Robert Lafyatis | Profiles RNS

Robert A. Lafyatis, MD

Adjunct Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Rheumatology

MD, University of Cincinnati
BS, Massachusetts Institute of Technology

Websites

	Program in Inflammatory Disorders Faculty
	Scleroderma Center of Research Translation
	National Scleroderma Core Centers
	LinkedIn

ORCID : 0000-0002-9398-5034

Dr. Lafyatis carries out patient oriented research into the cause and treatment of systemic sclerosis. This includes early phase clinical trials into new therapeutic agents in patients with systemic sclerosis. He has been investigating the mechanisms of actions and markers of response for novel therapeutics, such as the B cell depleting agent, rituximab and the immunosuppressant agent, mycophenlate. Additional studies are aimed at identifying biomarkers in systemic sclerosis using microarray gene expression analysis of skin and blood in scleroderma patients. Ongoing biomarker studies include investigation into molecular markers of pulmonary hypertension in systemic sclerosis. Dr. Lafyatis also carries out basic research into the cause of fibrosis and vasculopathy in systemic sclerosis using patient samples and murine disease models. His studies have provided key insights into one widely used model of systemic sclerosis, the tight skin mouse. His studies are currently focused on understanding how autoimmunity and the innate immune system lead to fibrosis and vascular damage. This has recently led to the discovery of increased interferon-regulated gene expression in white blood cells of patients with systemic sclerosis. Ongoing research is aimed at better understanding the cause of altered gene expression by monocytes and other cells in the innate immune system.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BU Research
NIH RePORTER Research

A Phase 2, Double-blind, Randomized, Placebo-controlled Multicenter Study to Evaluate Safety, Tolerability, Efficacy, and Pharmacokinetics of JBT-101 in Diffuse Cutaneous Systemic Sclerosis
12/01/2015 - 11/30/2021 (Co-Investigator)
PI: Robert W. Simms, MD
Corbus Pharmaceuticals Holdings, Inc.

A Phase 1 Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy volunteers and Subjects with Systemic Lupus Erythematosus
04/09/2015 - 04/08/2020 (Co-Investigator)
PI: Christina Lam, MD
Biogen Idec

Scleroderma Clinical Repository (SCaR)
10/01/2014 - 09/30/2019 (PI)
Regeneron Pharmaceuticals, Inc.

ASSET: A Phase II study to evaluate subcutaneous abatacept vs. placebo in diffuse cutaneous systemic sclerosis - a double-blind, placebo-controlled, randomized controlled trial [IMI101-344]
03/31/2015 - 06/30/2019 (Subcontract PI)
Regents of the University of Michigan Bristol-Myers Squibb

Randomized, double-blind, placebo-controlled trial of IL1-Trap, Rilonacept, in Systemic Sclerosis-A Phase I/II Biomarker Trial
12/01/2011 - 02/05/2019 (PI)
Regeneron Pharmaceuticals, Inc.

Scleroderma Workshop
02/01/2010 - 01/31/2018 (PI)
MedImmune, Inc.

Nox4 Inhibitor in Systemic Sclerosis
11/14/2014 - 11/13/2017 (PI)
Mistral Therapeutics, Inc.

NIAMS: CORT
09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5P50AR060780-05

Rheumatic Diseases Research Core Centers
09/01/2011 - 08/31/2017 (PI of Sub-Project / SP)
PI: Robert W. Simms, MD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5P30AR061271-05

A Randomized, Double-Blind, Placebo-Controlled Trial of Topical C-82 in Systemic Sclerosis-A Phase I/II Biomarker and Safety Trial
04/02/2015 - 04/01/2017 (PI)
PRISM Pharma Co Ltd

Showing 10 of 42 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2024	Molecular Basis for Altered Natural Killer Cells in Systemic Sclerosis associated-Interstitial Lung Disease	3P50AR080612-03S1
2024	Pathways regulating profibrotic macrophages in a novel explant model of systemic sclerosis-associated interstitial lung disease	1R21AR084251-01
2024	Cell epigenetics & communication in systemic sclerosis and localized scleroderma skin disease	5P50AR080612-03-9847
2024	Administrative Core	5P50AR080612-03-9032
2024	Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic Sclerosis	5P50AR080612-03
2023	Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic Sclerosis	5P50AR080612-02
2023	Administrative Core	5P50AR080612-02-9032
2023	Cell epigenetics & communication in systemic sclerosis and localized scleroderma skin disease	5P50AR080612-02-9847
2022	Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic Sclerosis	1P50AR080612-01
2022	Administrative Core	1P50AR080612-01-9844

