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MD, University of Pittsburgh
DPhil, University of Oxford
BA, Columbia College

Websites

	Department of Medicine Faculty
	Endocrinology, Diabetes & Nutrition Faculty

ORCID : 0000-0002-6589-6587

Research
Publications

Metabolism, Endocrinology, and Obesity Training Grant
05/15/1998 - 04/30/2008 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 T32 DK07201 31

Mentor Based Postdoctoral Fellowship Program
07/01/1997 - 06/30/2000 (PI)
American Diabetes Association

Epidermal Homeostasis and the SIRT1/LKB1/AMPK Signaling Pathway
07/01/2015 - 06/30/2017 (PI)
L'Oreal USA

The AMPK/SIRT1 Partnership and its Biological Relevance
06/17/2011 - 05/31/2017 (PI)
NIH-NIDDK
5R01 DK019514-35

AMPK, SIRT1 and mTOR: Mediators of Nutrient Excess
08/10/2011 - 06/30/2015 (PI)
NIH-NIDDK
5R01 DK067509-09

AMPK Regulation and Biological Relevance
07/01/2011 - 06/30/2015 (PI)
Amer Diabetes Asso

AMPK Core A
04/15/2009 - 01/31/2015 (PI)
NIH-NHLBI
5P01 HL068758-10

AMPK Project 1
04/15/2009 - 01/31/2015 (PI)
NIH-NHLBI
5P01 HL068758-10

AMPK & Adipose Tissue Biology in Bariatric Surgery Patients
07/16/2012 - 06/30/2014 (PI)
NIH-NIDDK
1R24 DK094749-01

Determinants and Cardiovascular Consequences of Diabetes in Older Adults
09/01/2009 - 06/30/2014 (PI)
Beth Israel NIH-NHLBI
5R01 HL094555-04

Metabolism Endocrinology and Obesity Training Grant
05/01/2008 - 06/30/2014 (PI)
NIH-NIDDK
5T32 DK007201-36

Oxymax System with Treadmill for Quantifying Exercise in Mice
05/01/2012 - 04/30/2013 (PI)
NIH-OD
1S10 OD010379-01

Showing 10 of 34 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2015	Metabolism, Endocrinology and Obesity Training Grant	5T32DK007201-38	75
2015	The AMPK/SIRT1 Partnershipand Its Biological Relevance	5R01DK019514-35	92
2014	AMPK, SIRT1 and mTOR:Mediators of Nutrient Excess	5R01DK067509-09	36
2014	Metabolism, Endocrinology and Obesity Training Grant	2T32DK007201-37	75
2014	The AMPK/SIRT1 Partnershipand Its Biological Relevance	5R01DK019514-34	92
2013	AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)	5P01HL068758-10	102
2013	AMPK, SIRT1 and mTOR:Mediators of Nutrient Excess	5R01DK067509-08	36
2013	The AMPK/SIRT1 Partnershipand Its Biological Relevance	5R01DK019514-33	92
2013	Administrative Core	5P01HL068758-10-5226	102
2013	AMPK, Metabolic and Inflammatory Stress and the Endothelial Cell	5P01HL068758-10-5223	102

Showing 10 of 108 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57.View Related Profiles.

Saha, Asish
Coughlan, Kimberly
Ruderman, Neil
Valentine, Rudy John

PMID: 28526426

Attané C, Peyot ML, Lussier R, Poursharifi P, Zhao S, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman NB, Mitchell GA, Simons B, Madiraju SR, Joly E, Prentki M. A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice. Diabetologia. 2016 Dec; 59(12):2654-2663. PMID: 27677764

Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3ß increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Oct; 36(5).View Related Profiles.

Cacicedo, Jose
Weikel, Karen
Ruderman, Neil
Ido, Yasuo

PMID: 27534430; PMCID: PMC5025810; DOI: 10.1042/BSR20160174;

Pepin É, Al-Mass A, Attané C, Zhang K, Lamontagne J, Lussier R, Madiraju SR, Joly E, Ruderman NB, Sladek R, Prentki M, Peyot ML. Pancreatic ß-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Ce, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression. PLoS One. 2016; 11(4):e0153017. PMID: 27043434; PMCID: PMC4820227; DOI: 10.1371/journal.pone.0153017;

Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75.View Related Profiles.

Saha, Asish
Coughlan, Kimberly
Ruderman, Neil
Valentine, Rudy John

PMID: 26797128; PMCID: PMC4786706; DOI: 10.1074/jbc.M115.696849;

Weikel KA, Ruderman NB, Cacicedo JM. Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism. 2016 May; 65(5):634-45.View Related Profiles.

Cacicedo, Jose
Weikel, Karen
Ruderman, Neil

PMID: 27085772; PMCID: PMC4834453; DOI: 10.1016/j.metabol.2016.01.005;

Nolan CJ, Ruderman NB, Kahn SE, Pedersen O, Prentki M. Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673-686. Diabetes. 2015 Oct; 64(10):e38-9. PMID: 26405280; DOI: 10.2337/dbi15-0002;

Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 2015 Sep; 64(9):3155-9.View Related Profiles.

Saha, Asish
Carmine, Brian
Apovian, Caroline
Hess, Donald
Xu, Xiaolai
Ruderman, Neil

PMID: 26001396; PMCID: PMC4542447; DOI: 10.2337/db14-1765;

Coughlan KA, Balon TW, Valentine RJ, Petrocelli R, Schultz V, Brandon A, Cooney GJ, Kraegen EW, Ruderman NB, Saha AK. Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats. PLoS One. 2015; 10(5):e0127388.View Related Profiles.

Saha, Asish
Coughlan, Kimberly
Ruderman, Neil
Valentine, Rudy John
Balon, Thomas

PMID: 25996822; PMCID: PMC4440828; DOI: 10.1371/journal.pone.0127388;

Brandon AE, Tid-Ang J, Wright LE, Stuart E, Suryana E, Bentley N, Turner N, Cooney GJ, Ruderman NB, Kraegen EW. Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. PLoS One. 2015; 10(3):e0121959. PMID: 25798922; PMCID: PMC4370576; DOI: 10.1371/journal.pone.0121959;

Showing 10 of 325 results. Show More

Nolan CJ, Ruderman NB, Kahn SE, Pedersen O, Prentki M. Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes. Diabetes. 2015 Mar; 64(3):673-86. PMID: 25713189; PMCID: PMC4338588; DOI: 10.2337/db14-0694;

Ido Y, Duranton A, Lan F, Weikel KA, Breton L, Ruderman NB. Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes. PLoS One. 2015; 10(2):e0115341.View Related Profiles.

Weikel, Karen
Ruderman, Neil
Ido, Yasuo

PMID: 25647160; PMCID: PMC4315597; DOI: 10.1371/journal.pone.0115341;

Gauthier MS, Pérusse JR, Lavoie MÈ, Sladek R, Madiraju SR, Ruderman NB, Coulombe B, Prentki M, Rabasa-Lhoret R. Increased subcutaneous adipose tissue expression of genes involved in glycerolipid-fatty acid cycling in obese insulin-resistant versus -sensitive individuals. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2518-28. PMID: 25210878; DOI: 10.1210/jc.2014-1662;

Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol. 2015 Feb 1; 308(3):C249-63.View Related Profiles.

Cacicedo, Jose
Weikel, Karen
Ruderman, Neil
Ido, Yasuo

PMID: 25354528; PMCID: PMC4312840; DOI: 10.1152/ajpcell.00265.2014;

Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/4?¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys. 2014 Nov 15; 562:62-9.View Related Profiles.

Saha, Asish
Coughlan, Kimberly
Ruderman, Neil
Valentine, Rudy John

PMID: 25172224; PMCID: PMC4437572; DOI: 10.1016/j.abb.2014.08.013;

Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53.View Related Profiles.

Saha, Asish
Coughlan, Kimberly
Ruderman, Neil
Valentine, Rudy John

PMID: 25018645; PMCID: PMC4075959; DOI: 10.2147/DMSO.S43731;

Xu XJ, Valentine RJ, Ruderman NB. AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity? Curr Obes Rep. 2014 Jun 1; 3(2):248-55.View Related Profiles.

Ruderman, Neil
Valentine, Rudy John

PMID: 24891985; PMCID: PMC4039173; DOI: 10.1007/s13679-014-0095-x;

Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One. 2014; 9(5):e97554.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil
Ido, Yasuo

PMID: 24835252; PMCID: PMC4023984; DOI: 10.1371/journal.pone.0097554;

Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013 Jul 1; 123(7):2764-72.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil

PMID: 23863634; PMCID: PMC3696539; DOI: 10.1172/JCI67227;

Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. Nutrient Excess in AMPK Downregulation and Insulin Resistance. J Endocrinol Diabetes Obes. 2013 Jul-Sep; 1(1):1008.View Related Profiles.

Saha, Asish
Coughlan, Kimberly
Ruderman, Neil
Valentine, Rudy John

PMID: 26120590; PMCID: PMC4479300

Nolan CJ, Ruderman NB, Prentki M. Intensive insulin for type 2 diabetes: the risk of causing harm. Lancet Diabetes Endocrinol. 2013 Sep; 1(1):9-10. PMID: 24622256; DOI: 10.1016/S2213-8587(13)70027-5;

Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 6; 50(5):686-98.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 23746352; PMCID: PMC3721068; DOI: 10.1016/j.molcel.2013.05.012;

Xu XJ, Pories WJ, Dohm LG, Ruderman NB. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant? Curr Opin Lipidol. 2013 Feb; 24(1):49-56.View Related Profiles.

Xu, Xiaolai
Ruderman, Neil

PMID: 23298959; PMCID: PMC3575680; DOI: 10.1097/MOL.0b013e32835b465b;

Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Diabetes. 2013 Jun; 62(6):2122-9. PMID: 23378607; PMCID: PMC3661607; DOI: 10.2337/db12-0428;

Tabit CE, Shenouda SM, Holbrook M, Fetterman JL, Kiani S, Frame AA, Kluge MA, Held A, Dohadwala MM, Gokce N, Farb MG, Rosenzweig J, Ruderman N, Vita JA, Hamburg NM. Protein kinase C-ß contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation. 2013 Jan 1; 127(1):86-95.View Related Profiles.

Frame, Alissa
Rosenzweig, James
Fetterman, Jessica
Vita, Joseph
Farb, Melissa
Hamburg, Naomi
Ruderman, Neil
Gokce, Noyan

PMID: 23204109; PMCID: PMC3572725; DOI: 10.1161/CIRCULATIONAHA.112.127514;

Ix JH, Biggs ML, Mukamal KJ, Kizer JR, Zieman SJ, Siscovick DS, Mozzaffarian D, Jensen MK, Nelson L, Ruderman N, Djousse L. Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study. Circulation. 2012 May 15; 125(19):2316-22. PMID: 22511752; PMCID: PMC3390925; DOI: 10.1161/CIRCULATIONAHA.111.072751;

Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One. 2012; 7(4):e35092.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil
Chen, Tai
Ido, Yasuo

PMID: 22514710; PMCID: PMC3325987; DOI: 10.1371/journal.pone.0035092;

Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil
Valentine, Rudy John
Ido, Yasuo

PMID: 22378745; PMCID: PMC3404529; DOI: 10.1152/ajpcell.00296.2011;

Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801.View Related Profiles.

