Keywords
Last Name

James A. Hamilton, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address700 Albany St - CABR
Boston MA 02118
Phone(617) 638-5048
ORCID ORCID Icon0000-0002-4747-7071
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentRadiology

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGeneral Internal Medicine

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA. Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog. 2014 Jul; 10(7):e1004215.
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  2. Hua N, Chen Z, Phinikaridou A, Pham T, Qiao Y, LaValley MP, Bigornia SJ, Ruth MR, Apovian CM, Ruberg FL, Hamilton JA. The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect. J Cardiovasc Magn Reson. 2014; 16(1):37.
    View in: PubMed
  3. Park YC, Smith JB, Pham T, Whitaker RD, Sucato CA, Hamilton JA, Bartolak-Suki E, Wong JY. Effect of PEG molecular weight on stability, T2 contrast, cytotoxicity, and cellular uptake of superparamagnetic iron oxide nanoparticles (SPIONs). Colloids Surf B Biointerfaces. 2014 Jul 1; 119:106-14.
    View in: PubMed
  4. Wong S, Kirkland JL, Schwanz HA, Simmons AL, Hamilton JA, Corkey BE, Guo W. Effects of thiol antioxidant ß-mercaptoethanol on diet-induced obese mice. Life Sci. 2014 Jun 27; 107(1-2):32-41.
    View in: PubMed
  5. Wan T, Madabhushi A, Phinikaridou A, Hamilton JA, Hua N, Pham T, Danagoulian J, Kleiman R, Buckler AJ. Spatio-temporal texture (SpTeT) for distinguishing vulnerable from stable atherosclerotic plaque on dynamic contrast enhancement (DCE) MRI in a rabbit model. Med Phys. 2014 Apr; 41(4):042303.
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  6. Xu S, Jay A, Brunaldi K, Huang N, Hamilton JA. CD36 enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane. Biochemistry. 2013 Oct 15; 52(41):7254-61.
    View in: PubMed
  7. Denis GV, Hamilton JA. Healthy obese persons: how can they be identified and do metabolic profiles stratify risk? Curr Opin Endocrinol Diabetes Obes. 2013 Oct; 20(5):369-76.
    View in: PubMed
  8. Hamilton JA. NMR reveals molecular interactions and dynamics of fatty acid binding to albumin. Biochim Biophys Acta. 2013 Dec; 1830(12):5418-26.
    View in: PubMed
  9. Krenzel ES, Chen Z, Hamilton JA. Correspondence of fatty acid and drug binding sites on human serum albumin: a two-dimensional nuclear magnetic resonance study. Biochemistry. 2013 Mar 5; 52(9):1559-67.
    View in: PubMed
  10. Phinikaridou A, Hua N, Pham T, Hamilton JA. Regions of low endothelial shear stress colocalize with positive vascular remodeling and atherosclerotic plaque disruption: an in vivo magnetic resonance imaging study. Circ Cardiovasc Imaging. 2013 Mar 1; 6(2):302-10.
    View in: PubMed
  11. Park DW, Kruger GH, Rubin JM, Hamilton J, Gottschalk P, Dodde RE, Shih AJ, Weitzel WF. In vivo vascular wall shear rate and circumferential strain of renal disease patients. Ultrasound Med Biol. 2013 Feb; 39(2):241-52.
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  12. Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, LaValley M, Gibson FC, Hamilton JA, Genco CA. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1; 189(7):3681-8.
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  13. Phinikaridou A, Qiao Y, Giordano N, Hamilton JA. Detection of thrombus size and protein content by ex vivo magnetization transfer and diffusion weighted MRI. J Cardiovasc Magn Reson. 2012; 14:45.
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  14. Cai J, Lücke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA. Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited. Biophys J. 2012 Jun 6; 102(11):2585-94.
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  15. Qiao Y, Hallock KJ, Hamilton JA. Magnetization transfer magnetic resonance of human atherosclerotic plaques ex vivo detects areas of high protein density. J Cardiovasc Magn Reson. 2011; 13:73.
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  16. Anderson SW, Jara H, Ozonoff A, O'Brien M, Hamilton JA, Soto JA. Effect of disease progression on liver apparent diffusion coefficient and T2 values in a murine model of hepatic fibrosis at 11.7 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):140-6.
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  17. Souza SL, Hallock KJ, Funari SS, Vaz WL, Hamilton JA, Melo E. Study of the miscibility of cholesteryl oleate in a matrix of ceramide, cholesterol and fatty acid. Chem Phys Lipids. 2011 Oct; 164(7):664-71.
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  18. Phinikaridou A, Hamilton JA. Application of MRI to detect high-risk atherosclerotic plaque. Expert Rev Cardiovasc Ther. 2011 May; 9(5):545-50.
    View in: PubMed
  19. Anderson SW, Soto JA, Milch HN, Ozonoff A, O'Brien M, Hamilton JA, Jara HJ. Effect of disease progression on liver apparent diffusion coefficient values in a murine model of NASH at 11.7 Tesla MRI. J Magn Reson Imaging. 2011 Apr; 33(4):882-8.
    View in: PubMed
  20. Potter JJ, Koteish A, Hamilton J, Liu X, Liu K, Agre P, Mezey E. Effects of acetaldehyde on hepatocyte glycerol uptake and cell size: implication of aquaporin 9. Alcohol Clin Exp Res. 2011 May; 35(5):939-45.
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  21. Hayashi C, Viereck J, Hua N, Phinikaridou A, Madrigal AG, Gibson FC, Hamilton JA, Genco CA. Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis. 2011 Mar; 215(1):52-9.
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  22. Liu Y, Atkinson D. Enhancing the contrast of ApoB to locate the surface components in the 3D density map of human LDL. J Mol Biol. 2011 Jan 7; 405(1):274-83.
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  23. Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22.
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  24. Phinikaridou A, Ruberg FL, Hallock KJ, Qiao Y, Hua N, Viereck J, Hamilton JA. In vivo detection of vulnerable atherosclerotic plaque by MRI in a rabbit model. Circ Cardiovasc Imaging. 2010 May; 3(3):323-32.
