Asish K. Saha, PhD
Research Associate Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition Section

PhD, University of Calcutta
MS, University of Calcutta



Expertise in invitro muscle incubation. Determine proteon expression by SDS-gel electrophoresis. Gene analysis by RT-PCR. Cell culture. Expertise in spectrophotometric and radioactive assay methods.

Boston Medical Center





AMPK Core B
04/15/2009 - 01/31/2015 (PI)
NIH-NHLBI
5P01 HL068758-10

Core B-Oxidative Stress, AMPK, and Diabetic Cardiovascular Disease
05/01/2003 - 01/30/2009 (PI)
NIH-NHLBI
5 P01 HL068758-05(A)

Oxidative Stress, AMPK, and Diabetic
03/01/2003 - 04/30/2006 (PI)
Juvenile Diab Fdtn

Oxidative Stress, AMPK, and Diabetic
03/01/2002 - 02/28/2005 (PI)
Juvenile Diab Fdtn



Yr Title Project-Sub Proj Pubs
2013 Biochemistry and Molecular Biology Core 5P01HL068758-10-5227 93
2012 Biochemistry and Molecular Biology Core 5P01HL068758-09-5227 93
2011 Biochemistry and Molecular Biology Core 5P01HL068758-08-5227 93
2011 Biochemistry and Molecular Biology Core 5P01HL068758-08-5227 93
2010 Biochemistry and Molecular Biology Core 5P01HL068758-07-5227 93
2009 Biochemistry and Molecular Biology Core 2P01HL068758-06A1-5227 93
2007 Biochemistry and Molecular Biology 5P01HL068758-05-9001 93
2006 Biochemistry and Molecular Biology 5P01HL068758-04-9001 93
2005 Biochemistry and Molecular Biology 5P01HL068758-03-9001 93
2004 Biochemistry and Molecular Biology 5P01HL068758-02-9001 93
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57.View Related Profiles. PMID: 28526426.
  2. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R, Harwood HJ. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1796-805. PMID: 26976583; PMCID: PMC4822632; DOI: 10.1073/pnas.1520686113;.
  3. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75.View Related Profiles. PMID: 26797128; PMCID: PMC4786706; DOI: 10.1074/jbc.M115.696849;.
  4. Doménech E, Maestre C, Esteban-Martínez L, Partida D, Pascual R, Fernández-Miranda G, Seco E, Campos-Olivas R, Pérez M, Megias D, Allen K, López M, Saha AK, Velasco G, Rial E, Méndez R, Boya P, Salazar-Roa M, Malumbres M. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat Cell Biol. 2015 Oct; 17(10):1304-16. PMID: 26322680; DOI: 10.1038/ncb3231;.
  5. Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 2015 Sep; 64(9):3155-9.View Related Profiles. PMID: 26001396; PMCID: PMC4542447; DOI: 10.2337/db14-1765;.
  6. Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388.View Related Profiles. PMID: 25996822; PMCID: PMC4440828; DOI: 10.1371/journal.pone.0127388;.
  7. Martínez de Morentin PB, Lage R, González-García I, Ruíz-Pino F, Martins L, Fernández-Mallo D, Gallego R, Fernø J, Señarís R, Saha AK, Tovar S, Diéguez C, Nogueiras R, Tena-Sempere M, López M. Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. Endocrinology. 2015 Mar; 156(3):947-60. PMID: 25535827; PMCID: PMC4330316; DOI: 10.1210/en.2014-1611;.
  8. Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/4?¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys. 2014 Nov 15; 562:62-9.View Related Profiles. PMID: 25172224; PMCID: PMC4437572; DOI: 10.1016/j.abb.2014.08.013;.
  9. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53.View Related Profiles. PMID: 25018645; DOI: 10.2147/DMSO.S43731;.
  10. Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab. 2014 Jul 1; 20(1):41-53. PMID: 24856932; PMCID: PMC4082097; DOI: 10.1016/j.cmet.2014.03.031;.
Showing 10 of 70 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 70 publications over 21 distinct years, with a maximum of 7 publications in 2005 and 2010

YearPublications
19941
19951
19961
19973
19981
19992
20003
20025
20036
20045
20057
20066
20083
20093
20107
20113
20133
20144
20153
20162
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

ACC
AMPK
mTOR/p70S6 kinase
Protein synthesis
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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