Apovian, Caroline
Hess, Donald
Cacicedo, Jose
Xu, Xiaolai
Farb, Melissa
Ruderman, Neil
Gokce, Noyan
Valentine, Rudy John
Xu, Xinjie

PMID: 22323564; PMCID: PMC3307656; DOI: 10.1194/jlr.P022905;

Xu X.J., Gauthier M.S., Hess D.T., Apovian C., Cacicedo J.M., Gokce N., Farb M.G., Valentine R.J., Ruderman N.B. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012; In press.

Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation? Cell Cycle. 2011 Oct 15; 10(20):3447-51.View Related Profiles.

Saha, Asish
Xu, Xiaolai
Ruderman, Neil
Balon, Thomas
Xu, Xinjie

PMID: 22067655; PMCID: PMC3356833; DOI: 10.4161/cc.10.20.17886;

Chuang JH, Kao YJ, Ruderman NB, Tung LC, Lin Y. Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins. Anal Biochem. 2011 Nov 15; 418(2):298-300. PMID: 21871431; DOI: 10.1016/j.ab.2011.08.006;

Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13.View Related Profiles.

Pimentel, David
Siwik, Deborah
Qin, Fuzhong
Luptak, Ivan
Xu, Xiaolai
Liesa Roig, Marc
Ruderman, Neil
Shirihai, Orian
Doctrow, Susan
Colucci, Wilson
Xu, Xinjie
Zhu, Zheng

PMID: 21788586; PMCID: PMC4491919; DOI: 10.1161/CIRCULATIONAHA.110.003418;

Cacicedo JM, Gauthier MS, Lebrasseur NK, Jasuja R, Ruderman NB, Ido Y. Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1255-65.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil
Jasuja, Ravi
Ido, Yasuo

PMID: 21724864; PMCID: PMC3197351; DOI: 10.1152/ajpheart.01279.2010;

Cacicedo JM, Benjachareonwong S, Chou E, Yagihashi N, Ruderman NB, Ido Y. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3630-9.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil
Ido, Yasuo

PMID: 21345991; PMCID: PMC3109045; DOI: 10.1167/iovs.10-5784;

Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW. The evolution of insulin resistance in muscle of the glucose infused rat. Arch Biochem Biophys. 2011 May 15; 509(2):133-41.View Related Profiles.

Saha, Asish
Xu, Xiaolai
Ruderman, Neil

PMID: 21420928; PMCID: PMC3087290; DOI: 10.1016/j.abb.2011.03.008;

Tornheim, K. and Ruderman, N.B. Intermediary metabolism of carbohydrate, protein and fat. In Ahima, R.S. ed. Metabolic Basis of Obesity. Springer, 2011:25-51. Cited: N/A. Intermediary metabolism of carbohydrate, protein and fat. Ahima, R.S. ed. Metabolic Basis of Obesity. Springer. 2011; 25-51.

Gauthier MS, O'Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun. 2011 Jan 7; 404(1):382-7.View Related Profiles.

Apovian, Caroline
Cacicedo, Jose
Xu, Xiaolai
Mott, Melanie
Ruderman, Neil
Gokce, Noyan
Xu, Xinjie

PMID: 21130749; PMCID: PMC3061625; DOI: 10.1016/j.bbrc.2010.11.127;

Gauthier MS, Ruderman NB. Adipose tissue inflammation and insulin resistance: all obese humans are not created equal. Biochem J. 2010 Sep 1; 430(2):e1-4. PMID: 20704568; DOI: 10.1042/BJ20101062;

Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB. Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes. 2010 Oct; 59(10):2426-34.View Related Profiles.

Saha, Asish
Xu, Xiaolai
Ruderman, Neil
Xu, Xinjie

PMID: 20682696; PMCID: PMC3279521; DOI: 10.2337/db09-1870;

Liu Q, Gauthier MS, Sun L, Ruderman N, Lodish H. Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio. FASEB J. 2010 Nov; 24(11):4229-39. PMID: 20667975; PMCID: PMC2974418; DOI: 10.1096/fj.10-159723;

Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 4; 464(7285):121-5.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 20203611; PMCID: PMC2841477; DOI: 10.1038/nature08778;

Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E751-60.View Related Profiles.

Saha, Asish
Cacicedo, Jose
Xu, Xiaolai
Ruderman, Neil
Xu, Xinjie
Ido, Yasuo

PMID: 20103737; PMCID: PMC2853213; DOI: 10.1152/ajpendo.00745.2009;

Xu X.J., Nelson L., Ruderman, N.B. Do AMPK and SIRT1 talk to each other?. Cell Science Reviews. 2010; 7(1).
Ruderman NB, Shulman, G.I. The metabolic syndrome. De Groot L.J., Jamieson, J.L., Endocrinology. Elsevier, Saunders. Philadelphia. 2010; 822-839.

Ritov VB, Menshikova EV, Azuma K, Wood R, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE. Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity. Am J Physiol Endocrinol Metab. 2010 Jan; 298(1):E49-58. PMID: 19887598; PMCID: PMC2806111; DOI: 10.1152/ajpendo.00317.2009;

Joly E, Roduit R, Peyot ML, Habinowski SA, Ruderman NB, Witters LA, Prentki M. Glucose represses PPARa gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic ß-cell. J Diabetes. 2009 Dec; 1(4):263-72. PMID: 20923527; DOI: 10.1111/j.1753-0407.2009.00043.x;

Bendayan M, Londono I, Kemp BE, Hardie GD, Ruderman N, Prentki M. Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy. J Histochem Cytochem. 2009 Oct; 57(10):963-71. PMID: 19581628; PMCID: PMC2746729; DOI: 10.1369/jhc.2009.954016;

Kelly M, Gauthier MS, Saha AK, Ruderman NB. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes. 2009 Sep; 58(9):1953-60.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 19502419; PMCID: PMC2731526; DOI: 10.2337/db08-1293;

Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 19416713; PMCID: PMC2803070; DOI: 10.1016/j.cmet.2009.04.001;

Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology. 2009 Aug; 150(8):3465-74. PMID: 19406947; PMCID: PMC2717855; DOI: 10.1210/en.2008-1557;

Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M. Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem. 2009 Jun 19; 284(25):16848-59. PMID: 19389712; PMCID: PMC2719321; DOI: 10.1074/jbc.M109.006650;

Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 2009 Mar 1; 418(2):261-75. PMID: 19196246; PMCID: PMC2779044; DOI: 10.1042/BJ20082055;

Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):836-41.View Related Profiles.

Saha, Asish
Ruderman, Neil
Ido, Yasuo

PMID: 19071085; PMCID: PMC2764524; DOI: 10.1016/j.bbrc.2008.11.130;

Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem. 2008 Oct 10; 283(41):27628-35.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil
Ido, Yasuo

PMID: 18687677; PMCID: PMC2562073; DOI: 10.1074/jbc.M805711200;

Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem. 2008 Jun 13; 283(24):16514-24.View Related Profiles.

Saha, Asish
Cacicedo, Jose
Ruderman, Neil

PMID: 18390901; PMCID: PMC2423258; DOI: 10.1074/jbc.M708177200;

Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2650-6.View Related Profiles.

Vita, Joseph
Hamburg, Naomi
Ruderman, Neil
Gokce, Noyan

PMID: 17932315; PMCID: PMC2596308; DOI: 10.1161/ATVBAHA.107.153288;

Ruderman NB, Chisholm D., Pi-Sunyer X., Schneider S. The metabolically-obese, normal-weight individual: Revisited. Perspectives in Diabetes, ed. by R.P. Robertson. American Diabetes Association. Alexandria, VA. 2007.

Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M. Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes. 2006 Dec; 55 Suppl 2:S48-54.View Related Profiles.

Saha, Asish
Ruderman, Neil
Luo, Zhijun

PMID: 17130644

Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB. AMPK regulation of the growth of cultured human keratinocytes. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):519-24.View Related Profiles.

Saha, Asish
Safer, Joshua
Holick, Michael
Ruderman, Neil
Luo, Zhijun

PMID: 16949049

LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E175-81.View Related Profiles.

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Ruderman, Neil
Farmer, Stephen

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Ruderman NB, Saha AK. Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity (Silver Spring). 2006 Feb; 14 Suppl 1:25S-33S.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 16642960

Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1296-303.View Related Profiles.

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Ruderman, Neil

PMID: 16434556

Kelly, M., Ruderman, N.B., Tomas, E. AMP-activated protein kinase and its regulation by adiponectin and interleukin-6. Swedish Journal of Food and Nutrition. 2006; 50:85-91.

Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem. 2006 Feb 3; 281(5):2654-60.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 16326714

LeBrasseur NK, Ruderman NB. Why might thiazolidinediones increase exercise capacity in patients with type 2 diabetes? Diabetes Care. 2005 Dec; 28(12):2975-7. PMID: 16306565

Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes. 2005 Dec; 54(12):3458-65.View Related Profiles.

Ruderman, Neil
Luo, Zhijun

PMID: 16306362

Joly E, Bendayan M, Roduit R, Saha AK, Ruderman NB, Prentki M. Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes. FEBS Lett. 2005 Dec 5; 579(29):6581-6.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 16298369

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. Am J Physiol Endocrinol Metab. 2006 Mar; 290(3):E471-9.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 16234268

Miller TA, LeBrasseur NK, Cote GM, Trucillo MP, Pimentel DR, Ido Y, Ruderman NB, Sawyer DB. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochem Biophys Res Commun. 2005 Oct 14; 336(1):309-15.View Related Profiles.

Pimentel, David
Ruderman, Neil
Ido, Yasuo

PMID: 16126172

Ruderman N. Cardiorespiratory fitness attenuates mortality associated with the metabolic syndrome. Clin J Sport Med. 2005 Jul; 15(4):282-3. PMID: 16003046

Assifi MM, Suchankova G, Constant S, Prentki M, Saha AK, Ruderman NB. AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E794-800.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 15956049

Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes. 2005 Jun; 54(6):1838-45.View Related Profiles.

Cacicedo, Jose
Ruderman, Neil
Ido, Yasuo

PMID: 15919807

Luo Z, Saha AK, Xiang X, Ruderman NB. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci. 2005 Feb; 26(2):69-76.View Related Profiles.

