Barbara S Nikolajczyk, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of North Carolina



Work in the lab is divided into multiple projects. The first project aims to understand the role T cell play in human obesity and type 2 diabetes. Th17 cells are expanded in type 2 while Tregs are under-represented; Th1s and Th2s are unchanged. What do these subset changes have to do with disease etiology and pathogenesis in human, and how does this skewing occur in vivo? The second project aims to understand the role B cells play in type 2 diabetes as an example systemic inflammatory diseases. We have unexpected found human B ells express surface TLR4 and that engagement of this receptor prevents B cells activation. Fundamental differences in TLR4 regulation and function between B cells and monocytes has implications in treatment of these inflammatory diseases. This project also have a mouse component where we will aim to identify roles B cells play in the response to high fat diet in vivo. Finally, a new project will similar explore the role B cells play in periodontal disease in a mouse model of chronic periodontitis.

Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Associate Professor
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center




Does salt drive a human immune profile in a mouse model of obesity?
03/01/2017 - 03/31/2018 (PI)
Boston Nutrition Obesity Research Center NIH NIDDK
4P30DK046200-24

Inflammation in human obesity and type 2 diabetes
07/01/2016 - 09/30/2017 (PI)
NIH/National Diabetes & Digestive & Kidn
5R01DK108056-02

Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes
07/01/2016 - 09/30/2017 (PI)
NIH/National Institute of Dental & Crani
1R01DE025383-01A1

Epigenetic harbingers of vascular endothelial dysfunction in type 2 diabetes
10/01/2013 - 09/30/2015 (PI)
Augusta University NIH NIDDK
3U24DK076169-08S4

The Role of Lymphocytes in Diet-Induced Metabolic Disease
09/01/2012 - 08/31/2014 (PI)
NIH/National Diabetes & Digestive & Kidn
1R56DK096525-01

The Role of B Cells and B Cell Toll-Like Receptors in Periodontal Disease
04/01/2011 - 03/31/2014 (PI)
NIH/National Institute of Dental & Crani NIH NIDCR
5R21DE021154-02

The Role of B Cells and B Cell Toll-Like Receptors in Glucose Intolerance
07/01/2010 - 06/30/2013 (PI)
NIH/National Diabetes & Digestive & Kidn
5R21DK089270-02

The Role of T Cells in the Transition of Type 2 Diabetes
03/01/2011 - 03/31/2013 (PI)
Boston Medical Center Corporation NIH NIDDK


The Role of B Cells in a Mouse Model of Type 2 Diabetes
05/01/2010 - 03/31/2013 (PI)
Massachusetts General Hospital NIH NIDDK
3P30DK057521-11S1

Mechanisms Regulating Immunoglobulin Gene Transcription
09/01/2005 - 03/31/2009 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5 R01 AI54611 06

Showing 10 of 11 results. Show All Results

Mechanisms Regulating Immunoglobulin Gene Transcription
04/01/2003 - 03/31/2008 (PI)
NIH-NIAID

Regulating the Regulator: Mechanism Controling Macrophages
07/01/2002 - 06/30/2004 (PI)
American Lung Asso

Mechanisms Regulating Ig
07/01/2000 - 12/31/2003 (PI)
Arthritis Foundation

The Role Of Ets Oncogenes
01/15/2000 - 01/14/2002 (PI)
Cancer Research Inst



Yr Title Project-Sub Proj Pubs
2017 Inflammation in human obesity and type 2 diabetes 5R01DK108056-02 1
2016 Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes 1R01DE025383-01A1 1
2016 Inflammation in human obesity and type 2 diabetes 1R01DK108056-01A1 1
2012 The Role of Lymphocytes in Diet-Induced Metabolic Disease 1R56DK096525-01 5
2012 The Role of B Cells and B Cell Toll-like Receptors in Periodontal Disease 5R21DE021154-02 7
2011 The Role of B Cells and B Cell Toll-like Receptors in Periodontal Disease 1R21DE021154-01A1 7
2011 The Role of B Cells and B Cell Toll-like Receptors in Glucose Intolerance 5R21DK089270-02 12
2010 The Role of B Cells and B Cell Toll-like Receptors in Glucose Intolerance 1R21DK089270-01 12
2007 Mechanisms regulating immunoglobulin gene transcription 5R01AI054611-06 15
2006 Mechanisms regulating immunoglobulin gene transcription 5R01AI054611-05 15
Showing 10 of 18 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Jones Iv AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS One. 2017; 12(12):e0188474.View Related Profiles. PMID: 29206239; DOI: 10.1371/journal.pone.0188474;.
  2. Bharath LP, Ip BC, Nikolajczyk BS. Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging. Compr Physiol. 2017 Sep 12; 7(4):1307-1337. PMID: 28915326.
  3. Agrawal M, Kern PA, Nikolajczyk BS. The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths. Curr Diab Rep. 2017 Aug 15; 17(10):87. PMID: 28812211.
  4. Nicholas D, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA, Nikolajczyk BS. Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis. PLoS One. 2017; 12(2):e0170975.View Related Profiles. PMID: 28178278; DOI: 10.1371/journal.pone.0170975;.
  5. Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17; 292(7):2754-2772.View Related Profiles. PMID: 28039360; DOI: 10.1074/jbc.M116.755132;.
  6. Hafida S, Mirshahi T, Nikolajczyk BS. The impact of bariatric surgery on inflammation: quenching the fire of obesity? Curr Opin Endocrinol Diabetes Obes. 2016 Oct; 23(5):373-8. PMID: 27455515; DOI: 10.1097/MED.0000000000000277;.
  7. Nicholas DA, Andrieu G, Strissel KJ, Nikolajczyk BS, Denis GV. BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer. Cell Mol Life Sci. 2017 Jan; 74(2):231-243.View Related Profiles. PMID: 27491296; DOI: 10.1007/s00018-016-2320-0;.
  8. Nicholas DA, Nikolajczyk BS. B cells shed light on diminished vaccine responses in obesity. Obesity (Silver Spring). 2016 Mar; 24(3):551. PMID: 26847721; DOI: 10.1002/oby.21429;.
  9. Zhu M, Nikolajczyk BS. Comment on "The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis.". J Immunol. 2015 Dec 1; 195(11):5099. PMID: 26589743; DOI: 10.4049/jimmunol.1502059;.
  10. Ip B, Cilfone NA, Belkina AC, DeFuria J, Jagannathan-Bogdan M, Zhu M, Kuchibhatla R, McDonnell ME, Xiao Q, Kepler TB, Apovian CM, Lauffenburger DA, Nikolajczyk BS. Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFa production. Obesity (Silver Spring). 2016 Jan; 24(1):102-12.View Related Profiles. PMID: 26576827; PMCID: PMC4688084; DOI: 10.1002/oby.21243;.
Showing 10 of 54 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 54 publications over 27 distinct years, with a maximum of 5 publications in 2010

YearPublications
19911
19921
19931
19941
19951
19961
19971
19982
19992
20001
20011
20021
20031
20041
20052
20062
20071
20082
20093
20105
20112
20122
20134
20143
20154
20164
20174
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cytokines
immunology
immunometabolism
lymphocyte function
periodontal disease
systemic inflammatory diseases

Available to Mentor as: (Review Mentor Role Definitions):
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  • Project Mentor
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  • Work / Life Integration Mentor
Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
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