Keywords
Last Name

Ian R. Rifkin, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7330
ORCID ORCID Icon0000-0002-2674-3991
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine

 Research Expertise & Professional Interests
Expertise includes: Immunology; Autoimmunity; Systemic lupus erythematosus; and Nephrology.

 Self-Described Keywords
  • atherosclerosis
  • Autoimmunity
  • interferon regulatory factors
  • systemic lupus erythematosus
  • Toll like receptors
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57. PMID: 26315890.
    View in: PubMed
  2. Aprahamian TR, Zhong X, Amir S, Binder CJ, Chiang LK, Al-Riyami L, Gharakhanian R, Harnett MM, Harnett W, Rifkin IR. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. Int J Parasitol. 2015 Mar; 45(4):203-7. PMID: 25666929.
    View in: PubMed
  3. Watkins AA, Yasuda K, Wilson GE, Aprahamian T, Xie Y, Maganto-Garcia E, Shukla P, Oberlander L, Laskow B, Menn-Josephy H, Wu Y, Duffau P, Fried SK, Lichtman AH, Bonegio RG, Rifkin IR. IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis. J Immunol. 2015 Feb 15; 194(4):1467-79. PMID: 25595782.
    View in: PubMed
  4. Mathes AL, Rice L, Affandi AJ, DiMarzio M, Rifkin IR, Stifano G, Christmann RB, Lafyatis R. CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin. Exp Dermatol. 2015 Feb; 24(2):133-9. PMID: 25425469.
    View in: PubMed
  5. Tan Y, Watkins AA, Freeman BB, Meyers JA, Rifkin IR, Lerner A. Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. J Immunol. 2015 Jan 1; 194(1):101-12. PMID: 25416804.
    View in: PubMed
  6. Ericson JA, Duffau P, Yasuda K, Ortiz-Lopez A, Rothamel K, Rifkin IR, Monach PA. Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways. PLoS One. 2014; 9(10):e108553. PMID: 25279834.
    View in: PubMed
  7. Yasuda K, Watkins AA, Kochar GS, Wilson GE, Laskow B, Richez C, Bonegio RG, Rifkin IR. Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2. PLoS One. 2014; 9(7):e103478. PMID: 25076492.
    View in: PubMed
  8. Aprahamian TR, Bonegio RG, Weitzner Z, Gharakhanian R, Rifkin IR. Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. Immunology. 2014 Jul; 142(3):363-73. PMID: 24456224.
    View in: PubMed
  9. Watkins AA, Bonegio RG, Rifkin IR. Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus. Methods Mol Biol. 2014; 1169:143-58. PMID: 24957237.
    View in: PubMed
  10. Richez C, Richards RJ, Duffau P, Weitzner Z, Andry CD, Rifkin IR, Aprahamian T. The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus. PLoS One. 2013; 8(4):e61042. PMID: 23577189.
    View in: PubMed
  11. Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306. PMID: 23291967.
    View in: PubMed
  12. Richez C, Blanco P, Rifkin I, Moreau JF, Schaeverbeke T. Role for toll-like receptors in autoimmune disease: the example of systemic lupus erythematosus. Joint Bone Spine. 2011 Mar; 78(2):124-30. PMID: 20961794.
    View in: PubMed
  13. Richez C, Barnetche T, Miceli-Richard C, Blanco P, Moreau JF, Rifkin I, Schaeverbeke T. Role for interferon regulatory factors in autoimmunity. Joint Bone Spine. 2010 Dec; 77(6):525-31. PMID: 20863736.
    View in: PubMed
  14. Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R. Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010 Nov; 130(11):2583-93. PMID: 20613770.
    View in: PubMed
  15. Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol. 2010 Jan 15; 184(2):796-806. PMID: 20007534.
    View in: PubMed
  16. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17. PMID: 19648272.
    View in: PubMed
  17. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76. PMID: 19587008.
