Keywords
Last Name

Keith Tornheim, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-8296
ORCID ORCID Icon0000-0002-6235-5128
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

InstitutionBoston Medical Center

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Martínez-Costa OH, Sánchez V, Lázaro A, Hernández ED, Tornheim K, Aragón JJ. Distinct functional roles of the two terminal halves of eukaryotic phosphofructokinase. Biochem J. 2012 Jul 15; 445(2):213-8. PMID: 22530721.
    View in: PubMed
  2. Haller JF, Smith C, Liu D, Zheng H, Tornheim K, Han GS, Carman GM, Zoeller RA. Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase. J Biol Chem. 2010 Jan 8; 285(2):866-77. PMID: 19903819.
    View in: PubMed
  3. Getty-Kaushik L, Viereck JC, Goodman JM, Guo Z, LeBrasseur NK, Richard AM, Flanagan JN, Yaney GC, Hamilton JA, Tornheim K. Mice deficient in phosphofructokinase-M have greatly decreased fat stores. Obesity (Silver Spring). 2010 Mar; 18(3):434-40. PMID: 19779479.
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  4. Richard AM, Webb DL, Goodman JM, Schultz V, Flanagan JN, Getty-Kaushik L, Deeney JT, Yaney GC, Dunaway GA, Berggren PO, Tornheim K. Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E794-801. PMID: 17595219.
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  5. Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 1; 403(1):197-205. PMID: 17181533.
    View in: PubMed
  6. Nascimben L, Ingwall JS, Lorell BH, Pinz I, Schultz V, Tornheim K, Tian R. Mechanisms for increased glycolysis in the hypertrophied rat heart. Hypertension. 2004 Nov; 44(5):662-7. PMID: 15466668.
    View in: PubMed
  7. Juntti-Berggren L, Webb DL, Arkhammar PO, Schultz V, Schweda EK, Tornheim K, Berggren PO. Dihydroxyacetone-induced oscillations in cytoplasmic free Ca2+ and the ATP/ADP ratio in pancreatic beta-cells at substimulatory glucose. J Biol Chem. 2003 Oct 17; 278(42):40710-6. PMID: 12917415.
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  8. Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003 Jul; 52(7):1635-40. PMID: 12829626.
    View in: PubMed
  9. Cunningham BA, Richard AM, Dillon JS, Daley JT, Civelek VN, Deeney JT, Yaney GC, Corkey BE, Tornheim K. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J. 2003 Jan 1; 369(Pt 1):173-8. PMID: 12356335.
    View in: PubMed
  10. Yaney GC, Fairbanks JM, Deeney JT, Korchak HM, Tornheim K, Corkey BE. Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E880-8. PMID: 12376314.
    View in: PubMed
  11. Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, Keaney JF. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C560-6. PMID: 11832341.
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  12. Deeney JT, Köhler M, Kubik K, Brown G, Schultz V, Tornheim K, Corkey BE, Berggren PO. Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior. J Biol Chem. 2001 Oct 5; 276(40):36946-50. PMID: 11481328.
    View in: PubMed
  13. Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J Biol Chem. 2001 Sep 28; 276(39):36695-702. PMID: 11443115.
    View in: PubMed
  14. Dagher Z, Ruderman N, Tornheim K, Ido Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res. 2001 Jun 22; 88(12):1276-82. PMID: 11420304.
    View in: PubMed
  15. Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. 2001 Jan; 50(1):56-62. PMID: 11147795.
    View in: PubMed
  16. Porterfield DM, Corkey RF, Sanger RH, Tornheim K, Smith PJ, Corkey BE. Oxygen consumption oscillates in single clonal pancreatic beta-cells (HIT). Diabetes. 2000 Sep; 49(9):1511-6. PMID: 10969835.
    View in: PubMed
  17. Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem. 2000 Aug 11; 275(32):24279-83. PMID: 10854420.
    View in: PubMed
  18. Corkey BE, Deeney JT, Yaney GC, Tornheim K, Prentki M. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr. 2000 Feb; 130(2S Suppl):299S-304S. PMID: 10721892.
    View in: PubMed
  19. Dagher Z, Ruderman N, Tornheim K, Ido Y. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1999 Nov; 265(1):112-5. PMID: 10548499.
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  20. Liu YQ, Tornheim K, Leahy JL. Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets. Diabetes. 1999 Sep; 48(9):1747-53. PMID: 10480604.