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  25. Guo Y, Tan LJ, Lei SF, Yang TL, Chen XD, Zhang F, Chen Y, Pan F, Yan H, Liu X, Tian Q, Zhang ZX, Zhou Q, Qiu C, Dong SS, Xu XH, Guo YF, Zhu XZ, Liu SL, Wang XL, Li X, Luo Y, Zhang LS, Li M, Wang JT, Wen T, Drees B, Hamilton J, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet. 2010 Jan; 6(1):e1000806.
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  26. Brunaldi K, Huang N, Hamilton JA. Fatty acids are rapidly delivered to and extracted from membranes by methyl-beta-cyclodextrin. J Lipid Res. 2010 Jan; 51(1):120-31.
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  27. Miller J, Agarwal A, Devi LA, Fontanini K, Hamilton JA, Pin JP, Shields DC, Spek CA, Sakmar TP, Kuliopulos A, Hunt SW. Insider access: pepducin symposium explores a new approach to GPCR modulation. Ann N Y Acad Sci. 2009 Nov; 1180 Suppl 1:E1-12.
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  28. Ruberg FL, Chen Z, Hua N, Bigornia S, Guo Z, Hallock K, Jara H, LaValley M, Phinikaridou A, Qiao Y, Viereck J, Apovian CM, Hamilton JA. The relationship of ectopic lipid accumulation to cardiac and vascular function in obesity and metabolic syndrome. Obesity (Silver Spring). 2010 Jun; 18(6):1116-21.
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  29. Pillai BK, Jasuja R, Simard JR, Hamilton JA. Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. J Biol Chem. 2009 Nov 27; 284(48):33296-304.
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  30. Getty-Kaushik L, Viereck JC, Goodman JM, Guo Z, LeBrasseur NK, Richard AM, Flanagan JN, Yaney GC, Hamilton JA, Tornheim K. Mice deficient in phosphofructokinase-M have greatly decreased fat stores. Obesity (Silver Spring). 2010 Mar; 18(3):434-40.
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  31. Guo W, Wong S, Pudney J, Jasuja R, Hua N, Jiang L, Miller A, Hruz PW, Hamilton JA, Bhasin S. Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir. Arterioscler Thromb Vasc Biol. 2009 Dec; 29(12):2028-32.
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  32. Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W. Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes. 2009 Aug; 58(8):1739-48.
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  33. Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24; 119(11):1501-9.
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  34. Phinikaridou A, Hallock KJ, Qiao Y, Hamilton JA. A robust rabbit model of human atherosclerosis and atherothrombosis. J Lipid Res. 2009 May; 50(5):787-97.
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  35. Lacey DC, Simmons PJ, Graves SE, Hamilton JA. Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation. Osteoarthritis Cartilage. 2009 Jun; 17(6):735-42.
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  36. Qiao Y, Farber A, Semaan E, Hamilton JA. Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration. Circulation. 2008 Sep 2; 118(10):e147-8.
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  37. Gupta V, Bhasin S, Guo W, Singh R, Miki R, Chauhan P, Choong K, Tchkonia T, Lebrasseur NK, Flanagan JN, Hamilton JA, Viereck JC, Narula NS, Kirkland JL, Jasuja R. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol. 2008 Dec 16; 296(1-2):32-40.
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  38. Simard JR, Pillai BK, Hamilton JA. Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase. Biochemistry. 2008 Sep 2; 47(35):9081-9.
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  39. Simard JR, Kamp F, Hamilton JA. Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes. Biophys J. 2008 Jun; 94(11):4493-503.
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  40. Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, Hamilton JA, Ouchi N, LeBrasseur NK, Walsh K. Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. 2008 Feb; 7(2):159-72.
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  41. Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, Deng HW. Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res. 2008 Jan; 23(1):17-29.
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  42. Hamilton JA. New insights into the roles of proteins and lipids in membrane transport of fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec; 77(5-6):355-61.
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  43. Watkins PA, Hamilton JA. Roundtable discussion of session 4: fatty acids and lipids in brain disorders. J Mol Neurosci. 2007 Sep; 33(1):120-4.
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  44. Katz R, Hamilton JA, Pownall HJ, Deckelbaum RJ, Hillard CJ, Leboeuf RC, Watkins PA. Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research. J Mol Neurosci. 2007 Sep; 33(1):146-50.
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  45. Watkins PA, Hamilton JA. Roundtable discussion of session 3: eicosanoids in brain function. J Mol Neurosci. 2007 Sep; 33(1):100-4.
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  46. Watkins PA, Hamilton JA. Roundtable discussion of session 2: lipoproteins and polyunsaturated fatty acids. J Mol Neurosci. 2007 Sep; 33(1):74-9.
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  47. Hamilton JA, Brunaldi K. A model for fatty acid transport into the brain. J Mol Neurosci. 2007 Sep; 33(1):12-7.
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  48. Watkins PA, Hamilton JA. Roundtable discussion of session 1: mechanisms of lipid uptake and transport in the brain. J Mol Neurosci. 2007 Sep; 33(1):45-50.
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  49. Hamilton JA, Hillard CJ, Spector AA, Watkins PA. Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders. J Mol Neurosci. 2007 Sep; 33(1):2-11.
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  50. Duncanson WJ, Figa MA, Hallock K, Zalipsky S, Hamilton JA, Wong JY. Targeted binding of PLA microparticles with lipid-PEG-tethered ligands. Biomaterials. 2007 Nov; 28(33):4991-9.
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  51. Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, Viereck J, Hamilton JA, Tang G, Dolnikowski GG, Vogel S, Duester G, Plutzky J. Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med. 2007 Jun; 13(6):695-702.
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  52. Qiao Y, Ronen I, Viereck J, Ruberg FL, Hamilton JA. Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1440-6.
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  53. Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, Deng HW. Relationship of obesity with osteoporosis. J Clin Endocrinol Metab. 2007 May; 92(5):1640-6.
