidants form protein cysteine thiol adducts with the low molecular weight antioxidant glutathione. Targeted proteins include the sarcoplasmic reticulum calcium ATPase, p21ras, and sirtuin-1, whose function is thereby altered, consequently modulating cell calcium and signaling. High levels of peroxynitrite can be blamed for inactivating these and other important proteins, such as endothelial nitric oxide synthase and manganese superoxide dismutase. As part of the BU Cardiovascular Proteomics Center, Dr. Cohen and his group are identifying chemical modifications of proteins formed by oxidants with mass spectrometric and protein tagging strategies. These modifications may serve as biomarkers for abnormal tissue and cell signaling as well as abnormal cell function in disease. Such markers have been discovered in diseased human arteries and platelets. A new program focuses on arterial stiffness and hypertension associated with obesity and metabolic disease.

 Self-Described Keywords
  • Cardiovascular disease
  • Vascular Biology
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Shao D, Han J, Hou X, Fry JL, Behring JB, Seta F, Long M, Roy H, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 deficiency causes fatty liver and dyslipidemia by inhibiting sirtuin-1. Antioxid Redox Signal. 2016 Dec 13. PMID: 27958883.
    View in: PubMed
  2. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YM, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319. PMID: 27693992.
    View in: PubMed
  3. Fry JL, Al Sayah L, Weisbrod RM, Van Roy I, Weng X, Cohen RA, Bachschmid MM, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness. Hypertension. 2016 Sep; 68(3):775-84. PMID: 27432859.
    View in: PubMed
  4. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64. PMID: 26927696.
    View in: PubMed
  5. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1a and improve limb revascularization. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6011-6. PMID: 27162359.
    View in: PubMed
  6. Watanabe Y, Cohen RA, Matsui R. Redox Regulation of Ischemic Angiogenesis - Another Aspect of Reactive Oxygen Species. Circ J. 2016 May 25; 80(6):1278-84. PMID: 27151566.
    View in: PubMed
  7. Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016 Mar; 92:30-40. PMID: 26812119.
    View in: PubMed
  8. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1). PMID: 26755553.
    View in: PubMed
  9. Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015 Dec 31; 5(1). PMID: 26722122.
    View in: PubMed
  10. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025. PMID: 26642319.
    View in: PubMed
  11. Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J, Cohen RA. Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):185-94. PMID: 26582463.
    View in: PubMed
  12. Fry JL, Shiraishi Y, Turcotte R, Yu X, Gao YZ, Akiki R, Bachschmid M, Zhang Y, Morgan KG, Cohen RA, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc. 2015 Sep; 4(9):e002384. PMID: 26376991.
    View in: PubMed
  13. Chen L, Xiao J, Kuroda J, Ago T, Sadoshima J, Cohen RA, Tong X. Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines. Biochim Biophys Acta. 2014 Dec; 1842(12 Pt A):2489-99. PMID: 25315297.
    View in: PubMed
  14. Mei Y, Thompson MD, Shiraishi Y, Cohen RA, Tong X. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. J Mol Cell Cardiol. 2014 Nov; 76:275-82. PMID: 25260714.
    View in: PubMed
  15. Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol. 2015 Jan; 78:165-73. PMID: 25109264.
    View in: PubMed
  16. Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16. PMID: 24920669.
    View in: PubMed
  17. Mei Y, Thompson MD, Cohen RA, Tong X. Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta. 2015 Feb; 1852(2):243-51. PMID: 24834848.
    View in: PubMed
  18. Seta F, Cohen RA. The endothelium: paracrine mediator of aortic dissection. Circulation. 2014 Jun 24; 129(25):2629-32. PMID: 24807873.
    View in: PubMed
  19. Qin F, Siwik DA, Pimentel DR, Morgan RJ, Biolo A, Tu VH, Kang YJ, Cohen RA, Colucci WS. Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload. Am J Physiol Heart Circ Physiol. 2014 May 15; 306(10):H1453-63. PMID: 24633550.
    View in: PubMed
  20. Qin Z, Hou X, Weisbrod RM, Seta F, Cohen RA, Tong X. Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells. J Mol Cell Cardiol. 2014 Jul; 72:56-63. PMID: 24631774.
    View in: PubMed
  21. Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization. J Biol Chem. 2014 Mar 21; 289(12):8633-44. PMID: 24482236.
    View in: PubMed
  22. Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87. PMID: 24469991.
    View in: PubMed
  23. Shao D, Fry JL, Han J, Hou X, Pimentel DR, Matsui R, Cohen RA, Bachschmid MM. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem. 2014 Mar 14; 289(11):7293-306. PMID: 24451382.
    View in: PubMed
  24. Mei Y, Thompson MD, Cohen RA, Tong X. Endoplasmic Reticulum Stress and Related Pathological Processes. J Pharmacol Biomed Anal. 2013 Nov 15; 1(2):1000107. PMID: 24611136.
    View in: PubMed
  25. Weisbrod RM, Shiang T, Al Sayah L, Fry JL, Bajpai S, Reinhart-King CA, Lob HE, Santhanam L, Mitchell G, Cohen RA, Seta F. Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension. 2013 Dec; 62(6):1105-10. PMID: 24060894.
    View in: PubMed
  26. Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug; 2(4):e000184. PMID: 23963753.
    View in: PubMed
  27. Hobai IA, Buys ES, Morse JC, Edgecomb J, Weiss EH, Armoundas AA, Hou X, Khandelwal AR, Siwik DA, Brouckaert P, Cohen RA, Colucci WS. SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis. Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8):H1189-200. PMID: 23934853.
    View in: PubMed
  28. Liu CC, Karimi Galougahi K, Weisbrod RM, Hansen T, Ravaie R, Nunez A, Liu YB, Fry N, Garcia A, Hamilton EJ, Sweadner KJ, Cohen RA, Figtree GA. Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent ß1-subunit glutathionylation: implications for angiotensin II-induced vascular dysfunction. Free Radic Biol Med. 2013 Dec; 65:563-72. PMID: 23816524.
    View in: PubMed
  29. Li Y, Xu S, Jiang B, Cohen RA, Zang M. Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS One. 2013; 8(6):e67532. PMID: 23825667.
    View in: PubMed
  30. Haeussler DJ, Pimentel DR, Hou X, Burgoyne JR, Cohen RA, Bachschmid MM. Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration. J Biol Chem. 2013 May 24; 288(21):15380-9. PMID: 23548900.
    View in: PubMed
  31. Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34. PMID: 23089226.
    View in: PubMed
  32. Kumar V, Calamaras TD, Haeussler D, Colucci WS, Cohen RA, McComb ME, Pimentel D, Bachschmid MM. Cardiovascular redox and ox stress proteomics. Antioxid Redox Signal. 2012 Dec 1; 17(11):1528-59. PMID: 22607061.
    View in: PubMed
  33. Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012 Oct 15; 17(8):1099-108. PMID: 22472004.
    View in: PubMed
  34. Pimentel D, Haeussler DJ, Matsui R, Burgoyne JR, Cohen RA, Bachschmid MM. Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal. 2012 Mar 15; 16(6):524-42. PMID: 22010840.