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  21. Garrett GS, McPhail SJ, Tornheim K, Correa PE, McIver JM. Synthesis of potent and selective inhibitors of human plasma kallikrein. Bioorg Med Chem Lett. 1999 Feb 8; 9(3):301-6. PMID: 10091673.
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  22. Liu YQ, Tornheim K, Leahy JL. Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity. Diabetes. 1998 Dec; 47(12):1889-93. PMID: 9836520.
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  23. Garrett GS, Correa PE, McPhail SJ, Tornheim K, Burton JA, Eickhoff DJ, Engerholm GG, McIver JM. Peptide aldehyde inhibitors of the kallikreins: an investigation of subsite interactions with tripeptides containing structural variations at the amino terminus. J Pept Res. 1998 Jul; 52(1):60-71. PMID: 9716252.
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  24. Liu YQ, Tornheim K, Leahy JL. Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content. J Clin Invest. 1998 May 1; 101(9):1870-5. PMID: 9576750.
    View in: PubMed
  25. Tornheim K. Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes. 1997 Sep; 46(9):1375-80. PMID: 9287034.
    View in: PubMed
  26. Prentki M, Tornheim K, Corkey BE. Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia. 1997 Jul; 40 Suppl 2:S32-41. PMID: 9248699.
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  27. Civelek VN, Deeney JT, Fusonie GE, Corkey BE, Tornheim K. Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio. Diabetes. 1997 Jan; 46(1):51-6. PMID: 8971081.
    View in: PubMed
  28. Cunningham BA, Deeney JT, Bliss CR, Corkey BE, Tornheim K. Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT). Am J Physiol. 1996 Oct; 271(4 Pt 1):E702-10. PMID: 8897858.
    View in: PubMed
  29. Civelek VN, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10139-44. PMID: 8816765.
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  30. Civelek VN, Deeney JT, Shalosky NJ, Tornheim K, Hansford RG, Prentki M, Corkey BE. Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP. Biochem J. 1996 Sep 1; 318 ( Pt 2):615-21. PMID: 8809055.
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  31. Civelek VN, Deeney JT, Kubik K, Schultz V, Tornheim K, Corkey BE. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT). Biochem J. 1996 May 1; 315 ( Pt 3):1015-9. PMID: 8645138.
    View in: PubMed
  32. Nilsson T, Schultz V, Berggren PO, Corkey BE, Tornheim K. Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic beta-cells. Biochem J. 1996 Feb 15; 314 ( Pt 1):91-4. PMID: 8660314.
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  33. Kim NN, Kim JJ, Hypolite J, García-Díaz JF, Broderick GA, Tornheim K, Daley JT, Levin R, Saenz de Tejada I. Altered contractility of rabbit penile corpus cavernosum smooth muscle by hypoxia. J Urol. 1996 Feb; 155(2):772-8. PMID: 8558723.
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  34. Ito Y, Pagano PJ, Tornheim K, Brecher P, Cohen RA. Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aorta. Am J Physiol. 1996 Jan; 270(1 Pt 2):H81-7. PMID: 8769737.
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  35. Yaney GC, Schultz V, Cunningham BA, Dunaway GA, Corkey BE, Tornheim K. Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1). Diabetes. 1995 Nov; 44(11):1285-9. PMID: 7589825.
    View in: PubMed
  36. Pagano PJ, Ito Y, Tornheim K, Gallop PM, Tauber AI, Cohen RA. An NADPH oxidase superoxide-generating system in the rabbit aorta. Am J Physiol. 1995 Jun; 268(6 Pt 2):H2274-80. PMID: 7611477.
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  37. Shimazaki J, Tsubota K, Yoshida A, Tornheim K, Laing RA. Changes of corneal redox state in diabetic animal models. Cornea. 1995 Mar; 14(2):196-201. PMID: 7743804.
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  38. Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT). J Biol Chem. 1994 Aug 19; 269(33):20852-6. PMID: 8063701.
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  39. Tornheim K. Kinetic applications using high substrate and competitive inhibitor concentrations to determine Ki or Km. Anal Biochem. 1994 Aug 15; 221(1):53-6. PMID: 7985803.
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  40. Hocker CG, Epstein IR, Kustin K, Tornheim K. Glycolytic pH oscillations in a flow reactor. Biophys Chem. 1994 Jul; 51(1):21-35. PMID: 8061224.