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  54. Hamilton JA, Deckelbaum RJ. Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease? Nat Struct Mol Biol. 2007 Feb; 14(2):95-7.
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  55. Brunaldi K, Simard JR, Kamp F, Rewal C, Asawakarn T, O'Shea P, Hamilton JA. Fluorescence assays for measuring fatty acid binding and transport through membranes. Methods Mol Biol. 2007; 400:237-55.
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  56. Simard JR, Kamp F, Hamilton JA. Acrylodan-labeled intestinal fatty acid-binding protein to measure concentrations of unbound fatty acids. Methods Mol Biol. 2007; 400:27-43.
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  57. Hallock KJ, Hamilton JA. Ex vivo identification of atherosclerotic plaque calcification by a 31P solid-state magnetic resonance imaging technique. Magn Reson Med. 2006 Dec; 56(6):1380-3.
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  58. Kamp F, Hamilton JA. How fatty acids of different chain length enter and leave cells by free diffusion. Prostaglandins Leukot Essent Fatty Acids. 2006 Sep; 75(3):149-59.
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  59. Simard JR, Zunszain PA, Hamilton JA, Curry S. Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis. J Mol Biol. 2006 Aug 11; 361(2):336-51.
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  60. Lücke C, Qiao Y, van Moerkerk HT, Veerkamp JH, Hamilton JA. Fatty-acid-binding protein from the flight muscle of Locusta migratoria: evolutionary variations in fatty acid binding. Biochemistry. 2006 May 23; 45(20):6296-305.
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  61. Lücke C, Gantz DL, Klimtchuk E, Hamilton JA. Interactions between fatty acids and alpha-synuclein. J Lipid Res. 2006 Aug; 47(8):1714-24.
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  62. Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 2006 Mar 7; 45(9):2882-93.
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  63. Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids. 2006 Mar; 41(3):267-71.
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  64. Simard JR, Zunszain PA, Ha CE, Yang JS, Bhagavan NV, Petitpas I, Curry S, Hamilton JA. Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):17958-63.
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  65. Ruberg FL, Viereck J, Phinikaridou A, Qiao Y, Loscalzo J, Hamilton JA. Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS. J Lipid Res. 2006 Feb; 47(2):310-7.
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  66. Guo W, Huang N, Cai J, Xie W, Hamilton JA. Fatty acid transport and metabolism in HepG2 cells. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G528-34.
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  67. Guo W, Xie W, Lei T, Hamilton JA. Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes. Lipids. 2005 Aug; 40(8):815-21.
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  68. Skinner NA, MacIsaac CM, Hamilton JA, Visvanathan K. Regulation of Toll-like receptor (TLR)2 and TLR4 on CD14dimCD16+ monocytes in response to sepsis-related antigens. Clin Exp Immunol. 2005 Aug; 141(2):270-8.
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  69. Viereck J, Ruberg FL, Qiao Y, Perez AS, Detwiller K, Johnstone M, Hamilton JA. MRI of atherothrombosis associated with plaque rupture. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):240-5.
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  70. Johnstone MT, Perez AS, Nasser I, Stewart R, Vaidya A, Al Ammary F, Schmidt B, Horowitz G, Dolgoff J, Hamilton J, Quist WC. Angiotensin receptor blockade with candesartan attenuates atherosclerosis, plaque disruption, and macrophage accumulation within the plaque in a rabbit model. Circulation. 2004 Oct 5; 110(14):2060-5.
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  71. Hamilton JA. Fatty acid interactions with proteins: what X-ray crystal and NMR solution structures tell us. Prog Lipid Res. 2004 May; 43(3):177-99.
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  72. Botnar RM, Perez AS, Witte S, Wiethoff AJ, Laredo J, Hamilton J, Quist W, Parsons EC, Vaidya A, Kolodziej A, Barrett JA, Graham PB, Weisskoff RM, Manning WJ, Johnstone MT. In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent. Circulation. 2004 Apr 27; 109(16):2023-9.
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  73. Lei T, Xie W, Han J, Corkey BE, Hamilton JA, Guo W. Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation. Obes Res. 2004 Apr; 12(4):599-611.
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  74. Kamp F, Kizilbash N, Corkey BE, Berggren PO, Hamilton JA. Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism. Diabetes. 2003 Oct; 52(10):2526-31.
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  75. Pownall HJ, Hamilton JA. Energy translocation across cell membranes and membrane models. Acta Physiol Scand. 2003 Aug; 178(4):357-65.
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  76. Zhang F, Lücke C, Baier LJ, Sacchettini JC, Hamilton JA. Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism. Biochemistry. 2003 Jun 24; 42(24):7339-47.
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  77. Hamilton JA. Fast flip-flop of cholesterol and fatty acids in membranes: implications for membrane transport proteins. Curr Opin Lipidol. 2003 Jun; 14(3):263-71.
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  78. Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obes Res. 2003 Jun; 11(6):734-44.
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  79. Lücke C, Kizilbash N, van Moerkerk HT, Veerkamp JH, Hamilton JA. NMR assignment and structural characterization of the fatty acid binding protein from the flight muscle of Locusta migratoria. J Biomol NMR. 2003 Apr; 25(4):355-6.
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  80. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 2003 Feb 20; 37(4):583-95.
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  81. Johnson RA, Hamilton JA, Worgall TS, Deckelbaum RJ. Free fatty acids modulate intermembrane trafficking of cholesterol by increasing lipid mobilities: novel 13C NMR analyses of free cholesterol partitioning. Biochemistry. 2003 Feb 18; 42(6):1637-45.
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  82. Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA. Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem. 2003 Mar 7; 278(10):7988-95.
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  83. Hamilton JA, Guo W, Kamp F. Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins? Mol Cell Biochem. 2002 Oct; 239(1-2):17-23.
