Keywords
Last Name

Nawfal W. Istfan, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 638-5980
ORCID ORCID Icon0000-0001-7163-8309
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Research expertise includes obesity and insulin resistance in humans; and flow cytometry for cell cycle analysis and measurement of cell proliferation.

 Self-Described Keywords
  • cell cycle kinetics
  • nutrition and cancer
  • obesity
  • omega 3 fatty acids
  • prostate cancer
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Velazquez A, Apovian CM, Istfan NW. The Complexities of Iron Deficiency in Patients After Bariatric Surgery. Am J Med. 2017 Feb 24. PMID: 28238687.
    View in: PubMed
  2. Apovian CM, Istfan NW. ETHNIC AND RACIAL DISPARITIES IN THE BEHAVIORAL, PHARMACOLOGIC, AND SURGICAL TREATMENT OF OBESITY. Endocr Pract. 2016 Nov; 22(11):1347-1349. PMID: 27631851.
    View in: PubMed
  3. Apovian CM, Istfan NW. Obesity: Guidelines, Best Practices, New Research. Endocrinol Metab Clin North Am. 2016 Sep; 45(3):xvii-xviii. PMID: 27519142.
    View in: PubMed
  4. Istfan N, Anderson WA, Apovian C, Ruth M, Carmine B, Hess D. Racial differences in weight loss, hemoglobin A1C, and blood lipid profiles after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2016 Aug; 12(7):1329-1336. PMID: 27150343.
    View in: PubMed
  5. Hasson BR, Apovian C, Istfan N. Racial/Ethnic Differences in Insulin Resistance and Beta Cell Function: Relationship to Racial Disparities in Type 2 Diabetes among African Americans versus Caucasians. Curr Obes Rep. 2015 Jun; 4(2):241-9. PMID: 26627219.
    View in: PubMed
  6. Ruth MR, Port AM, Shah M, Bourland AC, Istfan NW, Nelson KP, Gokce N, Apovian CM. Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects. Metabolism. 2013 Dec; 62(12):1779-87. PMID: 24075505.
    View in: PubMed
  7. Port AM, Ruth MR, Istfan NW. Fructose consumption and cancer: is there a connection? Curr Opin Endocrinol Diabetes Obes. 2012 Oct; 19(5):367-74. PMID: 22922366.
    View in: PubMed
  8. Istfan NW, Anderson WA, Apovian CM, Hess DT, Forse RA. Preoperative weight gain might increase risk of gastric bypass surgery. Surg Obes Relat Dis. 2011 Mar-Apr; 7(2):157-64. PMID: 21111687.
    View in: PubMed
  9. Chiang KC, Persons KS, Istfan NW, Holick MF, Chen TC. Fish oil enhances the antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 on liver cancer cells. Anticancer Res. 2009 Sep; 29(9):3591-6. PMID: 19667153.
    View in: PubMed
  10. Apovian C, Bigornia S, Cullum-Dugan D, Schoonmaker C, Radziejowska J, Phipps J, Gokce N, Istfan N, Meyers A, Lenders C. Milk-Based Nutritional Supplements in Conjunction With Lifestyle Intervention in Overweight Adolescents. Infant Child Adolesc Nutr. 2009 Feb; 1(1):37-44. PMID: 22347517.
    View in: PubMed
  11. Arkin JM, Alsdorf R, Bigornia S, Palmisano J, Beal R, Istfan N, Hess D, Apovian CM, Gokce N. Relation of cumulative weight burden to vascular endothelial dysfunction in obesity. Am J Cardiol. 2008 Jan 1; 101(1):98-101. PMID: 18157973.
    View in: PubMed
  12. Anderson WA, Greene GW, Forse RA, Apovian CM, Istfan NW. Weight loss and health outcomes in African Americans and whites after gastric bypass surgery. Obesity (Silver Spring). 2007 Jun; 15(6):1455-63. PMID: 17557983.
