Keywords
Last Name

Asish K. Saha, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7169
ORCID ORCID Icon0000-0003-1001-5110
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Expertise in invitro muscle incubation. Determine proteon expression by SDS-gel electrophoresis. Gene analysis by RT-PCR. Cell culture. Expertise in spectrophotometric and radioactive assay methods.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2013 Biochemistry and Molecular Biology Core 5P01HL068758-10-5227 90
2012 Biochemistry and Molecular Biology Core 5P01HL068758-09-5227 90
2011 Biochemistry and Molecular Biology Core 5P01HL068758-08-5227 90
2011 Biochemistry and Molecular Biology Core 5P01HL068758-08-5227 90
2010 Biochemistry and Molecular Biology Core 5P01HL068758-07-5227 90
2009 Biochemistry and Molecular Biology Core 2P01HL068758-06A1-5227 90
2007 Biochemistry and Molecular Biology 5P01HL068758-05-9001 90
2006 Biochemistry and Molecular Biology 5P01HL068758-04-9001 90
2005 Biochemistry and Molecular Biology 5P01HL068758-03-9001 90
2004 Biochemistry and Molecular Biology 5P01HL068758-02-9001 90


 Self-Described Keywords
  • ACC
  • AMPK
  • mTOR/p70S6 kinase
  • Protein synthesis
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R, Harwood HJ. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1796-805. PMID: 26976583.
    View in: PubMed
  2. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75. PMID: 26797128.
    View in: PubMed
  3. Doménech E, Maestre C, Esteban-Martínez L, Partida D, Pascual R, Fernández-Miranda G, Seco E, Campos-Olivas R, Pérez M, Megias D, Allen K, López M, Saha AK, Velasco G, Rial E, Méndez R, Boya P, Salazar-Roa M, Malumbres M. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat Cell Biol. 2015 Oct; 17(10):1304-16. PMID: 26322680.
    View in: PubMed
  4. Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 2015 Sep; 64(9):3155-9. PMID: 26001396.
    View in: PubMed
  5. Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388. PMID: 25996822.
    View in: PubMed
  6. Martínez de Morentin PB, Lage R, González-García I, Ruíz-Pino F, Martins L, Fernández-Mallo D, Gallego R, Fernø J, Señarís R, Saha AK, Tovar S, Diéguez C, Nogueiras R, Tena-Sempere M, López M. Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. Endocrinology. 2015 Mar; 156(3):947-60. PMID: 25535827.
    View in: PubMed
  7. Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/4?¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys. 2014 Nov 15; 562:62-9. PMID: 25172224.
    View in: PubMed
  8. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53. PMID: 25018645.
    View in: PubMed
  9. Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab. 2014 Jul 1; 20(1):41-53. PMID: 24856932.
    View in: PubMed
  10. Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E, Kolthur-Seetharam U. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 2013 Nov; 5(11):835-49. PMID: 24296486.
    View in: PubMed
  11. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. Nutrient Excess in AMPK Downregulation and Insulin Resistance. J Endocrinol Diabetes Obes. 2013 Jul-Sep; 1(1):1008. PMID: 26120590.
    View in: PubMed
  12. Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 6; 50(5):686-98. PMID: 23746352.
    View in: PubMed
  13. Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation? Cell Cycle. 2011 Oct 15; 10(20):3447-51. PMID: 22067655.
    View in: PubMed
  14. Blanco Martínez de Morentin P, González CR, Saha AK, Martins L, Diéguez C, Vidal-Puig A, Tena-Sempere M, López M. Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance. Rev Endocr Metab Disord. 2011 Sep; 12(3):127-40. PMID: 21347863.
    View in: PubMed
  15. Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW. The evolution of insulin resistance in muscle of the glucose infused rat. Arch Biochem Biophys. 2011 May 15; 509(2):133-41. PMID: 21420928.
    View in: PubMed
  16. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med. 2010 Sep; 16(9):1001-8. PMID: 20802499.
    View in: PubMed
  17. Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB. Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes. 2010 Oct; 59(10):2426-34. PMID: 20682696.
    View in: PubMed
  18. Persons KS, Eddy VJ, Chadid S, Deoliveira R, Saha AK, Ray R. Anti-growth effect of 1,25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranoside in pancreatic cancer cells. Anticancer Res. 2010 Jun; 30(6):1875-80. PMID: 20651329.
    View in: PubMed
  19. Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M. Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB J. 2010 Aug; 24(8):2670-9. PMID: 20335227.