Showing 10 of 82 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Shehabeldin M, Kobyra J, Cho Y, Gao J, Chong R, Tabib T, Lafyatis R, Little SR, Sfeir C. Local Controlled Delivery of IL-4 Decreases Inflammatory Bone Loss in a Murine Model of Periodontal Disease. J Immunol. 2024 Dec 01; 213(11):1635-1643. PMID: 39465979

Valenzi E, Jia M, Gerges P, Fan J, Tabib T, Behara R, Zhou Y, Sembrat J, Das J, Benos PV, Singh H, Lafyatis R. Altered AP-1, RUNX and EGR chromatin dynamics drive fibrotic lung disease. bioRxiv. 2024 Oct 28. PMID: 39554071; PMCID: PMC11565795; DOI: 10.1101/2024.10.23.619858;

Tirelli F, Pachera E, Gmür S, Lafyatis R, Huang M, Zulian F, Camarillo Retamosa E, Kania G, Distler O. Long non-coding RNA H19X as a regulator of mononuclear cell adhesion to the endothelium in systemic sclerosis. Rheumatology (Oxford). 2024 Oct 01; 63(10):2846-2855. PMID: 38305495; PMCID: PMC11443020; DOI: 10.1093/rheumatology/keae034;

Huang M, Tabib T, Khanna D, Assassi S, Domsic R, Lafyatis R. Single-cell transcriptomes and chromatin accessibility of endothelial cells unravel transcription factors associated with dysregulated angiogenesis in systemic sclerosis. Ann Rheum Dis. 2024 Sep 30; 83(10):1335-1344. PMID: 38754983; PMCID: PMC11442142; DOI: 10.1136/ard-2023-225415;

Hutchins T, Sanyal A, Esencan D, Lafyatis R, Jacobe H, Torok KS. Characterization of Endothelial Cell Subclusters in Localized Scleroderma Skin with Single-Cell RNA Sequencing Identifies NOTCH Signaling Pathway. Int J Mol Sci. 2024 Sep 28; 25(19). PMID: 39408800; PMCID: PMC11477421; DOI: 10.3390/ijms251910473;

Shehabeldin M, Gao J, Cho Y, Chong R, Tabib T, Li L, Smardz M, Gaffen SL, Diaz PI, Lafyatis R, Little SR, Sfeir C. Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis. Proc Natl Acad Sci U S A. 2024 Sep 03; 121(36):e2400528121. PMID: 39186644; PMCID: PMC11388407; DOI: 10.1073/pnas.2400528121;

Zhou Y, Tabib T, Huang M, Yuan K, Kim Y, Morse C, Sembrat J, Valenzi E, Lafyatis R. Molecular Changes Implicate Angiogenesis and Arterial Remodeling in Systemic Sclerosis-Associated and Idiopathic Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. 2024 Aug; 44(8):e210-e225. PMID: 38841857; PMCID: PMC11269037; DOI: 10.1161/ATVBAHA.123.320005;

Renaud L, Wilson CL, Lafyatis R, Schnapp LM, Feghali-Bostwick CA. Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis. iScience. 2024 Jun 21; 27(6):110010. PMID: 38868196; PMCID: PMC11167435; DOI: 10.1016/j.isci.2024.110010;

Harvey LD, Alotaibi M, Kim HJ, Tai YY, Tang Y, Sun W, El Khoury W, Woodcock CC, Aaraj YA, St Croix CM, Stolz DB, Lee J, Cheng MH, Schwantes-An TH, Desai AA, Pauciulo MW, Nichols WC, Webb A, Lafyatis R, Nouraie M, Wu H, McDonald JG, Chauvet C, Cheng S, Bahar I, Bertero T, Benza RL, Jain M, Chan SY. Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension. bioRxiv. 2024 Mar 01. PMID: 38464060; PMCID: PMC10925169; DOI: 10.1101/2024.02.26.582142;

