Keywords
Last Name

Jude Deeney, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7088
ORCID ORCID Icon0000-0003-0988-9419
 Research Expertise & Professional Interests
Dr. Deeney's research is designed to discern the nutrient-derived metabolic signals leading to glucose- and fatty acid (FA)-induced insulin exocytosis from the pancreatic ß-cell. FA acutely stimulates glucose-induced insulin secretion (GSIS) while chronic exposure to elevated FA and glucose can result in glucolipotoxicity (GLT) with basal hypersecretion and inhibition of GSIS. Despite the adverse effects of chronic exposure, FA is known to be required for normal exocytosis from the ß-cell. Deciphering the dual effects of FA on GSIS will lead to the possible development of therapies that would reduce the inhibitory effects while sparing the stimulatory effects of FA on the ß-cell. Studies in his laboratory are aimed at identifying the lipids or lipid classes involved in enhancing and suppressing GSIS and assessing their effects on lipid-modulated or modulating proteins.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pizarro-Delgado J, Deeney JT, Corkey BE, Tamarit-Rodriguez J. Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets. PLoS One. 2016; 11(11):e0166111. PMID: 27851770.
    View in: PubMed
  2. Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV. BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic ß-Cell. PLoS One. 2016; 11(3):e0151329. PMID: 27008626.
    View in: PubMed
  3. Berdan CA, Erion KA, Burritt NE, Corkey BE, Deeney JT. Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets. PLoS One. 2016; 11(2):e0149008. PMID: 26867016.
    View in: PubMed
  4. Rameh LE, Deeney JT. Phosphoinositide signalling in type 2 diabetes: a ß-cell perspective. Biochem Soc Trans. 2016 Feb; 44(1):293-8. PMID: 26862218.
    View in: PubMed
  5. Xie Z, Jones A, Deeney JT, Hur SK, Bankaitis VA. Inborn Errors of Long-Chain Fatty Acid ß-Oxidation Link Neural Stem Cell Self-Renewal to Autism. Cell Rep. 2016 Feb 9; 14(5):991-9. PMID: 26832401.
    View in: PubMed
  6. Pizarro-Delgado J, Deeney JT, Martín-del-Río R, Corkey BE, Tamarit-Rodriguez J. KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion. PLoS One. 2015; 10(10):e0140096. PMID: 26444014.
    View in: PubMed
  7. Erion KA, Berdan CA, Burritt NE, Corkey BE, Deeney JT. Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic ß-Cells. J Biol Chem. 2015 Jun 26; 290(26):16191-201. PMID: 25934392.
    View in: PubMed
  8. Wang F, Deeney JT, Denis GV. Brd2 gene disruption causes "metabolically healthy" obesity: epigenetic and chromatin-based mechanisms that uncouple obesity from type 2 diabetes. Vitam Horm. 2013; 91:49-75. PMID: 23374712.
    View in: PubMed
  9. Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012; 7(1):e30200. PMID: 22272304.
    View in: PubMed
  10. Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE. Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring). 2010 Aug; 18(8):1493-502. PMID: 20035277.
    View in: PubMed
  11. Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE. The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct; 17(10):1856-60. PMID: 19644453.
    View in: PubMed
  12. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. PMID: 18223655.
    View in: PubMed
  13. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46. PMID: 18200046.
    View in: PubMed
  14. Trus M, Corkey RF, Nesher R, Richard AM, Deeney JT, Corkey BE, Atlas D. The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells. Biochemistry. 2007 Dec 18; 46(50):14461-7. PMID: 18027971.
    View in: PubMed
  15. Deeney JT, Bränström R, Corkey BE, Larsson O, Berggren PO. 3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1). FEBS Lett. 2007 Aug 21; 581(21):4080-4. PMID: 17686476.
    View in: PubMed
  16. Richard AM, Webb DL, Goodman JM, Schultz V, Flanagan JN, Getty-Kaushik L, Deeney JT, Yaney GC, Dunaway GA, Berggren PO, Tornheim K. Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E794-801. PMID: 17595219.
    View in: PubMed
  17. Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 1; 403(1):197-205. PMID: 17181533.
    View in: PubMed
  18. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S. Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. 2007 Jul; 56(7):1783-91. PMID: 17400930.