    View in: PubMed
  20. Sangiao-Alvarellos S, Varela L, Vázquez MJ, Da Boit K, Saha AK, Cordido F, Diéguez C, López M. Influence of ghrelin and growth hormone deficiency on AMP-activated protein kinase and hypothalamic lipid metabolism. J Neuroendocrinol. 2010 Jun; 22(6):543-56. PMID: 20298456.
    View in: PubMed
  21. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 4; 464(7285):121-5. PMID: 20203611.
    View in: PubMed
  22. Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E751-60. PMID: 20103737.
    View in: PubMed
  23. Sangiao-Alvarellos S, Vázquez MJ, Varela L, Nogueiras R, Saha AK, Cordido F, López M, Diéguez C. Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology. 2009 Oct; 150(10):4562-74. PMID: 19608647.
    View in: PubMed
  24. Kelly M, Gauthier MS, Saha AK, Ruderman NB. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes. 2009 Sep; 58(9):1953-60. PMID: 19502419.
    View in: PubMed
  25. Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39. PMID: 19416713.
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  26. Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):836-41. PMID: 19071085.
    View in: PubMed
  27. López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab. 2008 May; 7(5):389-99. PMID: 18460330.
    View in: PubMed
  28. Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem. 2008 Jun 13; 283(24):16514-24. PMID: 18390901.
    View in: PubMed
  29. Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M. Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes. 2006 Dec; 55 Suppl 2:S48-54. PMID: 17130644.
    View in: PubMed
  30. Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB. AMPK regulation of the growth of cultured human keratinocytes. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):519-24. PMID: 16949049.
    View in: PubMed
  31. López M, Lelliott CJ, Tovar S, Kimber W, Gallego R, Virtue S, Blount M, Vázquez MJ, Finer N, Powles TJ, O'Rahilly S, Saha AK, Diéguez C, Vidal-Puig AJ. Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. Diabetes. 2006 May; 55(5):1327-36. PMID: 16644689.
    View in: PubMed
  32. LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E175-81. PMID: 16464908.
    View in: PubMed
  33. Ruderman NB, Saha AK. Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity (Silver Spring). 2006 Feb; 14 Suppl 1:25S-33S. PMID: 16642960.
    View in: PubMed
  34. Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1296-303. PMID: 16434556.
    View in: PubMed
  35. Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem. 2006 Feb 3; 281(5):2654-60. PMID: 16326714.
    View in: PubMed
  36. Joly E, Bendayan M, Roduit R, Saha AK, Ruderman NB, Prentki M. Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes. FEBS Lett. 2005 Dec 5; 579(29):6581-6. PMID: 16298369.
    View in: PubMed
  37. Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. Am J Physiol Endocrinol Metab. 2006 Mar; 290(3):E471-9. PMID: 16234268.
    View in: PubMed
  38. Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O'Rahilly S, Griffin JL, Gibbons GF, Vidal-Puig A. Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. FASEB J. 2005 Jul; 19(9):1108-19. PMID: 15985534.
    View in: PubMed
  39. Assifi MM, Suchankova G, Constant S, Prentki M, Saha AK, Ruderman NB. AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E794-800. PMID: 15956049.
    View in: PubMed
  40. Luo Z, Saha AK, Xiang X, Ruderman NB. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci. 2005 Feb; 26(2):69-76. PMID: 15681023.
    View in: PubMed
  41. Suchankova G, Tekle M, Saha AK, Ruderman NB, Clarke SD, Gettys TW. Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochem Biophys Res Commun. 2005 Jan 28; 326(4):851-8. PMID: 15607747.
    View in: PubMed
  42. Roepstorff C, Halberg N, Hillig T, Saha AK, Ruderman NB, Wojtaszewski JF, Richter EA, Kiens B. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E133-42. PMID: 15383373.
    View in: PubMed
  43. Xiang X, Saha AK, Wen R, Ruderman NB, Luo Z. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun. 2004 Aug 13; 321(1):161-7. PMID: 15358229.
    View in: PubMed
  44. Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun. 2004 Jul 23; 320(2):449-54. PMID: 15219849.
    View in: PubMed
  45. Tomas E, Kelly M, Xiang X, Tsao TS, Keller C, Keller P, Luo Z, Lodish H, Saha AK, Unger R, Ruderman NB. Metabolic and hormonal interactions between muscle and adipose tissue. Proc Nutr Soc. 2004 May; 63(2):381-5. PMID: 15294059.
    View in: PubMed
  46. Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun. 2004 Feb 6; 314(2):580-5. PMID: 14733947.
