Caroline M. Apovian, MD
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition Section

MD, University of Medicine and Dentistry of New Jersey

Dr. Apovian’s focus is on clinical research in obesity and diabetes. Her group investigates weight loss and its effects on endothelial cell function, adipose cell metabolism and inflammation, research in the bariatric surgery population and novel pharmacotherapeutic antiobesity agents. She has become an expert in the technique for subcutaneous adipose tissue aspirations, and has been performing these aspirations on research subjects at Boston University for over 5 years. Other research projects include dietary and physical activity interventions in underserved post-partum women and the investigation into the effects of increased dietary protein on lean body mass, maximal voluntary muscle strength and power in older men with mobility limitations.

Boston University School of Medicine
Diabetes & Endocrinology Section

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Active Staff Privileges
Boston Medical Center
Endocrinology, Diabetes & Nutrition Section

2000-2002 American Society of Clinic Nutrition: Physician Nutrition Specialist Award
1993-1996 Geisinger Medical Center: Clinician-Investigator Career Development Award

Inflammation in human obesity and type 2 diabetes
04/01/2016 - 03/31/2018 (Co-PI)
PI: Barbara S Nikolajczyk, PhD
NIH/National Diabetes & Digestive & Kidn

Pivotal Aspiration Therapy with Adjusted Lifestyle (PATHWAY) Study
01/29/2013 - 03/31/2018 (PI)
Aspire Bariatrics, Inc.

A multicenter, randomized, double-blind, placebo-controlled study assessing the occurrence of major adverse cardiovascular events (MACE) in overweight and obese subjects with cardiovascular risk facto
07/01/2012 - 06/30/2017 (PI)
Orexigen Therapeutics, Inc.

A Randomized Multi-center pivotal efficacy and safety study comparing the endobarrier gastrointestinal liner system vs. sham for glycemic improvement in inadequately controlled
05/15/2013 - 12/31/2016 (PI)
GI Dynamics, Inc.

A Multicenter, Randomized, Double Blind, Placebo Controlled Study Comparing the Safety and Efficacy of Naltrexone Sustained Release (S/R)/Bupropion Sustained Release (S/R) and Placebo in Obese S
12/19/2007 - 12/31/2012 (PI)
Orexigen Therapeutics, Inc.

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Examine the Efficacy and Safety of Pramlintide+Metreleptin in Obese Subjects Following a Low-Calorie Diet Lead-In
01/01/2011 - 06/30/2012 (PI)
Amylin Pharmaceuticals, Inc.

Inspire ME IAA C_00046: International Study of Prediction of Intra-Abdominal Adiposity and its Relationships with CardioMetabolic Risk/Intra-Abdominal Adiposity
01/02/2008 - 01/02/2011 (PI)
Sanofi-Aventis, U.S., LLC

A Phase IIB, Multi-Center, Dose-Parallel, Randomized, Double-Blind, Monotherapy and Placebo-Controled Safety and Efficacy Study of Zonisamid SR Alone and Zomisamide SR plus Bupropion SR Combinati
07/22/2008 - 07/22/2010 (PI)
Orexigen Therapeutics, Inc.

Improving Family Communication to Reduce Obesity Among Children in Framingham, MA
12/31/2005 - 12/30/2008 (Co-PI)
MetroWest Community Health Care Foundation

Self Monitoring of Blood Glucose with Finger Tip Sampling vs. Alternative Site Sampling: Sources of Variability and Effect on Long Term Glycemic Control
09/30/2002 - 09/21/2008 (PI)

Showing 10 of 23 results. Show All Results

Inflammation in human obesity and type 2 diabetes
04/01/2016 - 03/31/2018 (PI)
Trustees of Boston University NIH-NIDDK

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gele…
03/31/2016 - 03/31/2018 (PI)
Gelesis, Srl.

02/27/2017 - 02/27/2018 (PI)
Gelesis, Srl.

Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance
10/01/2014 - 07/31/2017 (PI)
Children's Hospital Nutrition Science In

Conversion of Human Muscle Cells to Brown Adipocytes: In Vitro Studies
01/01/2017 - 07/19/2017 (PI)
Energesis Pharmaceuticals Dept of Defense

Comparison of Surgical vs. Lifestyle Weight Treatment in Obese Older Adults
07/01/2016 - 06/30/2017 (PI)
Beth Israel Center for Nutrition

Dietary Patterns and Biomarkers of Liver and Kidney Injury
02/01/2016 - 01/31/2017 (PI)
Coherence Lab

Optimizing Protein Intake in Older Americans with Mobility Limitations
09/01/2013 - 05/31/2016 (PI)
Brigham & Women's NIH-NIA

Apovian - AMPK & Adipose Tissue Biology in Bariatric Surgery Patients
07/16/2012 - 06/30/2014 (PI)
1R24 DK094749-01

Optimizing Protein Intake in Older Americans with Mobility Limitations
09/15/2010 - 08/31/2013 (Activity-level PI)
PI: Shalender Bhasin, MBBS
5R01 AG037547-04

