Robert A. Lafyatis, MD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology (Arthritis) Section

MD, University of Cincinnati

A Phase 1 Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy volunteers and Subjects with Systemic Lupus Erythematosus
04/09/2015 - 04/08/2020 (Co-PI)
PI: Christina Lam, MD
Biogen Idec

Scleroderma Clinical Repository (SCaR)
10/01/2014 - 09/30/2019 (PI)
Regeneron Pharmaceuticals, Inc.

A Phase 2, Double-blind, Randomized, Placebo-controlled Multicenter Study to Evaluate Safety, Tolerability, Efficacy, and Pharmacokinetics of JBT-101 in Diffuse Cutaneous Systemic Sclerosis
12/01/2015 - 11/30/2018 (Co-PI)
PI: Robert W. Simms, MD
Corbus Pharmaceuticals Holdings, Inc.

Scleroderma Workshop
02/01/2010 - 01/31/2018 (PI)
MedImmune, Inc.

ASSET: A Phase II study to evaluate subcutaneous abatacept vs. placebo in diffuse cutaneous systemic sclerosis - a double-blind, placebo-controlled, randomized controlled trial [IMI101-344]
03/31/2015 - 11/30/2017 (PI)
Regents of the Univ. of Michigan Bristol-Myers Squibb

Nox4 Inhibitor in Systemic Sclerosis
11/14/2014 - 11/13/2017 (PI)
Inception Sciences, Inc.

09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Mu

Rheumatic Diseases Research Core Centers
09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Mu

Randomized, double-blind, placebo-controlled trial of IL1-Trap, Rilonacept, in Systemic Sclerosis-A Phase I/II Biomarker Trial
12/01/2011 - 04/30/2017 (PI)
Regeneron Pharmaceuticals, Inc.

A Randomized, Double-Blind, Placebo-Controlled Trial of Topical C-82 in Systemic Sclerosis-A Phase I/II Biomarker and Safety Trial
04/02/2015 - 04/01/2017 (PI)
PRISM Pharma Co Ltd

Showing 10 of 43 results. Show All Results

Yr Title Project-Sub Proj Pubs
2017 Dimethyl Fumarate In Systemic Sclerosis-Associated Pulmonary Arterial Hypertension 1R21AR069285-01A1
2015 Innate immunity in dermal fibrosis and systemic sclerosis 7R01AR051089-11 26
2015 NIAMS: CORT 5P50AR060780-05 25
2015 Rheumatic Diseases Research Core Centers 5P30AR061271-05 12
2015 Project 1 Biomarkers of disease activity and progression in systemic sclerosis 5P50AR060780-05-8686 25
2014 NIAMS: CORT 5P50AR060780-04 25
2014 Rheumatic Diseases Research Core Centers 5P30AR061271-04 12
2014 Innate immunity in dermal fibrosis and systemic sclerosis 5R01AR051089-09 26
2014 Project 1 Biomarkers of disease activity and progression in systemic sclerosis 5P50AR060780-04-8686 25
2013 NIAMS: CORT 5P50AR060780-03 25
Showing 10 of 41 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lafyatis R, Mantero JC, Gordon J, Kishore N, Carns M, Dittrich H, Spiera R, Simms RW, Varga J. Inhibition of beta-catenin signaling in the skin rescues cutaneous adipogenesis in systemic sclerosis: a randomized, double blind, placebo-controlled trial of C-82. J Invest Dermatol. 2017 Aug 11.View Related Profiles. PMID: 28807667.
  2. Derrett-Smith EC, Martyanov V, Chighizola CB, Moinzadeh P, Campochiaro C, Khan K, Wood TA, Meroni PL, Abraham DJ, Ong VH, Lafyatis R, Whitfield ML, Denton CP. Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature. Arthritis Res Ther. 2017 Jul 04; 19(1):156. PMID: 28676069.
  3. Makino K, Makino T, Stawski L, Mantero JC, Lafyatis R, Simms R, Trojanowska M. Blockade of PDGF Receptors by Crenolanib Has Therapeutic Effect in Patient Fibroblasts and in Preclinical Models of Systemic Sclerosis. J Invest Dermatol. 2017 Aug; 137(8):1671-1681.View Related Profiles. PMID: 28433542.
  4. Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML. A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis. Genome Med. 2017 Mar 23; 9(1):27.View Related Profiles. PMID: 28330499; DOI: 10.1186/s13073-017-0417-1;.
  5. Man A, Correa JK, Ziemek J, Simms RW, Felson DT, Lafyatis R. Development and validation of a patient-reported outcome instrument for skin involvement in patients with systemic sclerosis. Ann Rheum Dis. 2017 Aug; 76(8):1374-1380.View Related Profiles. PMID: 28213563; DOI: 10.1136/annrheumdis-2016-210534;.
  6. Xiong Y, Berrueta L, Urso K, Olenich S, Muskaj I, Badger GJ, Aliprantis A, Lafyatis R, Langevin HM. Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis. Front Immunol. 2017; 8:124. PMID: 28261202; DOI: 10.3389/fimmu.2017.00124;.
  7. Li G, Larregina AT, Domsic RT, Stolz DB, Medsger TA, Lafyatis R, Fuschiotti P. Skin-Resident Effector Memory CD8+CD28- T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis. J Invest Dermatol. 2017 May; 137(5):1042-1050. PMID: 28012718; DOI: 10.1016/j.jid.2016.11.037;.
  8. Lafyatis R. Editorial: Epigenetics in Systemic Sclerosis. Arthritis Rheumatol. 2016 Dec; 68(12):2841-2844. PMID: 27482953; DOI: 10.1002/art.39830;.
  9. Castelino FV, Bain G, Pace VA, Black KE, George L, Probst CK, Goulet L, Lafyatis R, Tager AM. An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. Arthritis Rheumatol. 2016 Dec; 68(12):2964-2974. PMID: 27390295; DOI: 10.1002/art.39797;.
  10. Goswami R, Cohen J, Sharma S, Zhang DX, Lafyatis R, Bhawan J, Rahaman SO. TRPV4 ION Channel Is Associated with Scleroderma. J Invest Dermatol. 2017 Apr; 137(4):962-965.View Related Profiles. PMID: 27889423; DOI: 10.1016/j.jid.2016.10.045;.
Showing 10 of 137 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 137 publications over 28 distinct years, with a maximum of 16 publications in 2016

Contact for Mentoring:

75 E. Newton St Evans Building
Boston MA 02118
Google Map

Lafyatis's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department