    View in: PubMed
  35. Bayat H, Schröder K, Pimentel DR, Brandes RP, Verbeuren TJ, Cohen RA, Jiang B. Activation of thromboxane receptor modulates interleukin-1ß-induced monocyte adhesion--a novel role of Nox1. Free Radic Biol Med. 2012 May 1; 52(9):1760-6. PMID: 22406435.
    View in: PubMed
  36. Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation. 2012 Apr 10; 125(14):1757-64, S1-6. PMID: 22388319.
    View in: PubMed
  37. Bachschmid MM, Schildknecht S, Matsui R, Zee R, Haeussler D, Cohen RA, Pimental D, Loo Bv. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med. 2013 Feb; 45(1):17-36. PMID: 22380696.
    View in: PubMed
  38. Vanhoutte PM, Cooke JP, Cohen RA. In Memoriam of John T. Shepherd, MD, DSc. Circulation. 2012 Jan 17; 125(2):393-4. PMID: 22359738.
    View in: PubMed
  39. Mazzini M, Tadros T, Siwik D, Joseph L, Bristow M, Qin F, Cohen R, Monahan K, Klein M, Colucci W. Primary carnitine deficiency and sudden death: in vivo evidence of myocardial lipid peroxidation and sulfonylation of sarcoendoplasmic reticulum calcium ATPase 2. Cardiology. 2011; 120(1):52-8. PMID: 22116472.
    View in: PubMed
  40. Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2012 Feb; 26(2):832-41. PMID: 22085642.
    View in: PubMed
  41. Xu S, Jiang B, Hou X, Shi C, Bachschmid MM, Zang M, Verbeuren TJ, Cohen RA. High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol. 2011 Sep; 58(3):263-71. PMID: 21654327.
    View in: PubMed
  42. Haeussler DJ, Evangelista AM, Burgoyne JR, Cohen RA, Bachschmid MM, Pimental DR. Checkpoints in adenoviral production: cross-contamination and E1A. PLoS One. 2011; 6(8):e23160. PMID: 21826235.
    View in: PubMed
  43. Xu S, Zhi H, Hou X, Cohen RA, Jiang B. I?Bß attenuates angiotensin II-induced cardiovascular inflammation and fibrosis in mice. Hypertension. 2011 Aug; 58(2):310-6. PMID: 21646597.
    View in: PubMed
  44. Shao JS, Sierra OL, Cohen R, Mecham RP, Kovacs A, Wang J, Distelhorst K, Behrmann A, Halstead LR, Towler DA. Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1821-33. PMID: 21597007.
    View in: PubMed
  45. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 6; 13(4):376-88. PMID: 21459323.
    View in: PubMed
  46. Zee RS, Yoo CB, Pimentel DR, Perlman DH, Burgoyne JR, Hou X, McComb ME, Costello CE, Cohen RA, Bachschmid MM. Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal. 2010 Oct 1; 13(7):1023-32. PMID: 20392170.
    View in: PubMed
  47. Tong X, Hou X, Jourd'heuil D, Weisbrod RM, Cohen RA. Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Circ Res. 2010 Oct 15; 107(8):975-83. PMID: 20724704.
    View in: PubMed
  48. Bachschmid MM, Xu S, Maitland-Toolan KA, Ho YS, Cohen RA, Matsui R. Attenuated cardiovascular hypertrophy and oxidant generation in response to angiotensin II infusion in glutaredoxin-1 knockout mice. Free Radic Biol Med. 2010 Oct 15; 49(7):1221-9. PMID: 20638471.
    View in: PubMed
  49. Lancel S, Qin F, Lennon SL, Zhang J, Tong X, Mazzini MJ, Kang YJ, Siwik DA, Cohen RA, Colucci WS. Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice. Circ Res. 2010 Jul 23; 107(2):228-32. PMID: 20508180.
    View in: PubMed
  50. Cohen RA, Tong X. Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease. J Cardiovasc Pharmacol. 2010 Apr; 55(4):308-16. PMID: 20422735.
    View in: PubMed
  51. Kuster GM, Lancel S, Zhang J, Communal C, Trucillo MP, Lim CC, Pfister O, Weinberg EO, Cohen RA, Liao R, Siwik DA, Colucci WS. Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med. 2010 May 1; 48(9):1182-7. PMID: 20132882.
    View in: PubMed
  52. Tong X, Evangelista A, Cohen RA. Targeting the redox regulation of SERCA in vascular physiology and disease. Curr Opin Pharmacol. 2010 Apr; 10(2):133-8. PMID: 20045379.
    View in: PubMed
  53. Félétou M, Cohen RA, Vanhoutte PM, Verbeuren TJ. TP receptors and oxidative stress hand in hand from endothelial dysfunction to atherosclerosis. Adv Pharmacol. 2010; 60:85-106. PMID: 21081216.
    View in: PubMed
  54. Lancel S, Zhang J, Evangelista A, Trucillo MP, Tong X, Siwik DA, Cohen RA, Colucci WS. Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674. Circ Res. 2009 Mar 27; 104(6):720-3. PMID: 19265039.
    View in: PubMed
  55. Ying J, Sharov V, Xu S, Jiang B, Gerrity R, Schöneich C, Cohen RA. Cysteine-674 oxidation and degradation of sarcoplasmic reticulum Ca(2+) ATPase in diabetic pig aorta. Free Radic Biol Med. 2008 Sep 15; 45(6):756-62. PMID: 18590812.
    View in: PubMed
  56. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008 Jul 18; 283(29):20015-26. PMID: 18482975.
    View in: PubMed
  57. Park KM, Trucillo M, Serban N, Cohen RA, Bolotina VM. Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1183-7. PMID: 18156193.
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  58. Randriamboavonjy V, Pistrosch F, Bölck B, Schwinger RH, Dixit M, Badenhoop K, Cohen RA, Busse R, Fleming I. Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. Circulation. 2008 Jan 1; 117(1):52-60. PMID: 18071073.
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  59. Bayat H, Xu S, Pimentel D, Cohen RA, Jiang B. Activation of thromboxane receptor upregulates interleukin (IL)-1beta-induced VCAM-1 expression through JNK signaling. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):127-34. PMID: 18032781.
    View in: PubMed
  60. Tong X, Ying J, Pimentel DR, Trucillo M, Adachi T, Cohen RA. High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration. J Mol Cell Cardiol. 2008 Feb; 44(2):361-9. PMID: 18164028.
    View in: PubMed
  61. Schildknecht S, Daiber A, Ghisla S, Cohen RA, Bachschmid MM. Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite. FASEB J. 2008 Jan; 22(1):215-24. PMID: 17724253.
    View in: PubMed
  62. Ying J, Clavreul N, Sethuraman M, Adachi T, Cohen RA. Thiol oxidation in signaling and response to stress: detection and quantification of physiological and pathophysiological thiol modifications. Free Radic Biol Med. 2007 Oct 15; 43(8):1099-108. PMID: 17854705.