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  84. Guo W, Kurze V, Huber T, Afdhal NH, Beyer K, Hamilton JA. A solid-state NMR study of phospholipid-cholesterol interactions: sphingomyelin-cholesterol binary systems. Biophys J. 2002 Sep; 83(3):1465-78.
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  85. Ho JK, Duclos RI, Hamilton JA. Interactions of acyl carnitines with model membranes: a (13)C-NMR study. J Lipid Res. 2002 Sep; 43(9):1429-39.
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  86. Hamilton JA. How fatty acids bind to proteins: the inside story from protein structures. Prostaglandins Leukot Essent Fatty Acids. 2002 Aug-Sep; 67(2-3):65-72.
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  87. Choi JK, Ho J, Curry S, Qin D, Bittman R, Hamilton JA. Interactions of very long-chain saturated fatty acids with serum albumin. J Lipid Res. 2002 Jul; 43(7):1000-10.
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  88. Johnstone MT, Botnar RM, Perez AS, Stewart R, Quist WC, Hamilton JA, Manning WJ. In vivo magnetic resonance imaging of experimental thrombosis in a rabbit model. Arterioscler Thromb Vasc Biol. 2001 Sep; 21(9):1556-60.
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  89. McMahon KA, Wilson NJ, Marks DC, Beecroft TL, Whitty GA, Hamilton JA, Csar XF. Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity. Biochem J. 2001 Sep 1; 358(Pt 2):431-6.
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  90. Hamilton JA, Benson MD. Transthyretin: a review from a structural perspective. Cell Mol Life Sci. 2001 Sep; 58(10):1491-521.
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  91. Yang YH, Carmeliet P, Hamilton JA. Tissue-type plasminogen activator deficiency exacerbates arthritis. J Immunol. 2001 Jul 15; 167(2):1047-52.
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  92. Hamilton JA, Jessup W, Brown AJ, Whitty G. Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. Biochem J. 2001 Apr 1; 355(Pt 1):207-14.
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  93. Katz R, Hamilton JA, Spector AA, Moore SA, Moser HW, Noetzel MJ, Watkins PA. Brain uptake and utilization of fatty acids: recommendations for future research. J Mol Neurosci. 2001 Apr-Jun; 16(2-3):333-5.
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  94. Hamilton JA, Johnson RA, Corkey B, Kamp F. Fatty acid transport: the diffusion mechanism in model and biological membranes. J Mol Neurosci. 2001 Apr-Jun; 16(2-3):99-108; discussion 151-7.
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  95. Watkins PA, Hamilton JA, Leaf A, Spector AA, Moore SA, Anderson RE, Moser HW, Noetzel MJ, Katz R. Brain uptake and utilization of fatty acids: applications to peroxisomal biogenesis diseases. J Mol Neurosci. 2001 Apr-Jun; 16(2-3):87-92; discussion 151-7.
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  96. Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL. Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am J Physiol Endocrinol Metab. 2001 Feb; 280(2):E238-47.
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  97. Ek-Von Mentzer BA, Zhang F, Hamilton JA. Binding of 13-HODE and 15-HETE to phospholipid bilayers, albumin, and intracellular fatty acid binding proteins. implications for transmembrane and intracellular transport and for protection from lipid peroxidation. J Biol Chem. 2001 May 11; 276(19):15575-80.
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  98. Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. 2001 Jan; 50(1):56-62.
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  99. Peng S, Guo W, Morrisett JD, Johnstone MT, Hamilton JA. Quantification of cholesteryl esters in human and rabbit atherosclerotic plaques by magic-angle spinning (13)C-NMR. Arterioscler Thromb Vasc Biol. 2000 Dec; 20(12):2682-8.
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  100. Hamilton JA, Whitty G, Jessup W. Oxidized LDL can promote human monocyte survival. Arterioscler Thromb Vasc Biol. 2000 Oct; 20(10):2329-31.
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  101. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. Biochem J. 2000 Jul 15; 349(Pt 2):463-71.
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  102. Guo W, Morrisett JD, DeBakey ME, Lawrie GM, Hamilton JA. Quantification in situ of crystalline cholesterol and calcium phosphate hydroxyapatite in human atherosclerotic plaques by solid-state magic angle spinning NMR. Arterioscler Thromb Vasc Biol. 2000 Jun; 20(6):1630-6.
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  103. Lücke C, Zhang F, Hamilton JA, Sacchettini JC, Rüterjans H. Solution structure of ileal lipid binding protein in complex with glycocholate. Eur J Biochem. 2000 May; 267(10):2929-38.
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  104. Fowles LF, Stacey KJ, Marks D, Hamilton JA, Hume DA. Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor. Biochem J. 2000 Apr 1; 347 Pt 1:313-20.
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  105. Hamilton JA, Kamp F. How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? Diabetes. 1999 Dec; 48(12):2255-69.
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  106. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells. Lipids. 1999 Aug; 34(8):825-31.
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  107. Hamilton JA. Transport of fatty acids across membranes by the diffusion mechanism. Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun; 60(5-6):291-7.
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  108. Lücke C, Fushman D, Ludwig C, Hamilton JA, Sacchettini JC, Rüterjans H. A comparative study of the backbone dynamics of two closely related lipid binding proteins: bovine heart fatty acid binding protein and porcine ileal lipid binding protein. Mol Cell Biochem. 1999 Feb; 192(1-2):109-21.
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  109. Hamilton JA, Myers D, Jessup W, Cochrane F, Byrne R, Whitty G, Moss S. Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF. Arterioscler Thromb Vasc Biol. 1999 Jan; 19(1):98-105.
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  110. Hamilton JA, Chan J, Byrne RJ, Bischof RJ, Jaworowski A, Kanagasundaram V. MRL/lpr and MRL+/+ macrophage DNA synthesis in the absence and the presence of colony-stimulating factor-1 and granulocyte-macrophage colony-stimulating factor. J Immunol. 1998 Dec 15; 161(12):6802-11.
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  111. Ward AC, Monkhouse JL, Hamilton JA, Csar XF. Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor. Biochim Biophys Acta. 1998 Nov 19; 1448(1):70-6.