Saha, Asish
Ruderman, Neil
Luo, Zhijun

PMID: 15681023

Suchankova G, Tekle M, Saha AK, Ruderman NB, Clarke SD, Gettys TW. Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochem Biophys Res Commun. 2005 Jan 28; 326(4):851-8.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 15607747

Ruderman NB, Myers, M., Chipkin, S.R., Tornheim, K. Hormone-fuel interrelationships: Fed state, starvation, and diabetes mellitus. Joslin’s Diabetes Mellitus. 2005; Chapter 6: 127-144.
Ye, J., Ruderman, N.B., Kraegen, E.W. AMP-activated protein kinase and malonyl CoA: targets for treating insulin resistance?. Drug Discovery Today, Therapeutic Strategies. 2005; 2:157-163.
Ruderman NB, Shulman, G.I. The metabolic syndrome. De Groot L.J., Jamieson, J.L., Endocrinology. Elsevier, Saunders. Philadelphia. 2005; pp 1149-1166.
Panzer, C., Ido, Y., Ruderman, N.B. Diabetes mellitus as an atherogenic factor. In Molecular mechanisms of atherosclerosis. J. Loscalzo, ed. United Kingdom, Taylor & Francis, 2005, pp 175-193. Cited: N/A. Diabetes mellitus as an atherogenic factor. Molecular mechanisms of atherosclerosis. J. Loscalzo, ed. Taylor & Francis. United Kingdom. 2005; pp 175-193.

Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 2004 Nov; 47(11):2012-21. PMID: 15578153

Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1204-9.View Related Profiles.

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Ruderman, Neil
Ido, Yasuo

PMID: 15504342

Roepstorff C, Halberg N, Hillig T, Saha AK, Ruderman NB, Wojtaszewski JF, Richter EA, Kiens B. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E133-42.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 15383373

Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem. 2004 Nov 12; 279(46):47898-905.View Related Profiles.

Herscovitz, Haya
Zang, Mengwei
Ruderman, Neil
Brecher, Peter
Cohen, Richard

PMID: 15371448

Xiang X, Saha AK, Wen R, Ruderman NB, Luo Z. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun. 2004 Aug 13; 321(1):161-7.View Related Profiles.

Saha, Asish
Ruderman, Neil
Luo, Zhijun

PMID: 15358229

Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, Petrova NL, Foster AV, Edmonds ME, Ferraresi R, Caravaggi C, De Giglio R, Cavaiani P, Pogliaghi I, Sommariva E, Katz IA, Harlan A, Miranda-Palma B, Prieto-Sanchez L, Armstrong DG, Bowker JH, Mizel MS, Cernea S, Wohlgelernter J, Kidron M, Modi P, Raz I, Arbit E, Nosek L, Kapitza C, Beckett P, Gelfand R, Goldberg M, Heise T, Testa MA, Turner RR, Hayes JF, Scranton RE, Simonson DC, Yang YW, Hsu YJ, Naujok O, Francini F, Jörns A, Tiedge M, Lenzen S, Abdel-Wahab YH, Marenah L, Orr DF, Shaw C, Flatt PR, Chokkalingam K, Mansell PI, Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER, Feldt-Rasmussen B, Dewan S, Da Silva N, Ternan PM, Leong KS, Wilding JP, Asatiani N, Kurashvili R, Dundua M, Shelestova E, Pagava K, Ramazashvili M, Hod M, Smirnov S, Petersen JL, Justesen TI, Ringholm Nielsen L, Müller C, Højlund K, Wensaas A, Kase ET, Aas V, Rustan AC, Thoresen GH, Levin K, Beck-Nielsen H, Gaster M, Im SS, Kang SY, Kim SY, Ahn YH, Lihn AS, Schmoll D, Werner T, Kienitz A, Meyer M, Barthel A, Ailett F, Sutherland C, Walther R, Grempler R, Sasson S, Reich R, Tenenbaum T, Alpert E, Anfossi G, Russo I, Traversa M, Massucco P, Mattiello L, Doronzo G, Trovati M, Lally S, Tan CY, Owens D, Tomkin GH, Porchay I, Péan F, Bellili N, Betoulle D, Balkau B, Tichet J, Marre M, Fumeron F, Chatellier G, Alhenc-Gelas F, Nichols GA, Brown JB, Hayes RP, Bowman L, Drexel H, Saely CH, Marte T, Benzer W, Langer P, Hoefle G, Moll W, Aczel S, Karagiannis E, Lübben G, Urquhart R, Edwards G, Bruce S, Howlett HS, Cugnardey N, Turner KC, Park JS, Fiedorek FT, Avogaro A, Gallo A, Pinton P, Rizzuto R, Murphy E, Ceolotto G, Caterson I, Guy-Grand B, Hill J, Barone M, Aiello A, Allochis G, Borzì V, Cannatà F, Caronna S, D'Avanzo A, Elli R, Formoso G, Paroli A, Scardapane R, Sorichetti P, Tatti P, Viviani G, Santeusanio F, Manzella D, Grella R, Abbatecola AM, Paolisso G, Søndergaard LG, Monster TB, Johnsen SP, Olsen ML, McLaughlin JK, Sørensen HT, Lervang HH, Rungby J, Lyssenko V, Fredriksson J, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Tuomi T, Groop L, Jaziri R, Aubert R, Tuomilehto J, Hu G, Jousilahti P, Peltonen M, Lindstrom J, Laina A, Alevizaki M, Philippou G, Souvatzoglou A, Anastasiou E, Alba S, Metcalf BS, Voss LD, Jeffery AN, Wilkin TJ, Glüimer C, Colagiuri S, Vistisen D, Borch-Johnsen K, Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA, Mortensen HB, Hougaard P, Holl R, Swift P, Pociot F, Knip M, Hansen L, Szadkowska A, Pietrzak I, Zmyslowska A, Wyka K, Bodalski J, Holl RW, Swift R, Hougaard R, Gerstl EM, Engelsberger I, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, Krause U, Dabelea D, Morgan T, Pettitt DJ, Dolan L, Mayer-Davis EJ, Pihoker C, Hillier TA, Imperatore G, Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, et al. 40th EASD View Related Profiles.

Sorensen, Henrik
Ruderman, Neil
Shirihai, Orian
Sivakumaran, Sudhir

PMID: 27770180; PMCID: PMC7096100; DOI: 10.1007/BF03375463;

Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun. 2004 Jul 23; 320(2):449-54.View Related Profiles.

Saha, Asish
Ruderman, Neil
Luo, Zhijun

PMID: 15219849

Tomas E, Kelly M, Xiang X, Tsao TS, Keller C, Keller P, Luo Z, Lodish H, Saha AK, Unger R, Ruderman NB. Metabolic and hormonal interactions between muscle and adipose tissue. Proc Nutr Soc. 2004 May; 63(2):381-5.View Related Profiles.

Saha, Asish
Ruderman, Neil
Luo, Zhijun

PMID: 15294059

Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 2004 Apr; 53(4):1007-19. PMID: 15047616

Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov. 2004 Apr; 3(4):340-51. PMID: 15060529

Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun. 2004 Feb 6; 314(2):580-5.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 14733947

Saha AK, Ruderman NB. Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Mol Cell Biochem. 2003 Nov; 253(1-2):65-70.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 14619957

Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem. 2003 Dec 12; 278(50):50810-7. PMID: 14522956

Ruderman NB, Saha AK, Kraegen EW. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology. 2003 Dec; 144(12):5166-71.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 14500570

Ruderman NB, Park H, Kaushik VK, Dean D, Constant S, Prentki M, Saha AK. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Acta Physiol Scand. 2003 Aug; 178(4):435-42.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 12864749

Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003 Jul; 52(7):1635-40.View Related Profiles.

Saha, Asish
Tornheim, Keith
Ruderman, Neil

PMID: 12829626

Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6.View Related Profiles.

Saha, Asish
Cacicedo, Jose
Ruderman, Neil
Cohen, Richard
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PMID: 12546685

Michael, M.D., Ruderman, N.B. Insulin, insulin-like growth factors, and their receptors. The Liver: Biology and Pathobiology. (Arias, I., Boyer, J., Chisari, F., Fausto, N., Schachter, D., Shafritz, D., eds.). Lippincott, Williams and Wilkins. 2003; 511-523.
Panzer, C., Brieke, A. & Ruderman, N.B. Prevention of type 2 diabetes and its macrovascular complications: whom, when, and how should we treat?. Current Opinion in Endocrinology & Diabetes. 2003; 10:229-236.
Riddell, M.C., Ruderman, N.B., Tsiani, E., Vranic, M. The endocrine system: metabolic effects of the pancreatic, adrenal, thyroidal, and growth hormones. Exercise Physiology: People and Ideas. Am. Physiological Society. Oxford University Press. 2003; 361-422.

Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. J Clin Endocrinol Metab. 2003 Jan; 88(1):82-7.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 12519834

Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH. Physical activity/exercise and diabetes mellitus. Diabetes Care. 2003 Jan; 26 Suppl 1:S73-7. PMID: 12502622

Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc Cc, Itani SI, Lodish HF, Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16309-13.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 12456889; PMCID: PMC138607

Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 2002 Oct; 51(10):2886-94.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 12351423

Lin Y, Brady MJ, Wolanske K, Holbert R, Ruderman NB, Yaney GC. Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E318-25.View Related Profiles.

Brady, Matthew
Ruderman, Neil

PMID: 12110537

Tomás E, Zorzano A, Ruderman NB. Exercise and insulin signaling: a historical perspective. J Appl Physiol (1985). 2002 Aug; 93(2):765-72. PMID: 12133890

Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 2002 Jul; 51(7):2005-11. PMID: 12086926

Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem. 2002 Sep 6; 277(36):32571-7.View Related Profiles.

Saha, Asish
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PMID: 12065578

Tomás E, Lin YS, Dagher Z, Saha A, Luo Z, Ido Y, Ruderman NB. Hyperglycemia and insulin resistance: possible mechanisms. Ann N Y Acad Sci. 2002 Jun; 967:43-51.View Related Profiles.

Saha, Asish
Ruderman, Neil
Ido, Yasuo
Luo, Zhijun

PMID: 12079834

Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation. 2002 May 7; 105(18):e138-43. PMID: 11994264

Shafrir E, Ziv E, Saha AK, Ruderman NB. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. Diabetes Metab Res Rev. 2002 May-Jun; 18(3):217-23.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 12112940

Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, Keaney JF. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C560-6.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 11832341

Xiang X, Yuan M, Song Y, Ruderman N, Wen R, Luo Z. 14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1. Mol Endocrinol. 2002 Mar; 16(3):552-62.View Related Profiles.