    View in: PubMed
  63. Ying J, Tong X, Pimentel DR, Weisbrod RM, Trucillo MP, Adachi T, Cohen RA. Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):783-90. PMID: 17234728.
    View in: PubMed
  64. Sethuraman M, Clavreul N, Huang H, McComb ME, Costello CE, Cohen RA. Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry. Free Radic Biol Med. 2007 Mar 15; 42(6):823-9. PMID: 17320764.
    View in: PubMed
  65. Cohen RA, McComb ME. Preconditioning enters the era of "physiological proteomics". Circ Res. 2006 Sep 29; 99(7):663-5. PMID: 17008594.
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  66. Clavreul N, Bachschmid MM, Hou X, Shi C, Idrizovic A, Ido Y, Pimentel D, Cohen RA. S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2454-61. PMID: 16931794.
    View in: PubMed
  67. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006 Aug; 55(8):2180-91. PMID: 16873680.
    View in: PubMed
  68. Zhao C, Sethuraman M, Clavreul N, Kaur P, Cohen RA, O'Connor PB. Detailed map of oxidative post-translational modifications of human p21ras using Fourier transform mass spectrometry. Anal Chem. 2006 Jul 15; 78(14):5134-42. PMID: 16841939.
    View in: PubMed
  69. Pimentel DR, Adachi T, Ido Y, Heibeck T, Jiang B, Lee Y, Melendez JA, Cohen RA, Colucci WS. Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation. J Mol Cell Cardiol. 2006 Oct; 41(4):613-22. PMID: 16806262.
    View in: PubMed
  70. Cohen RA, Adachi T. Nitric-oxide-induced vasodilatation: regulation by physiologic s-glutathiolation and pathologic oxidation of the sarcoplasmic endoplasmic reticulum calcium ATPase. Trends Cardiovasc Med. 2006 May; 16(4):109-14. PMID: 16713532.
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  71. Matsui R, Xu S, Maitland KA, Mastroianni R, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):910-6. PMID: 16439706.
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  72. Clavreul N, Adachi T, Pimental DR, Ido Y, Schöneich C, Cohen RA. S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. FASEB J. 2006 Mar; 20(3):518-20. PMID: 16415107.
    View in: PubMed
  73. Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH. Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. J Biol Chem. 2006 Mar 10; 281(10):6366-75. PMID: 16407220.
    View in: PubMed
  74. Xu S, Ying J, Jiang B, Guo W, Adachi T, Sharov V, Lazar H, Menzoian J, Knyushko TV, Bigelow D, Schöneich C, Cohen RA. Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2220-7. PMID: 16399855.
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  75. Xu S, Jiang B, Maitland KA, Bayat H, Gu J, Nadler JL, Corda S, Lavielle G, Verbeuren TJ, Zuccollo A, Cohen RA. The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. Diabetes. 2006 Jan; 55(1):110-9. PMID: 16380483.
    View in: PubMed
  76. Sethuraman M, McComb ME, Huang H, Huang S, Heibeck T, Costello CE, Cohen RA. Protein Modifications to Cellular Dysfunction and Diseases, Eds. Isabella Dalle-Donne, Andrea Scaloni and D. Allan Butterfield. ICAT (Isotope-coded affinity tag) approach to redox proteomics. John Wiley & Sons, Inc. 2006; 267-285.
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  78. Zuccollo A, Shi C, Mastroianni R, Maitland-Toolan KA, Weisbrod RM, Zang M, Xu S, Jiang B, Oliver-Krasinski JM, Cayatte AJ, Corda S, Lavielle G, Verbeuren TJ, Cohen RA. The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitus. Circulation. 2005 Nov 8; 112(19):3001-8. PMID: 16260636.
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  79. Matsui R, Xu S, Maitland KA, Hayes A, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005 Jul 12; 112(2):257-63. PMID: 15998684.
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  80. Kuster GM, Pimentel DR, Adachi T, Ido Y, Brenner DA, Cohen RA, Liao R, Siwik DA, Colucci WS. Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. Circulation. 2005 Mar 8; 111(9):1192-8. PMID: 15723974.
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  81. Cohen RA. The endothelium-derived hyperpolarizing factor puzzle: a mechanism without a mediator? Circulation. 2005 Feb 15; 111(6):724-7. PMID: 15710775.
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  83. Sethuraman M, McComb ME, Huang H, Huang S, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures. J Proteome Res. 2004 Nov-Dec; 3(6):1228-33. PMID: 15595732.
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  84. Adachi T, Weisbrod RM, Pimentel DR, Ying J, Sharov VS, Schöneich C, Cohen RA. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med. 2004 Nov; 10(11):1200-7. PMID: 15489859.
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  85. Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem. 2004 Nov 12; 279(46):47898-905. PMID: 15371448.
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  86. Cohen RA. ATVB in focus: Diabetic vascular disease: pathophysiological mechanisms in the diabetic milieu and therapeutic implications. Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):1340-1. PMID: 15297288.
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  87. Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA, Kagan HM, Cohen RA, Ravid K. A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem. 2004 Aug 1; 92(5):1034-43. PMID: 15258925.
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  88. Adachi T, Pimentel DR, Heibeck T, Hou X, Lee YJ, Jiang B, Ido Y, Cohen RA. S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J Biol Chem. 2004 Jul 9; 279(28):29857-62. PMID: 15123696.
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  89. Jiang B, Xu S, Hou X, Pimentel DR, Cohen RA. Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK. J Biol Chem. 2004 May 7; 279(19):20363-8. PMID: 15001568.
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  90. Zou MH, Cohen R, Ullrich V. Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. Endothelium. 2004 Mar-Apr; 11(2):89-97. PMID: 15370068.
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  91. Sethuraman M, McComb ME, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag approach to identify and quantify oxidant-sensitive protein thiols. Mol Cell Proteomics. 2004 Mar; 3(3):273-8. PMID: 14726493.
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  92. Cohen RA. Kardiovasculäre Medizin. Special issues in diabetes: nitric oxide and oxidants in diabetic vascular complications. 2004.
  93. Jiang B, Xu S, Hou X, Pimentel DR, Brecher P, Cohen RA. Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression. J Biol Chem. 2004 Jan 9; 279(2):1323-9. PMID: 14581482.
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  94. Zou MH, Hou XY, Shi CM, Kirkpatick S, Liu F, Goldman MH, Cohen RA. Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. J Biol Chem. 2003 Sep 5; 278(36):34003-10. PMID: 12824177.
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  95. Guo W, Adachi T, Matsui R, Xu S, Jiang B, Zou MH, Kirber M, Lieberthal W, Cohen RA. Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney. Am J Physiol Heart Circ Physiol. 2003 Oct; 285(4):H1396-403. PMID: 12791589.
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  96. Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6. PMID: 12546685.
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  97. Johns DG, Cohen RA. Thrombosis and Hemorrhage Third Edition, Eds. Joseph Loscalzo and Andrew I. Schafer. Endothelium-derived vasoactive factors. Lippincott Williams & Wilkins. Philadelphia, PA. 2003; 278-293.