    View in: PubMed
  19. Hu L, Deeney JT, Nolan CJ, Peyot ML, Ao A, Richard AM, Luc E, Faergeman NJ, Knudsen J, Guo W, Sorhede-Winzell M, Prentki M, Corkey BE. Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1085-92. PMID: 16091387.
    View in: PubMed
  20. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83. PMID: 12852853.
    View in: PubMed
  21. Cunningham BA, Richard AM, Dillon JS, Daley JT, Civelek VN, Deeney JT, Yaney GC, Corkey BE, Tornheim K. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J. 2003 Jan 1; 369(Pt 1):173-8. PMID: 12356335.
    View in: PubMed
  22. Yaney GC, Fairbanks JM, Deeney JT, Korchak HM, Tornheim K, Corkey BE. Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E880-8. PMID: 12376314.
    View in: PubMed
  23. Deeney JT, Köhler M, Kubik K, Brown G, Schultz V, Tornheim K, Corkey BE, Berggren PO. Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior. J Biol Chem. 2001 Oct 5; 276(40):36946-50. PMID: 11481328.
    View in: PubMed
  24. Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. 2001 Jan; 50(1):56-62. PMID: 11147795.
    View in: PubMed
  25. Deeney JT, Prentki M, Corkey BE. Metabolic control of beta-cell function. Semin Cell Dev Biol. 2000 Aug; 11(4):267-75. PMID: 10966860.
    View in: PubMed
  26. Deeney JT, Gromada J, Høy M, Olsen HL, Rhodes CJ, Prentki M, Berggren PO, Corkey BE. Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). J Biol Chem. 2000 Mar 31; 275(13):9363-8. PMID: 10734079.
    View in: PubMed
  27. Brown H, Meister B, Deeney J, Corkey BE, Yang SN, Larsson O, Rhodes CJ, Seino S, Berggren PO, Fried G. Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes. 2000 Mar; 49(3):383-91. PMID: 10868959.
    View in: PubMed
  28. Corkey BE, Deeney JT, Yaney GC, Tornheim K, Prentki M. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr. 2000 Feb; 130(2S Suppl):299S-304S. PMID: 10721892.
    View in: PubMed
  29. Brown H, Larsson O, Bränström R, Yang SN, Leibiger B, Leibiger I, Fried G, Moede T, Deeney JT, Brown GR, Jacobsson G, Rhodes CJ, Braun JE, Scheller RH, Corkey BE, Berggren PO, Meister B. Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J. 1998 Sep 1; 17(17):5048-58. PMID: 9724640.
    View in: PubMed
  30. Civelek VN, Deeney JT, Fusonie GE, Corkey BE, Tornheim K. Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio. Diabetes. 1997 Jan; 46(1):51-6. PMID: 8971081.
    View in: PubMed
  31. Cunningham BA, Deeney JT, Bliss CR, Corkey BE, Tornheim K. Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT). Am J Physiol. 1996 Oct; 271(4 Pt 1):E702-10. PMID: 8897858.
    View in: PubMed
  32. Civelek VN, Deeney JT, Shalosky NJ, Tornheim K, Hansford RG, Prentki M, Corkey BE. Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP. Biochem J. 1996 Sep 1; 318 ( Pt 2):615-21. PMID: 8809055.
    View in: PubMed
  33. Deeney JT, Cunningham BA, Chheda S, Bokvist K, Juntti-Berggren L, Lam K, Korchak HM, Corkey BE, Berggren PO. Reversible Ca2+-dependent translocation of protein kinase C and glucose-induced insulin release. J Biol Chem. 1996 Jul 26; 271(30):18154-60. PMID: 8663368.
    View in: PubMed
  34. Larsson O, Deeney JT, Bränström R, Berggren PO, Corkey BE. Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity. J Biol Chem. 1996 May 3; 271(18):10623-6. PMID: 8631866.
    View in: PubMed
  35. Civelek VN, Deeney JT, Kubik K, Schultz V, Tornheim K, Corkey BE. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT). Biochem J. 1996 May 1; 315 ( Pt 3):1015-9. PMID: 8645138.
    View in: PubMed
  36. Eliasson L, Renström E, Ammälä C, Berggren PO, Bertorello AM, Bokvist K, Chibalin A, Deeney JT, Flatt PR, Gäbel J, Gromada J, Larsson O, Lindström P, Rhodes CJ, Rorsman P. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. Science. 1996 Feb 9; 271(5250):813-5. PMID: 8628999.
