Rudy John Valentine
Postdoctoral Fellow
Boston University School of Medicine

Rudy Valentine is an Assistant Professor within the department of Kinesiology at Iowa State University. His lab is focused on improving our understanding of bio-behavioral factors linking excess body fat and sedentary lifestyle with risk for cardiometabolic diseases. As both a basic and applied exercise physiologist, his work probes him into mechanistic pathways and addresses public health issues associated with obesity, diabetes, and aging. To tackle these challenges, they use a variety of methods, including cell culture, rodent models, and clinical human studies.

Toward the ultimate goal of improving human health and quality of life, his research agenda is focused on three intersecting themes:

(1) identifying the mechanism(s) through which behavioral (e.g., exercise and diet) and pharmacologic therapies mitigate cardiometabolic disease pathogenesis, with a focus on inflammation;

(2) examining the relationships between physical activity/fitness, diet, and risk factors for physical disability (e.g., muscle strength, muscle quality, and physical function); and

(3) investigating the interactions of fitness, obesity, sleep, inflammation and behavior.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57.View Related Profiles. PMID: 28526426.
  2. Fuller KNZ, Summers CM, Valentine RJ. Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation. Metabolism. 2017 Jun; 71:144-152. PMID: 28521867.
  3. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75.View Related Profiles. PMID: 26797128; PMCID: PMC4786706; DOI: 10.1074/jbc.M115.696849;.
  4. Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388.View Related Profiles. PMID: 25996822; PMCID: PMC4440828; DOI: 10.1371/journal.pone.0127388;.
  5. Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/4?¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys. 2014 Nov 15; 562:62-9.View Related Profiles. PMID: 25172224; PMCID: PMC4437572; DOI: 10.1016/;.
  6. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53.View Related Profiles. PMID: 25018645; DOI: 10.2147/DMSO.S43731;.
  7. Xu XJ, Valentine RJ, Ruderman NB. AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity? Curr Obes Rep. 2014 Jun 1; 3(2):248-55.View Related Profiles. PMID: 24891985; PMCID: PMC4039173; DOI: 10.1007/s13679-014-0095-x;.
  8. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. Nutrient Excess in AMPK Downregulation and Insulin Resistance. J Endocrinol Diabetes Obes. 2013 Jul-Sep; 1(1):1008.View Related Profiles. PMID: 26120590.
  9. Ward CL, Valentine RJ, Evans EM. Greater effect of adiposity than physical activity or lean mass on physical function in community-dwelling older adults. J Aging Phys Act. 2014 Apr; 22(2):284-93. PMID: 23799829; DOI: 10.1123/japa.2012-0098;.
  10. Baynard T, Vieira-Potter VJ, Valentine RJ, Woods JA. Exercise training effects on inflammatory gene expression in white adipose tissue of young mice. Mediators Inflamm. 2012; 2012:767953. PMID: 23319832; PMCID: PMC3540918.
Showing 10 of 32 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 12 distinct years, with a maximum of 6 publications in 2009

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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