Keywords
Last Name

Jennifer Snyder-Cappione, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4296
ORCID ORCID Icon0000-0002-0941-5582
Other Positions
TitleDirector
InstitutionBoston University School of Medicine
DepartmentFlow Cytometry Core Facility

 Research Expertise & Professional Interests
Dr. Snyder-Cappione received her B.S. from Brandeis University and her Ph.D. from the University of Rochester Medical Center. Her doctoral research focus was the regulation of IFN-gamma and cytotoxic effector functions by CD8+ T cells. During her post-doctoral work at UCSF, she investigated the role of iNKT cells in HIV and Mycobacterium tuberculosis infections as well as sarcoidosis. Her current research interests include: (1) determining the diagnostic and prognostic potential of ex vivo immune functional profiling in human inflammatory diseases, (2) investigating the differentiation potential and lineage relationships of iNKT cell subsets, and (3) elucidating the role of T cell and iNKT cell exhaustion in the progression of infectious diseases and cancer.

 Self-Described Keywords
  • Cancer
  • Cytokines
  • HIV Infection
  • Immunologic Memory
  • Immunophenotyping
  • Mycobacterium tuberculosis
  • Natural Killer Cells
  • Natural Killer T-Cells
  • Sarcoidosis
  • T-Lymphocyte Subsets
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lentucci C, Belkina A, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development. J Biol Chem. 2016 Dec 30. PMID: 28039360.
    View in: PubMed
  2. Merlini E, Tincati C, Biasin M, Saulle I, Cazzaniga FA, d'Arminio Monforte A, Cappione AJ, Snyder-Cappione J, Clerici M, Marchetti GC. Stimulation of PBMC and Monocyte-Derived Macrophages via Toll-Like Receptor Activates Innate Immune Pathways in HIV-Infected Patients on Virally Suppressive Combination Antiretroviral Therapy. Front Immunol. 2016; 7:614. PMID: 28066424.
    View in: PubMed
  3. Belkina AC, Snyder-Cappione JE. OMIP-037: 16-color panel to measure inhibitory receptor signatures from multiple human immune cell subsets. Cytometry A. 2016 Oct 5. PMID: 27706900.
    View in: PubMed
  4. Snyder-Cappione JE, Nixon DF, Chi JC, Nguyen ML, Kirby CK, Milush JM, Koth LL. Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis. Eur J Immunol. 2013 Aug; 43(8):2194-205. PMID: 23661497.
    View in: PubMed
  5. DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian C, Denis GV, Nikolajczyk BS. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):5133-8. PMID: 23479618.
    View in: PubMed
  6. Snyder-Cappione JE, Nikolajczyk BS. When diet and exercise are not enough, think immunomodulation. Mol Aspects Med. 2013 Feb; 34(1):30-8. PMID: 23078865.
    View in: PubMed
  7. Tincati C, Cappione Iii AJ, Snyder-Cappione JE. Distinguishing Latent from Active Mycobacterium tuberculosis Infection Using Elispot Assays: Looking Beyond Interferon-gamma. Cells. 2012; 1(2):89-99. PMID: 24710416.
    View in: PubMed
  8. Carvalho KI, Bruno FR, Snyder-Cappione JE, Maeda SM, Tomimori J, Xavier MB, Haslett PA, Nixon DF, Kallas EG. Lower numbers of natural killer T cells in HIV-1 and Mycobacterium leprae co-infected patients. Immunology. 2012 May; 136(1):96-102. PMID: 22269018.
    View in: PubMed
  9. Tincati C, Cappione A.J., Snyder-Cappione J.E. Distinguishing Latent from Active Mycobacterium Tuberculosis Infection Using Elispot Assays: Looking Beyond Interferon-gamma. Cells. 2012; (1):89-99.
  10. Kuylenstierna C, Snyder-Cappione JE, Loo CP, Long BR, Gonzalez VD, Michaëlsson J, Moll M, Spotts G, Hecht FM, Nixon DF, Sandberg JK. NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection. Scand J Immunol. 2011 Feb; 73(2):141-6. PMID: 21198755.
