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Last Name

Rudy John Valentine

TitlePostdoctoral Fellow
InstitutionBoston University School of Medicine
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7191
 Research Expertise & Professional Interests
Rudy Valentine is an Assistant Professor within the department of Kinesiology at Iowa State University. His lab is focused on improving our understanding of bio-behavioral factors linking excess body fat and sedentary lifestyle with risk for cardiometabolic diseases. As both a basic and applied exercise physiologist, his work probes him into mechanistic pathways and addresses public health issues associated with obesity, diabetes, and aging. To tackle these challenges, they use a variety of methods, including cell culture, rodent models, and clinical human studies.

Toward the ultimate goal of improving human health and quality of life, his research agenda is focused on three intersecting themes:

(1) identifying the mechanism(s) through which behavioral (e.g., exercise and diet) and pharmacologic therapies mitigate cardiometabolic disease pathogenesis, with a focus on inflammation;

(2) examining the relationships between physical activity/fitness, diet, and risk factors for physical disability (e.g., muscle strength, muscle quality, and physical function); and

(3) investigating the interactions of fitness, obesity, sleep, inflammation and behavior.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fuller KN, Summers CM, Valentine RJ. Effect of a Single Bout of Aerobic Exercise on NF-?B in Peripheral Blood Mononuclear Cells: 3181 Board #246 June 3, 2: 00 PM - 3: 30 PM. Med Sci Sports Exerc. 2016 May; 48(5 Suppl 1):907. PMID: 27361750.
    View in: PubMed
  2. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75. PMID: 26797128.
    View in: PubMed
  3. Koh GY, Derscheid R, Fuller KN, Valentine RJ, Leow SE, Reed L, Wisecup E, Schalinske KL, Rowling MJ. Circulating adiponectin concentrations are increased by dietary resistant starch and correlate with serum 25-hydroxycholecalciferol concentrations and kidney function in Zucker diabetic fatty rats. Nutr Res. 2016 Apr; 36(4):311-9. PMID: 27001276.
    View in: PubMed
  4. Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388. PMID: 25996822.
    View in: PubMed
  5. Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/4?¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys. 2014 Nov 15; 562:62-9. PMID: 25172224.
    View in: PubMed
  6. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53. PMID: 25018645.
    View in: PubMed
  7. Xu XJ, Valentine RJ, Ruderman NB. AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity? Curr Obes Rep. 2014 Jun 1; 3(2):248-55. PMID: 24891985.
    View in: PubMed
  8. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. Nutrient Excess in AMPK Downregulation and Insulin Resistance. J Endocrinol Diabetes Obes. 2013 Jul-Sep; 1(1):1008. PMID: 26120590.
    View in: PubMed
  9. Ward CL, Valentine RJ, Evans EM. Greater effect of adiposity than physical activity or lean mass on physical function in community-dwelling older adults. J Aging Phys Act. 2014 Apr; 22(2):284-93. PMID: 23799829.
    View in: PubMed
  10. Baynard T, Vieira-Potter VJ, Valentine RJ, Woods JA. Exercise training effects on inflammatory gene expression in white adipose tissue of young mice. Mediators Inflamm. 2012; 2012:767953. PMID: 23319832.
    View in: PubMed
  11. Evans EM, Mojtahedi MC, Thorpe MP, Valentine RJ, Kris-Etherton PM, Layman DK. Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial. Nutr Metab (Lond). 2012; 9(1):55. PMID: 22691622.
    View in: PubMed
  12. Shin S, Valentine RJ, Evans EM, Sosnoff JJ. Lower extremity muscle quality and gait variability in older adults. Age Ageing. 2012 Sep; 41(5):595-9. PMID: 22417983.
    View in: PubMed
  13. Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13. PMID: 22378745.
    View in: PubMed
  14. Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801. PMID: 22323564.
    View in: PubMed
  15. Modrall JG, Rosero EB, Timaran CH, Anthony T, Chung J, Valentine RJ, Trimmer C. Assessing outcomes to determine whether symptoms related to hypertension justify renal artery stenting. J Vasc Surg. 2012 Feb; 55(2):413-9; discussion 419-20. PMID: 22133456.
    View in: PubMed
  16. Valentine RJ, Woods JA, McAuley E, Dantzer R, Evans EM. The associations of adiposity, physical activity and inflammation with fatigue in older adults. Brain Behav Immun. 2011 Oct; 25(7):1482-90. PMID: 21693185.
