Nelson Ruiz-Opazo, PhD
Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

PhD, Albert Einstein College of Medicine
MS, Albert Einstein College of Medicine
MS, Universidad Austral de Chile



Expertise includes molecular biology and genetics.


Novel targeted therapy for pancreatic peritoneal carcinomatosis:a potential therapeutic platform for other cancers
02/01/2016 - 01/31/2018 (PI)
Ellison Foundation


Genetic Mechanisms of Arterial Stiffness in Polygenic Salt-Sensitive Hypertension
09/20/2010 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Inst
5R01HL105286-04

Gender-specific Genetic Determinants of Hypertension and End Organ Disease
09/01/2008 - 07/31/2013 (PI)
NIH/National Heart, Lung, and Blood Inst
5R01HL086532-04

Genetic Determinants of Hypertension Susceptibility in Humans
09/21/2004 - 09/19/2007 (PI)
Philip Morris Inc

Molecular Genetics of the ET-1/AngII Receptor
04/01/2002 - 03/31/2007 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL69937 04

Role of Na+ Transporter Genes in Essential Hypertension
01/15/1998 - 03/31/2007 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL58136 07

Novel AngII and AVP Isoreceptors in Blood Pressure Regulation
12/15/1998 - 11/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL60071 04




Yr Title Project-Sub Proj Pubs
2013 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 5R01HL105286-04 2
2012 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 5R01HL105286-03 2
2011 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 5R01HL105286-02 2
2011 Gender-specific genetic determinants of hypertension and end organ disease 5R01HL086532-04 8
2010 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 1R01HL105286-01 2
2010 Functional characterization of ATP1A1 and DEspR variants associated with essentia 5R21HL098939-02 2
2010 Gender-specific genetic determinants of hypertension and end organ disease 5R01HL086532-03 8
2009 Functional characterization of ATP1A1 and DEspR variants associated with essentia 1R21HL098939-01 2
2009 Gender-specific genetic determinants of hypertension and end organ disease 5R01HL086532-02 8
2008 Gender-specific genetic determinants of hypertension and end organ disease 1R01HL086532-01A2 8
Showing 10 of 35 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circ Res. 2017 Nov 10; 121(11):1216-1218.View Related Profiles. PMID: 29122942.
  2. Colby AH, Berry SM, Moran AM, Pasion KA, Liu R, Colson YL, Ruiz-Opazo N, Grinstaff MW, Herrera VL. Highly Specific and Sensitive Fluorescent Nanoprobes for Image-Guided Resection of Sub-Millimeter Peritoneal Tumors. ACS Nano. 2017 Feb 28; 11(2):1466-1477.View Related Profiles. PMID: 28099801; DOI: 10.1021/acsnano.6b06777;.
  3. Herrera VL, Steffen M, Moran AM, Tan GA, Pasion KA, Rivera K, Pappin DJ, Ruiz-Opazo N. Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein. BMC Mol Biol. 2016 Jun 14; 17(1):15.View Related Profiles. PMID: 27301377; PMCID: PMC4906906; DOI: 10.1186/s12867-016-0066-8;.
  4. Herrera VL, Colby AH, Tan GA, Moran AM, O'Brien MJ, Colson YL, Ruiz-Opazo N, Grinstaff MW. Evaluation of expansile nanoparticle tumor localization and efficacy in a cancer stem cell-derived model of pancreatic peritoneal carcinomatosis. Nanomedicine (Lond). 2016 May; 11(9):1001-15.View Related Profiles. PMID: 27078118; PMCID: PMC4910944; DOI: 10.2217/nnm-2015-0023;.
  5. Decano JL, Pasion KA, Black N, Giordano NJ, Herrera VL, Ruiz-Opazo N. Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats. BMC Genet. 2016; 17:19.View Related Profiles. PMID: 26754450; PMCID: PMC4709875; DOI: 10.1186/s12863-015-0324-7;.
  6. Herrera VL, Pasion KA, Moran AM, Zaninello R, Ortu MF, Fresu G, Piras DA, Argiolas G, Troffa C, Glorioso V, Masala W, Glorioso N, Ruiz-Opazo N. A functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population. PLoS One. 2015; 10(1):e0116724.View Related Profiles. PMID: 25615575; PMCID: PMC4304799; DOI: 10.1371/journal.pone.0116724;.
  7. Herrera VL, Decano JL, Giordano N, Moran AM, Ruiz-Opazo N. Aortic and carotid arterial stiffness and epigenetic regulator gene expression changes precede blood pressure rise in stroke-prone Dahl salt-sensitive hypertensive rats. PLoS One. 2014; 9(9):e107888.View Related Profiles. PMID: 25229245; PMCID: PMC4168262; DOI: 10.1371/journal.pone.0107888;.
  8. Herrera VL, Decano JL, Tan GA, Moran AM, Pasion KA, Matsubara Y, Ruiz-Opazo N. DEspR roles in tumor vasculo-angiogenesis, invasiveness, CSC-survival and anoikis resistance: a ''common receptor coordinator'' paradigm. PLoS One. 2014; 9(1):e85821.View Related Profiles. PMID: 24465725; PMCID: PMC3897535; DOI: 10.1371/journal.pone.0085821;.
  9. Glorioso N, Herrera VL, Didishvili T, Ortu MF, Zaninello R, Fresu G, Argiolas G, Troffa C, Ruiz-Opazo N. Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population. PLoS One. 2013; 8(10):e77562.View Related Profiles. PMID: 24147025; PMCID: PMC3795764; DOI: 10.1371/journal.pone.0077562;.
  10. Herrera VL, Ponce LR, Ruiz-Opazo N. Multiple susceptibility loci for radiation-induced mammary tumorigenesis in F2[Dahl S x R]-intercross rats. PLoS One. 2013; 8(8):e72143.View Related Profiles. PMID: 23967281; PMCID: PMC3743793; DOI: 10.1371/journal.pone.0072143;.
Showing 10 of 86 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 86 publications over 34 distinct years, with a maximum of 6 publications in 2004 and 2013

YearPublications
19802
19812
19822
19832
19842
19851
19873
19883
19902
19912
19921
19931
19945
19951
19973
19984
19991
20015
20022
20032
20046
20053
20062
20073
20082
20092
20101
20113
20124
20136
20142
20151
20163
20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

genetics
hypertension
learning and memory
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700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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