Padilla CM, Valenzi E, Tabib T, Nazari B, Sembrat J, Rojas M, Fuschiotti P, Lafyatis R. Increased CD8+ tissue resident memory T cells, regulatory T cells and activated natural killer cells in systemic sclerosis lungs. Rheumatology (Oxford). 2024 Mar 01; 63(3):837-845. PMID: 37310903; PMCID: PMC10907815; DOI: 10.1093/rheumatology/kead273;

Showing 10 of 258 results. Show More

Rahimikollu J, Xiao H, Rosengart A, Rosen ABI, Tabib T, Zdinak PM, He K, Bing X, Bunea F, Wegkamp M, Poholek AC, Joglekar AV, Lafyatis RA, Das J. SLIDE: Significant Latent Factor Interaction Discovery and Exploration across biological domains. Nat Methods. 2024 May; 21(5):835-845. PMID: 38374265

Bahudhanapati H, Tan J, Apel RM, Seeliger B, Schupp J, Li X, Sullivan DI, Sembrat J, Rojas M, Tabib T, Valenzi E, Lafyatis R, Mitash N, Hernandez Pineda R, Jawale C, Peroumal D, Biswas P, Tedrow J, Adams T, Kaminski N, Wuyts WA, McDyer JF, Gibson KF, Alder JK, Königshoff M, Zhang Y, Nouraie M, Prasse A, Kass DJ. Increased expression of CXCL6 in secretory cells drives fibroblast collagen synthesis and is associated with increased mortality in idiopathic pulmonary fibrosis. Eur Respir J. 2024 Jan; 63(1).View Related Profiles.

Tedrow, John
Lafyatis, Robert

PMID: 37918852

Ma F, Tsou PS, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis. Nat Commun. 2024 Jan 03; 15(1):210. PMID: 38172207; PMCID: PMC10764940; DOI: 10.1038/s41467-023-44645-6;

Zhu H, Luo H, Skaug B, Tabib T, Li YN, Tao Y, Matei AE, Lyons MA, Schett G, Lafyatis R, Assassi S, Distler JHW. Fibroblast Subpopulations in Systemic Sclerosis: Functional Implications of Individual Subpopulations and Correlations with Clinical Features. J Invest Dermatol. 2024 Jun; 144(6):1251-1261.e13. PMID: 38147960; PMCID: PMC11116078; DOI: 10.1016/j.jid.2023.09.288;

Jia M, Sayed K, Kapetanaki MG, Dion W, Rosas L, Irfan S, Valenzi E, Mora AL, Lafyatis RA, Rojas M, Zhu B, Benos PV. LEF1 isoforms regulate cellular senescence and aging. Aging Cell. 2023 Dec; 22(12):e14024. PMID: 37961030; PMCID: PMC10726832; DOI: 10.1111/acel.14024;

Gaydosik AM, Stonesifer CJ, Tabib T, Lafyatis R, Geskin LJ, Fuschiotti P. The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis. JCI Insight. 2023 Oct 09; 8(19). PMID: 37669110; PMCID: PMC10619438; DOI: 10.1172/jci.insight.170015;

Cruz T, Agudelo Garcia PA, Chamucero-Millares JA, Bondonese A, Mitash N, Sembrat J, Tabib T, Zhang W, Seyed N, Peters V, Stacey S, Vignali D, Mora AL, Lafyatis R, Rojas M. End-Stage Idiopathic Pulmonary Fibrosis Lung Microenvironment Promotes Impaired NK Activity. J Immunol. 2023 Oct 01; 211(7):1073-1081. PMID: 37566492

Reay DP, Tabib T, Wang Y, Oriss TB, Young NA, Lafyatis RA, Jarjour WN, Clemens PR, Ascherman DP. Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositis. Front Immunol. 2023; 14:1238221. PMID: 37809058; PMCID: PMC10556668; DOI: 10.3389/fimmu.2023.1238221;

Jia M, Agudelo Garcia PA, Ovando-Ricardez JA, Tabib T, Bittar HT, Lafyatis RA, Mora AL, Benos PV, Rojas M. Transcriptional changes of the aging lung. Aging Cell. 2023 Oct; 22(10):e13969. PMID: 37706427; PMCID: PMC10577555; DOI: 10.1111/acel.13969;