    View in: PubMed
  17. Thorpe MP, Valentine RJ, Moulton CJ, Wagoner Johnson AJ, Evans EM, Layman DK. Breast tumors induced by N-methyl-N-nitrosourea are damaging to bone strength, structure, and mineralization in the absence of metastasis in rats. J Bone Miner Res. 2011 Apr; 26(4):769-76. PMID: 20939066.
    View in: PubMed
  18. Parrett AL, Valentine RJ, Arngrímsson SA, Castelli DM, Evans EM. Adiposity and aerobic fitness are associated with metabolic disease risk in children. Appl Physiol Nutr Metab. 2011 Feb; 36(1):72-9. PMID: 21326380.
    View in: PubMed
  19. Parrett AL, Valentine RJ, Arngrímsson SA, Castelli DM, Evans EM. Adiposity, activity, fitness, and C-reactive protein in children. Med Sci Sports Exerc. 2010 Nov; 42(11):1981-6. PMID: 20386340.
    View in: PubMed
  20. Moulton CJ, Valentine RJ, Layman DK, Devkota S, Singletary KW, Wallig MA, Donovan SM. A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats. Nutr Metab (Lond). 2010; 7:1. PMID: 20148110.
    View in: PubMed
  21. Vieira VJ, Valentine RJ. Mitochondrial biogenesis in adipose tissue: can exercise make fat cells 'fit'? J Physiol. 2009 Jul 15; 587(Pt 14):3427-8. PMID: 19602637.
    View in: PubMed
  22. Misic MM, Valentine RJ, Rosengren KS, Woods JA, Evans EM. Impact of training modality on strength and physical function in older adults. Gerontology. 2009; 55(4):411-6. PMID: 19590159.
    View in: PubMed
  23. Valentine RJ, Misic MM, Rosengren KS, Woods JA, Evans EM. Sex impacts the relation between body composition and physical function in older adults. Menopause. 2009 May-Jun; 16(3):518-23. PMID: 19423997.
    View in: PubMed
  24. Vieira VJ, Valentine RJ, Wilund KR, Woods JA. Effects of diet and exercise on metabolic disturbances in high-fat diet-fed mice. Cytokine. 2009 Jun; 46(3):339-45. PMID: 19362852.
    View in: PubMed
  25. Vieira VJ, Valentine RJ, Wilund KR, Antao N, Baynard T, Woods JA. Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. Am J Physiol Endocrinol Metab. 2009 May; 296(5):E1164-71. PMID: 19276393.
    View in: PubMed
  26. Valentine RJ, Vieira VJ, Woods JA, Evans EM. Stronger relationship between central adiposity and C-reactive protein in older women than men. Menopause. 2009 Jan-Feb; 16(1):84-9. PMID: 18791482.
    View in: PubMed
  27. Valentine RJ, McAuley E, Vieira VJ, Baynard T, Hu L, Evans EM, Woods JA. Sex differences in the relationship between obesity, C-reactive protein, physical activity, depression, sleep quality and fatigue in older adults. Brain Behav Immun. 2009 Jul; 23(5):643-8. PMID: 19133324.
    View in: PubMed
  28. Kim K, Valentine RJ, Shin Y, Gong K. Associations of visceral adiposity and exercise participation with C-reactive protein, insulin resistance, and endothelial dysfunction in Korean healthy adults. Metabolism. 2008 Sep; 57(9):1181-9. PMID: 18702942.
    View in: PubMed
  29. Valentine RJ, Saunders MJ, Todd MK, St Laurent TG. Influence of carbohydrate-protein beverage on cycling endurance and indices of muscle disruption. Int J Sport Nutr Exerc Metab. 2008 Aug; 18(4):363-78. PMID: 18708686.
    View in: PubMed
  30. Heffernan KS, Vieira VJ, Valentine RJ. Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth. J Physiol. 2008 Apr 15; 586(8):2041-2. PMID: 18325977.
    View in: PubMed
  31. Kim K, Lee S, Valentine RJ. Association of pro12Ala polymorphism in the peroxisome proliferative-activated receptor gamma2 gene with obesity and hypertension in Korean women. J Nutr Sci Vitaminol (Tokyo). 2007 Jun; 53(3):239-46. PMID: 17874829.
    View in: PubMed
  32. Vieira VJ, Valentine RJ, McAuley E, Evans E, Woods JA. Independent relationship between heart rate recovery and C-reactive protein in older adults. J Am Geriatr Soc. 2007 May; 55(5):747-51. PMID: 17493195.
    View in: PubMed
  33. Luque RM, Gahete MD, Valentine RJ, Kineman RD. Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis. J Mol Endocrinol. 2006 Aug; 37(1):25-38. PMID: 16901921.
    View in: PubMed
  34. Jackson MR, Johnson WC, Williford WO, Valentine RJ, Clagett GP. The effect of anticoagulation therapy and graft selection on the ischemic consequences of femoropopliteal bypass graft occlusion: results from a multicenter randomized clinical trial. J Vasc Surg. 2002 Feb; 35(2):292-8. PMID: 11854727.
    View in: PubMed
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