Ruderman, Neil
Luo, Zhijun

PMID: 11875115

Devlin, J.T., Ruderman, N.B. Diabetes and exercise: The risk-benefit profile revisited. N. Ruderman, J.T. Devlin, S.H. Schneider, A. Kriska eds. Handbook of Exercise in Diabetes. American Diabetes Association. Alexandria, VA. 2002; 17-20.
Dean, D.J., Ruderman, N.B. Role of AMP kinase and malonyl CoA in exercise-stimulated skeletal muscle metabolism and insulin action. Zierath, J.R., Wallberg-Henriksson, H., eds. Muscle Metabolism. Taylor and Francis. New York, NY. 2002; 211-225.
Tomas, E., Zorzano, A., Ruderman, N.B. Exercise effects on muscle insulin signaling and action. Exercise and insulin signaling: A historical perspective. J Appl Physiol. 2002; 93:765-72.
Riddell, M.C., Ruderman, N.B., Berger, M., Vranic, M. Exercise physiology and diabetes: from antiquity to the age of the exercise sciences. N. Ruderman, J.T. Devlin, S.H. Schneider, A. Kriska eds. Handbook of Exercise in Diabetes. American Diabetes Association. Alexandria, VA. 2002; 3-15.
Ruderman NB. A target population for diabetes prevention: The metabolically obese, normal-weight individual. N. Ruderman, J.T. Devlin, S.H. Schneider, A. Kriska eds. Handbook of Exercise in Diabetes. American Diabetes Association. Alexandria, VA. 2002; 235-249.
Sternthal, E. and Ruderman, N. Insulin: Promise and problems at 80 years. Current Opinion in Endocrinology & Diabetes. 2002; 9:283-284.

Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 2002 Jan; 51(1):159-67.View Related Profiles.

Ruderman, Neil
Ido, Yasuo

PMID: 11756336

Kaushik VK, Young ME, Dean DJ, Kurowski TG, Saha AK, Ruderman NB. Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E335-40. PMID: 11440910

Patel N, Khayat ZA, Ruderman NB, Klip A. Dissociation of 5' AMP-activated protein kinase activation and glucose uptake stimulation by mitochondrial uncoupling and hyperosmolar stress: differential sensitivities to intracellular Ca2+ and protein kinase C inhibition. Biochem Biophys Res Commun. 2001 Jul 27; 285(4):1066-70. PMID: 11467861

Lin Y, Itani SI, Kurowski TG, Dean DJ, Luo Z, Yaney GC, Ruderman NB. Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E8-E15.View Related Profiles.

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Luo, Zhijun

PMID: 11404218

Dagher Z, Ruderman N, Tornheim K, Ido Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res. 2001 Jun 22; 88(12):1276-82.View Related Profiles.

Tornheim, Keith
Ruderman, Neil
Ido, Yasuo

PMID: 11420304

Ruderman N, Flier JS. Cell biology. Chewing the fat--ACC and energy balance. Science. 2001 Mar 30; 291(5513):2558-9. PMID: 11286278

Ruderman NB, Tornheim, K., Goodman, M.N. Fuel homeostasis and intermediary metabolism of carbohydrate, fat, and protein. Becker, K.L., et al. ed . Principles and Practice of Endocrinology and Metabolism. Lippincott Williams and Wilkins. Philadelphia, PA. 2001; 1257-1271.

Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem. 2000 Aug 11; 275(32):24279-83.View Related Profiles.

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Tornheim, Keith
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PMID: 10854420

Chien D, Dean D, Saha AK, Flatt JP, Ruderman NB. Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab. 2000 Aug; 279(2):E259-65.View Related Profiles.

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Ruderman, Neil

PMID: 10913024

Dean D, Daugaard JR, Young ME, Saha A, Vavvas D, Asp S, Kiens B, Kim KH, Witters L, Richter EA, Ruderman N. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes. 2000 Aug; 49(8):1295-300.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 10923628

Båvenholm PN, Pigon J, Saha AK, Ruderman NB, Efendic S. Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. Diabetes. 2000 Jul; 49(7):1078-83. PMID: 10909961

Zinman, B, Ruderman, N., Campaigne, B.N., Devlin, J.T., Schneider, S.H. . Diabetes mellitus and exercise. Diabetes Care. 2000; 23(Suppl. 1):S50-S54.

Laybutt DR, Schmitz-Peiffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am J Physiol. 1999 Dec; 277(6 Pt 1):E1070-6. PMID: 10600797

McDonnell ME, Ruderman NB. Cutting the Gordian knot. Addition of metformin to insulin therapy in a patient with uncontrolled diabetes and schizophrenia. Diabetes Care. 1999 Nov; 22(11):1912-3.View Related Profiles.

McDonnell, Marie
Ruderman, Neil

PMID: 10546035

Dagher Z, Ruderman N, Tornheim K, Ido Y. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1999 Nov; 265(1):112-5.View Related Profiles.

Tornheim, Keith
Ruderman, Neil
Ido, Yasuo

PMID: 10548499

Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F, Juhl C, Pørksen N, Sturis J, Hollingdal M, Pincus S, Veldhuis J, Dejgaard A, Schmitz O, Kristensen JS, Frandsen KB, Bayer T, Müller P, Dunning BE, Paladini S, Gutierrez C, Deacon R, Valentin M, Grunberger G, Weston WM, Patwardhan R, Rappaport EB, Sargeant LA, Wareham NJ, Khaw KT, Zethelius B, Lithell H, Hales CN, Berne C, Lakka HM, Oksanen L, Tuomainen TP, Kontula K, Salonen JT, Dekker JM, de Boks P, de Vegt F, Stehouwer CD, Nijpels G, Bouter LM, Heine RJ, Bruno G, Cavallo-Perin P, Bargero G, D'Errico N, Borra M, Macchia G, Pagano G, Newton RW, Ruta DA, New JP, Wallace C, Roxburgh MA, Young RJ, Vaughan NJ, Elliott P, Brennan G, Devers M, MacAlpine R, Steinke D, Lawson DH, Decallonne B, Casteels K, Gysemans C, Bouillon R, Mathieu C, Linn T, Strate C, Schneider K, Funda DP, Jirsa M, Kozáková H, Kaas A, Kofronová O, Tlaskalová-Hogenová H, Buschard K, Wanka H, Hartmann A, Kuttler B, Rasmussen SB, Sørensen TS, Markholst H, Petersen JS, Karounos D, Dyrberg T, Mabley JG, Haskó G, Szabó C, Seissler J, Nguyen TB, Steinbrenner H, Scherbaum WA, Cipriani R, Gabriele A, Sensi M, Guidobaldi L, Pantellini F, Cerrito MG, Scarpa S, Di Mario U, Morano S, Ceolotto G, Iori E, Baritono E, Del Prato S, Semplicini A, Trevisan R, Zerbini G, Meregalli G, Asnaghi V, Tentori F, Maestroni A, Mangili R, Marescotti C, Vedovato M, Tiengo A, Tadjieva J, Mankovsky BN, Van Aken S, Raes A, Vande Walle J, Matthys D, Craen M, Hansen HP, Lund SS, Rossing P, Jensen T, Parving HH, Andersen S, Tarnow L, Hansen BV, Trautner C, Haastert B, Ennenbach N, Willich S, Tabák ÁG, Orchard TJ, Spranger J, Preissner KT, Schatz H, Pfeiffer A, Cantón A, Burgos R, Hernández C, Lecube A, Mesa J, Segura RM, Mateo C, Simó R, Fathallah L, Greene DA, Obrosova I, Gilbert RE, Kelly DJ, Cox AJ, Berka-Wilkinson JL, Taylor HR, Panagiotopoulos S, Lee V, Jerums G, Cooper ME, Hitman GA, Aganna E, Ogunkolade WB, Rema M, Deepa R, Shanthi-Rani CS, Barakat K, Kumarajeewa TR, Cassell PG, McDermott MF, Mohan V, Ways K, Bursell S, Devries T, Woodworth J, Alatorre C, King G, Aiello LP, Karisen AE, Pavlovic D, Nielsen K, Jensen J, Andersen HU, Pociot F, Mandrup-Poulsen T, Eizirik DL, Nerup J, Lortz S, Tiedge M, Lenzen S, Lally FJ, Bone AJ, Darville MI, Ho YS, Sternesjö J, Sandler S, Chen MC, Schuit F, Pipeleers DG, Merezak S, Hardikar A, Hoet JJ, Remacle C, Reusens B, Bréant B, Garofano A, Czernichow P, Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Nakano R, Komeda K, Eto K, Tobe K, Kimura S, Kadowaki T, Ide T, Murakami K, Tsunoda M, Mochizuki T, Ozanne SE, Nave BT, Wang CL, Dorling MW, Petry CJ, Koopmans SJ, van der Bent C, Que I, Radder JK, Sebokova E, Sana AK, Klimes I, Ruderman N, Morviducci L, Pastore L, Morelli S, Sagratella E, Zorretta D, Buongiomo A, Tamburrano G, Giaccari A, Martinenghi S, De Angelis GC, Ravasi F, Bifari F, Bordignon C, Falqui L, Kessler A, Dransfeld O, Sasson S, Tomas E, Zorzano A, Eckel J, Thorsby P, Rosenfalck AM, Kjems L, Hanssen KF, Madsbad S, Birkeland KI, Hamilton-Wessler M, Markussen J, Bergman RN, Melki V, Hanaire-Broutin H, Bessières-Lacombe S, Tauber JP, Home PD, Lindholm A, Riis A, Rosenstock J, Schwartz S, Clark C, Edwards M, Donley D, Swift P, Mortensen HB, Lynggaard H, Hougaard P, Cull CA, Neil HA, Frighi V, Manley SE, Holman RR, Turner RC, Steiner G, Davis WA, Weeraratna T, Bruce DG, Davis TM, Vergès B, Duvillard L, Pont F, Florentin E, Gambert P, Benko B, Ljubic S, Turk Z, Granic M, März W, Wollschläger H, Klein G, Neiss A, Wehling M, Huxtable SJ, Saker PJ, Walker M, Frayling TM, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI, Orecchio A, Giacchini A, Dominici R, Canettieri G, Trinti B, Zani M, Andreoli M, Sciacchitano S, de Silva AM, Whitecross K, Pasco J, Kotowicz M, Nicholson G, Zimmet P, Boyko EJ, Collier GR, Frittitta L, Pizzuti A, Argiolas A, Graci S, Goldfine ID, Bozzali M, Ercolino T, et al. 35th AnnView Related Profiles.

Habershaw, Geoffrey
Ruderman, Neil
D'Agostino, Ralph

PMID: 27770183

Saha AK, Laybutt DR, Dean D, Vavvas D, Sebokova E, Ellis B, Klimes I, Kraegen EW, Shafrir E, Ruderman NB. Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. Am J Physiol. 1999 Jun; 276(6 Pt 1):E1030-7.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 10362615

Kurowski TG, Lin Y, Luo Z, Tsichlis PN, Buse MG, Heydrick SJ, Ruderman NB. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes. 1999 Mar; 48(3):658-63.View Related Profiles.

