Jude Deeney, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition

PhD, Karolinska Institutet
MS, Virginia Polytechnic Institute and State University



Dr. Deeney's research is designed to discern the nutrient-derived metabolic signals leading to glucose- and fatty acid (FA)-induced insulin exocytosis from the pancreatic ß-cell. FA acutely stimulates glucose-induced insulin secretion (GSIS) while chronic exposure to elevated FA and glucose can result in glucolipotoxicity (GLT) with basal hypersecretion and inhibition of GSIS. Despite the adverse effects of chronic exposure, FA is known to be required for normal exocytosis from the ß-cell. Deciphering the dual effects of FA on GSIS will lead to the possible development of therapies that would reduce the inhibitory effects while sparing the stimulatory effects of FA on the ß-cell. Studies in his laboratory are aimed at identifying the lipids or lipid classes involved in enhancing and suppressing GSIS and assessing their effects on lipid-modulated or modulating proteins.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Jones Iv AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS One. 2017; 12(12):e0188474.View Related Profiles. PMID: 29206239; DOI: 10.1371/journal.pone.0188474;.
  2. Pizarro-Delgado J, Deeney JT, Corkey BE, Tamarit-Rodriguez J. Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets. PLoS One. 2016; 11(11):e0166111. PMID: 27851770; DOI: 10.1371/journal.pone.0166111;.
  3. Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV. BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic ß-Cell. PLoS One. 2016; 11(3):e0151329.View Related Profiles. PMID: 27008626; PMCID: PMC4805167; DOI: 10.1371/journal.pone.0151329;.
  4. Berdan CA, Erion KA, Burritt NE, Corkey BE, Deeney JT. Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets. PLoS One. 2016; 11(2):e0149008.View Related Profiles. PMID: 26867016; PMCID: PMC4750965; DOI: 10.1371/journal.pone.0149008;.
  5. Rameh LE, Deeney JT. Phosphoinositide signalling in type 2 diabetes: a ß-cell perspective. Biochem Soc Trans. 2016 Feb; 44(1):293-8.View Related Profiles. PMID: 26862218; DOI: 10.1042/BST20150229;.
  6. Xie Z, Jones A, Deeney JT, Hur SK, Bankaitis VA. Inborn Errors of Long-Chain Fatty Acid ß-Oxidation Link Neural Stem Cell Self-Renewal to Autism. Cell Rep. 2016 Feb 9; 14(5):991-9. PMID: 26832401; PMCID: PMC4749429; DOI: 10.1016/j.celrep.2016.01.004;.
  7. Pizarro-Delgado J, Deeney JT, Martín-del-Río R, Corkey BE, Tamarit-Rodriguez J. KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion. PLoS One. 2015; 10(10):e0140096. PMID: 26444014; PMCID: PMC4596849; DOI: 10.1371/journal.pone.0140096;.
  8. Erion KA, Berdan CA, Burritt NE, Corkey BE, Deeney JT. Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic ß-Cells. J Biol Chem. 2015 Jun 26; 290(26):16191-201.View Related Profiles. PMID: 25934392; PMCID: PMC4481219; DOI: 10.1074/jbc.M114.620351;.
  9. Wang F, Deeney JT, Denis GV. Brd2 gene disruption causes "metabolically healthy" obesity: epigenetic and chromatin-based mechanisms that uncouple obesity from type 2 diabetes. Vitam Horm. 2013; 91:49-75.View Related Profiles. PMID: 23374712; DOI: 10.1016/B978-0-12-407766-9.00003-1;.
  10. Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012; 7(1):e30200.View Related Profiles. PMID: 22272304; PMCID: PMC3260220; DOI: 10.1371/journal.pone.0030200;.
Showing 10 of 54 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 54 publications over 26 distinct years, with a maximum of 6 publications in 1996

YearPublications
19841
19851
19861
19871
19882
19892
19902
19913
19922
19942
19966
19971
19981
20004
20012
20021
20032
20051
20075
20082
20092
20121
20131
20152
20165
20171
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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