  98. Jiang B, Xu S, Brecher P, Cohen RA. Growth factors enhance interleukin-1 beta-induced persistent activation of nuclear factor-kappa B in rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2002 Nov 1; 22(11):1811-6. PMID: 12426209.
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  99. Zou MH, Hou XY, Shi CM, Nagata D, Walsh K, Cohen RA. Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J Biol Chem. 2002 Sep 6; 277(36):32552-7. PMID: 12107173.
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  100. Adachi T, Matsui R, Xu S, Kirber M, Lazar HL, Sharov VS, Schöneich C, Cohen RA. Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation. Circ Res. 2002 May 31; 90(10):1114-21. PMID: 12039802.
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  101. Wang HD, Johns DG, Xu S, Cohen RA. Role of superoxide anion in regulating pressor and vascular hypertrophic response to angiotensin II. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1697-702. PMID: 11959633.
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  102. Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest. 2002 Mar; 109(6):817-26. PMID: 11901190.
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  103. Zou MH, Shi C, Cohen RA. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Diabetes. 2002 Jan; 51(1):198-203. PMID: 11756341.
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  104. Cohen RA. Does EDCF contribute to diabetic endothelial cell dysfunction?. Dialogues in Cardiovascular Medicine. 2002; 7(4):225-231.
  105. Jiang B, Brecher P, Cohen RA. Persistent activation of nuclear factor-kappaB by interleukin-1beta and subsequent inducible NO synthase expression requires extracellular signal-regulated kinase. Arterioscler Thromb Vasc Biol. 2001 Dec; 21(12):1915-20. PMID: 11742864.
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  106. Cayatte AJ, Rupin A, Oliver-Krasinski J, Maitland K, Sansilvestri-Morel P, Boussard MF, Wierzbicki M, Verbeuren TJ, Cohen RA. S17834, a new inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase. Arterioscler Thromb Vasc Biol. 2001 Oct; 21(10):1577-84. PMID: 11597929.
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  107. Adachi T, Matsui R, Weisbrod RM, Najibi S, Cohen RA. Reduced sarco/endoplasmic reticulum Ca(2+) uptake activity can account for the reduced response to NO, but not sodium nitroprusside, in hypercholesterolemic rabbit aorta. Circulation. 2001 Aug 28; 104(9):1040-5. PMID: 11524399.
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  108. Wang HD, Xu S, Johns DG, Du Y, Quinn MT, Cayatte AJ, Cohen RA. Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice. Circ Res. 2001 May 11; 88(9):947-53. PMID: 11349005.
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  109. Li Y, Adachi T, Bolotina VM, Knowles C, Ault KA, Cohen RA. Abnormal platelet function and calcium handling in Dahl salt-hypertensive rats. Hypertension. 2001 Apr; 37(4):1129-35. PMID: 11304514.
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  110. Cohen RA. Vascular Disease in Diabetes - A Report of the Hemovascular Study Group,. Ed. John Tooke. Nitric oxide bioavailability and diabetic endotheial cell dysfunction. Wells Healthcare Communications Limited. Kent, UK. 2001; 87-106.
  111. Cohen RA. Endothelial dysfunction in type 2 diabetes – a metabolic monitor and therapeutic target?. International Monitor in Peripheral Vascular Disease. 2001; 3:5-8.
  112. Trepakova ES, Gericke M, Hirakawa Y, Weisbrod RM, Cohen RA, Bolotina VM. Properties of a native cation channel activated by Ca2+ store depletion in vascular smooth muscle cells. J Biol Chem. 2001 Mar 16; 276(11):7782-90. PMID: 11113149.
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  113. Yaghoubi M, Oliver-Krasinski J, Cayatte AJ, Cohen RA. Decreased sensitivity to nitric oxide in the aorta of severely hypercholesterolemic apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 2000 Dec; 36(6):751-7. PMID: 11117375.
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  114. Trepakova ES, Csutora P, Hunton DL, Marchase RB, Cohen RA, Bolotina VM. Calcium influx factor directly activates store-operated cation channels in vascular smooth muscle cells. J Biol Chem. 2000 Aug 25; 275(34):26158-63. PMID: 10851243.
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  115. Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000 Aug; 106(4):483-91. PMID: 10953023.
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  116. Cayatte AJ, Du Y, Oliver-Krasinski J, Lavielle G, Verbeuren TJ, Cohen RA. The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis. Arterioscler Thromb Vasc Biol. 2000 Jul; 20(7):1724-8. PMID: 10894809.
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  117. Wang D, Yu X, Cohen RA, Brecher P. Distinct effects of N-acetylcysteine and nitric oxide on angiotensin II-induced epidermal growth factor receptor phosphorylation and intracellular Ca(2+) levels. J Biol Chem. 2000 Apr 21; 275(16):12223-30. PMID: 10766859.
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  118. Adachi T, Cohen RA. Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia. Br J Pharmacol. 2000 Mar; 129(5):1014-20. PMID: 10696103.
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  119. Cohen RA. Role of nitric oxide in vasomotor regulation. Nitric oxide and the cardiovascular system, Eds. J. Loscalzo, J.A. Vita. Humana Press. Totowa, New Jersey. 2000; 105-122.
  120. Verbeuren TJ, Bouskela E, Cohen RA, Vanhoutte PM. Regulation of adhesion molecules: a new target for the treatment of chronic venous insufficiency. Microcirculation. 2000; 7(6 Pt 2):S41-8. PMID: 11151971.
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  121. Pagano PJ, Griswold MC, Najibi S, Marklund SL, Cohen RA. Resistance of endothelium-dependent relaxation to elevation of O(-)(2) levels in rabbit carotid artery. Am J Physiol. 1999 Nov; 277(5 Pt 2):H2109-14. PMID: 10564167.
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  122. Hirakawa Y, Gericke M, Cohen RA, Bolotina VM. Ca(2+)-dependent Cl(-) channels in mouse and rabbit aortic smooth muscle cells: regulation by intracellular Ca(2+) and NO. Am J Physiol. 1999 Nov; 277(5 Pt 2):H1732-44. PMID: 10564126.
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  123. Di Wang H, Hope S, Du Y, Quinn MT, Cayatte A, Pagano PJ, Cohen RA. Paracrine role of adventitial superoxide anion in mediating spontaneous tone of the isolated rat aorta in angiotensin II-induced hypertension. Hypertension. 1999 May; 33(5):1225-32. PMID: 10334816.
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  124. Zhang H, Du Y, Cohen RA, Chobanian AV, Brecher P. Adventitia as a source of inducible nitric oxide synthase in the rat aorta. Am J Hypertens. 1999 May; 12(5):467-75. PMID: 10342784.
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  125. Cohen RA. The potential clinical impact of 20 years of nitric oxide research. Am J Physiol. 1999 Apr; 276(4 Pt 2):H1404-7. PMID: 10199869.
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  126. Trepakova ES, Cohen RA, Bolotina VM. Nitric oxide inhibits capacitative cation influx in human platelets by promoting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase-dependent refilling of Ca2+ stores. Circ Res. 1999 Feb 5; 84(2):201-9. PMID: 9933252.
