Jude Deeney, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

PhD, Karolinska Institutet
MS, Virginia Polytechnic Institute and State University
BS, Saint Joseph College



Dr. Deeney's research is designed to discern the nutrient-derived metabolic signals leading to glucose- and fatty acid (FA)-induced insulin exocytosis from the pancreatic ß-cell. FA acutely stimulates glucose-induced insulin secretion (GSIS) while chronic exposure to elevated FA and glucose can result in glucolipotoxicity (GLT) with basal hypersecretion and inhibition of GSIS. Despite the adverse effects of chronic exposure, FA is known to be required for normal exocytosis from the ß-cell. Deciphering the dual effects of FA on GSIS will lead to the possible development of therapies that would reduce the inhibitory effects while sparing the stimulatory effects of FA on the ß-cell. Studies in his laboratory are aimed at identifying the lipids or lipid classes involved in enhancing and suppressing GSIS and assessing their effects on lipid-modulated or modulating proteins.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Associate Member
Boston University Medical Center
Boston Nutrition Obesity Research Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences





Elucidating the effects of statins on pancreatic B-cell metabolism and functions
08/02/2018 - 12/31/2022 (PI)
Trustees of Boston University, BUMC Kowa Pharmaceuticals


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Yuan M, Hu FB, Li Y, Cabral HJ, Das SK, Deeney JT, Zhou X, Paik JM, Moore LL. Types of dairy foods and risk of fragility fracture in the prospective Nurses' Health Study cohort. Am J Clin Nutr. 2023 Dec; 118(6):1172-1181.View Related Profiles. PMID: 37777015; PMCID: PMC10797505; DOI: 10.1016/j.ajcnut.2023.09.015;
     
  2. Zheng A, Huang N, Bean D, Rayapaneni S, Deeney J, Sagar M, Hamilton JA. Resolvin E1 heals injured cardiomyocytes: Therapeutic implications and H-FABP as a readout for cardiovascular disease & systemic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2023 Oct; 197:102586.View Related Profiles. PMID: 37604082
     
  3. Yuan M, Hu FB, Li Y, Cabral HJ, Das SK, Deeney JT, Moore LL. Dairy Foods, Weight Change, and Risk of Obesity During the Menopausal Transition. J Nutr. 2023 Mar; 153(3):811-819.View Related Profiles. PMID: 36931753; PMCID: PMC10196560; DOI: 10.1016/j.tjnut.2023.01.001;
     
  4. Yuan M, Hu FB, Li Y, Cabral HJ, Das SK, Deeney JT, Moore LL. Dairy Food Intakes, Postpartum Weight Retention, and Risk of Obesity. Nutrients. 2022 Dec 27; 15(1).View Related Profiles. PMID: 36615778; PMCID: PMC9824318; DOI: 10.3390/nu15010120;
     
  5. Corkey BE, Deeney JT, Merrins MJ. What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia? Diabetes. 2021 10; 70(10):2174-2182.View Related Profiles. PMID: 34593535; PMCID: PMC8576498; DOI: 10.2337/dbi21-0009;
     
  6. Corkey BE, Deeney JT. The Redox Communication Network as a Regulator of Metabolism. Front Physiol. 2020; 11:567796.View Related Profiles. PMID: 33178037; PMCID: PMC7593883; DOI: 10.3389/fphys.2020.567796;
     
  7. Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020 07 07; 32(1):44-55.e6.View Related Profiles. PMID: 32402267; PMCID: PMC7217133; DOI: 10.1016/j.cmet.2020.04.015;
     
  8. Rumala CZ, Liu J, Locasale JW, Corkey BE, Deeney JT, Rameh LE. Exposure of Pancreatic ß-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration. iScience. 2020 Feb 21; 23(2):100858.View Related Profiles. PMID: 32058969; PMCID: PMC7005503; DOI: 10.1016/j.isci.2020.100858;
     
  9. Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200.View Related Profiles. PMID: 31869355; PMCID: PMC6927614; DOI: 10.1371/journal.pone.0226200;
     
  10. Petcherski A, Trudeau KM, Wolf DM, Segawa M, Lee J, Taddeo EP, Deeney JT, Liesa M. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 ß-cells. J Mol Biol. 2018 12 07; 430(24):4823-4833.View Related Profiles. PMID: 30389435; PMCID: PMC6290358; DOI: 10.1016/j.jmb.2018.10.020;
     
Showing 10 of 65 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 65 publications over 32 distinct years, with a maximum of 6 publications in 1996

YearPublications
19841
19851
19861
19871
19882
19892
19902
19913
19922
19942
19966
19971
19981
20004
20012
20021
20032
20051
20075
20082
20092
20121
20131
20152
20165
20171
20182
20191
20203
20211
20221
20233

Contact for Mentoring:

650 Albany St
Boston MA 02118
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358.652.5
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