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  112. Campbell IK, Rich MJ, Bischof RJ, Dunn AR, Grail D, Hamilton JA. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol. 1998 Oct 1; 161(7):3639-44.
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  113. Guo W, Kirkland JL, Corkey B, Hamilton JA. A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes. Lipids. 1998 May; 33(5):449-54.
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  114. Hamilton JA. Fatty acid transport: difficult or easy? J Lipid Res. 1998 Mar; 39(3):467-81.
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  115. Kanagasundaram V, Christy E, Hamilton JA, Jaworowski A. Different pathways of colony-stimulating factor 1 degradation in macrophage populations revealed by wortmannin sensitivity. Biochem J. 1998 Feb 15; 330 ( Pt 1):197-202.
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  116. Guo W, Morrisett JD, Lawrie GM, DeBakey ME, Hamilton JA. Identification of different lipid phases and calcium phosphate deposits in human carotid artery plaques by MAS NMR spectroscopy. Magn Reson Med. 1998 Feb; 39(2):184-9.
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  117. Johnson WC, Watkins MT, Baldwin D, Hamilton J. Foot TcPO2 response to lumbar sympathectomy in patients with focal ischemic necrosis. Ann Vasc Surg. 1998 Jan; 12(1):70-4.
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  118. Vadiveloo PK, Filonzi EL, Stanton HR, Hamilton JA. G1 phase arrest of human smooth muscle cells by heparin, IL-4 and cAMP is linked to repression of cyclin D1 and cdk2. Atherosclerosis. 1997 Aug; 133(1):61-9.
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  119. Ek BA, Cistola DP, Hamilton JA, Kaduce TL, Spector AA. Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. Biochim Biophys Acta. 1997 May 17; 1346(1):75-85.
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  120. Zhang F, Lücke C, Baier LJ, Sacchettini JC, Hamilton JA. Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. J Biomol NMR. 1997 Apr; 9(3):213-28.
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  121. Johnson WC, Watkins MT, Hamilton J, Baldwin D. Transcutaneous partial oxygen pressure changes following skew flap and Burgess-type below-knee amputations. Arch Surg. 1997 Mar; 132(3):261-3.
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  122. Csar XF, Ward AC, Hoffmann BW, Guy GG, Hamilton JA. Identification of phosphoproteins specific to granulocyte colony-stimulating factor-mediated signaling using 2D-SDS-PAGE. J Interferon Cytokine Res. 1997 Feb; 17(2):77-86.
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  123. Hamilton JA. CSF-1 and cell cycle control in macrophages. Mol Reprod Dev. 1997 Jan; 46(1):19-23.
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  124. Zhang F, Kamp F, Hamilton JA. Dissociation of long and very long chain fatty acids from phospholipid bilayers. Biochemistry. 1996 Dec 17; 35(50):16055-60.
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  125. Kanagasundaram V, Jaworowski A, Hamilton JA. Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages. Biochem J. 1996 Nov 15; 320 ( Pt 1):69-77.
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  126. Guo W, Hamilton JA. 13C MAS NMR studies of crystalline cholesterol and lipid mixtures modeling atherosclerotic plaques. Biophys J. 1996 Nov; 71(5):2857-68.
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  127. Ward AC, Hoffmann BW, Csar XF, Hamilton JA. Granulocyte colony-stimulating factor-stimulated proliferation of myeloid cells: mode of cell cycle control by a range of inhibitors. J Interferon Cytokine Res. 1996 Oct; 16(10):869-77.
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  128. Civelek VN, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10139-44.
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  129. Gavin AL, Hamilton JA, Hogarth PM. Extracellular mutations of non-obese diabetic mouse FcgammaRI modify surface expression and ligand binding. J Biol Chem. 1996 Jul 19; 271(29):17091-9.
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  130. Lücke C, Zhang F, Rüterjans H, Hamilton JA, Sacchettini JC. Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. Structure. 1996 Jul 15; 4(7):785-800.
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  131. Bird DA, Laposata M, Hamilton JA. Binding of ethyl oleate to low density lipoprotein, phospholipid vesicles, and albumin: a 13C NMR study. J Lipid Res. 1996 Jul; 37(7):1449-58.
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  132. Udagawa N, Chan J, Wada S, Findlay DM, Hamilton JA, Martin TJ. c-fos antisense DNA inhibits proliferation of osteoclast progenitors in osteoclast development but not macrophage differentiation in vitro. Bone. 1996 Jun; 18(6):511-6.
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  133. Boyle E, Small DM, Gantz D, Hamilton JA, German JB. Monoacylglycerols alter the lipid composition and molecular mobility of phosphatidylcholine bilayers: 13C NMR evidence of dynamic lipid remodeling. J Lipid Res. 1996 Apr; 37(4):764-72.
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  134. Hamilton JA, Vural JM, Carpentier YA, Deckelbaum RJ. Incorporation of medium chain triacylglycerols into phospholipid bilayers: effect of long chain triacylglycerols, cholesterol, and cholesteryl esters. J Lipid Res. 1996 Apr; 37(4):773-82.
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  135. Salmon A, Hamilton JA. Magic-angle spinning and solution 13C nuclear magnetic resonance studies of medium- and long-chain cholesteryl esters in model bilayers. Biochemistry. 1995 Dec 12; 34(49):16065-73.
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  136. Guo W, Hamilton JA. A multinuclear solid-state NMR study of phospholipid-cholesterol interactions. Dipalmitoylphosphatidylcholine-cholesterol binary system. Biochemistry. 1995 Oct 31; 34(43):14174-84.
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  137. Kamp F, Zakim D, Zhang F, Noy N, Hamilton JA. Fatty acid flip-flop in phospholipid bilayers is extremely fast. Biochemistry. 1995 Sep 19; 34(37):11928-37.
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  138. Ho JK, Moser H, Kishimoto Y, Hamilton JA. Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy. J Clin Invest. 1995 Sep; 96(3):1455-63.