Walsh SLF, Lafyatis RA, Cottin V. Imaging Features of Autoimmune Disease-Related Interstitial Lung Diseases. J Thorac Imaging. 2023 Nov 01; 38(Suppl 1):S30-S37. PMID: 37732704

Bondonese A, Craig A, Fan L, Valenzi E, Bain W, Lafyatis R, Sembrat J, Chen K, Snyder ME. Impact of enzymatic digestion on single cell suspension yield from peripheral human lung tissue. Cytometry A. 2023 Oct; 103(10):777-785. PMID: 37449375; PMCID: PMC10592386; DOI: 10.1002/cyto.a.24777;

Berkowitz JS, Tabib T, Xiao H, Sadej GM, Khanna D, Fuschiotti P, Lafyatis RA, Das J. Cell Type-Specific Biomarkers of Systemic Sclerosis Disease Severity Capture Cell-Intrinsic and Cell-Extrinsic Circuits. Arthritis Rheumatol. 2023 Oct; 75(10):1819-1830. PMID: 37096444; PMCID: PMC10543405; DOI: 10.1002/art.42536;

Jia M, Sayed K, Kapetanaki MG, Dion W, Rosas L, Irfan S, Valenzi E, Mora AL, Lafyatis RA, Rojas M, Zhu B, Benos PV. LEF1 isoforms regulate cellular senescence and aging. bioRxiv. 2023 Jul 21. PMID: 37502913; PMCID: PMC10370160; DOI: 10.1101/2023.07.20.549883;

Valenzi E, Bahudhanapati H, Tan J, Tabib T, Sullivan DI, Nouraie M, Sembrat J, Fan L, Chen K, Liu S, Rojas M, Lafargue A, Felsher DW, Tran PT, Kass DJ, Lafyatis R. Single-nucleus chromatin accessibility identifies a critical role for TWIST1 in idiopathic pulmonary fibrosis myofibroblast activity. Eur Respir J. 2023 Jul; 62(1). PMID: 37142338; PMCID: PMC10411550; DOI: 10.1183/13993003.00474-2022;

Valenzi E, Cody B, Lafyatis R. Usual interstitial pneumonia is the predominant histopathology in patients with systemic sclerosis receiving a lung transplant. Clin Exp Rheumatol. 2023 Aug; 41(8):1670-1678. PMID: 37382449; PMCID: PMC10528864; DOI: 10.55563/clinexprheumatol/icr6hy;

Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung MI, Collin A, Gay ACA, Gote-Schniering J, Hooshiar Kashani B, Inecik K, Jain M, Kapellos TS, Kole TM, Leroy S, Mayr CH, Oliver AJ, von Papen M, Peter L, Taylor CJ, Walzthoeni T, Xu C, Bui LT, De Donno C, Dony L, Faiz A, Guo M, Gutierrez AJ, Heumos L, Huang N, Ibarra IL, Jackson ND, Kadur Lakshminarasimha Murthy P, Lotfollahi M, Tabib T, Talavera-López C, Travaglini KJ, Wilbrey-Clark A, Worlock KB, Yoshida M, van den Berge M, Bossé Y, Desai TJ, Eickelberg O, Kaminski N, Krasnow MA, Lafyatis R, Nikolic MZ, Powell JE, Rajagopal J, Rojas M, Rozenblatt-Rosen O, Seibold MA, Sheppard D, Shepherd DP, Sin DD, Timens W, Tsankov AM, Whitsett J, Xu Y, Banovich NE, Barbry P, Duong TE, Falk CS, Meyer KB, Kropski JA, Pe'er D, Schiller HB, Tata PR, Schultze JL, Teichmann SA, Misharin AV, Nawijn MC, Luecken MD, Theis FJ. An integrated cell atlas of the lung in health and disease. Nat Med. 2023 Jun; 29(6):1563-1577. PMID: 37291214; PMCID: PMC10287567; DOI: 10.1038/s41591-023-02327-2;

Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA. Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. Eur Respir J. 2023 Jun; 61(6). PMID: 37024132; PMCID: PMC10259331; DOI: 10.1183/13993003.01625-2022;

Werner G, Sanyal A, Mirizio E, Hutchins T, Tabib T, Lafyatis R, Jacobe H, Torok KS. Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized Scleroderma. Int J Mol Sci. 2023 Jun 06; 24(12). PMID: 37372943; PMCID: PMC10298454; DOI: 10.3390/ijms24129796;

Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M. GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension. Sci Rep. 2023 Apr 22; 13(1):6593.View Related Profiles.