    View in: PubMed
  13. Istfan NW, Person KS, Holick MF, Chen TC. 1alpha,25-Dihydroxyvitamin D and fish oil synergistically inhibit G1/S-phase transition in prostate cancer cells. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):726-30. PMID: 17223546.
    View in: PubMed
  14. Sabin J, Fanelli R, Flaherty H, Istfan N, Mariner W, Barnes JN, Pratt JS, Rossi L, Samour P. Best practice guidelines on informed consent for weight loss surgery patients. Obes Res. 2005 Feb; 13(2):250-3. PMID: 15800281.
    View in: PubMed
  15. Gokce N, Vita JA, McDonnell M, Forse AR, Istfan N, Stoeckl M, Lipinska I, Keaney JF, Apovian CM. Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients. Am J Cardiol. 2005 Jan 15; 95(2):266-8. PMID: 15642566.
    View in: PubMed
  16. Rex S, Kukuruzinska MA, Istfan NW. Inhibition of DNA replication by fish oil-treated cytoplasm is counteracted by fish oil-treated nuclear extract. Am J Physiol Cell Physiol. 2002 Nov; 283(5):C1365-75. PMID: 12372797.
    View in: PubMed
  17. Istfan NW, Chen ZY, Rex S. Fish oil slows S phase progression and may cause upstream shift of DHFR replication origin ori-beta in CHO cells. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1009-24. PMID: 12225965.
    View in: PubMed
  18. Istfan NW, Khauli RB. Evaluation of the effect of fish oil on cell kinetics: implications for clinical immunosuppression. Transplant Proc. 2001 Aug; 33(5):2854-5. PMID: 11498187.
    View in: PubMed
  19. Chen ZY, Istfan NW. Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. Prostaglandins Leukot Essent Fatty Acids. 2001 Jan; 64(1):67-73. PMID: 11161587.
    View in: PubMed
  20. Chen ZY, Istfan NW. Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. Prostaglandins Leukot Essent Fatty Acids. 2000 Nov; 63(5):301-8. PMID: 11090257.
    View in: PubMed
  21. Sierra P, Ling PR, Istfan NW, Bistrian BR. Fish oil feeding improves muscle glucose uptake in tumor necrosis factor-treated rats. Metabolism. 1995 Oct; 44(10):1365-70. PMID: 7476299.
    View in: PubMed
  22. Ling PR, Istfan NW, Colon E, Bistrian BR. Differential effects of interleukin-1 receptor antagonist in cytokine- and endotoxin-treated rats. Am J Physiol. 1995 Feb; 268(2 Pt 1):E255-61. PMID: 7864101.
    View in: PubMed
  23. Ling PR, Gollaher C, Colon E, Istfan N, Bistrian BR. IGF-I alters energy expenditure and protein metabolism during parenteral feeding in rats. Am J Clin Nutr. 1995 Jan; 61(1):116-20. PMID: 7825522.
    View in: PubMed
  24. Istfan NW, Wan J, Chen ZY. Fish oil and cell proliferation kinetics in a mammary carcinoma tumor model. Adv Exp Med Biol. 1995; 375:149-56. PMID: 7645425.
    View in: PubMed
  25. Wan JM, Istfan NW, Ye SL, Bistrian BR. Insulin-like growth factor-1 is not mitogenic for the Walker-256 carcinosarcoma. Life Sci. 1995; 56(10):747-56. PMID: 7885190.
    View in: PubMed
  26. Istfan NW, Wan JM, Bistrian BR, Chen ZY. DNA replication time accounts for tumor growth variation induced by dietary fat in a breast carcinoma model. Cancer Lett. 1994 Nov 11; 86(2):177-86. PMID: 7982205.
    View in: PubMed
  27. Fogt F, Vortmeyer A, Tahan S, Stavrou D, Istfan N. Cell-cycle kinetics of permanent glioma-cells measured by pulse labeling with bromodeoxyuridine. Int J Oncol. 1994 Jun; 4(6):1315-21. PMID: 21567055.
    View in: PubMed
  28. Ling PR, Bistrian BR, Mendez B, Istfan NW. Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism. 1994 Mar; 43(3):279-84. PMID: 8139474.