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  41. Juntti-Berggren L, Civelek VN, Berggren PO, Schultz V, Corkey BE, Tornheim K. Glucose-stimulated increase in cytoplasmic pH precedes increase in free Ca2+ in pancreatic beta-cells. A possible role for pyruvate. J Biol Chem. 1994 May 20; 269(20):14391-5. PMID: 8182044.
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  42. Schultz V, Sussman I, Bokvist K, Tornheim K. Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: assay of ADP after enzymatic removal of ATP. Anal Biochem. 1993 Dec; 215(2):302-4. PMID: 8122794.
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  43. Sussman I, Schultz V, Gupta S, Grady C, Ruderman NB, Tornheim K. Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels. Am J Physiol. 1993 Nov; 265(5 Pt 1):E777-82. PMID: 7902010.
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  44. Pagano PJ, Tornheim K, Cohen RA. Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide. Am J Physiol. 1993 Aug; 265(2 Pt 2):H707-12. PMID: 7690193.
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  45. Tornheim K, Schultz V. Specific enzymatic spectrophotometric assay of adenosine 5'-diphosphate. Anal Biochem. 1993 Jun; 211(2):329-30. PMID: 8317712.
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  46. Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE. Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells. J Biol Chem. 1992 Oct 5; 267(28):19840-5. PMID: 1400300.
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  47. Gupta S, Sussman I, McArthur CS, Tornheim K, Cohen RA, Ruderman NB. Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest. 1992 Sep; 90(3):727-32. PMID: 1325996.
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  48. Tornheim K, Andrés V, Schultz V. Modulation by citrate of glycolytic oscillations in skeletal muscle extracts. J Biol Chem. 1991 Aug 25; 266(24):15675-8. PMID: 1831450.
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  49. Longo EA, Tornheim K, Deeney JT, Varnum BA, Tillotson D, Prentki M, Corkey BE. Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J Biol Chem. 1991 May 15; 266(14):9314-9. PMID: 1902835.
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  50. Andrés V, Schultz V, Tornheim K. Oscillatory synthesis of glucose 1,6-bisphosphate and frequency modulation of glycolytic oscillations in skeletal muscle extracts. J Biol Chem. 1990 Dec 15; 265(35):21441-7. PMID: 2254306.
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  51. Tornheim K, Schultz V. Adenosine diphosphate and adenosine monophosphate: enzymatic spectrophotometric determination. J Nutr Biochem. 1990 Aug; 1(8):440-4. PMID: 15539235.
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  52. Tornheim K, Schultz V. Adenosine triphosphate: enzymatic spectrophotometric determination. J Nutr Biochem. 1990 Mar; 1(3):172-6. PMID: 15539201.
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  53. Gaposchkin CG, Tornheim K, Sussman I, Ruderman NB, McCall AL. Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels. Am J Physiol. 1990 Mar; 258(3 Pt 1):E543-7. PMID: 2316646.
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  54. Shimazaki J, Tornheim K, Laing RA. Correlation of redox fluorometry and analytical measurements of pyridine nucleotide. Invest Ophthalmol Vis Sci. 1989 Oct; 30(10):2274-8. PMID: 2793366.
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  55. Sussman I, Carson MP, Schultz V, Wu XP, McCall AL, Ruderman NB, Tornheim K. Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium. Diabetologia. 1988 Oct; 31(10):771-5. PMID: 3240840.
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  56. McCall AL, Valente J, Cordero R, Ruderman NB, Tornheim K. Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrations. Microvasc Res. 1988 May; 35(3):325-33. PMID: 3393093.
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  57. Corkey BE, Tornheim K, Deeney JT, Glennon MC, Parker JC, Matschinsky FM, Ruderman NB, Prentki M. Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem. 1988 Mar 25; 263(9):4254-8. PMID: 2831225.
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  58. McCall AL, Sussman I, Tornheim K, Cordero R, Ruderman NB. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. Am J Physiol. 1988 Mar; 254(3 Pt 1):E272-8. PMID: 2964787.
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  59. Sussman I, Carson MP, McCall AL, Schultz V, Ruderman NB, Tornheim K. Energy state of bovine cerebral microvessels: comparison of isolation methods. Microvasc Res. 1988 Mar; 35(2):167-78. PMID: 2897072.