Ichihara, Asako
Seta, Francesca
Trojanowska, Maria
Lafyatis, Robert
Lenna, Stefania

PMID: 37087509; PMCID: PMC10122657; DOI: 10.1038/s41598-023-33779-8;

Jia M, Rosas L, Kapetanaki MG, Tabib T, Sebrat J, Cruz T, Bondonese A, Mora AL, Lafyatis R, Rojas M, Benos PV. Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis. Respir Res. 2023 Apr 21; 24(1):116. PMID: 37085855; PMCID: PMC10122312; DOI: 10.1186/s12931-023-02419-0;

Domsic RT, Medsger TA, Gao S, Laffoon M, Huang S, Wisniewski S, Spino C, Steen V, Lafyatis R, Khanna D. A data-driven approach finds RNA polymerase III antibody and tendon friction rubs as enrichment tools for early diffuse scleroderma trials. Rheumatology (Oxford). 2023 Apr 03; 62(4):1543-1551. PMID: 36031807; PMCID: PMC10072884; DOI: 10.1093/rheumatology/keac501;

Chen L, Zhao J, Chao Y, Roy A, Guo W, Qian J, Xu W, Domsic RT, Lafyatis R, Lu B, Deng F, Wang QJ. Loss of Protein Kinase D2 Activity Protects Against Bleomycin-Induced Dermal Fibrosis in Mice. Lab Invest. 2023 Feb; 103(2):100018. PMID: 37039152; PMCID: PMC10507682; DOI: 10.1016/j.labinv.2022.100018;

Sanges S, Rice L, Tu L, Valenzi E, Cracowski JL, Montani D, Mantero JC, Ternynck C, Marot G, Bujor AM, Hachulla E, Launay D, Humbert M, Guignabert C, Lafyatis R. Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis. Ann Rheum Dis. 2023 Mar; 82(3):365-373.View Related Profiles.

Bujor, Andreea
Rice, Lisa
Lafyatis, Robert

PMID: 36600187; PMCID: PMC9918672; DOI: 10.1136/ard-2022-223237;

Papazoglou A, Huang M, Bulik M, Lafyatis A, Tabib T, Morse C, Sembrat J, Rojas M, Valenzi E, Lafyatis R. Epigenetic Regulation of Profibrotic Macrophages in Systemic Sclerosis-Associated Interstitial Lung Disease. Arthritis Rheumatol. 2022 Dec; 74(12):2003-2014. PMID: 35849803; PMCID: PMC9771864; DOI: 10.1002/art.42286;

Fu D, Blobner BM, Greer PJ, Lafyatis R, Bellin MD, Whitcomb DC. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression. Gastroenterology. 2023 Feb; 164(2):289-292.e4. PMID: 36191639; PMCID: PMC9892203; DOI: 10.1053/j.gastro.2022.09.036;

Shi B, Tsou PS, Ma F, Mariani MP, Mattichak MN, LeBrasseur NK, Chini EN, Lafyatis R, Khanna D, Whitfield ML, Gudjonsson JE, Varga J. Senescent Cells Accumulate in Systemic Sclerosis Skin. J Invest Dermatol. 2023 Apr; 143(4):661-664.e5. PMID: 36191640; PMCID: PMC10038878; DOI: 10.1016/j.jid.2022.09.652;

Khanna D, Padilla C, Tsoi LC, Nagaraja V, Khanna PP, Tabib T, Kahlenberg JM, Young A, Huang S, Gudjonsson JE, Fox DA, Lafyatis R. Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial. JCI Insight. 2022 Sep 08; 7(17). PMID: 35943798; PMCID: PMC9536259; DOI: 10.1172/jci.insight.159566;

Alotaibi M, Shao J, Pauciulo MW, Nichols WC, Hemnes AR, Malhotra A, Kim NH, Yuan JX, Fernandes T, Kerr KM, Alshawabkeh L, Desai AA, Bujor AM, Lafyatis R, Watrous JD, Long T, Cheng S, Chan SY, Jain M. Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Chest. 2023 Jan; 163(1):204-215.View Related Profiles.