Ruderman, Neil
Heydrick, Stanley

PMID: 10078574

Goalstone ML, Wall K, Leitner JW, Kurowski T, Ruderman N, Pan SJ, Ivy JL, Moller DE, Draznin B. Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals. Diabetologia. 1999 Mar; 42(3):310-6. PMID: 10096783

Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999 Jan; 276(1 Pt 1):E1-E18.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 9886945

Zinman, B., Ruderman, N.B., Campaigne, B.N., Devlin, J.T., Schneider, S.H. Diabetes mellitus and exercise. Diabetes Care. 1999; 22(Suppl. 1): S49-S53.
Ruderman NB, Saha, A.K., Vavvas, D., Kurowski, T., Laybutt, D.R., Kraegen, E.W. The malonyl CoA fuel sensing mechanism in muscle of insulin-resistant rodents. Lessons from Animal Diabetes IIV (E. Shafrir, ed.). Birkhauser. 1999.
Ruderman NB. Diabetes and exercise: An overview. West Indian Medical Journal. 1999.

Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes. 1998 May; 47(5):699-713. PMID: 9588440

Ruderman NB, Saha AK, Vavvas D, Kurowski T, Laybutt DR, Schmitz-Peiffer C, Biden T, Kraegen EW. Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. Adv Exp Med Biol. 1998; 441:263-70.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 9781332

Ruderman NB, Dean D. Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):295-308. PMID: 10212840

Oakes ND, Bell KS, Furler SM, Camilleri S, Saha AK, Ruderman NB, Chisholm DJ, Kraegen EW. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes. 1997 Dec; 46(12):2022-8. PMID: 9392490

Ruderman NB, Saha AK, Vavvas D, Heydrick SJ, Kurowski TG. Lipid abnormalities in muscle of insulin-resistant rodents. The malonyl CoA hypothesis. Ann N Y Acad Sci. 1997 Sep 20; 827:221-30.View Related Profiles.

Saha, Asish
Ruderman, Neil
Heydrick, Stanley

PMID: 9329757

Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, Ruderman NB. Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. J Biol Chem. 1997 May 16; 272(20):13255-61.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 9148944

Saha AK, Vavvas D, Kurowski TG, Apazidis A, Witters LA, Shafrir E, Ruderman NB. Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol. 1997 Apr; 272(4 Pt 1):E641-8.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 9142886

Schneider, S. and Ruderman, N.B. Use of exercise in the treatment of Type 2 Diabetes Mellitus. Clinical Diabetes. 1997; 15:176-179.

Gupta S, Phipps K, Ruderman NB. Differential stimulation of Na+ pump activity by insulin and nitric oxide in rabbit aorta. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1287-93. PMID: 8967368

Kurowski TG, Saha AK, Cunningham BA, Holbert RI, Colca JR, Corkey BE, Ruderman NB. Malonyl coenzyme A and adiposity in the Dahl salt-sensitive rat: effects of pioglitazone. Metabolism. 1996 Apr; 45(4):519-25.View Related Profiles.

Saha, Asish
Corkey, Barbara
Ruderman, Neil

PMID: 8609842

Khan F, Cohen RA, Ruderman NB, Chipkin SR, Coffman JD. Vasodilator responses in the forearm skin of patients with insulin-dependent diabetes mellitus. Vasc Med. 1996; 1(3):187-93.View Related Profiles.

Ruderman, Neil
Cohen, Richard

PMID: 9546937

Saha AK, Kurowski TG, Ruderman NB. A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation. Am J Physiol. 1995 Aug; 269(2 Pt 1):E283-9.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 7653546

Ruderman NB, and Devlin, J. Exercise in diabetics with complications. Diabetes (S. Baba, T. Kaneko, eds.). Elsevier. Amsterdam. 1995; pp 782-786.
Ruderman NB. Exercise in special patient groups. Pre-diabetics and the insulin resistance syndrome. Health Professionals Guide to Diabetes and Exercise (N Ruderman and J. Devlin eds.). American Diabetes Association. Alexandria VA. 1995; pp 243-248.
Devlin, J. and Ruderman, N.B. Handbook of diabetes and exercise: The risk-benefit profile. Health Professionals Guide to Diabetes and Exercise (NB Ruderman, J Devlin Eds.). Am. Diabetes Association. 1995; pp 3-4.
Ruderman NB, Tornheim, K., and Goodman, M.N. Fuel homeostasis and intermediary metabolism of carbohydrate, fat and protein. Principles and Practice of Endocrinology and Metabolism. K. Becker, C.R. Kahn, et al., eds. Lippincott. Philadelphia. 1995; pp 1174-1187.

Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem. 1994 Aug 12; 269(32):20648-52.View Related Profiles.

Friel, John
Ruderman, Neil

PMID: 8051164

Saha AK, Kurowski TG, Colca JR, Ruderman NB. Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol. Am J Physiol. 1994 Jul; 267(1 Pt 1):E95-101.View Related Profiles.

Saha, Asish
Ruderman, Neil

PMID: 8048519

Gupta S, McArthur C, Grady C, Ruderman NB. Stimulation of vascular Na(+)-K(+)-ATPase activity by nitric oxide: a cGMP-independent effect. Am J Physiol. 1994 May; 266(5 Pt 2):H2146-51. PMID: 7911280

Chen KS, Heydrick SJ, Brown ML, Friel JC, Ruderman NB. Insulin increases a biochemically distinct pool of diacylglycerol in the rat soleus muscle. Am J Physiol. 1994 Mar; 266(3 Pt 1):E479-85.View Related Profiles.

Friel, John
Ruderman, Neil
Heydrick, Stanley

PMID: 8166270

Gupta S, McArthur C, Grady C, Ruderman NB. Role of endothelium-derived nitric oxide in stimulation of Na(+)-K(+)-ATPase activity by endothelin in rabbit aorta. Am J Physiol. 1994 Feb; 266(2 Pt 2):H577-82. PMID: 8141359

Chipkin, S.R., Kelly, K.K. and Ruderman, N.B. Hormone-fuel interrelationships in the fed state, starvation and diabetes. Joslin’s Diabetes C.R. Kahn , G.C. Weir,eds. Lea and Febiger. Philadelphia. 1994; pp 97-115.
Ruderman NB, Moses, A.C., and Moller, D.E. Insulin, insulin-like growth factors and their receptors. The Liver: Biology and Pathophysiology (I. Arias et al. eds.). Raven Press. New York. 1994; pp 969-996.

Sussman I, Schultz V, Gupta S, Grady C, Ruderman NB, Tornheim K. Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels. Am J Physiol. 1993 Nov; 265(5 Pt 1):E777-82.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 7902010

Chen KS, Friel JC, Ruderman NB. Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle. Am J Physiol. 1993 Nov; 265(5 Pt 1):E736-42.View Related Profiles.

Friel, John
Ruderman, Neil

PMID: 8238500

Tesfamariam B, Gupta S, Oates PJ, Ruderman NB, Cohen RA. Reduced Na(+)-K+ pump activity in diabetic rabbit carotid artery: reversal by aldose reductase inhibition. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1189-94.View Related Profiles.

Ruderman, Neil
Cohen, Richard

PMID: 8238405

Ruderman N, Horton E, Kemmer F, Berger M. The lost symposium. Diabetes and exercise 1990. Diabetes Care. 1993 Jun; 16(6):959-60. PMID: 8325223

Kelly KL, Ruderman NB. Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle. J Biol Chem. 1993 Feb 25; 268(6):4391-8. PMID: 8382701

Young, J.C., Treadway, J.D. and Ruderman, N.B. . Effect of acarbose on glucose uptake in skeletal muscle. Drugs in Development. 1993; 1:75-84.
Young, J., and Ruderman, N.B. Exercise and metabolic disorders. Principles of Exercise Biochemistry (J. Poortmans, ed.). Med Sport Sci. Basel, Karger. 1993; 28:269-298.

Ruderman NB, Schneider SH. Diabetes, exercise, and atherosclerosis. Diabetes Care. 1992 Nov; 15(11):1787-93. PMID: 1468316

Schneider SH, Khachadurian AK, Amorosa LF, Clemow L, Ruderman NB. Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus. Diabetes Care. 1992 Nov; 15(11):1800-10. PMID: 1468318

Coderre L, Monfar MM, Chen KS, Heydrick SJ, Kurowski TG, Ruderman NB, Pilch PF. Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles. Endocrinology. 1992 Oct; 131(4):1821-5.View Related Profiles.

Ruderman, Neil
Pilch, Paul
Heydrick, Stanley

PMID: 1396328

Gupta S, Sussman I, McArthur CS, Tornheim K, Cohen RA, Ruderman NB. Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest. 1992 Sep; 90(3):727-32.View Related Profiles.

Tornheim, Keith
Ruderman, Neil
Cohen, Richard

PMID: 1325996; PMCID: PMC329923

Ruderman NB, Williamson JR, Brownlee M. Glucose and diabetic vascular disease. FASEB J. 1992 Aug; 6(11):2905-14. PMID: 1644256

Balon TW, Treadway JL, Hughes JB, Young JC, Ruderman NB. Effect of prior exercise and insulin on potential thermogenic systems in rat skeletal muscle. J Appl Physiol (1985). 1992 Jun; 72(6):2203-9.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 1629074

Kelly KL, Ruderman NB, Chen KS. Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution. J Biol Chem. 1992 Feb 15; 267(5):3423-8. PMID: 1310686

Ruderman NB, Gupta, S., and Sussman, I. Hyperglycemia, diabetes, and vascular disease: an overview. Hyperglycemia, Diabetes and Vascular Disease. Ruderman NB, Brownlee, M. and Williamson, J.R. eds. Oxford Press. New York. 1992; pp 3-20.
Ruderman NB, Chen, K., Heydrick, S., and Kurowski, T. Diacylglycerol-protein kinase C signaling in normal and denervated rat skeletal muscle. Diabetes Mellitus and Exercise. J. Devlin and E. Horton, eds. Smith Gordon. 1992; pp. 81-87.
Ruderman NB, Brownlee, M., and Williamson, J.R.,eds. Ruderman NB, Brownlee, M., and Williamson, J.R.,eds. Hyperglycemia, diabetes and vascular disease. American Physiological Society, Clinical Physiology Series. Oxford Press. New York. 1992; pp 1-300.

Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS. Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance. Diabetes. 1991 Dec; 40(12):1707-11.View Related Profiles.

