Keywords
Last Name

Nelson Ruiz-Opazo, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-4384
ORCID ORCID Icon0000-0001-8234-1332
 Research Expertise & Professional Interests
Expertise includes molecular biology and genetics.

 Self-Described Keywords
  • genetics
  • hypertension
  • learning and memory
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Colby AH, Berry S, Moran AM, Pasion KA, Liu R, Colson YL, Ruiz-Opazo N, Grinstaff MW, Herrera VL. Highly Specific and Sensitive Fluorescent Nanoprobes for Image-Guided Resection of Sub-Millimeter Peritoneal Tumors. ACS Nano. 2017 Jan 18. PMID: 28099801.
    View in: PubMed
  2. Herrera VL, Steffen M, Moran AM, Tan GA, Pasion KA, Rivera K, Pappin DJ, Ruiz-Opazo N. Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein. BMC Mol Biol. 2016 Jun 14; 17(1):15. PMID: 27301377.
    View in: PubMed
  3. Herrera VL, Colby AH, Tan GA, Moran AM, O'Brien MJ, Colson YL, Ruiz-Opazo N, Grinstaff MW. Evaluation of expansile nanoparticle tumor localization and efficacy in a cancer stem cell-derived model of pancreatic peritoneal carcinomatosis. Nanomedicine (Lond). 2016 May; 11(9):1001-15. PMID: 27078118.
    View in: PubMed
  4. Decano JL, Pasion KA, Black N, Giordano NJ, Herrera VL, Ruiz-Opazo N. Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats. BMC Genet. 2016; 17:19. PMID: 26754450.
    View in: PubMed
  5. Herrera VL, Pasion KA, Moran AM, Zaninello R, Ortu MF, Fresu G, Piras DA, Argiolas G, Troffa C, Glorioso V, Masala W, Glorioso N, Ruiz-Opazo N. A functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population. PLoS One. 2015; 10(1):e0116724. PMID: 25615575.
    View in: PubMed
  6. Herrera VL, Decano JL, Giordano N, Moran AM, Ruiz-Opazo N. Aortic and carotid arterial stiffness and epigenetic regulator gene expression changes precede blood pressure rise in stroke-prone Dahl salt-sensitive hypertensive rats. PLoS One. 2014; 9(9):e107888. PMID: 25229245.
    View in: PubMed
  7. Herrera VL, Decano JL, Tan GA, Moran AM, Pasion KA, Matsubara Y, Ruiz-Opazo N. DEspR roles in tumor vasculo-angiogenesis, invasiveness, CSC-survival and anoikis resistance: a 'common receptor coordinator' paradigm. PLoS One. 2014; 9(1):e85821. PMID: 24465725.
    View in: PubMed
  8. Glorioso N, Herrera VL, Didishvili T, Ortu MF, Zaninello R, Fresu G, Argiolas G, Troffa C, Ruiz-Opazo N. Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population. PLoS One. 2013; 8(10):e77562. PMID: 24147025.
    View in: PubMed
  9. Herrera VL, Ponce LR, Ruiz-Opazo N. Multiple susceptibility loci for radiation-induced mammary tumorigenesis in F2[Dahl S x R]-intercross rats. PLoS One. 2013; 8(8):e72143. PMID: 23967281.
    View in: PubMed
  10. Herrera VL, Pasion KA, Tan GA, Moran AM, Ruiz-Opazo N. Sex-specific effects on spatial learning and memory, and sex-independent effects on blood pressure of a <3.3 Mbp rat chromosome 2 QTL region in Dahl salt-sensitive rats. PLoS One. 2013; 8(7):e67673. PMID: 23861781.
    View in: PubMed
  11. Herrera VL, Pasion KA, Tan GA, Ruiz-Opazo N. Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp. PLoS One. 2013; 8(2):e58280. PMID: 23469157.
    View in: PubMed
  12. Herrera VL, Pasion KA, Moran AM, Ruiz-Opazo N. Worse renal disease in postmenopausal F2[Dahl S x R]-intercross rats: detection of novel QTLs affecting hypertensive kidney disease. PLoS One. 2013; 8(2):e56096. PMID: 23393608.
    View in: PubMed
  13. Decano JL, Moran AM, Giordano N, Ruiz-Opazo N, Herrera VL. Analysis of CD45- [CD34+/KDR+] endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic stroke. PLoS One. 2013; 8(1):e55222. PMID: 23383116.