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  128. Zakharov SI, Mongayt DA, Cohen RA, Bolotina VM. Monovalent cation and L-type Ca2+ channels participate in calcium paradox-like phenomenon in rabbit aortic smooth muscle cells. J Physiol. 1999 Jan 1; 514 ( Pt 1):71-81. PMID: 9831717.
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  129. Cohen, RA. Endothelium, Nitric Oxide, and Atherosclerosis, Eds. J.A. Panza, R.O. Canon III. Nitric oxide signaling mediating relaxation of vascular smooth muscle. Futura Publishing Co. Armonk, NY. 1999; 49-56.
  130. Verbeuren TJ, Vallez MO, Rupin A, Wierzbicki M, Cayatte A, Cohen RA, Bouskela E. Prog Appl Microcirc. New synthetic diosmetin derivatives: effects on different experimental models of the microcirculation, Microcirculation in Chronic Venous Insufficiency Ed: Messmer, K. Karger. Basel. 1999; 23:104-113.
  131. Zakharov SL, Cohen RA, Bolotina VM. Endothelium-Dependent Hyperpolarizations, Ed. P.M. Vanhoutte. The role of nonselective cation current in regulation of membrane potential in vascular smooth muscle cells. Harwood Academic Publishers. Courbevoie Cedex, France. 1999; 243-252.
  132. Cohen RA, Weisbrod RM, Griswold MC, Plane F, Garland CJ, Malonski T, Komalavilas P, Lincoln TM. Endothelium-Dependent Hyperpolarizations, Eds. P.M. Vanhoutte. Hyperpolarization and relaxation of vascular smooth muscle to endothelium-derived nitric oxide. Harwood Academic Publishers. Courbevoie Cedex, France. 1999; 117-124.
  133. Cohen RA. Is type 1 diabetes a useful model for type 2 diabetic vascular disease?. Medicographia. 1999; 52(4):334.
  134. Weisbrod RM, Griswold MC, Yaghoubi M, Komalavilas P, Lincoln TM, Cohen RA. Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide. Br J Pharmacol. 1998 Dec; 125(8):1695-707. PMID: 9886761.
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  135. Wang HD, Pagano PJ, Du Y, Cayatte AJ, Quinn MT, Brecher P, Cohen RA. Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide. Circ Res. 1998 Apr 20; 82(7):810-8. PMID: 9562441.
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  136. Plane F, Wiley KE, Jeremy JY, Cohen RA, Garland CJ. Evidence that different mechanisms underlie smooth muscle relaxation to nitric oxide and nitric oxide donors in the rabbit isolated carotid artery. Br J Pharmacol. 1998 Apr; 123(7):1351-8. PMID: 9579730.
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  137. Cohen RA. Thrombosis and Hemorrhage, Second Edition, Eds. J. Loscalzo, A.I. Schafer. Endothelium-derived vasoactive factors. Williams & Wilkens. Baltimore, MD. 1998; 387-404.
  138. Pagano PJ, Griswold MC, Ravel D, Cohen RA. Vascular action of the hypoglycaemic agent gliclazide in diabetic rabbits. Diabetologia. 1998 Jan; 41(1):9-15. PMID: 9498623.
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  139. Cohen R. [Glycotoxicity and mediators: nitric oxide, arachidonic acid, superoxide anion]. Therapie. 1997 Sep-Oct; 52(5):387-8. PMID: 9501562.
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  141. Weisbrod RM, Griswold MC, Du Y, Bolotina VM, Cohen RA. Reduced responsiveness of hypercholesterolemic rabbit aortic smooth muscle cells to nitric oxide. Arterioscler Thromb Vasc Biol. 1997 Feb; 17(2):394-402. PMID: 9081696.
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  142. Cohen RA. Endothelial dysfunction in diabetic vascular disease. Medicographia. 1997; 157-161.
  143. Diaz MN, Cohen RA. Textbook of Coronary Thrombosis and Thrombolysis, Ed. C. Becker. Coronary vascular pharmacology. Kluwer Academic Publishers. Norwell, MA. 1997; 155-168.
  144. Cohen RA, Pagano PJ. Endothelium in Hypertension. D. Webb, P. Vallance Eds. Other factors in endothelial cell dysfunction in hypertension and diabetes. Springer-Verlag. Heidelberg. 1997; 39-51.
  145. Gupta S, Yang S, Cohen RA, Krane RJ, Saenz De Tejada I. Altered contractility of urinary bladder in diabetic rabbits: relationship to reduced Na+ pump activity. Am J Physiol. 1996 Dec; 271(6 Pt 1):C2045-52. PMID: 8997207.
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  146. Ito Y, Pagano PJ, Tornheim K, Brecher P, Cohen RA. Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aorta. Am J Physiol. 1996 Jan; 270(1 Pt 2):H81-7. PMID: 8769737.
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  147. Khan F, Cohen RA, Ruderman NB, Chipkin SR, Coffman JD. Vasodilator responses in the forearm skin of patients with insulin-dependent diabetes mellitus. Vasc Med. 1996; 1(3):187-93. PMID: 9546937.
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  148. Cohen RA. Plasticity of Vascular Form and Function. The International Monitor - Peripheral Vascular Disease. 1996; 2:1-3.
  149. Cohen RA, Najibi S, Bolotina VM. Endothelium-Derived Hyperpolarizing Factor . P.M. Vanhoutte, Ed. The other role of nitric oxide as an endothelium-derived hyperpolarizing factor. Harwood Academic Publishers. 1996; 161-172.
  150. Cohen RA. Vasoreactivity of human vessels, Fabiani J.-N., Yacoub, M., Carpentier, A., Eds. Diabetes mellitus and endothelial vasomotor function. A. Blackwell S.A. Paris. 1996; 27-36.
  151. Faller DV, Barnett H, Weisbrod R, Cohen RA. Regulation of nitric oxide synthase induction in cultured vascular smooth muscle cells by lipopolysaccharide and interferon. Endothelium. 1996; 4:99-112.
  152. Cohen RA, Vanhoutte PM. Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP. Circulation. 1995 Dec 1; 92(11):3337-49. PMID: 7586323.
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  153. Hou J, Kato H, Cohen RA, Chobanian AV, Brecher P. Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase. J Clin Invest. 1995 Nov; 96(5):2469-77. PMID: 7593636.
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  154. Cohen RA. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Dis. 1995 Sep-Oct; 38(2):105-28. PMID: 7568902.
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  155. Najibi S, Cohen RA. Enhanced role of K+ channels in relaxations of hypercholesterolemic rabbit carotid artery to NO. Am J Physiol. 1995 Sep; 269(3 Pt 2):H805-11. PMID: 7573521.
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  156. Fonger JD, Yang XM, Cohen RA, Haudenschild CC, Shemin RJ. Human mammary artery endothelial sparing with fibrous jaw clamping. Ann Thorac Surg. 1995 Sep; 60(3):551-5. PMID: 7677479.