Ruderman, Neil
Heydrick, Stanley

PMID: 1756911

Kimmerle R, Griffing G, McCall A, Ruderman NB, Stoltz E, Melby JC. Could intranasal insulin be useful in the treatment of non-insulin-dependent diabetes mellitus? Diabetes Res Clin Pract. 1991 Aug; 13(1-2):69-75. PMID: 1773716

Gupta S, Ruderman NB, Cragoe EJ, Sussman I. Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta. Am J Physiol. 1991 Jul; 261(1 Pt 2):H38-45. PMID: 1650145

Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB. Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol Endocrinol. 1991 Jun; 5(6):769-77. PMID: 1656240

Young JC, Kurowski TG, Maurice AM, Nesher R, Ruderman NB. Polymyxin B inhibits contraction-stimulated glucose uptake in rat skeletal muscle. J Appl Physiol (1985). 1991 Apr; 70(4):1650-4. PMID: 2055846

Chen KS, Heydrick S, Kurowski T, Ruderman NB. Diacylglycerol-protein kinase C signalling in skeletal muscle: a possible link to insulin resistance. Trans Assoc Am Physicians. 1991; 104:206-12.View Related Profiles.

Ruderman, Neil
Heydrick, Stanley

PMID: 1845146

Schneider, S.H. and Ruderman, N.B. Exercise and NIDDM. Technical Review. Diabetes Care. 13. 1991; 785-789.
Ruderman NB and Schneider, S.H. Reducing cardiovascular risk factors in type 2 diabetes: In Diabetes, H. Rifkin, J.A. Colwell and S.I. Taylor, eds. New York: Elsevier, pp 1110-1113, 1991. Cited: N/A. Reducing cardiovascular risk factors in type 2 diabetes. Diabetes, H. Rifkin, J.A. Colwell and S.I. Taylor, eds. Elsevier. New York. 1991; pp 1110-1113.

Ruderman N, Apelian AZ, Schneider SH. Exercise in therapy and prevention of type II diabetes. Implications for blacks. Diabetes Care. 1990 Nov; 13(11):1163-8. PMID: 2261837

Gaposchkin CG, Tornheim K, Sussman I, Ruderman NB, McCall AL. Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels. Am J Physiol. 1990 Mar; 258(3 Pt 1):E543-7.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 2316646

Ruderman NB, Kapeller R, White MF, Cantley LC. Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1411-5. PMID: 2154747; PMCID: PMC53485

Balon TW, Zorzano A, Treadway JL, Goodman MN, Ruderman NB. Effect of insulin on protein synthesis and degradation in skeletal muscle after exercise. Am J Physiol. 1990 Jan; 258(1 Pt 1):E92-7.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 2405703

Treadway JL, James DE, Burcel E, Ruderman NB. Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle. Am J Physiol. 1989 Jan; 256(1 Pt 1):E138-44. PMID: 2643337

Ruderman NB, Tornheim, K., and Goodman, M.N. Fuel homeostasis and intermediary metabolism of carbohydrate, fat and protein. Principles and Practice of Endocrinology and Metabolism. K. Becker, C.R. Kahn, et al., eds. Lippincott. Philadelphia. 1989; pp 1054-1064.
Corkey, B.E., Tornheim, K., Deeney, J.T., Glennon, M.C., Parker, J.C., Matschinsky, F.M., Ruderman, N.B., and Prenki, M. Metabolic regulation of Ca2+ handling in permeabilized cells. Cell Calcium Metabolism '87 (G. Fiskum, ed.). Plenum Press. New York. 1989; pp 369-377.
Ruderman NB and Schneider, S.H. Diabetes, exercise and atherosclerosis. Pfizer Publication. 1989.

Schneider SH, Kim HC, Khachadurian AK, Ruderman NB. Impaired fibrinolytic response to exercise in type II diabetes: effects of exercise and physical training. Metabolism. 1988 Oct; 37(10):924-9. PMID: 3173111

Sussman I, Carson MP, Schultz V, Wu XP, McCall AL, Ruderman NB, Tornheim K. Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium. Diabetologia. 1988 Oct; 31(10):771-5.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 3240840

Zorzano A, James DE, Ruderman NB, Pilch PF. Insulin-like growth factor I binding and receptor kinase in red and white muscle. FEBS Lett. 1988 Jul 18; 234(2):257-62.View Related Profiles.

Ruderman, Neil
Pilch, Paul

PMID: 2968920

McCall AL, Valente J, Cordero R, Ruderman NB, Tornheim K. Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrations. Microvasc Res. 1988 May; 35(3):325-33.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 3393093

Corkey BE, Tornheim K, Deeney JT, Glennon MC, Parker JC, Matschinsky FM, Ruderman NB, Prentki M. Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem. 1988 Mar 25; 263(9):4254-8.View Related Profiles.

Corkey, Barbara
Deeney, Jude
Tornheim, Keith
Ruderman, Neil

PMID: 2831225

McCall AL, Sussman I, Tornheim K, Cordero R, Ruderman NB. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. Am J Physiol. 1988 Mar; 254(3 Pt 1):E272-8.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 2964787

Sussman I, Carson MP, McCall AL, Schultz V, Ruderman NB, Tornheim K. Energy state of bovine cerebral microvessels: comparison of isolation methods. Microvasc Res. 1988 Mar; 35(2):167-78.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 2897072

Vitug A, Schneider SH, Ruderman NB. Exercise and type I diabetes mellitus. Exerc Sport Sci Rev. 1988; 16:285-304. PMID: 3292260

Young, J., and Ruderman, N.B. . Exercise and metabolic disorders. Principles of Exercise Biochemistry (J. Poortmans, ed.). Med Sport Sci. Basel, Karger. 1988; 27:pp. 230-254.
Corkey, B.E., Tornheim, K., Deeney, J.T., Glennon, M.C., Matschinsky, F.M., Ruderman, N.B., and Prenki, M. Integrated mitochondrial and microsomal regulation of free Ca2+ in permeabilized insulinoma cells. integration of mitochondrial function (J.J. Lemasters, C.R. Hackenbrock, R.G. Thurman and H.B. Westerhoff, eds.). Plenum Press. New York. 1988; pp 543-550.

Schneider SH, Khachadurian AK, Amorosa LF, Gavras H, Fineberg SE, Ruderman NB. Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes. Metabolism. 1987 Dec; 36(12):1161-6.View Related Profiles.

Gavras, Haralambos
Ruderman, Neil

PMID: 3316925

Lowell BB, Ruderman NB, Goodman MN. Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation. Metabolism. 1986 Dec; 35(12):1121-7. PMID: 3537631

Zorzano A, Balon TW, Goodman MN, Ruderman NB. Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise. Am J Physiol. 1986 Dec; 251(6 Pt 1):E664-9.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 3538900

Zorzano A, Balon TW, Jakubowski JA, Goodman MN, Deykin D, Ruderman NB. Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake. Biochem J. 1986 Dec 1; 240(2):437-43.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 3545188; PMCID: PMC1147436

James DE, Zorzano A, Böni-Schnetzler M, Nemenoff RA, Powers A, Pilch PF, Ruderman NB. Intrinsic differences of insulin receptor kinase activity in red and white muscle. J Biol Chem. 1986 Nov 15; 261(32):14939-44.View Related Profiles.

Ruderman, Neil
Pilch, Paul

PMID: 3021758

Young JC, Treadway JL, Balon TW, Gavras HP, Ruderman NB. Prior exercise potentiates the thermic effect of a carbohydrate load. Metabolism. 1986 Nov; 35(11):1048-53.View Related Profiles.

Gavras, Haralambos
Ruderman, Neil
Balon, Thomas

PMID: 3534517

McCall AL, Fixman LB, Fleming N, Tornheim K, Chick W, Ruderman NB. Chronic hypoglycemia increases brain glucose transport. Am J Physiol. 1986 Oct; 251(4 Pt 1):E442-7.View Related Profiles.

Tornheim, Keith
Ruderman, Neil

PMID: 3532819

Balon TW, Zorzano A, Goodman MN, Ruderman NB. Insulin-enhanced thermogenesis in skeletal muscle after exercise: regulatory factors. Am J Physiol. 1986 Sep; 251(3 Pt 1):E294-8.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 2875652

Zorzano A, Balon TW, Goodman MN, Ruderman NB. Additive effects of prior exercise and insulin on glucose and AIB uptake by rat muscle. Am J Physiol. 1986 Jul; 251(1 Pt 1):E21-6.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 3524258

Ruderman NB, Schneider S. Exercise and the insulin-dependent diabetic. Hosp Pract (Off Ed). 1986 May 30; 21(5A):41-51. PMID: 3084520

Lowell BB, Ruderman NB, Goodman MN. Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle. Biochem J. 1986 Feb 15; 234(1):237-40. PMID: 3707546; PMCID: PMC1146553

Zorzano A, Balon TW, Goodman MN, Ruderman NB. Insulin and exercise stimulate muscle alpha-aminoisobutyric acid transport by a Na+-K+-ATPase independent pathway. Biochem Biophys Res Commun. 1986 Feb 13; 134(3):1342-9.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 2418838

Schneider SH, Ruderman NB. Exercise and physical training in the treatment of diabetes mellitus. Compr Ther. 1986 Jan; 12(1):49-56. PMID: 3512156

Ruderman NB and Schneider, S. Exercise in type 2 diabetes. Biochemistry of Exercise. (B. Saltin, H. Galbo, and E.A. Richter, eds.). Human Kinetics Publishers. Champaign. 1986; pp 255-265.

Schneider SH, Vitug A, Ruderman N. Atherosclerosis and physical activity. Diabetes Metab Rev. 1986; 1(4):513-53. PMID: 3522141

Ruderman NB, Balon T, Zorzano A, Goodman M. The postexercise state: altered effects of insulin on skeletal muscle and their physiologic relevance. Diabetes Metab Rev. 1986; 1(4):425-44.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 3087715

Vitug, A., Schneider, S.H., and Ruderman, N.B. . Lifestyle studies indicate moderate exercise can decrease the threat of atherosclerosis. Diabetes Countdown. 1986; VII(3):21-23.

Ruderman NB, Balon T, Zorzano A, Goodman MN, Young J. Acute and chronic metabolism changes following exercise: mechanisms and physiological relevance. Curr Concepts Nutr. 1986; 15:1-8.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 3533435

Ruderman NB and Schneider, S.H. Exercise in type 2 diabetes. In, Diabetes 1985, (M. Serranos-Rios and P.J. Lefebvre, eds.), Elsevier Science Publishers, 1986, pp 949-953. Cited: N/A. Exercise in type 2 diabetes. Diabetes 1985, (M. Serranos-Rios and P.J. Lefebvre, eds.). Elsevier Science Publishers. 1986; pp 949-953.
Schneider, S.H., Young, J.C., Ruderman, N.B. Exercise studies in the diabetic. Methods in Diabetes Research, V2, Clinical Methods. J. Larner, S. Pohl and W. Clarke, eds. Wiley. New York. 1986; pp. 407-423.
Ruderman NB, McCall, A., and Schneider, S. Exercise and endocrine disorders. Scand. J. Sports Sci. 1986; 8:43-50.