    View in: PubMed
  37. Jacobsson G, Bean AJ, Scheller RH, Juntti-Berggren L, Deeney JT, Berggren PO, Meister B. Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12487-91. PMID: 7809063.
    View in: PubMed
  38. Olszewski S, Deeney JT, Schuppin GT, Williams KP, Corkey BE, Rhodes CJ. Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet. J Biol Chem. 1994 Nov 11; 269(45):27987-91. PMID: 7961732.
    View in: PubMed
  39. Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE. Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells. J Biol Chem. 1992 Oct 5; 267(28):19840-5. PMID: 1400300.
    View in: PubMed
  40. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem. 1992 Mar 25; 267(9):5802-10. PMID: 1556096.
    View in: PubMed
  41. Gilbert RJ, Valente G, Deeney JT, Corkey BE. ATP-dependent control of steady-state cytosolic calcium in cultured gastric smooth muscle. Am J Physiol. 1991 Oct; 261(4 Pt 1):G634-40. PMID: 1928349.
    View in: PubMed
  42. Longo EA, Tornheim K, Deeney JT, Varnum BA, Tillotson D, Prentki M, Corkey BE. Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J Biol Chem. 1991 May 15; 266(14):9314-9. PMID: 1902835.
    View in: PubMed
  43. Corkey BE, Geschwind JF, Deeney JT, Hale DE, Douglas SD, Kilpatrick L. Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome. J Clin Invest. 1991 Mar; 87(3):778-86. PMID: 1847937.
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  44. Farrell HM, Deeney JT, Hild EK, Kumosinski TF. Stopped flow and steady state kinetic studies of the effects of metabolites on the soluble form of NADP+:isocitrate dehydrogenase. J Biol Chem. 1990 Oct 15; 265(29):17637-43. PMID: 2211653.
    View in: PubMed
  45. Corkey BE, Deeney JT. Acyl CoA regulation of metabolism and signal transduction. Prog Clin Biol Res. 1990; 321:217-32. PMID: 2183233.
    View in: PubMed
  46. Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. J Biol Chem. 1989 Dec 25; 264(36):21608-12. PMID: 2689441.
    View in: PubMed
  47. Kelly KL, Deeney JT, Corkey BE. Cytosolic free calcium in adipocytes. Distinct mechanisms of regulation and effects on insulin action. J Biol Chem. 1989 Aug 5; 264(22):12754-7. PMID: 2666413.
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  48. Corkey BE, Deeney JT, Glennon MC, Matschinsky FM, Prentki M. Regulation of steady-state free Ca2+ levels by the ATP/ADP ratio and orthophosphate in permeabilized RINm5F insulinoma cells. J Biol Chem. 1988 Mar 25; 263(9):4247-53. PMID: 2831224.
    View in: PubMed
  49. Corkey BE, Tornheim K, Deeney JT, Glennon MC, Parker JC, Matschinsky FM, Ruderman NB, Prentki M. Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem. 1988 Mar 25; 263(9):4254-8. PMID: 2831225.
    View in: PubMed
  50. Farrell HM, Deeney JT, Tubbs K, Walsh RA. Role of the isocitrate dehydrogenases and other Krebs cycle enzymes in lactating bovine mammary gland. J Dairy Sci. 1987 Apr; 70(4):781-8. PMID: 3584614.
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  51. Prentki M, Deeney JT, Matschinsky FM, Joseph SK. Neomycin: a specific drug to study the inositol-phospholipid signalling system? FEBS Lett. 1986 Mar 3; 197(1-2):285-8. PMID: 3485059.
    View in: PubMed
  52. Deeney JT, Valivullah HM, Dapper CH, Dylewski DP, Keenan TW. Microlipid droplets in milk secreting mammary epithelial cells: evidence that they originate from endoplasmic reticulum and are precursors of milk lipid globules. Eur J Cell Biol. 1985 Jul; 38(1):16-26. PMID: 4040857.
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  53. Dylewski DP, Dapper CH, Valivullah HM, Deeney JT, Keenan TW. Morphological and biochemical characterization of possible intracellular precursors of milk lipid globules. Eur J Cell Biol. 1984 Sep; 35(1):99-111. PMID: 6489364.
    View in: PubMed
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