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  157. Pagano PJ, Ito Y, Tornheim K, Gallop PM, Tauber AI, Cohen RA. An NADPH oxidase superoxide-generating system in the rabbit aorta. Am J Physiol. 1995 Jun; 268(6 Pt 2):H2274-80. PMID: 7611477.
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  158. Tesfamariam B, Brown ML, Cohen RA. 15-Hydroxyeicosatetraenoic acid and diabetic endothelial dysfunction in rabbit aorta. J Cardiovasc Pharmacol. 1995 May; 25(5):748-55. PMID: 7630153.
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  159. Tesfamariam B, Cohen RA. Enhanced adrenergic neurotransmission in diabetic rabbit carotid artery. Cardiovasc Res. 1995 Apr; 29(4):549-54. PMID: 7540957.
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  160. Stegeman JJ, Hahn ME, Weisbrod R, Woodin BR, Joy JS, Najibi S, Cohen RA. Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Mol Pharmacol. 1995 Feb; 47(2):296-306. PMID: 7870038.
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  161. Cayatte AJ, Palacino JJ, Horten K, Cohen RA. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb. 1994 May; 14(5):753-9. PMID: 7513551.
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  162. Najibi S, Cowan CL, Palacino JJ, Cohen RA. Enhanced role of potassium channels in relaxations to acetylcholine in hypercholesterolemic rabbit carotid artery. Am J Physiol. 1994 May; 266(5 Pt 2):H2061-7. PMID: 7515589.
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  163. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature. 1994 Apr 28; 368(6474):850-3. PMID: 7512692.
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  164. Coffman JD, Cohen RA. Plasma levels of 5-hydroxytryptamine during sympathetic stimulation and in Raynaud's phenomenon. Clin Sci (Lond). 1994 Mar; 86(3):269-73. PMID: 8156737.
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  165. Shepherd JT, Bergan JJ, Cohen RA, Hawiger JJ, Hillis LD, Katzen BT, Mohr JP. Report of the Task Force on Vascular Medicine. Circulation. 1994 Jan; 89(1):532-5. PMID: 8281694.
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  166. Tesfamariam B, Gupta S, Oates PJ, Ruderman NB, Cohen RA. Reduced Na(+)-K+ pump activity in diabetic rabbit carotid artery: reversal by aldose reductase inhibition. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1189-94. PMID: 8238405.
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  167. Cohen RA. Pathways controlling healthy and diseased arterial smooth muscle. Am J Cardiol. 1993 Sep 9; 72(8):39C-46C; discussion 46C-47C. PMID: 8372800.
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  168. Cowan CL, Palacino JJ, Najibi S, Cohen RA. Potassium channel-mediated relaxation to acetylcholine in rabbit arteries. J Pharmacol Exp Ther. 1993 Sep; 266(3):1482-9. PMID: 8396636.
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  169. Khan F, Palacino JJ, Coffman JD, Cohen RA. Chronic inhibition of nitric oxide production augments skin vasoconstriction in the rabbit ear. J Cardiovasc Pharmacol. 1993 Aug; 22(2):280-6. PMID: 7692170.
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  170. Pagano PJ, Tornheim K, Cohen RA. Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide. Am J Physiol. 1993 Aug; 265(2 Pt 2):H707-12. PMID: 7690193.
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  171. Simon BC, Haudenschild CC, Cohen RA. Preservation of endothelium-dependent relaxation in atherosclerotic rabbit aorta by probucol. J Cardiovasc Pharmacol. 1993 Jun; 21(6):893-901. PMID: 7687713.
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  172. Weisbrod RM, Brown ML, Cohen RA. Effect of elevated glucose on cyclic GMP and eicosanoids produced by porcine aortic endothelium. Arterioscler Thromb. 1993 Jun; 13(6):915-23. PMID: 8388714.
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  173. Tesfamariam B, Palacino JJ, Weisbrod RM, Cohen RA. Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J Cardiovasc Pharmacol. 1993 Feb; 21(2):205-11. PMID: 7679153.
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  174. Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation. 1993; 87:V67-V76.
  175. Fonger JD, Yang XM, Cohen RA, Haudenschild CC, Shemin RJ. Impaired relaxation of the human mammary artery after temporary clamping. J Thorac Cardiovasc Surg. 1992 Oct; 104(4):966-71. PMID: 1405697.
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  176. Tesfamariam B, Brown ML, Cohen RA. Aldose reductase and myo-inositol in endothelial cell dysfunction caused by elevated glucose. J Pharmacol Exp Ther. 1992 Oct; 263(1):153-7. PMID: 1403781.
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  177. Tesfamariam B, Weisbrod RM, Cohen RA. Cyclic GMP modulators on vascular adrenergic neurotransmission. J Vasc Res. 1992 Sep-Oct; 29(5):396-404. PMID: 1358232.
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  178. Gupta S, Sussman I, McArthur CS, Tornheim K, Cohen RA, Ruderman NB. Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest. 1992 Sep; 90(3):727-32. PMID: 1325996.
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  179. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol. 1992 Aug; 263(2 Pt 2):H321-6. PMID: 1510128.
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  180. Tesfamariam B, Cohen RA. Role of superoxide anion and endothelium in vasoconstrictor action of prostaglandin endoperoxide. Am J Physiol. 1992 Jun; 262(6 Pt 2):H1915-9. PMID: 1320340.
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  181. Simon BC, Cohen RA. EDTA influences reactivity of isolated aorta from hypercholesterolemic rabbits. Am J Physiol. 1992 May; 262(5 Pt 2):H1606-10. PMID: 1590466.
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  182. Cunningham LD, Brecher P, Cohen RA. Platelet-derived growth factor receptors on macrovascular endothelial cells mediate relaxation via nitric oxide in rat aorta. J Clin Invest. 1992 Mar; 89(3):878-82. PMID: 1311719.
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  183. Cowan CL, Cohen RA. Different mechanisms of relaxation of pig coronary artery to bradykinin and cromakalim are distinguished by potassium channel blockers. J Pharmacol Exp Ther. 1992 Jan; 260(1):248-53. PMID: 1731041.
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  184. Azadzoi KM, Kim N, Brown ML, Goldstein I, Cohen RA, Saenz de Tejada I. Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. J Urol. 1992 Jan; 147(1):220-5. PMID: 1370329.
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  185. Coffman JD, Cohen RA. Current Management of Hypertensive and Vascular Disease. J.P. Cooke and E.D. Frohlich, Eds. Raynaud's Phenomenon. Mosby Year Book. St. Louis, MO. 1992; 244-247.
  186. Shepherd JT, Cohen RA, Katusic ZS. Vascular Diseases in the Limbs: Mechanisms and Principles of Treatment. J.T. Shepherd and D. Clement, Eds. Endothelium dysfunction in vascular disease. Mosby Year Book. St. Louis, MO. 1992; 1-22.
  187. Cohen RA, Tesfamariam B. Hyperglycemia, Diabetes and Vascular Disease. N. Ruderman, Ed. Diabetes mellitus and the vascular endothelium. Oxford University Press. New York. 1992; 44-49.