Zorzano A, Balon TW, Brady LJ, Rivera P, Garetto LP, Young JC, Goodman MN, Ruderman NB. Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle. Biochem J. 1985 Dec 1; 232(2):585-91.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 4091810; PMCID: PMC1152919

Ruderman NB, Berger M. Muscle glucose oxidation. Am J Physiol. 1985 Oct; 249(4 Pt 1):E433-4. PMID: 4050992

Zorzano A, Balon TW, Garetto LP, Goodman MN, Ruderman NB. Muscle alpha-aminoisobutyric acid transport after exercise: enhanced stimulation by insulin. Am J Physiol. 1985 May; 248(5 Pt 1):E546-52.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 3887941

Salzman R, Manson JE, Griffing GT, Kimmerle R, Ruderman N, McCall A, Stoltz EI, Mullin C, Small D, Armstrong J, et al. Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes. N Engl J Med. 1985 Apr 25; 312(17):1078-84. PMID: 3885035

Balon TW, Zorzano A, Goodman MN, Ruderman NB. Insulin increases thermogenesis in rat skeletal muscle following exercise. Am J Physiol. 1985 Jan; 248(1 Pt 1):E148-51.View Related Profiles.

Ruderman, Neil
Balon, Thomas

PMID: 3881047

McCall AL, Gould JB, Ruderman NB. Diabetes-induced alterations of glucose metabolism in rat cerebral microvessels. Am J Physiol. 1984 Oct; 247(4 Pt 1):E462-7. PMID: 6496667

Waldorf AR, Ruderman N, Diamond RD. Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus. J Clin Invest. 1984 Jul; 74(1):150-60. PMID: 6736246; PMCID: PMC425195

Garetto LP, Richter EA, Goodman MN, Ruderman NB. Enhanced muscle glucose metabolism after exercise in the rat: the two phases. Am J Physiol. 1984 Jun; 246(6 Pt 1):E471-5. PMID: 6377909

Richter EA, Garetto LP, Goodman MN, Ruderman NB. Enhanced muscle glucose metabolism after exercise: modulation by local factors. Am J Physiol. 1984 Jun; 246(6 Pt 1):E476-82. PMID: 6430094

Goodman MN, Lowell B, Belur E, Ruderman NB. Sites of protein conservation and loss during starvation: influence of adiposity. Am J Physiol. 1984 May; 246(5 Pt 1):E383-90. PMID: 6720943

Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB. Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1984 May; 26(5):355-60. PMID: 6376244

Ruderman NB, Haudenschild C. Diabetes as an atherogenic factor. Prog Cardiovasc Dis. 1984 Mar-Apr; 26(5):373-412. PMID: 6371895

Ruderman, N. B., Garetto, L.P., Richter, E.A., and Goodman, M.N. Enhanced muscle glucose metabolism following exercise: role of insulin. Lessons from Animal Diabetes, (E. Shafrir, ed.). J. Libbey. London. 1984; pp184-189.
Ruderman NB, Young, J.C., and Schneider, S.S. Exercise as a therapeutic tool in the type I diabetic. Practical Cardiology. 1984; 10:143-153.
Ruderman NB, McCall, A.L. and Hannon, C. Role of diet in the therapy and etiology human diabetes. Animal Models in Nutrition Research, Report of the Fifth Ross Conference on Medical Research. 1984; p28-32.
Garetto, L.P., Richter, E.A., Goodman, M.G., and Ruderman, N.B. Enhanced insulin sensitivity of skeletal muscle following exercise. Biochemistry of Exercise, H. Knuttgen, ed. Human Kinetics Publishers. Champaign, IL. 1983; pp. 681-687.

Goodman MN, Dluz SM, McElaney MA, Belur E, Ruderman NB. Glucose uptake and insulin sensitivity in rat muscle: changes during 3-96 weeks of age. Am J Physiol. 1983 Jan; 244(1):E93-100. PMID: 6336911

Ruderman NB, and McCall, A.L. Disorders of carbohydrate metabolism. Wilkin's Textbook of Medicine (N.G. Levinsky, ed.). Little, Brown and Co. Boston. 1983; pp. 778-797.
Richter, E.A., Ruderman, N.B. and Galbo, H. Alpha and Beta adrenergic effects on muscle metabolism in contracting perfused rat muscle. International Series of Sports Sciences, V13, Biochemistry of Exercise, (H.Knuttgen, ed.). U.S. Human Kinetics Publishers. Champaign, IL. 1983; pp. 766-772.

Richter EA, Ruderman NB, Galbo H. Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. Acta Physiol Scand. 1982 Nov; 116(3):215-22. PMID: 6132521

Conover C, Rozovski SJ, Ruderman NB. Partial characterization of an insulin-dependent serum factor that regulates ornithine decarboxylase in skeletal muscle. Diabetes. 1982 Jun; 31(6 Pt 1):500-5. PMID: 6759267

Richter EA, Garetto LP, Goodman MN, Ruderman NB. Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin. J Clin Invest. 1982 Apr; 69(4):785-93. PMID: 6804492; PMCID: PMC370132

Ruderman NB, Berchtold P, Schneider S. Obesity-associated disorders in normal-weight individuals: some speculations. Int J Obes. 1982; 6 Suppl 1:151-7. PMID: 6749721

Schneider, S.H. and Ruderman, N.B. Exercise and the diabetic. Diabetes Mellitus and Obesity (S. Bleicher and B. Brodoff, eds.). Williams and Wilkins. Baltimore. 1982.
Ruderman NB and Schneider, S.J. Exercise and diet in the therapy of diabetes. Diet and Exercise, Synergism in Health Maintenance. (P.L. White and T. Mondeika, eds.). Am. Med. Assoc. Chicago. 1982; pp. 143-152.

Goodman MN, Lowell B, Ruderman NB. Protein conservation during starvation: possible role of lipid fuels. Prog Clin Biol Res. 1982; 102 Pt C:317-31. PMID: 7167465

Goodman MN, Ruderman NB. Influence of muscle use on amino acid metabolism. Exerc Sport Sci Rev. 1982; 10:1-26. PMID: 6811282

Ruderman NB, Schneider S, Kramsch D. Physical training and cardiovascular disease in the diabetic. Curr Probl Clin Biochem. 1982; 11:166-70. PMID: 7083893

Richter EA, Ruderman NB, Gavras H, Belur ER, Galbo H. Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am J Physiol. 1982 Jan; 242(1):E25-32.View Related Profiles.

Gavras, Haralambos
Ruderman, Neil

PMID: 7058885

Goodman MN, McElaney MA, Ruderman NB. Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis. Am J Physiol. 1981 Oct; 241(4):E321-7. PMID: 7315958

Ruderman NB, Schneider SH, Berchtold P. The "metabolically-obese," normal-weight individual. Am J Clin Nutr. 1981 Aug; 34(8):1617-21. PMID: 7270486

Conover CA, Rozovski SJ, Ruderman NB. Regulation of ornithine decarboxylase in skeletal muscle: evidence for the involvement of an insulin-dependent serum factor. Diabetes. 1981 Aug; 30(8):678-84. PMID: 7018971

Schneider SH, Komanicky PM, Goodman MN, Ruderman NB. Dichloroacetate: effects on exercise endurance in untrained rats. Metabolism. 1981 Jun; 30(6):590-5. PMID: 7231196

Brady LJ, Goodman MN, Kalish FN, Ruderman NB. Insulin binding and sensitivity in rat skeletal muscle: effect of starvation. Am J Physiol. 1981 Feb; 240(2):E184-90. PMID: 7008629

Richter EA, Ruderman NB, Schneider SH. Diabetes and exercise. Am J Med. 1981 Jan; 70(1):201-9. PMID: 7006392

Conover CA, Rozovski SJ, Belur ER, Aoki TT, Ruderman NB. Ornithine decarboxylase activity in insulin-deficient states. Biochem J. 1980 Nov 15; 192(2):725-32. PMID: 7016116; PMCID: PMC1162390

Goodman MN, Larsen PR, Kaplan MM, Aoki TT, Young VR, Ruderman NB. Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol. 1980 Oct; 239(4):E277-E286. PMID: 7425120

Goodman MN, Ruderman NB. Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein. Am J Physiol. 1980 Oct; 239(4):E269-E276. PMID: 6158872

Ruderman NB, Kemmer FW, Goodman MN, Berger M. Oxygen consumption in perfused skeletal muscle. Effect of perfusion with aged, fresh and aged-rejuvenated erythrocytes on oxygen consumption, tissue metabolites and inhibition of glucose utilization by acetoacetate. Biochem J. 1980 Jul 15; 190(1):57-64. PMID: 7447936; PMCID: PMC1162064

Ruderman NB, Goodman MN. Brain metabolism in diabetes. Horm Metab Res Suppl. 1980; 9:1-8. PMID: 6769772

Ruderman NB. Glucose metabolism. Control of glucose production: Hepatic glycogenolysis and gluconeogenesis. Textbook of Diabetes (ed. by R. Assan, E. Marliss and J. Girard). 1980.
Ruderman NB, Brady, L., Kalish, P. and Goodman, M.N. Alterations of muscle metabolism in the diabetic rat. Diabetes, 1979, ed. by W.E. Waldhausl. Exerpta Medica, Int. Cong. Series 500, Amsterdam. Oxford-Princeton. 1980; pp. 329-332.

Rozovski SJ, Conover CA, Ruderman NB. Effect of diabetes on the induction of ornithine decarboxylase by refeeding. Life Sci. 1979 Aug 6; 25(6):553-9. PMID: 491851

Goodman MN, Ruderman NB. Insulin sensitivity of rat skeletal muscle: effects of starvation and aging. Am J Physiol. 1979 May; 236(5):E519-23. PMID: 443372

Michael B, Camejo M, Jacobs J, Parker J, St Cry M, Ruderman NB. H.D.L. in diabetes. Lancet. 1979 Jan 20; 1(8108):155. PMID: 84176

Plovnick H, Ruderman NB, Aoki T, Chideckel EW, Poffenbarger PL. Non-beta-cell tumor hypoglycemia associated with increased nonsuppressible insulin-like protein (NSILP). Am J Med. 1979 Jan; 66(1):154-9. PMID: 420243

Ruderman NB, Goodman MN, Conover CA, Berger M. Substrate utilization in perfused skeletal muscle. Diabetes. 1979 Jan; 28 Suppl 1:13-7. PMID: 761709

Ruderman NB, Ganda OP, Johansen K. The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes. Diabetes. 1979 Jan; 28 Suppl 1:89-92. PMID: 761721

Goodman MN, Ruderman NB, Aoki TT. Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate. Diabetes. 1978 Nov; 27(11):1065-74. PMID: 720766

Ruderman NB, Berger, M. and Hagg, S. Stimulation of muscle glucose uptake during exercise: Requirement for insulin. Aktuelle Probleme der Diabetesfurschurg, Proceedings of the First Symposium of the Diabetes Forshungsinstitut, ed by F.A. Gries and H. Reinauer. University Dusseldorf. 1978; pp. 64-77.
Ruderman, N. B., Berger, M., Hagg, S., Goodman, M. and Maizels, E. Muskelstoffwechsel, korperliche Leistungsfahigkeit und Diabetes mellitus: Theorie und Praxis. F.K. Schattauer Verlag. Stuttgart, New York. 1978; pp. 81-87.
Ruderman NB, Maizels, E., Rabban, M. and Goodman, M.N. Interaction between ketone body and carbohydrate metabolism in peripheral tissue. FEBS Symposium, Regulatory Mechanisms of Carbohydrate Metabolism, ed. by V. Esmann. Pergamon Press. New York. 1978; 42(A1):pp. 171- 182.