    View in: PubMed
  29. Wan JM, Bistrian BR, Figoni MA, Istfan NW. Influence of interleukin-2 infusion on cell cycle kinetics in the Walker-256 carcinosarcoma. J Leukoc Biol. 1994 Feb; 55(2):241-7. PMID: 8301220.
    View in: PubMed
  30. Wan JM, Fogt F, Bistrian BR, Istfan NW. Evaluation of antitumor effect of tumor necrosis factor in terms of protein metabolism and cell cycle kinetics. Am J Physiol. 1993 Aug; 265(2 Pt 1):C365-74. PMID: 8368266.
    View in: PubMed
  31. Wolpert HA, Steen SN, Istfan NW, Simonson DC. Insulin modulates circulating endothelin-1 levels in humans. Metabolism. 1993 Aug; 42(8):1027-30. PMID: 8345807.
    View in: PubMed
  32. Ling PR, Istfan N, Colon E, Bistrian BR. Effect of fish oil on glucose metabolism in the interleukin-1 alpha-treated rat. Metabolism. 1993 Jan; 42(1):81-5. PMID: 8446054.
    View in: PubMed
  33. Mendez B, Ling PR, Istfan NW, Babayan VK, Bistrian BR. Effects of different lipid sources in total parenteral nutrition on whole body protein kinetics and tumor growth. JPEN J Parenter Enteral Nutr. 1992 Nov-Dec; 16(6):545-51. PMID: 1494211.
    View in: PubMed
  34. Istfan NW, Wan JM, Bistrian BR. Nutrition and tumor promotion: in vivo methods for measurement of cellular proliferation and protein metabolism. JPEN J Parenter Enteral Nutr. 1992 Nov-Dec; 16(6 Suppl):76S-82S. PMID: 1287229.
    View in: PubMed
  35. Wolpert HA, Steen SN, Istfan NW, Simonson DC. Disparate effects of weight loss on insulin sensitivity and erythrocyte sodium-lithium countertransport activity. Am J Hypertens. 1992 Oct; 5(10):754-7. PMID: 1418840.
    View in: PubMed
  36. Pscheidl EM, Wan JM, Blackburn GL, Bistrian BR, Istfan NW. Influence of omega-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat model. Metabolism. 1992 Jul; 41(7):698-705. PMID: 1619987.
    View in: PubMed
  37. Bistrian BR, Schwartz J, Istfan NW. Cytokines, muscle proteolysis, and the catabolic response to infection and inflammation. Proc Soc Exp Biol Med. 1992 Jun; 200(2):220-3. PMID: 1579587.
    View in: PubMed
  38. Istfan NW, Plaisted CS, Bistrian BR, Blackburn GL. Insulin resistance versus insulin secretion in the hypertension of obesity. Hypertension. 1992 Apr; 19(4):385-92. PMID: 1555870.
    View in: PubMed
  39. Ye SL, Istfan NW, Driscoll DF, Bistrian BR. Tumor and host response to arginine and branched chain amino acid-enriched total parenteral nutrition. A study involving Walker 256 carcinosarcoma-bearing rats. Cancer. 1992 Jan 1; 69(1):261-70. PMID: 1370135.
    View in: PubMed
  40. Istfan NW, Ling PR, Blackburn GL, Bistrian BR. Enhancement of tumor proteolysis by TNF-alpha: correlation of in vivo isotope estimates with growth. Am J Physiol. 1991 Jul; 261(1 Pt 2):R106-16. PMID: 1858936.
    View in: PubMed
  41. Wan JM, Istfan NW, Chu CC, Blackburn GL, Bistrian BR. Comparative effects of omega-3 and omega-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma. Metabolism. 1991 Jun; 40(6):577-84. PMID: 1907711.
    View in: PubMed
  42. Ling PR, Istfan NW, Lopes SM, Babayan VK, Blackburn GL, Bistrian BR. Structured lipid made from fish oil and medium-chain triglycerides alters tumor and host metabolism in Yoshida-sarcoma-bearing rats. Am J Clin Nutr. 1991 May; 53(5):1177-84. PMID: 1902347.
