Kimberly Coughlan, PhD
Scientist, Rare Diseases
Moderna Therapeutics




Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Pharmacology, Physiology & Biophysics


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Greig JA, Jennis M, Dandekar A, Chorazeczewski JK, Param N, So M, Nayal M, Bell P, Coughlan K, Choi M, Giangrande PH, Martini PGV, Wilson JM. Lipid Nanoparticle mRNA Therapy Improves Survival and Reduces Serum Branched-Chain Amino Acids in Mouse Models of Maple Syrup Urine Disease. Hum Gene Ther. 2024 Sep; 35(17-18):726-733. PMID: 39001827
     
  2. Coughlan KA, Eybye M, Henderson N, DeAntonis CM, Frassetto A, Hanahoe E, Ketova T, Jacquinet E, Presnyak V, Jain R, Marshall J, Martini PGV. Improved therapeutic efficacy in two mouse models of methylmalonic acidemia (MMA) using a second-generation mRNA therapy. Mol Genet Metab. 2024; 143(1-2):108560. PMID: 39121792
     
  3. Baek R, Coughlan K, Jiang L, Liang M, Ci L, Singh H, Zhang H, Kaushal N, Rajlic IL, Van L, Dimen R, Cavedon A, Yin L, Rice L, Frassetto A, Guey L, Finn P, Martini PGV. Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria. Nat Commun. 2024 May 07; 15(1):3804.View Related Profiles. PMID: 38714648; PMCID: PMC11076592; DOI: 10.1038/s41467-024-47460-9;
     
  4. Zhao XJ, Mohsen AW, Mihalik S, Solo K, Basu S, Aliu E, Shi H, Kochersberger C, Karunanidhi A, Van't Land C, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, DeAntonis C, Giangrande PH, Martini PGV, Vockley J. Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model. Hum Mol Genet. 2023 Jul 04; 32(14):2347-2356.View Related Profiles. PMID: 37162351; PMCID: PMC10321387; DOI: 10.1093/hmg/ddad076;
     
  5. Greig JA, Chorazeczewski JK, Chowdhary V, Smith MK, Jennis M, Tarrant JC, Buza EL, Coughlan K, Martini PGV, Wilson JM. Lipid nanoparticle-encapsulated mRNA therapy corrects serum total bilirubin level in Crigler-Najjar syndrome mouse model. Mol Ther Methods Clin Dev. 2023 Jun 08; 29:32-39. PMID: 36936447; PMCID: PMC10017950; DOI: 10.1016/j.omtm.2023.02.007;
     
  6. Greig JA, Chorazeczewski JK, Chowdhary V, Smith MK, Jennis M, Tarrant JC, Buza EL, Coughlan K, Martini PGV, Wilson JM. Lipid nanoparticle-encapsulated mRNA therapy corrects serum total bilirubin level in Crigler-Najjar syndrome mouse model. Mol Ther Methods Clin Dev. 2023 Jun 08; 29:32-39. PMID: 36936447; PMCID: PMC10017950; DOI: 10.1016/j.omtm.2023.02.007;
     
  7. Zhao XJ, Mohsen AW, Mihalik S, Solo K, Aliu E, Shi H, Basu S, Kochersperger C, Van't Land C, Karunanidhi A, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, Giangrande PH, Martini PGV, Vockley J. Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model. Mol Genet Metab. 2023 Jan; 138(1):106982.View Related Profiles. PMID: 36580829; PMCID: PMC9877169; DOI: 10.1016/j.ymgme.2022.106982;
     
  8. Cao J, An D, Galduroz M, Zhuo J, Liang S, Eybye M, Frassetto A, Kuroda E, Funahashi A, Santana J, Mihai C, Benenato KE, Kumarasinghe ES, Sabnis S, Salerno T, Coughlan K, Miracco EJ, Levy B, Besin G, Schultz J, Lukacs C, Guey L, Finn P, Furukawa T, Giangrande PH, Saheki T, Martini PGV. mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency. Mol Ther. 2019 07 03; 27(7):1242-1251. PMID: 31056400; PMCID: PMC6612659; DOI: 10.1016/j.ymthe.2019.04.017;
     
  9. Allen KM, Coughlan KA, Mahmood FN, Valentine RJ, Ruderman NB, Saha AK. The effects of troglitazone on AMPK in HepG2 cells. Arch Biochem Biophys. 2017 Jun 01; 623-624:49-57.View Related Profiles. PMID: 28526426
     
  10. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75.View Related Profiles. PMID: 26797128; PMCID: PMC4786706; DOI: 10.1074/jbc.M115.696849;
     
Showing 10 of 16 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 11 distinct years, with a maximum of 3 publications in 2024

YearPublications
20111
20121
20131
20142
20151
20161
20171
20191
20221
20232
20243

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