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  60. Tornheim K. Fructose 2,6-bisphosphate and glycolytic oscillations in skeletal muscle extracts. J Biol Chem. 1988 Feb 25; 263(6):2619-24. PMID: 2963814.
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  61. McCall AL, Fixman LB, Fleming N, Tornheim K, Chick W, Ruderman NB. Chronic hypoglycemia increases brain glucose transport. Am J Physiol. 1986 Oct; 251(4 Pt 1):E442-7. PMID: 3532819.
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  62. Tornheim K, Pang H, Costello CE. The purine nucleotide cycle and ammoniagenesis in rat kidney tubules. J Biol Chem. 1986 Aug 5; 261(22):10157-62. PMID: 2874138.
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  63. Tornheim K. Activation of muscle phosphofructokinase by fructose 2,6-bisphosphate and fructose 1,6-bisphosphate is differently affected by other regulatory metabolites. J Biol Chem. 1985 Jul 5; 260(13):7985-9. PMID: 3159721.
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  64. Tornheim K, Lowenstein LM. Effect of acidosis and uninephrectomy on isozymes of adenylosuccinate synthetase in rat kidney. Biochim Biophys Acta. 1983 May 4; 757(1):137-9. PMID: 6838904.
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  65. Aragón JJ, Tornheim K, Goodman MN, Lowenstein JM. Replenishment of citric acid cycle intermediates by the purine nucleotide cycle in rat skeletal muscle. Curr Top Cell Regul. 1981; 18:131-49. PMID: 6456135.
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  66. Aragón JJ, Tornheim K, Lowenstein JM. On a possible role of IMP in the regulation of phosphorylase activity in skeletal muscle. FEBS Lett. 1980 Aug 25; 117 Suppl:K56-64. PMID: 6774892.
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  67. Tornheim K. Co-ordinate control of phosphofructokinase and pyruvate kinase by fructose diphosphate: a mechanism for amplification and step changes in the regulation of glycolysis in liver. J Theor Biol. 1980 Jul 21; 85(2):199-222. PMID: 6448938.
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  68. Tornheim K, Gilbert TR, Lowenstein JM. Metal contaminants in commercial preparations of nucleotides. Anal Biochem. 1980 Mar 15; 103(1):87-93. PMID: 7377548.
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  69. Tornheim K, Lowenstein JM. Creatine phosphate inhibition of heart lactate dehydrogenase and muscle pyruvate kinase is due to a contaminant. J Biol Chem. 1979 Nov 10; 254(21):10586-7. PMID: 574139.
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  70. Tornheim K. Oscillations of the glycolytic pathway and the purine nucleotide cycle. J Theor Biol. 1979 Aug 21; 79(4):491-541. PMID: 159983.
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  71. Tornheim K, Lowenstein JM. Control of phosphofructokinase from rat skeletal muscle. Effects of fructose diphosphate, AMP, ATP, and citrate. J Biol Chem. 1976 Dec 10; 251(23):7322-8. PMID: 12161.
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  72. Tornheim K, Lowenstein JM. The purine nucleotide cycle. Control of phosphofructokinase and glycolytic oscillations in muscle extracts. J Biol Chem. 1975 Aug 25; 250(16):6304-14. PMID: 169235.
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  73. Tornheim K, Lowenstein JM. The purine nucleotide cycle. IV. Interactions with oscillations of the glycolytic pathway in muscle extracts. J Biol Chem. 1974 May 25; 249(10):3241-7. PMID: 4275340.
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  74. Tornheim K, Lowenstein JM. The purine nucleotide cycle. 3. Oscillations in metabolite concentrations during the operation of the cycle in muscle extracts. J Biol Chem. 1973 Apr 25; 248(8):2670-7. PMID: 4348916.
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  75. Tornheim K, Lowenstein JM. The purine nucleotide cycle. The production of ammonia from aspartate by extracts of rat skeletal muscle. J Biol Chem. 1972 Jan 10; 247(1):162-9. PMID: 5017762.
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  76. Lowenstein J, Tornheim K. Ammonia production in muscle: the purine nucleotide cycle. Science. 1971 Jan 29; 171(3969):397-400. PMID: 4249969.
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  77. Tornheim K, O'Dell RG, Prosky L. Effects of cycloheximide on DNA and protein synthesis in rat liver. Proc Soc Exp Biol Med. 1969 Jun; 131(2):601-5. PMID: 5787143.
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