    View in: PubMed
  14. Herrera VL, Pasion KA, Moran AM, Ruiz-Opazo N. Differential genetic basis for pre-menopausal and post-menopausal salt-sensitive hypertension. PLoS One. 2012; 7(8):e43160. PMID: 22912817.
    View in: PubMed
  15. Herrera VL, Matsubara Y, Ponce LR, Ruiz-Opazo N. Distinct QTLs cosegregate with worse hypertension and renal disease in ovariectomized F2[Dahl S × R]-intercross rats. J Hypertens. 2012 Aug; 30(8):1572-80. PMID: 22688265.
    View in: PubMed
  16. Herrera VL, Pasion KA, Moran AM, Ruiz-Opazo N. Dahl (S x R) congenic strain analysis confirms and defines a chromosome 5 female-specific blood pressure quantitative trait locus to <7 Mbp. PLoS One. 2012; 7(7):e42214. PMID: 22860086.
    View in: PubMed
  17. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
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  18. Decano JL, Moran AM, Ruiz-Opazo N, Herrera VL. Molecular imaging of vasa vasorum neovascularization via DEspR-targeted contrast-enhanced ultrasound micro-imaging in transgenic atherosclerosis rat model. Mol Imaging Biol. 2011 Dec; 13(6):1096-106. PMID: 20972637.
    View in: PubMed
  19. Glorioso N, Herrera VL, Didishvili T, Argiolas G, Troffa C, Bulla P, Bulla E, Ruiz-Opazo N. DEspR T/CATAAAA-box promoter variant decreases DEspR transcription and is associated with increased BP in Sardinian males. Physiol Genomics. 2011 Nov 7; 43(21):1219-25. PMID: 21862670.
    View in: PubMed
  20. Bergerat A, Decano J, Wu CJ, Choi H, Nesvizhskii AI, Moran AM, Ruiz-Opazo N, Steffen M, Herrera VL. Prestroke proteomic changes in cerebral microvessels in stroke-prone, transgenic[hCETP]-Hyperlipidemic, Dahl salt-sensitive hypertensive rats. Mol Med. 2011; 17(7-8):588-98. PMID: 21519634.
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  21. Herrera VL, Bagamasbad P, Decano JL, Ruiz-Opazo N. AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice. Physiol Genomics. 2011 Jan 7; 43(1):32-42. PMID: 20923861.
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  22. Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24; 119(11):1501-9. PMID: 19273719.
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  23. Herrera VL, Decano JL, Steffen M, Ruiz-Opazo N. Autophagy: insights from DEspR-deficiency and haploinsufficiency. Autophagy. 2009 Feb; 5(2):259-62. PMID: 19139631.
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  24. Herrera VL, Decano JL, Bagamasbad P, Kufahl T, Steffen M, Ruiz-Opazo N. Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice. Physiol Genomics. 2008 Nov 12; 35(3):316-29. PMID: 18780760.
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  25. Herrera VL, Bagamasbad P, Didishvili T, Decano JL, Ruiz-Opazo N. Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR. Physiol Genomics. 2008 Jun 12; 34(1):65-77. PMID: 18413781.
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  26. Herrera VL, Ponce LR, Ruiz-Opazo N. Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats. J Hypertens. 2007 Aug; 25(8):1608-12. PMID: 17620956.
    View in: PubMed
  27. Glorioso N, Herrera VL, Bagamasbad P, Filigheddu F, Troffa C, Argiolas G, Bulla E, Decano JL, Ruiz-Opazo N. Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects. Circ Res. 2007 May 25; 100(10):1522-9. PMID: 17446437.
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  28. Kotlo K, Hughes DE, Herrera VL, Ruiz-Opazo N, Costa RH, Robey RB, Danziger RS. Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat. Hypertension. 2007 Mar; 49(3):467-72. PMID: 17242304.
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  29. Ruiz-Opazo N, Tonkiss J. Genome-wide scan for quantitative trait loci influencing spatial navigation and social recognition memory in Dahl rats. Physiol Genomics. 2006 Jul 12; 26(2):145-51. PMID: 16837653.
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  30. Herrera VL, Tsikoudakis A, Ponce LR, Matsubara Y, Ruiz-Opazo N. Sex-specific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S/jrHS hypertensive rats. Physiol Genomics. 2006 Aug 16; 26(3):172-9. PMID: 16720678.
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  31. Herrera VL, Ponce LR, Bagamasbad PD, VanPelt BD, Didishvili T, Ruiz-Opazo N. Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis. Physiol Genomics. 2005 Nov 17; 23(3):257-68. PMID: 16293765.