    View in: PubMed
  43. Fogt F, Wan J, O'Hara C, Bistrian BR, Blackburn GL, Istfan NW. Flow cytometric measurement of cell cycle kinetics in rat Walker-256 carcinoma following in vivo and in vitro pulse labelling with bromodeoxyuridine. Cytometry. 1991; 12(1):33-41. PMID: 1825629.
    View in: PubMed
  44. Jensen GL, Mascioli EA, Seidner DL, Istfan NW, Domnitch AM, Selleck K, Babayan VK, Blackburn GL, Bistrian BR. Parenteral infusion of long- and medium-chain triglycerides and reticuloendothelial system function in man. JPEN J Parenter Enteral Nutr. 1990 Sep-Oct; 14(5):467-71. PMID: 2122019.
    View in: PubMed
  45. Flores EA, Istfan N, Pomposelli JJ, Blackburn GL, Bistrian BR. Effect of interleukin-1 and tumor necrosis factor/cachectin on glucose turnover in the rat. Metabolism. 1990 Jul; 39(7):738-43. PMID: 2195296.
    View in: PubMed
  46. Hirschberg Y, Pomposelli JJ, Blackburn GL, Istfan NW, Babayan V, Bistrian BR. The effects of chronic fish oil feeding in rats on protein catabolism induced by recombinant mediators. Metabolism. 1990 Apr; 39(4):397-402. PMID: 2325561.
    View in: PubMed
  47. DeMichele SJ, Karlstad MD, Bistrian BR, Istfan N, Babayan VK, Blackburn GL. Enteral nutrition with structured lipid: effect on protein metabolism in thermal injury. Am J Clin Nutr. 1989 Dec; 50(6):1295-302. PMID: 2512802.
    View in: PubMed
  48. Seidner DL, Mascioli EA, Istfan NW, Porter KA, Selleck K, Blackburn GL, Bistrian BR. Effects of long-chain triglyceride emulsions on reticuloendothelial system function in humans. JPEN J Parenter Enteral Nutr. 1989 Nov-Dec; 13(6):614-9. PMID: 2519758.
    View in: PubMed
  49. Blackburn GL, Morgan JP, Lavin PT, Noble R, Funderburk FR, Istfan N. Determinants of the pressor effect of phenylpropanolamine in healthy subjects. JAMA. 1989 Jun 9; 261(22):3267-72. PMID: 2716162.
    View in: PubMed
  50. Ling PR, Bistrian BR, Blackburn GL, Istfan N. Effect of continuous feeding on maternal protein metabolism and fetal growth in the rat. Am J Physiol. 1989 Jun; 256(6 Pt 1):E852-62. PMID: 2500024.
    View in: PubMed
  51. Flores EA, Bistrian BR, Pomposelli JJ, Dinarello CA, Blackburn GL, Istfan NW. Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1. J Clin Invest. 1989 May; 83(5):1614-22. PMID: 2785120.
    View in: PubMed
  52. Karlstad MD, DeMichele SJ, Istfan N, Blackburn GL, Bistrian BR. Effect of burn and first-pass splanchnic leucine extraction on protein kinetics in rats. Am J Physiol. 1988 Aug; 255(2 Pt 2):R303-9. PMID: 3407804.
    View in: PubMed
  53. DeMichele SJ, Karlstad MD, Babayan VK, Istfan N, Blackburn GL, Bistrian BR. Enhanced skeletal muscle and liver protein synthesis with structured lipid in enterally fed burned rats. Metabolism. 1988 Aug; 37(8):787-95. PMID: 3136299.
    View in: PubMed
  54. Crosby LE, Bistrian BR, Ling PR, Istfan NW, Blackburn GL, Hoffman SB. Effects of branched chain amino acid-enriched total parenteral nutrition on amino acid utilization in rats bearing Yoshida sarcoma. Cancer Res. 1988 May 15; 48(10):2698-702. PMID: 3129186.