Bujor, Andreea
Lafyatis, Robert

PMID: 36087794; PMCID: PMC9899641; DOI: 10.1016/j.chest.2022.08.2230;

Lafyatis R, Tabib T. Reply. Arthritis Rheumatol. 2022 Oct; 74(10):1722-1723. PMID: 35644044

Rodor J, Chen SH, Scanlon JP, Monteiro JP, Caudrillier A, Sweta S, Stewart KR, Shmakova A, Dobie R, Henderson BEP, Stewart K, Hadoke PWF, Southwood M, Moore SD, Upton PD, Morrell NW, Li Z, Chan SY, Handen A, Lafyatis R, de Rooij LPMH, Henderson NC, Carmeliet P, Spiroski AM, Brittan M, Baker AH. Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension. Cardiovasc Res. 2022 Aug 24; 118(11):2519-2534. PMID: 34528097; PMCID: PMC9400412; DOI: 10.1093/cvr/cvab296;

Tuncer F, Bulik M, Villandre J, Lear T, Chen Y, Tuncer B, Kass DJ, Valenzi E, Morse C, Sembrat J, Lafyatis R, Chen B, Evankovich J. Fibronectin-EDA accumulates via reduced ubiquitination downstream of Toll-like receptor 9 activation in SSc-ILD fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2022 Oct 01; 323(4):L484-L494. PMID: 35997276; PMCID: PMC9550569; DOI: 10.1152/ajplung.00019.2022;

Wang X, Xu Z, Hu H, Zhou X, Zhang Y, Lafyatis R, Chen K, Huang H, Ding Y, Duerr RH, Chen W. SECANT: a biology-guided semi-supervised method for clustering, classification, and annotation of single-cell multi-omics. PNAS Nexus. 2022 Sep; 1(4):pgac165. PMID: 36157595; PMCID: PMC9491696; DOI: 10.1093/pnasnexus/pgac165;

Lafyatis R, Valenzi E. Assessment of disease outcome measures in systemic sclerosis. Nat Rev Rheumatol. 2022 Sep; 18(9):527-541. PMID: 35859133

Grebinoski S, Zhang Q, Cillo AR, Manne S, Xiao H, Brunazzi EA, Tabib T, Cardello C, Lian CG, Murphy GF, Lafyatis R, Wherry EJ, Das J, Workman CJ, Vignali DAA. Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat Immunol. 2022 Jun; 23(6):868-877. PMID: 35618829; PMCID: PMC9179227; DOI: 10.1038/s41590-022-01210-5;

Rice LM, Mantero JC, Stratton EA, Warburton R, Roberts K, Hill N, Simms RW, Domsic R, Farber HW, Lafyatis R. Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis. Arthritis Res Ther. 2022 May 23; 24(1):118.View Related Profiles.

Rice, Lisa
Lafyatis, Robert
Simms, Robert

PMID: 35606822; PMCID: PMC9125924; DOI: 10.1186/s13075-022-02816-8;

Snyder ME, Moghbeli K, Bondonese A, Craig A, Popescu I, Fan L, Tabib T, Lafyatis R, Chen K, Trejo Bittar HE, Lendermon E, Pilewski J, Johnson B, Kilaru S, Zhang Y, Sanchez PG, Alder JK, Sims PA, McDyer JF. Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation. J Exp Med. 2022 Apr 04; 219(4). PMID: 35285873; PMCID: PMC8924935; DOI: 10.1084/jem.20212059;

Xue D, Tabib T, Morse C, Yang Y, Domsic RT, Khanna D, Lafyatis R. Expansion of Fc? Receptor IIIa-Positive Macrophages, Ficolin 1-Positive Monocyte-Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis. Arthritis Rheumatol. 2022 02; 74(2):329-341. PMID: 34042322; PMCID: PMC8626521; DOI: 10.1002/art.41813;

Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL. Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing. Nat Commun. 2021 12 17; 12(1):7338. PMID: 34921143; PMCID: PMC8683505; DOI: 10.1038/s41467-021-27619-4;