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  32. Herrera VL, Ruiz-Opazo N. Genetic studies in rat models: insights into cardiovascular disease. Curr Opin Lipidol. 2005 Apr; 16(2):179-91. PMID: 15767858.
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  33. Kaneko Y, Cloix JF, Herrera VL, Ruiz-Opazo N. Corroboration of Dahl S Q276L alpha1Na,K-ATPase protein sequence: impact on affinities for ligands and on E1 conformation. J Hypertens. 2005 Apr; 23(4):745-52. PMID: 15775778.
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  34. Kaneko Y, Herrera VL, Didishvili T, Ruiz-Opazo N. Sex-specific effects of dual ET-1/ANG II receptor (Dear) variants in Dahl salt-sensitive/resistant hypertension rat model. Physiol Genomics. 2005 Jan 20; 20(2):157-64. PMID: 15561758.
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  35. Herrera VL, Tsikoudakis A, Didishvili T, Ponce LR, Bagamasbad P, Gantz D, Herscovitz H, Van Tol A, Ruiz-Opazo N. Analysis of gender-specific atherosclerosis susceptibility in transgenic[hCETP]25DS rat model. Atherosclerosis. 2004 Nov; 177(1):9-18. PMID: 15488860.
    View in: PubMed
  36. Ruiz-Opazo N, Lopez LV, Tonkiss J. Modulation of learning and memory in Dahl rats by dietary salt restriction. Hypertension. 2004 Apr; 43(4):797-802. PMID: 14967836.
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  37. Ruiz-Opazo N, Tonkiss J. X-linked loci influence spatial navigation performance in Dahl rats. Physiol Genomics. 2004 Feb 13; 16(3):329-33. PMID: 14665699.
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  38. Herrera VL, Didishvili T, Lopez LV, Myers RH, Ruiz-Opazo N. Genome-wide scan identifies novel QTLs for cholesterol and LDL levels in F2[Dahl RxS]-intercross rats. Circ Res. 2004 Mar 5; 94(4):446-52. PMID: 14739155.
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  39. Ruiz-Opazo N, Kosik KS, Lopez LV, Bagamasbad P, Ponce LR, Herrera VL. Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats. Mol Med. 2004 Jan-Jun; 10(1-6):36-44. PMID: 15502881.
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  40. Herrera VL, Shen L, Lopez LV, Didishvili T, Zhang YX, Ruiz-Opazo N. Chlamydia pneumoniae accelerates coronary artery disease progression in transgenic hyperlipidemia-genetic hypertension rat model. Mol Med. 2003 May-Aug; 9(5-8):135-42. PMID: 14571321.
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  41. Herrera VL, Traverse S, Lopez LV, Ruiz-Opazo N. X-linked locus associated with hypertensive renal disease susceptibility in Dahl rats. J Hypertens. 2003 Jan; 21(1):67-71. PMID: 12544437.
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  42. Herrera VM, Didishvili T, Lopez LV, Ruiz-Opazo N. Differential regulation of functional gene clusters in overt coronary artery disease in a transgenic atherosclerosis-hypertensive rat model. Mol Med. 2002 Jul; 8(7):367-75. PMID: 12393934.
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  43. Ruiz-Opazo N, Lopez LV, Herrera VL. The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model. Mol Med. 2002 Jan; 8(1):24-32. PMID: 11984003.
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  44. Herrera VM, Didishvili T, Lopez LV, Zander K, Traverse S, Gantz D, Herscovitz H, Ruiz-Opazo N. Hypertension exacerbates coronary artery disease in transgenic hyperlipidemic Dahl salt-sensitive hypertensive rats. Mol Med. 2001 Dec; 7(12):831-44. PMID: 11844871.
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  45. Song Y, Herrera VL, Filigheddu F, Troffa C, Lopez LV, Glorioso N, Ruiz-Opazo N. Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans. J Hypertens. 2001 Sep; 19(9):1547-51. PMID: 11564973.
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  46. Glorioso N, Filigheddu F, Troffa C, Soro A, Parpaglia PP, Tsikoudakis A, Myers RH, Herrera VL, Ruiz-Opazo N. Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. Hypertension. 2001 Aug; 38(2):204-9. PMID: 11509477.
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  47. Herrera VL, Ruiz-Opazo N. Identification of a novel V1-type AVP receptor based on the molecular recognition theory. Mol Med. 2001 Jul; 7(7):499-506. PMID: 11683375.