Showing 10 of 16 results. Show All Results

Yr Title Project-Sub Proj Pubs
2017 Inflammation in human obesity and type 2 diabetes 5R01DK108056-02 1
2016 Inflammation in human obesity and type 2 diabetes 1R01DK108056-01A1 1
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-05 1
2014 Optimizing Protein Intake in Older Americans with Mobility Limitations 3R01AG037547-05S1 1
2013 Optimizing Protein Intake in Older Americans with Mobility Limitations 7R01AG037547-04 1
2013 Optimizing Protein Intake in Older Americans with Mobility Limitations 3R01AG037547-04S1 1
2012 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-03 1
2011 Optimizing Protein Intake in Older Americans with Mobility Limitations 5R01AG037547-02 1
2010 Optimizing Protein Intake in Older Americans with Mobility Limitations 1R01AG037547-01 1
2010 Reducing Obesity in Underserved Postpartum African American Women 1R21HD061311-01A1 1
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Apovian CM, Riffenburg KM. Perspectives on the global obesity epidemic. Curr Opin Endocrinol Diabetes Obes. 2017 Oct; 24(5):307-309. PMID: 28841635.
  2. Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM. Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 May 15; 64(10):1422-1429. PMID: 28329372; DOI: 10.1093/cid/cix178;.
  3. Wee CC, Jones DB, Apovian C, Hess DT, Chiodi SN, Bourland AC, Davis RB, Schneider B, Blackburn GL, Marcantonio ER, Hamel MB. Weight Loss After Bariatric Surgery: Do Clinical and Behavioral Factors Explain Racial Differences? Obes Surg. 2017 May 12. PMID: 28500418.
  4. Bhasin S, Apovian CM, Travison TG, Pencina K, Huang G, Moore LL, Campbell WW, Howland A, Chen R, Singer MR, Shah M, Eder R, Schram H, Bearup R, Beleva YM, McCarthy AC, Li Z, Woodbury E, McKinnon J, Storer TW, Basaria S. Design of a randomized trial to determine the optimum protein intake to preserve lean body mass and to optimize response to a promyogenic anabolic agent in older men with physical functional limitation. Contemp Clin Trials. 2017 Jul; 58:86-93.View Related Profiles. PMID: 28483498.
  5. Thomas D, Apovian C. Macrophage functions in lean and obese adipose tissue. Metabolism. 2017 Jul; 72:120-143. PMID: 28641779.
  6. Semla TP, Ruser C, Good CB, Yanovski SZ, Ames D, Copeland LA, Billington C, Ferguson UI, Aronne LJ, Wadden TA, Garvey WT, Apovian CM, Atkins D. Pharmacotherapy for Weight Management in the VHA. J Gen Intern Med. 2017 Apr; 32(Suppl 1):70-73. PMID: 28271432; DOI: 10.1007/s11606-016-3949-y;.
  7. Velazquez A, Apovian CM, Istfan NW. The Complexities of Iron Deficiency in Patients After Bariatric Surgery. Am J Med. 2017 Jul; 130(7):e293-e294.View Related Profiles. PMID: 28238687; DOI: 10.1016/j.amjmed.2017.01.040;.
  8. Nicholas D, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA, Nikolajczyk BS. Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis. PLoS One. 2017; 12(2):e0170975.View Related Profiles. PMID: 28178278; DOI: 10.1371/journal.pone.0170975;.
  9. Apovian CM, Shah SN, Wolfe BM, Ikramuddin S, Miller CJ, Tweden KS, Billington CJ, Shikora SA. Two-Year Outcomes of Vagal Nerve Blocking (vBloc) for the Treatment of Obesity in the ReCharge Trial. Obes Surg. 2017 Jan; 27(1):169-176. PMID: 27506803; DOI: 10.1007/s11695-016-2325-7;.
  10. Thompson CC, Abu Dayyeh BK, Kushner R, Sullivan S, Schorr AB, Amaro A, Apovian CM, Fullum T, Zarrinpar A, Jensen MD, Stein AC, Edmundowicz S, Kahaleh M, Ryou M, Bohning JM, Ginsberg G, Huang C, Tran DD, Glaser JP, Martin JA, Jaffe DL, Farraye FA, Ho SB, Kumar N, Harakal D, Young M, Thomas CE, Shukla AP, Ryan MB, Haas M, Goldsmith H, McCrea J, Aronne LJ. Percutaneous Gastrostomy Device for the Treatment of Class II and Class III Obesity: Results of a Randomized Controlled Trial. Am J Gastroenterol. 2017 Mar; 112(3):447-457.View Related Profiles. PMID: 27922026; DOI: 10.1038/ajg.2016.500;.
Showing 10 of 150 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 150 publications over 24 distinct years, with a maximum of 19 publications in 2013

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adipose tissue
Contact for Mentoring:

72 E. Concord St Robinson (B)
Boston MA 02118
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