Caroline M. Apovian, MD
Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition

MD, University of Medicine and Dentistry of New Jersey



Dr. Apovian’s focus is on clinical research in obesity and diabetes. Her group investigates weight loss and its effects on endothelial cell function, adipose cell metabolism and inflammation, research in the bariatric surgery population and novel pharmacotherapeutic antiobesity agents. She has become an expert in the technique for subcutaneous adipose tissue aspirations, and has been performing these aspirations on research subjects at Boston University for over 5 years. Other research projects include dietary and physical activity interventions in underserved post-partum women and the investigation into the effects of increased dietary protein on lean body mass, maximal voluntary muscle strength and power in older men with mobility limitations.

Professor
Boston University School of Medicine
Pediatrics
Diabetes & Endocrinology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Active Staff Privileges
Boston Medical Center
Medicine
Endocrinology, Diabetes & Nutrition


2000-2002 American Society of Clinic Nutrition: Physician Nutrition Specialist Award
1993-1996 Geisinger Medical Center: Clinician-Investigator Career Development Award


Pivotal Aspiration Therapy with Adjusted Lifestyle (PATHWAY) Study
01/29/2013 - 03/31/2018 (PI)
Aspire Bariatrics, Inc.


Inflammation in human obesity and type 2 diabetes
07/01/2016 - 09/30/2017 (Co-PI)
PI: Barbara S Nikolajczyk, PhD
NIH/National Diabetes & Digestive & Kidn
5R01DK108056-02

A multicenter, randomized, double-blind, placebo-controlled study assessing the occurrence of major adverse cardiovascular events (MACE) in overweight and obese subjects with cardiovascular risk facto
07/01/2012 - 06/30/2017 (PI)
Orexigen Therapeutics, Inc.


A Randomized Multi-center pivotal efficacy and safety study comparing the endobarrier gastrointestinal liner system vs. sham for glycemic improvement in inadequately controlled
05/15/2013 - 12/31/2016 (PI)
GI Dynamics, Inc.


A Multicenter, Randomized, Double Blind, Placebo Controlled Study Comparing the Safety and Efficacy of Naltrexone Sustained Release (S/R)/Bupropion Sustained Release (S/R) and Placebo in Obese S
12/19/2007 - 12/31/2012 (PI)
Orexigen Therapeutics, Inc.


A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Examine the Efficacy and Safety of Pramlintide+Metreleptin in Obese Subjects Following a Low-Calorie Diet Lead-In
01/01/2011 - 06/30/2012 (PI)
Amylin Pharmaceuticals, Inc.


Inspire ME IAA C_00046: International Study of Prediction of Intra-Abdominal Adiposity and its Relationships with CardioMetabolic Risk/Intra-Abdominal Adiposity
01/02/2008 - 01/02/2011 (PI)
Sanofi-Aventis, U.S., LLC


A Phase IIB, Multi-Center, Dose-Parallel, Randomized, Double-Blind, Monotherapy and Placebo-Controled Safety and Efficacy Study of Zonisamid SR Alone and Zomisamide SR plus Bupropion SR Combinati
07/22/2008 - 07/22/2010 (PI)
Orexigen Therapeutics, Inc.


Improving Family Communication to Reduce Obesity Among Children in Framingham, MA
12/31/2005 - 12/30/2008 (Co-PI)
MetroWest Community Health Care Foundation

Self Monitoring of Blood Glucose with Finger Tip Sampling vs. Alternative Site Sampling: Sources of Variability and Effect on Long Term Glycemic Control
09/30/2002 - 09/21/2008 (PI)
DHHS OWH

Showing 10 of 23 results. Show All Results

Inflammation in human obesity and type 2 diabetes
10/01/2017 - 03/31/2018 (PI)
University of Kentucky Research Foundation NIH-NIDDK
R01DK108056-01

Inflammation in human obesity and type 2 diabetes
04/01/2016 - 03/31/2018 (PI)
Trustees of Boston University NIH-NIDDK

G-04/GEL3002: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing…
03/31/2016 - 03/31/2018 (PI)
Gelesis, Srl.

GLOW/GS-100-009 EXTENSION
02/27/2017 - 02/27/2018 (PI)
Gelesis, Srl.

Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance
10/01/2014 - 07/31/2017 (PI)
Children's Hospital Nutrition Science In

Conversion of Human Muscle Cells to Brown Adipocytes: In Vitro Studies
01/01/2017 - 07/19/2017 (PI)
Energesis Pharmaceuticals Dept of Defense

Comparison of Surgical vs. Lifestyle Weight Treatment in Obese Older Adults
07/01/2016 - 06/30/2017 (PI)
Beth Israel Center for Nutrition

Dietary Patterns and Biomarkers of Liver and Kidney Injury
02/01/2016 - 01/31/2017 (PI)
Coherence Lab

Optimizing Protein Intake in Older Americans with Mobility Limitations
09/01/2013 - 05/31/2016 (PI)
Brigham & Women's NIH-NIA

Apovian - AMPK & Adipose Tissue Biology in Bariatric Surgery Patients
07/16/2012 - 06/30/2014 (PI)
NIH-NIDDK