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  48. Herrera VL, Lopez LV, Ruiz-Opazo N. Alpha1 Na,K-ATPase and Na,K,2Cl-cotransporte/D3mit3 loci interact to increase susceptibility to salt-sensitive hypertension in Dahl S(HSD) rats. Mol Med. 2001 Feb; 7(2):125-34. PMID: 11471547.
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  49. Herrera VL, Makrides SC, Xie HX, Adari H, Krauss RM, Ryan US, Ruiz-Opazo N. Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein. Nat Med. 1999 Dec; 5(12):1383-9. PMID: 10581080.
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  50. Herrera VL, Xie HX, Lopez LV, Schork NJ, Ruiz-Opazo N. The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat. J Clin Invest. 1998 Sep 15; 102(6):1102-11. PMID: 9739044.
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  51. Tonkiss J, Trzcinska M, Galler JR, Ruiz-Opazo N, Herrera VL. Prenatal malnutrition-induced changes in blood pressure: dissociation of stress and nonstress responses using radiotelemetry. Hypertension. 1998 Jul; 32(1):108-14. PMID: 9674646.
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  52. Ruiz-Opazo N, Hirayama K, Akimoto K, Herrera VL. Molecular characterization of a dual endothelin-1/Angiotensin II receptor. Mol Med. 1998 Feb; 4(2):96-108. PMID: 9508787.
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  53. Ruiz-Opazo N. Identification of a novel dual angiotensin II/vasopressin receptor. Nephrologie. 1998; 19(7):417-20. PMID: 9857377.
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  54. Ruiz-Opazo N, Cloix JF, Melis MG, Xiang XH, Herrera VL. Characterization of a sodium-response transcriptional mechanism. Hypertension. 1997 Aug; 30(2 Pt 1):191-8. PMID: 9260979.
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  55. Gonzalez CB, Herrera VL, Ruiz-Opazo N. Renal immunocytochemical distribution and pharmacological properties of the dual angiotensin II/AVP receptor. Hypertension. 1997 Apr; 29(4):957-61. PMID: 9095083.
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  56. Ruiz-Opazo N, Xiang XH, Herrera VL. Pressure-overload deinduction of human alpha 2 Na,K-ATPase gene expression in transgenic rats. Hypertension. 1997 Feb; 29(2):606-12. PMID: 9040446.
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  57. Ruiz-Opazo N, Akimoto K, Herrera VL. Identification of a novel dual angiotensin II/vasopressin receptor on the basis of molecular recognition theory. Nat Med. 1995 Oct; 1(10):1074-81. PMID: 7489366.
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  58. Ruiz-Opazo N, Barany F, Hirayama K, Herrera VL. Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats. Hypertension. 1994 Sep; 24(3):260-70. PMID: 8082931.
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  59. Herrera VL, Ruiz-Opazo N. Beyond genetic markers: hypertension genes. J Hypertens. 1994 Aug; 12(8):847-56. PMID: 7814844.
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  60. Herrera VL, Cova T, Sassoon D, Ruiz-Opazo N. Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression. Am J Physiol. 1994 May; 266(5 Pt 1):C1301-12. PMID: 8203495.
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  61. Herrera VL, Ruiz-Opazo N. Genetic analysis of hypertension in animal models and human hypertensive patients. J Hypertens Suppl. 1994; 12(7):S47-55. PMID: 7769504.
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  62. Ruiz-Opazo N, Cloix JF, Herrera VL. Differential interaction of the dual alpha tropomyosin/N5 enhancer with multiple DNA binding proteins: N5 is a putative novel z-ZIP DNA binding protein. Cell Mol Biol Res. 1994; 40(4):265-72. PMID: 7866428.
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  63. Canessa M, Romero JR, Ruiz-Opazo N, Herrera VL. The alpha 1 Na(+)-K+ pump of the Dahl salt-sensitive rat exhibits altered Na+ modulation of K+ transport in red blood cells. J Membr Biol. 1993 Jun; 134(2):107-22. PMID: 8411114.
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  64. Ruiz-Opazo N, Herrera VL. Analysis of Na+ pump genes. Hypertension. 1992 May; 19(5):495-6. PMID: 1314780.
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  65. Estrada EF, Barra V, Caorsi CE, Troncoso S, Ruiz-Opazo N, González CB. Identification of the V1 vasopressin receptor by chemical cross-linking and ligand affinity blotting. Biochemistry. 1991 Sep 3; 30(35):8611-6. PMID: 1832297.
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  66. Herrera VL, Ruiz-Opazo N. Genetics of hypertension A multidisciplinary challenge. Trends Cardiovasc Med. 1991 Jul-Aug; 1(5):185-9. PMID: 21239308.