  188. Cohen RA. Endothelial Regulation of Vascular Tone, U. Ryan and G. Rubanyi, Eds. The role of the endothelium in vascular adrenergic neurotransmission. Marcel-Dekker, Inc. New York. 1992; 155-169.
  189. Cowan CL, Cohen RA. Two mechanisms mediate relaxation by bradykinin of pig coronary artery: NO-dependent and -independent responses. Am J Physiol. 1991 Sep; 261(3 Pt 2):H830-5. PMID: 1653538.
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  190. Tesfamariam B, Brown ML, Cohen RA. Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest. 1991 May; 87(5):1643-8. PMID: 2022734.
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  191. Takasaki I, Cohen RA, Chobanian AV, Brecher P. Effect of endothelial cell denudation on fatty acid metabolism by rabbit aorta. Am J Physiol. 1990 Aug; 259(2 Pt 2):H442-7. PMID: 2117402.
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  192. Blanco R, Saenz de Tejada I, Goldstein I, Krane RJ, Wotiz HH, Cohen RA. Dysfunctional penile cholinergic nerves in diabetic impotent men. J Urol. 1990 Aug; 144(2 Pt 1):278-80. PMID: 2374191.
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  193. Cohen RA, Tesfamariam B, Weisbrod RM, Zitnay KM. Adrenergic denervation in rabbits with diabetes mellitus. Am J Physiol. 1990 Jul; 259(1 Pt 2):H55-61. PMID: 2375413.
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  194. Simon BC, Cunningham LD, Cohen RA. Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J Clin Invest. 1990 Jul; 86(1):75-9. PMID: 2365828.
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  195. Beasley D, Cohen RA, Levinsky NG. Endotoxin inhibits contraction of vascular smooth muscle in vitro. Am J Physiol. 1990 Apr; 258(4 Pt 2):H1187-92. PMID: 2184681.
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  196. Tesfamariam B, Brown ML, Deykin D, Cohen RA. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J Clin Invest. 1990 Mar; 85(3):929-32. PMID: 2312734.
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  197. Cohen RA, Tesfamariam B, Weisbrod RM. Endothelium Derived Vasoactive Factors, G. M. Rubanyi and P. M. Vanhoutte, Eds. Endothelium inhibits adrenergic neurotransmission. Karger Publications. New York. 1990; 206-212.
  198. Coffman JD, Cohen RA. Alpha -2-adrenergic and 5-HT2 receptor hypersensitivity in Raynaud's phenomenon. J. Vasc. Med. Biol. 1990; 2:100-106.
  199. Tesfamariam B, Weisbrod RM, Cohen RA. The endothelium inhibits activation by calcium of vascular neurotransmission. Am J Physiol. 1989 Dec; 257(6 Pt 2):H1871-7. PMID: 2481404.
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  200. Tesfamariam B, Jakubowski JA, Cohen RA. Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2. Am J Physiol. 1989 Nov; 257(5 Pt 2):H1327-33. PMID: 2511765.
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  201. Tesfamariam B, Weisbrod RM, Cohen RA. Augmented adrenergic contractions of carotid arteries from cholesterol-fed rabbits due to endothelial cell dysfunction. J Cardiovasc Pharmacol. 1989 Jun; 13(6):820-5. PMID: 2484075.
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  202. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med. 1989 Apr 20; 320(16):1025-30. PMID: 2927481.
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  203. Beasley D, Cohen RA, Levinsky NG. Interleukin 1 inhibits contraction of vascular smooth muscle. J Clin Invest. 1989 Jan; 83(1):331-5. PMID: 2783426.
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  204. Cohen RA, Coffman JD. Reduced fingertip arterial pressures in Raynaud's Disease. J. Vasc. Med. Biol. 1989; 1:21-26.
  205. Cohen RA. Peripheral actions of 5Ähydroxytryptamine, Ed. J. R. Fozard. Interaction of 5-hydroxytryptamine with endothelial cells. Oxford University Press. Oxford. 1989.
  206. Cohen RA, Zitnay KM, Haudenschild CC, Cunningham LD. Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ Res. 1988 Nov; 63(5):903-10. PMID: 2460269.
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  207. Tesfamariam B, Cohen RA. Inhibition of adrenergic vasoconstriction by endothelial cell shear stress. Circ Res. 1988 Oct; 63(4):720-5. PMID: 2458859.
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  208. Coffman JD, Cohen RA. Role of alpha-adrenoceptor subtypes mediating sympathetic vasoconstriction in human digits. Eur J Clin Invest. 1988 Jun; 18(3):309-13. PMID: 2843379.
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  209. Coffman JD, Cohen RA. Serotonergic vasoconstriction in human fingers during reflex sympathetic response to cooling. Am J Physiol. 1988 May; 254(5 Pt 2):H889-93. PMID: 3364592.
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  210. Cohen RA, Weisbrod RM. Endothelium inhibits norepinephrine release from adrenergic nerves of rabbit carotid artery. Am J Physiol. 1988 May; 254(5 Pt 2):H871-8. PMID: 2896464.
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  211. Saenz de Tejada I, Blanco R, Goldstein I, Azadzoi K, de las Morenas A, Krane RJ, Cohen RA. Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue. Am J Physiol. 1988 Mar; 254(3 Pt 2):H459-67. PMID: 2894778.
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  212. Blanco R, Saenz de Tejada I, Goldstein I, Krane RJ, Wotiz HH, Cohen RA. Cholinergic neurotransmission in human corpus cavernosum. II. Acetylcholine synthesis. Am J Physiol. 1988 Mar; 254(3 Pt 2):H468-72. PMID: 2831739.
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  213. Cohen RA, Zitnay KM, Weisbrod RM, Tesfamariam B. Influence of the endothelium on tone and the response of isolated pig coronary artery to norepinephrine. J Pharmacol Exp Ther. 1988 Feb; 244(2):550-5. PMID: 2450195.
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  214. Coffman JD, Cohen RA. Alpha-adrenergic and serotonergic mechanisms in the human digit. J Cardiovasc Pharmacol. 1988; 11 Suppl 1:S49-53. PMID: 2459515.
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  215. Cohen, RA. Vasodilation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium. P. M. Vanhoutte, Ed. Platelet-derived serotonin and the vascular wall. Raven Press,Ltd. New York. 1988.
  216. Cohen RA. Platelet 5 hydroxytryptamine and vascular adrenergic nerves. News in Physiol. Sci. 1988; 3:185-189.
  217. Cohen RA, Zitnay KM, Weisbrod RM. Accumulation of 5-hydroxytryptamine leads to dysfunction of adrenergic nerves in canine coronary artery following intimal damage in vivo. Circ Res. 1987 Dec; 61(6):829-33. PMID: 3677339.
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  218. Tesfamariam B, Weisbrod RM, Cohen RA. Endothelium inhibits responses of rabbit carotid artery to adrenergic nerve stimulation. Am J Physiol. 1987 Oct; 253(4 Pt 2):H792-8. PMID: 3499086.