    View in: PubMed
  18. Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo. Arthritis Res Ther. 2009; 11(3):R79. PMID: 19476613.
    View in: PubMed
  19. Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol. 2009 Jan 15; 182(2):820-8. PMID: 19124725.
    View in: PubMed
  20. Aprahamian T, Bonegio RG, Richez C, Yasuda K, Chiang LK, Sato K, Walsh K, Rifkin IR. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol. 2009 Jan 1; 182(1):340-6. PMID: 19109165.
    View in: PubMed
  21. Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol. 2007 Jun 1; 178(11):6876-85. PMID: 17513736.
    View in: PubMed
  22. Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol. 2007; 25:419-41. PMID: 17378763.
    View in: PubMed
  23. Bijol V, Agrawal N, Abernethy VE, Rifkin IR, Nosé V, Rennke HG. A 57-year-old woman with recently diagnosed SLE, proteinuria, and microhematuria. Am J Kidney Dis. 2006 Dec; 48(6):1004-8. PMID: 17162159.
    View in: PubMed
  24. Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol. 2006 Sep 1; 177(5):3028-34. PMID: 16920939.
    View in: PubMed
  25. Beaudette-Zlatanova BC, Ling T, Shlomchik MJ, Marshak-Rothstein A, Rifkin IR. B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J Immunol. 2006 Jul 1; 177(1):45-52. PMID: 16785497.
    View in: PubMed
  26. Agrawal N, Chiang LK, Rifkin IR. Lupus nephritis. Semin Nephrol. 2006 Mar; 26(2):95-104. PMID: 16530602.
    View in: PubMed
  27. Busconi L, Lau CM, Tabor AS, Uccellini MB, Ruhe Z, Akira S, Viglianti GA, Rifkin IR, Marshak-Rothstein A. DNA and RNA autoantigens as autoadjuvants. J Endotoxin Res. 2006; 12(6):379-84. PMID: 17254393.
    View in: PubMed
  28. Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med. 2005 Nov 7; 202(9):1171-7. PMID: 16260486.
    View in: PubMed
  29. Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev. 2005 Apr; 204:27-42. PMID: 15790348.
    View in: PubMed
  30. Marshak-Rothstein A, Busconi L, Rifkin IR, Viglianti GA. The stimulation of Toll-like receptors by nuclear antigens: a link between apoptosis and autoimmunity. Rheum Dis Clin North Am. 2004 Aug; 30(3):559-74, ix. PMID: 15261341.
    View in: PubMed
  31. Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med. 2004 Jun 21; 199(12):1631-40. PMID: 15197227.
    View in: PubMed
  32. Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet JM, Sato K, Castellot JJ, Walsh K. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004 Apr 19; 199(8):1121-31. PMID: 15096538.
    View in: PubMed
  33. Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR. Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells. J Endotoxin Res. 2004; 10(4):247-51. PMID: 15373969.
    View in: PubMed
  34. Rifkin IR, Marshak-Rothstein A. T-bet: the Toll-bridge to class-switch recombination? Nat Immunol. 2003 Jul; 4(7):650-2. PMID: 12830144.
    View in: PubMed
  35. Leadbetter EA, Rifkin IR, Marshak-Rothstein A. Toll-like receptors and activation of autoreactive B cells. Curr Dir Autoimmun. 2003; 6:105-22. PMID: 12408049.
    View in: PubMed
  36. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 2002 Apr 11; 416(6881):603-7. PMID: 11948342.
    View in: PubMed
  37. Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, Marshak-Rothstein A. Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells. J Immunol. 2000 Aug 1; 165(3):1626-33. PMID: 10903773.
    View in: PubMed
  38. Zhu B, Beaudette BC, Rifkin IR, Marshak-Rothstein A. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Eur J Immunol. 2000 Jun; 30(6):1778-84. PMID: 10898516.