    View in: PubMed
  47. Saha AK, Ruderman NB. Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Mol Cell Biochem. 2003 Nov; 253(1-2):65-70. PMID: 14619957.
    View in: PubMed
  48. Ruderman NB, Saha AK, Kraegen EW. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology. 2003 Dec; 144(12):5166-71. PMID: 14500570.
    View in: PubMed
  49. Ruderman NB, Park H, Kaushik VK, Dean D, Constant S, Prentki M, Saha AK. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Acta Physiol Scand. 2003 Aug; 178(4):435-42. PMID: 12864749.
    View in: PubMed
  50. Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003 Jul; 52(7):1635-40. PMID: 12829626.
    View in: PubMed
  51. Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6. PMID: 12546685.
    View in: PubMed
  52. Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. J Clin Endocrinol Metab. 2003 Jan; 88(1):82-7. PMID: 12519834.
    View in: PubMed
  53. Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc Cc, Itani SI, Lodish HF, Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16309-13. PMID: 12456889.
    View in: PubMed
  54. Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 2002 Oct; 51(10):2886-94. PMID: 12351423.
    View in: PubMed
  55. Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem. 2002 Sep 6; 277(36):32571-7. PMID: 12065578.
    View in: PubMed
  56. Tomás E, Lin YS, Dagher Z, Saha A, Luo Z, Ido Y, Ruderman NB. Hyperglycemia and insulin resistance: possible mechanisms. Ann N Y Acad Sci. 2002 Jun; 967:43-51. PMID: 12079834.
    View in: PubMed
  57. Shafrir E, Ziv E, Saha AK, Ruderman NB. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. Diabetes Metab Res Rev. 2002 May-Jun; 18(3):217-23. PMID: 12112940.
    View in: PubMed
  58. Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem. 2000 Aug 11; 275(32):24279-83. PMID: 10854420.
    View in: PubMed
  59. Chien D, Dean D, Saha AK, Flatt JP, Ruderman NB. Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab. 2000 Aug; 279(2):E259-65. PMID: 10913024.
    View in: PubMed
  60. Dean D, Daugaard JR, Young ME, Saha A, Vavvas D, Asp S, Kiens B, Kim KH, Witters L, Richter EA, Ruderman N. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes. 2000 Aug; 49(8):1295-300. PMID: 10923628.
    View in: PubMed
  61. Saha AK, Laybutt DR, Dean D, Vavvas D, Sebokova E, Ellis B, Klimes I, Kraegen EW, Shafrir E, Ruderman NB. Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. Am J Physiol. 1999 Jun; 276(6 Pt 1):E1030-7. PMID: 10362615.
    View in: PubMed
  62. Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999 Jan; 276(1 Pt 1):E1-E18. PMID: 9886945.
    View in: PubMed
  63. Ruderman NB, Saha AK, Vavvas D, Kurowski T, Laybutt DR, Schmitz-Peiffer C, Biden T, Kraegen EW. Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. Adv Exp Med Biol. 1998; 441:263-70. PMID: 9781332.
    View in: PubMed
  64. Ruderman NB, Saha AK, Vavvas D, Heydrick SJ, Kurowski TG. Lipid abnormalities in muscle of insulin-resistant rodents. The malonyl CoA hypothesis. Ann N Y Acad Sci. 1997 Sep 20; 827:221-30. PMID: 9329757.
    View in: PubMed
  65. Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, Ruderman NB. Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. J Biol Chem. 1997 May 16; 272(20):13255-61. PMID: 9148944.
    View in: PubMed
  66. Saha AK, Vavvas D, Kurowski TG, Apazidis A, Witters LA, Shafrir E, Ruderman NB. Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol. 1997 Apr; 272(4 Pt 1):E641-8. PMID: 9142886.
    View in: PubMed
  67. Kurowski TG, Saha AK, Cunningham BA, Holbert RI, Colca JR, Corkey BE, Ruderman NB. Malonyl coenzyme A and adiposity in the Dahl salt-sensitive rat: effects of pioglitazone. Metabolism. 1996 Apr; 45(4):519-25. PMID: 8609842.
    View in: PubMed
  68. Saha AK, Kurowski TG, Ruderman NB. A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation. Am J Physiol. 1995 Aug; 269(2 Pt 1):E283-9. PMID: 7653546.
    View in: PubMed
  69. Saha AK, Kurowski TG, Colca JR, Ruderman NB. Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol. Am J Physiol. 1994 Jul; 267(1 Pt 1):E95-101. PMID: 8048519.
    View in: PubMed
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