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  219. Cohen RA. Inhibition of adrenergic neurotransmission in canine tibial artery after exposure to 5-hydroxytryptamine in vitro. J Pharmacol Exp Ther. 1987 Aug; 242(2):493-9. PMID: 3039118.
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  220. Coffman JD, Cohen RA. Intra-arterial vasodilator agents to reverse human finger vasoconstriction. Clin Pharmacol Ther. 1987 May; 41(5):574-9. PMID: 3105944.
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  221. Coffman JD, Cohen RA. Cholinergic vasodilator mechanism in human fingers. Am J Physiol. 1987 Mar; 252(3 Pt 2):H594-7. PMID: 3548439.
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  222. Cohen RA, Zitnay KM. Adenosine diphosphate potentiates the inhibition of norepinephrine-induced relaxation by 5-hydroxytryptamine in canine coronary arteries. Eur J Pharmacol. 1987 Jan 20; 133(3):335-40. PMID: 3493910.
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  223. Cohen, RA. Neuronal Messengers in Vascular Function, A. Nobin, C. Owman, B. Arneklo-Nobin, Eds. Vascular responses to platelets. Elsevier. Amsterdam. 1987; 75-83.
  224. Cohen RA. Contractions of isolated canine coronary arteries resistant to S2-serotonergic blockade. J Pharmacol Exp Ther. 1986 May; 237(2):548-52. PMID: 2939235.
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  225. Cohen RA. Adenine nucleotides and 5-hydroxytryptamine released by aggregating platelets inhibit adrenergic neurotransmission in canine coronary artery. J Clin Invest. 1986 Feb; 77(2):369-75. PMID: 3003158.
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  226. Cohen RA. Serotonin and the blood vessel wall. J. Hypertension. 1986; 4:S116-S118.
  227. Cohen RA. Recent Advances in Arterial Disease: Atherosclerosis, Hypertension, and Vasospasm, T. N. Tulenko and R. H. Cox, Eds. Role of autonomic nerves and endothelium in coronary vasospasm. A. R. Liss, Inc. New York. 1986.
  228. Cohen RA. Serotonergic prejunctional inhibition of canine coronary adrenergic nerves. J Pharmacol Exp Ther. 1985 Oct; 235(1):76-80. PMID: 4045729.
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  229. Cohen RA. Platelet-induced neurogenic coronary contractions due to accumulation of the false neurotransmitter, 5-hydroxytryptamine. J Clin Invest. 1985 Jan; 75(1):286-92. PMID: 3965509.
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  230. Cohen RA, Vanhoutte PM. Serotonin and the Cardiovascular System. Ed. P. M. Vanhoutte. Platelets, serotonin, and endothelial cells. Raven Press. New York. 1985.
  231. Vanhoutte PM, Cohen RA. Effects of acetylcholine on the coronary artery. Fed Proc. 1984 Nov; 43(14):2878-80. PMID: 6489530.
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  232. Cohen RA, Shepherd JT, Vanhoutte PM. Effects of the adrenergic transmitter on epicardial coronary arteries. Fed Proc. 1984 Nov; 43(14):2862-6. PMID: 6386529.
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  233. Cohen RA, Shepherd JT, Vanhoutte PM. Endothelium and asymmetrical responses of the coronary arterial wall. Am J Physiol. 1984 Sep; 247(3 Pt 2):H403-8. PMID: 6476135.
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  234. Cohen RA, Shepherd JT, Vanhoutte PM. Neurogenic cholinergic prejunctional inhibition of sympathetic beta adrenergic relaxation in the canine coronary artery. J Pharmacol Exp Ther. 1984 May; 229(2):417-21. PMID: 6325664.
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  235. Coffman JD, Cohen RA, Rasmussen HM. The effect of histamine on the human fingertip circulation. Clin Sci (Lond). 1984 Mar; 66(3):343-9. PMID: 6692664.
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  236. Cohen RA, Shepherd JT, Vanhoutte PM. Vasodilatation mediated by the coronary endothelium in response to aggregating platelets. Bibl Cardiol. 1984; (38):35-42. PMID: 6532453.
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  237. Vanhoutte PM, Cohen RA, Van Nueten JM. Serotonin and arterial vessels. J Cardiovasc Pharmacol. 1984; 6 Suppl 2:S421-8. PMID: 6206351.
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  238. Cohen RA, Coffman JD. Digital vasospasm: The pathophysiology of Raynaud's phenomenon. Int. Angiol. 1984; 3:47-55.
  239. Vanhoutte PM, Cohen RA. The elusory role of serotonin in vascular function and disease. Biochem Pharmacol. 1983 Dec 15; 32(24):3671-4. PMID: 6362673.
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  240. Cohen RA, Shepherd JT, Vanhoutte PM. 5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries. Am J Physiol. 1983 Dec; 245(6):H1077-80. PMID: 6660308.
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  241. Halperin JL, Cohen RA, Coffman JD. Digital vasodilatation during mental stress in patients with Raynaud's disease. Cardiovasc Res. 1983 Nov; 17(11):671-7. PMID: 6652643.
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  242. Vanhoutte PM, Cohen RA. Calcium-entry blockers and cardiovascular disease. Am J Cardiol. 1983 Jul 20; 52(2):99A-103A. PMID: 6869263.
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  243. Cohen RA, Shepherd JT, Vanhoutte PM. Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets. Science. 1983 Jul 15; 221(4607):273-4. PMID: 6574604.
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  244. Cohen RA, Shepherd JT, Vanhoutte PM. Prejunctional and postjunctional actions of endogenous norepinephrine at the sympathetic neuroeffector junction in canine coronary arteries. Circ Res. 1983 Jan; 52(1):16-25. PMID: 6129074.
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  245. Rooke T, Cohen RA, Verbeuren TJ, Vanhoutte PM. Non-neurogenic inhibitory effect of electrical impulses in isolated canine coronary arteries. Eur J Pharmacol. 1982 May 21; 80(2-3):251-4. PMID: 7106182.
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  246. Cohen RA, Coffman JD. Beta-adrenergic vasodilator mechanism in the finger. Circ Res. 1981 Nov; 49(5):1196-201. PMID: 6117377.
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  247. Coffman JD, Cohen RA. Vasospasm--ubiquitous? N Engl J Med. 1981 Mar 26; 304(13):780-2. PMID: 7464888.
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  248. Cohen RA, Coffman JD. Effect of morphine on limb capacitance and resistance vessels. Clin Sci (Lond). 1981 Jan; 60(1):5-9. PMID: 7237924.
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  249. Cohen RA, Coffman JD. Naloxone reversal of morphine-induced peripheral vasodilatation. Clin Pharmacol Ther. 1980 Oct; 28(4):541-4. PMID: 7408414.
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  250. Cohen RA, Cuatrecasas P. Stimulation and modulation of adenylate cyclase by Sendai virus. Life Sci. 1976 Nov 15; 19(10):1537-42. PMID: 186672.
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  251. Butcher SS, Cohen RA, Rounds TC. Microwave Spectrum of 1,2 -difluorethane. J. Chem. Phys. 1971; 54:4323.
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