    View in: PubMed
  39. Rifkin IR, Marshak-Rothstein A. Fas and Fas ligand in autoimmunity. Curr Dir Autoimmun. 1999; 1:31-55. PMID: 11791447.
    View in: PubMed
  40. Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15; 161(10):5164-70. PMID: 9820486.
    View in: PubMed
  41. McHugh S, Deighton J, Rifkin I, Ewan P. Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture. Eur J Immunol. 1996 Jun; 26(6):1260-5. PMID: 8647202.
    View in: PubMed
  42. McHugh SM, Rifkin IR, Deighton J, Wilson AB, Lachmann PJ, Lockwood CM, Ewan PW. The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures. Clin Exp Immunol. 1995 Feb; 99(2):160-7. PMID: 7851006.
    View in: PubMed
  43. Lai KN, Leung JC, Rifkin I, Lockwood CM. Effect of anti-neutrophil cytoplasm autoantibodies on the intracellular calcium concentration of human neutrophils. Lab Invest. 1994 Feb; 70(2):152-62. PMID: 7908069.
    View in: PubMed
  44. Keogan MT, Rifkin I, Ronda N, Lockwood CM, Brown DL. Anti-neutrophil cytoplasm antibodies (ANCA) increase neutrophil adhesion to cultured human endothelium. Adv Exp Med Biol. 1993; 336:115-9. PMID: 7905228.
    View in: PubMed
  45. Parsons V, Baldwin D, Moniz C, Marsden J, Ball E, Rifkin I. Successful control of hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis using magnesium carbonate and calcium carbonate as phosphate binders. Nephron. 1993; 63(4):379-83. PMID: 8459870.
    View in: PubMed
  46. Maheshwari HG, Rifkin I, Butler J, Norman M. Growth hormone binding protein in patients with renal failure. Acta Endocrinol (Copenh). 1992 Dec; 127(6):485-8. PMID: 1492536.
    View in: PubMed
  47. Deane C, Cowan N, Giles J, Walters H, Rifkin I, Severn A, Parsons V. Arteriovenous fistulas in renal transplants: color Doppler ultrasound observations. Urol Radiol. 1992; 13(4):211-7. PMID: 1598744.
    View in: PubMed
  48. Bateman AM, Larner AJ, McCartney SA, Rifkin IR. Rhabdomyolysis associated with lithium-induced hyperosmolal state. Nephrol Dial Transplant. 1991; 6(3):203-5. PMID: 1907725.
    View in: PubMed
  49. Sacks LV, Rifkin IR. Mirror image arrangement of the abdominal organs with a left-sided morphologically normal heart. Br Heart J. 1987 Nov; 58(5):534-6. PMID: 3676045.
    View in: PubMed
  50. Weiss G, O'Byrne M, Hochman JA, Goldsmith LT, Rifkin I, Steinetz BG. Secretion of progesterone and relaxin by the humancorpus luteum at midpregnancy and at term. Obstet Gynecol. 1977 Dec; 50(6):679-81. PMID: 927758.
    View in: PubMed
  51. Weiss G, Rifkin I, Atkinson LE. Induction of ovulation in premenarchial rhesus monkeys with human gonadotropins. Biol Reprod. 1976 May; 14(4):401-4. PMID: 819046.
    View in: PubMed
  52. Weiss G, Rifkin I. Progesterone and estrogen secretion by puerperal human ovaries. Obstet Gynecol. 1975 Nov; 46(5):557-9. PMID: 1196558.
    View in: PubMed
  53. Rifkin I, Nachtigall LE, Beckman EM. Amenorrhea following use of oral contraceptives. Am J Obstet Gynecol. 1972 Jun 1; 113(3):420-32. PMID: 4678381.
    View in: PubMed
  54. SENGER FL, WARRES HL, RIFKIN I. Penicillin in propylene glycol; a preliminary report. J Urol. 1946 Jan; 55:138-42. PMID: 21009433.
    View in: PubMed
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