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  139. Guo W, Hamilton JA. Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study. Biophys J. 1995 Jun; 68(6):2376-86.
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  140. Bhamidipati SP, Hamilton JA. Interactions of lyso 1-palmitoylphosphatidylcholine with phospholipids: a 13C and 31P NMR study. Biochemistry. 1995 Apr 25; 34(16):5666-77.
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  141. Guo W, Hamilton JA. Molecular organization and motions of crystalline monoacylglycerols and diacylglycerols: a C-13 MASNMR study. Biophys J. 1995 Apr; 68(4):1383-95.
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  142. Petrou S, Ordway RW, Kirber MT, Dopico AM, Hamilton JA, Walsh JV, Singer JJ. Direct effects of fatty acids and other charged lipids on ion channel activity in smooth muscle cells. Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar; 52(2-3):173-8.
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  143. Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT). J Biol Chem. 1994 Aug 19; 269(33):20852-6.
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  144. Johnson WC, Watkins MT, Hamilton J, Baldwin D, Walker N. Pentoxifylline therapy for chronic claudication: are patients dependent on therapy? Surgery. 1994 Jun; 115(6):735-9.
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  145. Ko J, Hamilton JA, Ton-Nu HT, Schteingart CD, Hofmann AF, Small DM. Effects of side chain length on ionization behavior and transbilayer transport of unconjugated dihydroxy bile acids: a comparison of nor-chenodeoxycholic acid and chenodeoxycholic acid. J Lipid Res. 1994 May; 35(5):883-92.
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  146. Kenyon MA, Hamilton JA. 13C NMR studies of the binding of medium-chain fatty acids to human serum albumin. J Lipid Res. 1994 Mar; 35(3):458-67.
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  147. Petrou S, Ordway RW, Hamilton JA, Walsh JV, Singer JJ. Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine. J Gen Physiol. 1994 Mar; 103(3):471-86.
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  148. Kamp F, Hamilton JA, Kamp F, Westerhoff HV, Hamilton JA. Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry. 1993 Oct 19; 32(41):11074-86.
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  149. Fosang AJ, Last K, Knäuper V, Neame PJ, Murphy G, Hardingham TE, Tschesche H, Hamilton JA. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. Biochem J. 1993 Oct 1; 295 ( Pt 1):273-6.
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  150. Guo W, Hamilton JA. Molecular organization and motions of cholesteryl esters in crystalline and liquid crystalline phases: a 13C and 1H magic angle spinning NMR study. Biochemistry. 1993 Sep 7; 32(35):9038-52.
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  151. Hudson NW, Albrecht M, Randhawa ZI, Steinrauf LK, Hamilton JA. Regeneration of antidigoxin binding activity in an antibody by changes surrounding the original binding defect. Mol Immunol. 1993 May; 30(7):685-93.
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  152. Filonzi EL, Zoellner H, Stanton H, Hamilton JA. Cytokine regulation of granulocyte-macrophage colony stimulating factor and macrophage colony-stimulating factor production in human arterial smooth muscle cells. Atherosclerosis. 1993 Mar; 99(2):241-52.
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  153. Hamilton JA, Steinrauf LK, Braden BC, Liepnieks J, Benson MD, Holmgren G, Sandgren O, Steen L. The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. J Biol Chem. 1993 Feb 5; 268(4):2416-24.
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  154. Bhamidipati SP, Hamilton JA. NMR studies of phospholipase C hydrolysis of phosphatidylcholine in model membranes. J Biol Chem. 1993 Feb 5; 268(4):2431-4.
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  155. Kamp F, Hamilton JA. pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11367-70.
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  156. Elliott MJ, Faulkner-Jones BE, Stanton H, Hamilton JA, Metcalf D. Plasminogen activator in granulocyte-macrophage-CSF transgenic mice. J Immunol. 1992 Dec 1; 149(11):3678-81.
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  157. Smith SO, Kustanovich I, Bhamidipati S, Salmon A, Hamilton JA. Interfacial conformation of dipalmitoylglycerol and dipalmitoylphosphatidylcholine in phospholipid bilayers. Biochemistry. 1992 Nov 24; 31(46):11660-4.
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  158. Hamilton JA, Vairo G, Cocks BG. Inhibition of S-phase progression in macrophages is linked to G1/S-phase suppression of DNA synthesis genes. J Immunol. 1992 Jun 15; 148(12):4028-35.
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  159. Hamilton JA, Steinrauf LK, Liepnieks J, Benson MD, Holmgren G, Sandgren O, Steen L. Alteration in molecular structure which results in disease: the Met-30 variant of human plasma transthyretin. Biochim Biophys Acta. 1992 Jun 9; 1139(1-2):9-16.
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  160. Boylan JG, Hamilton JA. Interactions of acyl-coenzyme A with phosphatidylcholine bilayers and serum albumin. Biochemistry. 1992 Jan 21; 31(2):557-67.
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  161. Bhaskar KR, Gong DH, Bansil R, Pajevic S, Hamilton JA, Turner BS, LaMont JT. Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Am J Physiol. 1991 Nov; 261(5 Pt 1):G827-32.
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  162. Hamilton JA, Piccoli DS, Leizer T, Butler DM, Croatto M, Royston AK. Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7180-4.
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  163. Deshpande MS, Boylan J, Hamilton JA, Burton J. Conformation and inhibitory properties of peptides based on the tissue kallikrein-aprotinin complex. Int J Pept Protein Res. 1991 Jun; 37(6):536-43.
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  164. Hamilton JA, Fujito DT, Hammer CF. Solubilization and localization of weakly polar lipids in unsonicated egg phosphatidylcholine: A 13C MAS NMR study. Biochemistry. 1991 Mar 19; 30(11):2894-902.
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  165. Hamilton JA, Era S, Bhamidipati SP, Reed RG. Locations of the three primary binding sites for long-chain fatty acids on bovine serum albumin. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2051-4.