    View in: PubMed
  11. Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF. A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-a and MIP1-ß, a lack of IL-17, and a Th1-bias in males. PLoS One. 2010; 5(11):e15412. PMID: 21082024.
    View in: PubMed
  12. Carvalho KI, Melo KM, Bruno FR, Snyder-Cappione JE, Nixon DF, Costa-Carvalho BT, Kallas EG. Skewed distribution of circulating activated natural killer T (NKT) cells in patients with common variable immunodeficiency disorders (CVID). PLoS One. 2010; 5(9). PMID: 20844745.
    View in: PubMed
  13. Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ, York VA, Ndhlovu LC, Lanier LL, Michaëlsson J, Nixon DF. Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4. Blood. 2009 Nov 26; 114(23):4823-31. PMID: 19805616.
    View in: PubMed
  14. Snyder-Cappione JE, Loo CP, Carvalho KI, Kuylenstierna C, Deeks SG, Hecht FM, Rosenberg MG, Sandberg JK, Kallas EG, Nixon DF. Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression. AIDS. 2009 Sep 24; 23(15):1965-70. PMID: 19590406.
    View in: PubMed
  15. Ndhlovu LC, Snyder-Cappione JE, Carvalho KI, Leal FE, Loo CP, Bruno FR, Jha AR, Devita D, Hasenkrug AM, Barbosa HM, Segurado AC, Nixon DF, Murphy EL, Kallas EG. Lower numbers of circulating Natural Killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease. Clin Exp Immunol. 2009 Dec; 158(3):294-9. PMID: 19778295.
    View in: PubMed
  16. Rebhahn JA, Bishop C, Divekar AA, Jiminez-Garcia K, Kobie JJ, Lee FE, Maupin GM, Snyder-Cappione JE, Zaiss DM, Mosmann TR. Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion. Comput Methods Programs Biomed. 2008 Oct; 92(1):54-65. PMID: 18644656.
    View in: PubMed
  17. Ndhlovu LC, Chapman JM, Jha AR, Snyder-Cappione JE, Pagán M, Leal FE, Boland BS, Norris PJ, Rosenberg MG, Nixon DF. Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection. AIDS. 2008 May 11; 22(8):990-2. PMID: 18453860.
    View in: PubMed
  18. Snyder-Cappione JE, Nixon DF, Loo CP, Chapman JM, Meiklejohn DA, Melo FF, Costa PR, Sandberg JK, Rodrigues DS, Kallas EG. Individuals with pulmonary tuberculosis have lower levels of circulating CD1d-restricted NKT cells. J Infect Dis. 2007 May 1; 195(9):1361-4. PMID: 17397008.
    View in: PubMed
  19. Snyder-Cappione JE, Divekar AA, Maupin GM, Jin X, Demeter LM, Mosmann TR. HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses. J Immunol. 2006 Feb 15; 176(4):2662-8. PMID: 16456029.
    View in: PubMed
  20. Moll M, Snyder-Cappione J, Spotts G, Hecht FM, Sandberg JK, Nixon DF. Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2. Blood. 2006 Apr 15; 107(8):3081-3. PMID: 16368878.
    View in: PubMed
  21. Lee FE, Walsh EE, Falsey AR, Liu N, Liu D, Divekar A, Snyder-Cappione JE, Mosmann TR. The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects. Mech Ageing Dev. 2005 Nov; 126(11):1223-9. PMID: 16098562.
    View in: PubMed
  22. Snyder JE, Mosmann TR. How to "spot" a real killer. Trends Immunol. 2003 May; 24(5):231; author reply 231-2. PMID: 12738412.
    View in: PubMed
  23. Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med. 2003 Feb; 9(2):231-5. PMID: 12539041.
    View in: PubMed
  24. Kuzin II, Snyder JE, Ugine GD, Wu D, Lee S, Bushnell T, Insel RA, Young FM, Bottaro A. Tetracyclines inhibit activated B cell function. Int Immunol. 2001 Jul; 13(7):921-31. PMID: 11431422.
    View in: PubMed
  25. Snyder JE, Filipov NM, Parsons PJ, Lawrence DA. The efficiency of maternal transfer of lead and its influence on plasma IgE and splenic cellularity of mice. Toxicol Sci. 2000 Sep; 57(1):87-94. PMID: 10966514.
    View in: PubMed
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