Nelson Ruiz-Opazo, PhD
Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

PhD, Albert Einstein College of Medicine
MS, Albert Einstein College of Medicine
MS, Universidad Austral de Chile




Expertise includes molecular biology and genetics.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Member
Boston University
Ambulatory Pediatrics




Humanized anti-DEspR antibody therapy for Acute Respiratory Distress Syndrome (ARDS)
09/01/2019 - 07/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5U54HL119145-07

Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs)
01/01/2019 - 12/31/2020 (Multi-PI)
PI: Nelson Ruiz-Opazo, PhD
NIH/National Heart, Lung, and Blood Institute
5R21HL144253-02

Neutrophils and NETs in Intra-Cerebral Hemorrhage Exacerbation
03/04/2020 - 12/04/2020 (PI)
NControl Therapeutics, Inc.


Novel targeted therapy for pancreatic peritoneal carcinomatosis:a potential therapeutic platform for other cancers
02/01/2016 - 06/30/2019 (PI)
Ellison Foundation


Fully humanized anti-DEspR antibody therapy for acute lung injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)
01/01/2018 - 04/30/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5U54HL119145-06

Novel Targeted Therapy for Pancreatic Cancer
04/01/2018 - 03/31/2019 (Subcontract PI)
Abtelum Biomedical, Inc. NIH NCI
1R43CA221555-01A1

Genetic Mechanisms of Arterial Stiffness in Polygenic Salt-Sensitive Hypertension
09/20/2010 - 06/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL105286-04

Gender-specific Genetic Determinants of Hypertension and End Organ Disease
09/01/2008 - 07/31/2013 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL086532-04

Genetic Determinants of Hypertension Susceptibility in Humans
09/21/2004 - 09/19/2007 (PI)
Philip Morris Inc

Molecular Genetics of the ET-1/AngII Receptor
04/01/2002 - 03/31/2007 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL69937 04

Showing 10 of 12 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs) 5R21HL144253-02
2019 Multi-functional targeted bio-conjugate platform to dismantle neutrophil extracellular traps (NETs) 1R21HL144253-01
2013 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 5R01HL105286-04 2
2012 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 5R01HL105286-03 2
2011 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 5R01HL105286-02 2
2011 Gender-specific genetic determinants of hypertension and end organ disease 5R01HL086532-04 8
2010 Genetic mechanisms of arterial stiffness in polygenic salt-sensitive hypertension 1R01HL105286-01 2
2010 Functional characterization of ATP1A1 and DEspR variants associated with essentia 5R21HL098939-02 3
2010 Gender-specific genetic determinants of hypertension and end organ disease 5R01HL086532-03 8
2009 Functional characterization of ATP1A1 and DEspR variants associated with essentia 1R21HL098939-01 3
Showing 10 of 37 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Herrera VL, Colby AH, Ruiz-Opazo N, Coleman DG, Grinstaff MW. Nucleic acid nanomedicines in Phase II/III clinical trials: translation of nucleic acid therapies for reprogramming cells. Nanomedicine (Lond). 2018 08; 13(16):2083-2098.View Related Profiles. PMID: 30204054
     
  2. Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circ Res. 2017 11 10; 121(11):1216-1218.View Related Profiles. PMID: 29122942
     
  3. Colby AH, Berry SM, Moran AM, Pasion KA, Liu R, Colson YL, Ruiz-Opazo N, Grinstaff MW, Herrera VL. Highly Specific and Sensitive Fluorescent Nanoprobes for Image-Guided Resection of Sub-Millimeter Peritoneal Tumors. ACS Nano. 2017 02 28; 11(2):1466-1477.View Related Profiles. PMID: 28099801; DOI: 10.1021/acsnano.6b06777;
     
  4. Herrera VL, Steffen M, Moran AM, Tan GA, Pasion KA, Rivera K, Pappin DJ, Ruiz-Opazo N. Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein. BMC Mol Biol. 2016 Jun 14; 17(1):15.View Related Profiles. PMID: 27301377; PMCID: PMC4906906; DOI: 10.1186/s12867-016-0066-8;
     
  5. Herrera VL, Colby AH, Tan GA, Moran AM, O'Brien MJ, Colson YL, Ruiz-Opazo N, Grinstaff MW. Evaluation of expansile nanoparticle tumor localization and efficacy in a cancer stem cell-derived model of pancreatic peritoneal carcinomatosis. Nanomedicine (Lond). 2016 May; 11(9):1001-15.View Related Profiles. PMID: 27078118; PMCID: PMC4910944; DOI: 10.2217/nnm-2015-0023;
     
  6. Decano JL, Pasion KA, Black N, Giordano NJ, Herrera VL, Ruiz-Opazo N. Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats. BMC Genet. 2016; 17:19.View Related Profiles. PMID: 26754450; PMCID: PMC4709875; DOI: 10.1186/s12863-015-0324-7;
     
  7. Herrera VL, Pasion KA, Moran AM, Zaninello R, Ortu MF, Fresu G, Piras DA, Argiolas G, Troffa C, Glorioso V, Masala W, Glorioso N, Ruiz-Opazo N. A functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population. PLoS One. 2015; 10(1):e0116724.View Related Profiles. PMID: 25615575; PMCID: PMC4304799; DOI: 10.1371/journal.pone.0116724;
     
  8. Herrera VL, Decano JL, Giordano N, Moran AM, Ruiz-Opazo N. Aortic and carotid arterial stiffness and epigenetic regulator gene expression changes precede blood pressure rise in stroke-prone Dahl salt-sensitive hypertensive rats. PLoS One. 2014; 9(9):e107888.View Related Profiles. PMID: 25229245; PMCID: PMC4168262; DOI: 10.1371/journal.pone.0107888;
     
  9. Herrera VL, Decano JL, Tan GA, Moran AM, Pasion KA, Matsubara Y, Ruiz-Opazo N. DEspR roles in tumor vasculo-angiogenesis, invasiveness, CSC-survival and anoikis resistance: a 'common receptor coordinator' paradigm. PLoS One. 2014; 9(1):e85821.View Related Profiles. PMID: 24465725; PMCID: PMC3897535; DOI: 10.1371/journal.pone.0085821;
     
  10. Glorioso N, Herrera VL, Didishvili T, Ortu MF, Zaninello R, Fresu G, Argiolas G, Troffa C, Ruiz-Opazo N. Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population. PLoS One. 2013; 8(10):e77562.View Related Profiles. PMID: 24147025; PMCID: PMC3795764; DOI: 10.1371/journal.pone.0077562;
     
Showing 10 of 87 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 87 publications over 35 distinct years, with a maximum of 6 publications in 2004 and 2013

YearPublications
19802
19812
19822
19832
19842
19851
19873
19883
19902
19912
19921
19931
19945
19951
19973
19984
19991
20015
20022
20032
20046
20053
20062
20073
20082
20092
20101
20113
20124
20136
20142
20151
20163
20172
20181

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

genetics
hypertension
learning and memory
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Google Map


Ruiz-Opazo's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department