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  166. Hamilton JA, Bhamidipati SP, Kodali DR, Small DM. The interfacial conformation and transbilayer movement of diacylglycerols in phospholipid bilayers. J Biol Chem. 1991 Jan 15; 266(2):1177-86.
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  167. Hudson NW, Bruccoleri RE, Steinrauf LK, Hamilton JA, Mudgett-Hunter M, Margolies MN. A V kappa-J kappa junctional change in an antidigoxin recombinant antibody destroys digoxin-binding activity. J Immunol. 1990 Oct 15; 145(8):2718-24.
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  168. Vairo G, Argyriou S, Bordun AM, Gonda TJ, Cragoe EJ, Hamilton JA. Na+/H+ exchange involvement in colony-stimulating factor-1-stimulated macrophage proliferation. Evidence for a requirement during late G1 of the cell cycle but not for early growth factor responses. J Biol Chem. 1990 Oct 5; 265(28):16929-39.
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  169. Spooner PJ, Gantz DL, Hamilton JA, Small DM. The distribution of oleic acid between chylomicron-like emulsions, phospholipid bilayers, and serum albumin. A model for fatty acid distribution between lipoproteins, membranes, and albumin. J Biol Chem. 1990 Jul 25; 265(21):12650-5.
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  170. Deckelbaum RJ, Hamilton JA, Moser A, Bengtsson-Olivecrona G, Butbul E, Carpentier YA, Gutman A, Olivecrona T. Medium-chain versus long-chain triacylglycerol emulsion hydrolysis by lipoprotein lipase and hepatic lipase: implications for the mechanisms of lipase action. Biochemistry. 1990 Feb 6; 29(5):1136-42.
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  171. Bhamidipati SP, Hamilton JA. Hydrolysis of a phospholipid in an inert lipid matrix by phospholipase A2: a 13C NMR study. Biochemistry. 1989 Aug 8; 28(16):6667-72.
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  172. Hamilton JA. Medium-chain fatty acid binding to albumin and transfer to phospholipid bilayers. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2663-7.
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  173. Hamilton JA. Interactions of triglycerides with phospholipids: incorporation into the bilayer structure and formation of emulsions. Biochemistry. 1989 Mar 21; 28(6):2514-20.
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  174. Cistola DP, Hamilton JA, Jackson D, Small DM. Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule. Biochemistry. 1988 Mar 22; 27(6):1881-8.
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  175. Cistola DP, Walsh MT, Corey RP, Hamilton JA, Brecher P. Interactions of oleic acid with liver fatty acid binding protein: a carbon-13 NMR study. Biochemistry. 1988 Jan 26; 27(2):711-7.
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  176. Spooner PJ, Clark SB, Gantz DL, Hamilton JA, Small DM. The ionization and distribution behavior of oleic acid in chylomicrons and chylomicron-like emulsion particles and the influence of serum albumin. J Biol Chem. 1988 Jan 25; 263(3):1444-53.
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  177. Walsh MT, Hamilton JA, Atkinson D, Small DM. Secondary and tertiary structure of apolipoproteins. Adv Exp Med Biol. 1988; 243:123-32.
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  178. Croll DH, Sripada PK, Hamilton JA. Temperature-dependent molecular motions and phase behavior of cholesteryl ester analogues. J Lipid Res. 1987 Dec; 28(12):1444-54.
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  179. Cistola DP, Small DM, Hamilton JA. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. J Biol Chem. 1987 Aug 15; 262(23):10971-9.
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  180. Cistola DP, Small DM, Hamilton JA. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. J Biol Chem. 1987 Aug 15; 262(23):10980-5.
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  181. Sripada PK, Maulik PR, Hamilton JA, Shipley GG. Partial synthesis and properties of a series of N-acyl sphingomyelins. J Lipid Res. 1987 Jun; 28(6):710-8.
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  182. Cabral DJ, Small DM, Lilly HS, Hamilton JA. Transbilayer movement of bile acids in model membranes. Biochemistry. 1987 Apr 7; 26(7):1801-4.
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  183. Spooner PJ, Hamilton JA, Gantz DL, Small DM. The effect of free cholesterol on the solubilization of cholesteryl oleate in phosphatidylcholine bilayers: A 13C-NMR study. Biochim Biophys Acta. 1986 Aug 21; 860(2):345-53.
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  184. Cistola DP, Atkinson D, Hamilton JA, Small DM. Phase behavior and bilayer properties of fatty acids: hydrated 1:1 acid-soaps. Biochemistry. 1986 May 20; 25(10):2804-12.
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  185. Cabral DJ, Hamilton JA, Small DM. The ionization behavior of bile acids in different aqueous environments. J Lipid Res. 1986 Mar; 27(3):334-43.
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  186. Hamilton JA, Morrisett JD. Nuclear magnetic resonance studies of lipoproteins. Methods Enzymol. 1986; 128:472-515.
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  187. Hamilton JA, Cistola DP. Transfer of oleic acid between albumin and phospholipid vesicles. Proc Natl Acad Sci U S A. 1986 Jan; 83(1):82-6.
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  188. Croll DH, Small DM, Hamilton JA. Molecular motions and thermotropic phase behavior of cholesteryl esters with triolein. Biochemistry. 1985 Dec 31; 24(27):7971-80.
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  189. Morrisett JD, Gaubatz JW, Tarver AP, Allen JK, Pownall HJ, Laggner P, Hamilton JA. Thermotropic properties and molecular dynamics of cholesteryl ester rich very low density lipoproteins: effect of hydrophobic core on polar surface. Biochemistry. 1984 Oct 23; 23(22):5343-52.
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  190. Small DM, Cabral DJ, Cistola DP, Parks JS, Hamilton JA. The ionization behavior of fatty acids and bile acids in micelles and membranes. Hepatology. 1984 Sep-Oct; 4(5 Suppl):77S-79S.
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  191. Hamilton JA, Cistola DP, Morrisett JD, Sparrow JT, Small DM. Interactions of myristic acid with bovine serum albumin: a 13C NMR study. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3718-22.