Showing 10 of 17 results. Show All Results


Yr Title Project-Sub Proj Pubs
2017 Inflammation in human obesity and type 2 diabetes 5R01DK108056-02 1
2016 Inflammation in human obesity and type 2 diabetes 1R01DK108056-01A1 1
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-05 1
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 3R01AG037547-05S1 1
2013 Optimizing Protein Intake in Older Americans with Mobility Limitations 7R01AG037547-04 1
2013 Optimizing Protein Intake in Older Americans with Mobility Limitations 3R01AG037547-04S1 1
2012 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-03 1
2011 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-02 1
2010 Optimizing Protein Intake in Older Americans with Mobility Limitations 1R01AG037547-01 1
2010 Reducing Obesity in Underserved Postpartum African American Women 1R21HD061311-01A1 1
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Demark-Wahnefried W, Schmitz KH, Alfano CM, Bail JR, Goodwin PJ, Thomson CA, Bradley DW, Courneya KS, Befort CA, Denlinger CS, Ligibel JA, Dietz WH, Stolley MR, Irwin ML, Bamman MM, Apovian CM, Pinto BM, Wolin KY, Ballard RM, Dannenberg AJ, Eakin EG, Longjohn MM, Raffa SD, Adams-Campbell LL, Buzaglo JS, Nass SJ, Massetti GM, Balogh EP, Kraft ES, Parekh AK, Sanghavi DM, Morris GS, Basen-Engquist K. Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin. 2017 Nov 22. PMID: 29165798.
  2. Wee CC, Jones DB, Apovian C, Hess DT, Chiodi SN, Bourland AC, Davis RB, Schneider B, Blackburn GL, Marcantonio ER, Hamel MB. Weight Loss After Bariatric Surgery: Do Clinical and Behavioral Factors Explain Racial Differences? Obes Surg. 2017 Nov; 27(11):2873-2884. PMID: 28500418.
  3. Srivastava G, Apovian CM. Current pharmacotherapy for obesity. Nat Rev Endocrinol. 2017 Oct 13.View Related Profiles. PMID: 29027993.
  4. Ryou M, McQuaid KR, Thompson CC, Edmundowicz S, Mergener K, Abu Dayyeh B, Apovian C, Burke C, Chand B, Chandraker A, Deas T, Dietz W, Dunkin B, Ernest O, Faigel D, Garber S, Hamdy O, Kaplan L, Kumar N, Kushner R, Larsen MC, Lerner H, Littenberg G, Mantzoros C, Mattar S, Moore R, Rinella M, Rothstein R, Schillinger D, Spring B, Sullivan S, Tice J, Vargo J, Wilson E, Woods K, Zundel N. ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management. Gastrointest Endosc. 2017 11; 86(5):757-767. PMID: 29031371.
  5. Apovian CM, Riffenburg KM. Perspectives on the global obesity epidemic. Curr Opin Endocrinol Diabetes Obes. 2017 Oct; 24(5):307-309. PMID: 28841635.
  6. Ryou M, McQuaid KR, Thompson CC, Edmundowicz S, Mergener K, Dayyeh BA, Apovian C, Burke C, Chand B, Chandraker A, Deas T, Dietz W, Dunkin B, Ernest O, Faigel D, Garber S, Hamdy O, Kaplan L, Kumar N, Kushner R, Larsen MC, Lerner H, Littenberg G, Mantzoros C, Mattar S, Moore R, Rinella M, Rothstein R, Schillinger D, Spring B, Sullivan S, Tice J, Vargo J, Wilson E, Woods K, Zundel N. ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management. Surg Obes Relat Dis. 2017 Nov; 13(11):1805-1816. PMID: 29030161.
  7. Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM. Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 May 15; 64(10):1422-1429. PMID: 28329372; DOI: 10.1093/cid/cix178;.
  8. Bhasin S, Apovian CM, Travison TG, Pencina K, Huang G, Moore LL, Campbell WW, Howland A, Chen R, Singer MR, Shah M, Eder R, Schram H, Bearup R, Beleva YM, McCarthy AC, Li Z, Woodbury E, McKinnon J, Storer TW, Basaria S. Design of a randomized trial to determine the optimum protein intake to preserve lean body mass and to optimize response to a promyogenic anabolic agent in older men with physical functional limitation. Contemp Clin Trials. 2017 Jul; 58:86-93.View Related Profiles. PMID: 28483498.
  9. Thomas D, Apovian C. Macrophage functions in lean and obese adipose tissue. Metabolism. 2017 Jul; 72:120-143. PMID: 28641779.
  10. Semla TP, Ruser C, Good CB, Yanovski SZ, Ames D, Copeland LA, Billington C, Ferguson UI, Aronne LJ, Wadden TA, Garvey WT, Apovian CM, Atkins D. Pharmacotherapy for Weight Management in the VHA. J Gen Intern Med. 2017 Apr; 32(Suppl 1):70-73. PMID: 28271432; DOI: 10.1007/s11606-016-3949-y;.
Showing 10 of 158 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 158 publications over 24 distinct years, with a maximum of 19 publications in 2013

YearPublications
19881
19903
19921
19951
19962
19972
19991
20011
20023
20031
20043
20057
20062
20076
200814
200912
201011
20118
201210
201319
201412
201511
201612
201715
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adipose tissue
Diabetes
Inflammation
Nutrition
Obesity
Contact for Mentoring:


72 E. Concord St Robinson (B)
Boston MA 02118
Google Map


Apovian's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department