Ruderman NB, Schmahl FW, Goodman MN. Regulation of alanine formation and release in rat muscle in vivo: effect of starvation and diabetes. Am J Physiol. 1977 Aug; 233(2):E109-14. PMID: 888947

Maizels EZ, Ruderman NB, Goodman MN, Lau D. Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat. Biochem J. 1977 Mar 15; 162(3):557-68. PMID: 869905; PMCID: PMC1164638

Ruderman NB, Goodman MN, Berger M, Hagg S. Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter. Fed Proc. 1977 Feb; 36(2):171-6. PMID: 838085

Berger, M., Kemmer, F.W., Goodman, M.N., Zimmerman-Telschow, H. and Ruderman, N.B. Ketone body metabolism in isolated perfused muscle. In, Biochemical and Clinical Aspects of Ketone Body Metabolism, ed. by Soling and Seufert, Academic Press, New York, 1977, pp. 193-203. Ketone body metabolism in isolated perfused muscle. Biochemical and Clinical Aspects of Ketone Body Metabolism, ed. by Soling and Seufert. Academic Press. New York. 1977; pp. 193-203.
Berger, M., Gries, F.A. and Ruderman, N.B. Effect of muscle work on glucose metabolism in vitro. Muscle Metabolism During Exercise in Diabetes Mellitus: Theory and Practice, ed. by K. Jahnke, H. Mehnert and H.E. Reis. Schattauer Varlag. Stuttgart, NY. 1977; pp. 99-108.

Berger M, Hagg SA, Goodman MN, Ruderman NB. Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. Biochem J. 1976 Aug 15; 158(2):191-202. PMID: 136249; PMCID: PMC1163959

MacDonald M, Neufeldt N, Park BN, Berger M, Ruderman N. Alanine metabolism and gluconeogenesis in the rat. Am J Physiol. 1976 Aug; 231(2):619-26. PMID: 961915

Ganda OP, Ruderman NB. Muscle nitrogen metabolism in chronic hepatic insufficiency. Metabolism. 1976 Apr; 25(4):427-35. PMID: 1263837

Hagg, S.A., Taylor, S.I. and Ruderman, N.B. Glucose metabolism in perfused skeletal muscle: Pyruvate dehydrogenase activity in starvation, diabetes and exercise. Biochem. J. 1976; 158:203-210.

Aoki TT, Toews CJ, Rossini AA, Ruderman NB, Cahill GF. Glucogenic substrate levels in fasting man. Adv Enzyme Regul. 1975; 13:329-36. PMID: 1211290

Ruderman NB. Muscle amino acid metabolism and gluconeogenesis. Annu Rev Med. 1975; 26:245-58. PMID: 1096762

Berger M, Hagg S, Ruderman NB. Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. Biochem J. 1975 Jan; 146(1):231-8. PMID: 807202; PMCID: PMC1165292

Ruderman NB, Aoki, T.T. and Cahill, G.F., Jr. Gluconeogenesis and its disorders in man. Gluconeogenesis, ed. by M. Mehlman and R. Hanson. Academic Press. New York. 1975; pp.515-532.

Shafrir E, Ruderman NB. Enzymes of carbohydrate and fat metabolism in anti-insulin serum diabetes; inactivation by free fatty acids and the protective effect of cellular protein. Diabetologia. 1974 Dec; 10(6):731-42. PMID: 4155389

Goodman MN, Berger M, Ruderman NB. Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies and free fatty acids. Diabetes. 1974 Nov; 23(11):881-8. PMID: 4279193

Ruderman NB, Berger M. The formation of glutamine and alanine in skeletal muscle. J Biol Chem. 1974 Sep 10; 249(17):5500-6. PMID: 4278315

Ordonez LA, Arbrus M, Boyson S, Goodman MN, Ruderman NB, Wurtman RJ. Skeletal muscle: reservoir for exogenous L-dopa. J Pharmacol Exp Ther. 1974 Jul; 190(1):187-91. PMID: 4847311

Ruderman NB, MacDonald, M., Neufeldt, N., Park, B.and Berger, M. On the regulation of blood alanine. Benzon Foundation Symposium, ed. by F. Lundquist and N. Tygstrup. Munksgaard. Copenhagen. 1974; 8:pp. 209-223.

Ruderman NB, Ross PS, Berger M, Goodman MN. Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J. 1974 Jan; 138(1):1-10. PMID: 4275704; PMCID: PMC1166169

Ruderman NB, Goodman MN. Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis. Am J Physiol. 1974 Jan; 226(1):136-43. PMID: 4203779

Walser M, Lund P, Ruderman NB, Coulter AW. Synthesis of essential amino acids from their alpha-keto analogues by perfused rat liver and muscle. J Clin Invest. 1973 Nov; 52(11):2865-77. PMID: 4748513; PMCID: PMC302555

Ruderman NB, Goodman MN. Regulation of ketone body metabolism in skeletal muscle. Am J Physiol. 1973 Jun; 224(6):1391-7. PMID: 4712152

Cahill GF, Aoki TT, Ruderman NB. Ketosis. Trans Am Clin Climatol Assoc. 1973; 84:184-202. PMID: 4199621; PMCID: PMC2441301

Ruderman NB, Lund P. Amino acid metabolism in skeletal muscle. Regulation of glutamine and alanine release in the perfused rat hindquarter. Isr J Med Sci. 1972 Mar; 8(3):295-302. PMID: 4402772

Ruderman NB, Houghton CR, Hems R. Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J. 1971 Sep; 124(3):639-51. PMID: 5135248; PMCID: PMC1177234

Salmon MA, Esiri MM, Ruderman NB. Myopathic disorder associated with mitochondrial abnormalities, hyperglycaemia, and hyperketonaemia. Lancet. 1971 Aug 7; 2(7719):290-2. PMID: 4104978

Ruderman NB, Jones AL, Krauss RM, Shafrir E. A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia. J Clin Invest. 1971 Jun; 50(6):1355-68. PMID: 5578237; PMCID: PMC292067

Ruderman NB. Regulation of carbohydrate, lipid and amino acid metabolism with special reference to muscle. D. Phil. Thesis. Oxford, England. 1971.

Houghton CR, Ruderman NB. Acetoacetate as a fuel for perfused rat skeletal muscle. Biochem J. 1971 Jan; 121(1):15P-16P. PMID: 5116529; PMCID: PMC1176525

Ruderman NB, Toews CJ, Lowy C, Vreeland I, Shafrir E. Inhibition of hepatic gluconeogenesis and fatty acid oxidation by pent-4-enoic acid. Am J Physiol. 1970 Jul; 219(1):51-7. PMID: 5424858

Ruderman NB, Toews CJ, Lowy C, Shafrir E. Inhibition of hepatic gluconeogenesis by 4-pentenoic acid. Hoppe Seylers Z Physiol Chem. 1970 Mar; 351(3):290-1. PMID: 5420699

Toews CJ, Lowy C, Ruderman NB. The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver. J Biol Chem. 1970 Feb 25; 245(4):818-24. PMID: 4313610

Ruderman NB, Toews CJ, Shafrir E. Role of free fatty acids in glucose homeostasis. Arch Intern Med. 1969 Mar; 123(3):299-313. PMID: 4303992

Jones, A.L., Ruderman, N.B. and Evans, J. An electron microscopic study of lipoprotein synthesis by rat liver following anti-insulin serum, nicotinic acid and puromycin administration. Gastroenterology. 1969; 56:402.

Ruderman N, Shafrir E, Bressler R. Relation of fatty acid oxidation tgluconeogenesis: effect of pentenoic acid. Life Sci. 1968 Oct 15; 7(20):1083-9. PMID: 4305726

Ruderman NB, Lauris V. Effect of acute insulin deprivation on rat liver glucokinase. Diabetes. 1968 Oct; 17(10):611-6. PMID: 5681078

Ruderman NB, Richards KC, Valles de Bourges V. Regulation of production and release of lipoprotein by the perfused rat liver. J Lipid Res. 1968 Sep; 9(5):613-9. PMID: 5726321

Ruderman NB, Herrera MG. Glucose regulation of hepatic gluconeogenesis. Am J Physiol. 1968 Jun; 214(6):1346-51. PMID: 5649490

Richards KC, Ruderman NB, Herrera MG. Effect of oleate concentration on its metabolism by the perfused rat liver. Biochim Biophys Acta. 1968 May 1; 152(3):632-5. PMID: 5656831

Jones AL, Ruderman NB, Herrera MG. Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J Lipid Res. 1967 Sep; 8(5):429-46. PMID: 6049670

Ruderman NB, Lauris V, Herrera MG. Insulin preservation of glucokinase activity in isolated perfused rat liver. Am J Physiol. 1967 May; 212(5):1169-73. PMID: 4290362

Ruderman NB, Herrera, M.G. and Lauris, V. Insulin preservation of glucokinase activity in isolated perfused rat liver. Am. J. Physiol. 1967; 212:1169-1172.

Jones AL, Ruderman NB, Herrera MG. An electron microscopic study of lipoprotein production and release by the isolated perfused rat liver. Proc Soc Exp Biol Med. 1966 Oct; 123(1):4-9. PMID: 5924455

Herrera MG, Kamm D, Ruderman N, Cahill. Non-hormonal factors in the control of gluconeogenesis. Adv Enzyme Regul. 1966; 4:225-35. PMID: 4862942

Ruderman NB and Hall, T.C. The palliative use of glucocorticoids in the treatment of metastatic brain tumors. Cancer. 1965; 18:298-306.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 24 distinct years, with a maximum of 6 publications in 2002

Bar chart showing 58 publications over 24 distinct years, with a maximum of 6 publications in 2002

Year	Publications
1980	2
1982	2
1983	3
1984	3
1986	5
1988	2
1989	3
1991	2
1992	3
1993	2
1994	2
1995	4
1997	1
1999	3
2000	1
2001	1
2002	6
2003	3
2005	4
2006	1
2007	1
2010	2
2011	1
2012	1

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