    View in: PubMed
  55. Istfan NW, Ling PR, Bistrian BR, Blackburn GL. Systemic exchangeability of enteral leucine: relationship to plasma flux. Am J Physiol. 1988 Apr; 254(4 Pt 2):R688-98. PMID: 3128123.
    View in: PubMed
  56. Ling PR, Bistrian BR, Blackburn GL, Istfan N. Effect of fetal growth on maternal protein metabolism in postabsorptive rat. Am J Physiol. 1987 Mar; 252(3 Pt 1):E380-90. PMID: 3826363.
    View in: PubMed
  57. Tayek JA, Istfan NW, Jones CT, Hamawy KJ, Bistrian BR, Blackburn GL. Influence of the Walker 256 carcinosarcoma on muscle, tumor, and whole-body protein synthesis and growth rate in the cancer-bearing rat. Cancer Res. 1986 Nov; 46(11):5649-54. PMID: 3756911.
    View in: PubMed
  58. Ling PR, Hamawy KJ, Moldawer LL, Istfan N, Bistrian BR, Blackburn GL. Evaluation of the protein quality of diets containing medium- and long-chain triglyceride in healthy rats. J Nutr. 1986 Mar; 116(3):343-9. PMID: 3950760.
    View in: PubMed
  59. Istfan N, Murray E, Janghorbani M, Evans WJ, Young VR. The nutritional value of a soy protein concentrate (STAPRO-3200) for long-term protein nutritional maintenance in young men. J Nutr. 1983 Dec; 113(12):2524-34. PMID: 6686255.
    View in: PubMed
  60. Istfan N, Murray E, Janghorbani M, Young VR. An evaluation of the nutritional value of a soy protein concentrate in young adult men using the short-term N-balance method. J Nutr. 1983 Dec; 113(12):2516-23. PMID: 6686254.
    View in: PubMed
  61. Istfan NW, Janghorbani M, Young VR. Absorption of stable70 Zn in healthy young men in relation to zinc intake. Am J Clin Nutr. 1983 Aug; 38(2):187-94. PMID: 6881077.
    View in: PubMed
  62. Christensen MJ, Janghorbani M, Steinke FH, Istfan N, Young VR. Simultaneous determination of absorption of selenium from poultry meat and selenite in young men: application of a triple stable-isotope method. Br J Nutr. 1983 Jul; 50(1):43-50. PMID: 6882731.
    View in: PubMed
  63. Solomons NW, Janghorbani M, Ting BT, Steinke FH, Christensen M, Bijlani R, Istfan N, Young VR. Bioavailability of zinc from a diet based on isolated soy protein: application in young men of the stable isotope tracer, 70Zn. J Nutr. 1982 Oct; 112(10):1809-21. PMID: 6889635.
    View in: PubMed
  64. Janghorbani M, Istfan NW, Pagounes JO, Steinke FH, Young VR. Absorption of dietary zinc in man: comparison of intrinsic and extrinsic labels using a triple stable isotope method. Am J Clin Nutr. 1982 Sep; 36(3):537-45. PMID: 7113958.
    View in: PubMed
  65. Green LC, Ruiz de Luzuriaga K, Wagner DA, Rand W, Istfan N, Young VR, Tannenbaum SR. Nitrate biosynthesis in man. Proc Natl Acad Sci U S A. 1981 Dec; 78(12):7764-8. PMID: 6950416.
    View in: PubMed
  66. Janghorbani M, Ting BT, Istfan NW, Young VR. Measurement of 68Zn and 70Zn in human blood in reference to the study of zinc metabolism. Am J Clin Nutr. 1981 Apr; 34(4):581-91. PMID: 7223708.
    View in: PubMed
  67. Salti IS, Istfan N. Bromocriptine fails to stop growth of eosinophilic adenomas in acromegaly. N Engl J Med. 1979 Aug 16; 301(7):386. PMID: 223052.
    View in: PubMed
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