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  67. Herrera VL, Ruiz-Opazo N. Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution. Science. 1990 Aug 31; 249(4972):1023-6. PMID: 1975705.
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  68. Herrera VL, Ruiz-Opazo N. Regulation of alpha-tropomyosin and N5 genes by a shared enhancer. Modular structure and hierarchical organization. J Biol Chem. 1990 Jun 5; 265(16):9555-62. PMID: 2160985.
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  69. Herrera VL, Chobanian AV, Ruiz-Opazo N. Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension. Science. 1988 Jul 8; 241(4862):221-3. PMID: 2838907.
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  70. Makrides SC, Ruiz-Opazo N, Hayden M, Nussbaum AL, Breslow JL, Zannis VI. Sequence and expression of Tangier apoA-I gene. Eur J Biochem. 1988 Apr 15; 173(2):465-71. PMID: 3129297.
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  71. Ruiz-Opazo N, Zannis VI. Expression of the human apolipoprotein A-I gene in rat myogenic L6E9 cells. DNA methylation and regulation of gene activity. J Biol Chem. 1988 Feb 5; 263(4):1739-44. PMID: 2828350.
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  72. Claffey KP, Herrera VL, Brecher P, Ruiz-Opazo N. Cloning and tissue distribution of rat heart fatty acid binding protein mRNA: identical forms in heart and skeletal muscle. Biochemistry. 1987 Dec 1; 26(24):7900-4. PMID: 3427112.
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  73. Herrera VL, Emanuel JR, Ruiz-Opazo N, Levenson R, Nadal-Ginard B. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. J Cell Biol. 1987 Oct; 105(4):1855-65. PMID: 2822726.
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  74. Ruiz-Opazo N, Nadal-Ginard B. Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms. J Biol Chem. 1987 Apr 5; 262(10):4755-65. PMID: 3558368.
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  75. Ruiz-Opazo N, Weinberger J, Nadal-Ginard B. Comparison of alpha-tropomyosin sequences from smooth and striated muscle. Nature. 1985 May 2-8; 315(6014):67-70. PMID: 3838802.
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  76. Periasamy M, Strehler EE, Garfinkel LI, Gubits RM, Ruiz-Opazo N, Nadal-Ginard B. Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing. J Biol Chem. 1984 Nov 10; 259(21):13595-604. PMID: 6092382.
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  78. Gatmaitan Z, Jefferson DM, Ruiz-Opazo N, Biempica L, Arias IM, Dudas G, Leinwand LA, Reid LM. Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata. J Cell Biol. 1983 Oct; 97(4):1179-90. PMID: 6137487.
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  79. Zern MA, Chakraborty PR, Ruiz-Opazo N, Yap SH, Shafritz DA. Development and use of a rat albumin cDNA clone to evaluate the effect of chronic ethanol administration on hepatic protein synthesis. Hepatology. 1983 May-Jun; 3(3):317-22. PMID: 6840678.
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  80. Ruiz-Opazo N, Chakraborty PR, Shafritz DA. Evidence for supercoiled hepatitis B virus DNA in chimpanzee liver and serum Dane particles: possible implications in persistent HBV infection. Cell. 1982 May; 29(1):129-36. PMID: 6286137.
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  82. Chakraborty PR, Ruiz-Opazo N, Shafritz DA. Transcription of human hepatitis B virus core antigen gene sequences in an in vitro HeLa cellular extract. Virology. 1981 Jun; 111(2):647-52. PMID: 6264676.
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  83. Shouval D, Reid LM, Chakraborty PR, Ruiz-Opazo N, Morecki R, Gerber MA, Thung SN, Shafritz DA. Tumorigenicity in nude mice of a human hepatoma cell line containing hepatitis B virus DNA. Cancer Res. 1981 Apr; 41(4):1342-50. PMID: 6260336.
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  84. Shouval D, Chakraborty PR, Ruiz-Opazo N, Baum S, Spigland I, Muchmore E, Gerber MA, Thung SN, Popper H, Shafritz DA. Chronic hepatitis in chimpanzee carriers of hepatitis B virus: morphologic, immunologic, and viral DNA studies. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):6147-51. PMID: 6934542.
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  85. Chakraborty PR, Ruiz-Opazo N, Shouval D, Shafritz DA. Identification of integrated hepatitis B virus DNA and expression of viral RNA in an HBsAg-producing human hepatocellular carcinoma cell line. Nature. 1980 Jul 31; 286(5772):531-3. PMID: 6250073.
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