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  192. Hamilton JA, Miller KW, Small DM. Solubilization of triolein and cholesteryl oleate in egg phosphatidylcholine vesicles. J Biol Chem. 1983 Nov 10; 258(21):12821-6.
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  193. Parks JS, Cistola DP, Small DM, Hamilton JA. Interactions of the carboxyl group of oleic acid with bovine serum albumin: a 13C NMR study. J Biol Chem. 1983 Aug 10; 258(15):9262-9.
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  194. Hamilton JA, Small DM, Parks JS. 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates. J Biol Chem. 1983 Jan 25; 258(2):1172-9.
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  195. Ginsburg GS, Small DM, Hamilton JA. Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study. Biochemistry. 1982 Dec 21; 21(26):6857-67.
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  196. Hamilton JA, Small DM. Solubilization and localization of cholesteryl oleate in egg phosphatidylcholine vesicles. A carbon 13 NMR study. J Biol Chem. 1982 Jul 10; 257(13):7318-21.
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  197. Cistola DP, Small DM, Hamilton JA. Ionization behavior of aqueous short-chain carboxylic acids: a carbon-13 NMR study. J Lipid Res. 1982 Jul; 23(5):795-9.
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  198. Hamilton JA, Zabriskie JB, Lachman LB, Chen YS. Streptococcal cell walls and synovial cell activation. Stimulation of synovial fibroblast plasminogen activator activity by monocytes treated with group A streptococcal cell wall sonicates and muramyl dipeptide. J Exp Med. 1982 Jun 1; 155(6):1702-18.
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  199. Clark SB, Atkinson D, Hamilton JA, Forte T, Russell B, Feldman EB, Small DM. Physical studies of d less than 1.006 g/ml lymph lipoproteins from rats fed palmitate-rich diets. J Lipid Res. 1982 Jan; 23(1):28-41.
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  200. Hamilton JA, Small DM. Solubilization and localization of triolein in phosphatidylcholine bilayers: a 13C NMR study. Proc Natl Acad Sci U S A. 1981 Nov; 78(11):6878-82.
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  201. Brainard JR, Hamilton JA, Cordes EH, Patsch JR, Gotto AM, Morrisett JD. Lipoprotein-X: carbon-13 nuclear magnetic resonance studies on native, reconstituted, and model systems. Biochemistry. 1980 Sep 2; 19(18):4266-73.
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  202. Hamilton JA, Cordes EH, Glueck CJ. Lipid dynamics in human low density lipoproteins and human aortic tissue with fibrous plaques. A study by high field 13C NMR spectroscopy. J Biol Chem. 1979 Jun 25; 254(12):5435-41.
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  203. Hamilton JA, Cordes EH. Molecular dynamics of lipids in human plasma high density lipoproteins. A high field 13C NMR study. J Biol Chem. 1978 Jul 25; 253(14):5193-8.
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  204. Avila EM, Hamilton JA, Harmony JA, Allerhand A, Cordes EH. Natural abundance 13C nuclear magnetic resonance studies of human plasma high density lipoproteins. J Biol Chem. 1978 Jun 10; 253(11):3983-7.
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  205. Hamilton JA, Oppenheimer N, Cordes EH. Carbon-13 nuclear magnetic resonance studies of cholesteryl esters and cholesteryl ester/triglyceride mixtures. J Biol Chem. 1977 Nov 25; 252(22):8071-80.
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  206. Avila-Bello EM, Hamilton JA, Talkowski C, Harmony JA, Allerhand A, Cordes EH, Camejo G. [Structure of plasma lipoproteins (author's transl)]. Acta Cient Venez. 1977; 28(1):37-43.
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  207. Hamilton JA, Oppenheimer NJ, Addleman R, Clouse AO, Cordes EH, Steiner PM, Glueck CJ. High-field 13C NMR Studies of certain normal and abnormal human plasma lipoproteins. Science. 1976 Dec 24; 194(4272):1424-7.
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  208. Hamilton JA, Miller JF. Hapten-specific tolerance in mice. I. Induction with hapten-coupled syngeneic erythrocytes. Eur J Immunol. 1974 Apr; 4(4):261-8.
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  209. Hamilton JA, Miller JF, Kettman J. Hapten-specific tolerance in mice. II. Adoptive transfer studies and evidence for unresponsiveness in the B cells. Eur J Immunol. 1974 Apr; 4(4):268-76.
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  210. Hamilton JA, Miller JF. Induction of a primary antihapten response in vivo by a graft-vs.-host reaction. J Exp Med. 1973 Oct 1; 138(4):1009-14.
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  211. Williams E, Hamilton JA, Jain MK, Allerhand A, Cordes EH, Ochs S. Natural abundance carbon-13 nuclear magnetic resonance spectra of the canine sciatic nerve. Science. 1973 Aug 31; 181(4102):869-71.
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  212. Hamilton JA, Miller JF. Hapten-specific tolerance: unresponsiveness in the T cell-depleted population. Eur J Immunol. 1973 Jul; 3(7):457-60.
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  213. Hamilton JA, Talkowski C, Williams E, Avila EM, Allerhand A, Cordes EH, Camejo G. Natural abundance carbon-13 nuclear magnetic resonance spectra of human serum lipoproteins. Science. 1973 Apr 15; 180(4082):193-5.
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  214. Young IG, Leppik RA, Hamilton JA, Gibson F. Biochemical and genetic studies on ubiquinone biosynthesis in Escherichia coli K-12:4-hydroxybenzoate octaprenyltransferase. J Bacteriol. 1972 Apr; 110(1):18-25.
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  215. Cox GB, Newton NA, Gibson F, Snoswell AM, Hamilton JA. The function of ubiquinone in Escherichia coli. Biochem J. 1970 Apr; 117(3):551-62.
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  216. Hamilton JA, Cox GB, Looney FD, Gibson F. Ubisemiquinone in membranes from Escherichia coli. Biochem J. 1970 Jan; 116(2):319-20.
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