Jussila AR, Zhang B, Caves E, Kirti S, Steele M, Hamburg-Shields E, Lydon J, Ying Y, Lafyatis R, Rajagopalan S, Horsley V, Atit RP. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4. J Invest Dermatol. 2022 Jun; 142(6):1597-1606.e9. PMID: 34808238; PMCID: PMC9120259; DOI: 10.1016/j.jid.2021.10.025;

Domsic RT, Gao S, Laffoon M, Wisniewski S, Zhang Y, Steen V, Lafyatis R, Medsger TA. Defining the optimal disease duration of early diffuse systemic sclerosis for clinical trial design. Rheumatology (Oxford). 2021 10 02; 60(10):4662-4670. PMID: 33506859; PMCID: PMC8677444; DOI: 10.1093/rheumatology/keab075;

Blobner BM, Saloman JL, Shelton Ohlsen CA, Brand R, Lafyatis R, Bottino R, Wijkstrom M, Zureikat AH, Lee KK, Singhi AD, Ross MA, Stolz D, Whitcomb DC. Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2021 11 01; 321(5):G449-G460. PMID: 34523348; PMCID: PMC8616588; DOI: 10.1152/ajpgi.00482.2020;

Moghbeli K, Valenzi E, Naramore R, Sembrat JC, Chen K, Rojas MM, Wenzel SE, Lafyatis R, Modena B, Weathington NM. ß-Agonist exposure preferentially impacts lung macrophage cyclic AMP-related gene expression in asthma and asthma COPD overlap syndrome. Am J Physiol Lung Cell Mol Physiol. 2021 11 01; 321(5):L837-L843. PMID: 34494468; PMCID: PMC8616616; DOI: 10.1152/ajplung.00260.2021;

Lescoat A, Roofeh D, Kuwana M, Lafyatis R, Allanore Y, Khanna D. Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies. Clin Rev Allergy Immunol. 2023 Jun; 64(3):239-261. PMID: 34468946; PMCID: PMC9034469; DOI: 10.1007/s12016-021-08891-0;

Cruz T, Jia M, Sembrat J, Tabib T, Agostino N, Bruno TC, Vignali D, Sanchez P, Lafyatis R, Mora AL, Benos P, Rojas M. Reduced Proportion and Activity of Natural Killer Cells in the Lung of Patients with Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 09 01; 204(5):608-610. PMID: 34077698; PMCID: PMC8491266; DOI: 10.1164/rccm.202012-4418LE;

Tabib T, Huang M, Morse N, Papazoglou A, Behera R, Jia M, Bulik M, Monier DE, Benos PV, Chen W, Domsic R, Lafyatis R. Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin. Nat Commun. 2021 07 19; 12(1):4384. PMID: 34282151; PMCID: PMC8289865; DOI: 10.1038/s41467-021-24607-6;

Ruffin AT, Cillo AR, Tabib T, Liu A, Onkar S, Kunning SR, Lampenfeld C, Atiya HI, Abecassis I, Kürten CHL, Qi Z, Soose R, Duvvuri U, Kim S, Oesterrich S, Lafyatis R, Coffman LG, Ferris RL, Vignali DAA, Bruno TC. B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma. Nat Commun. 2021 06 07; 12(1):3349. PMID: 34099645; PMCID: PMC8184766; DOI: 10.1038/s41467-021-23355-x;

Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. J Clin Invest. 2021 06 01; 131(11). PMID: 33905372; PMCID: PMC8159699; DOI: 10.1172/JCI136459;

Kong K, Koontz D, Morse C, Roth E, Domsic RT, Simon MA, Stratton E, Buchholz C, Tobin-Finch K, Simms R, George MP, Hassoun PM, Farber H, Lafyatis R. A Pilot Study of Dimethyl Fumarate in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis. J Scleroderma Relat Disord. 2021 Oct 01; 6(3):242-246.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 35005243; PMCID: PMC8741170; DOI: 10.1177/23971983211016196;

Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation. 2021 07 27; 144(4):286-302. PMID: 34030460; PMCID: PMC8300155; DOI: 10.1161/CIRCULATIONAHA.120.052318;

Gaydosik AM, Tabib T, Domsic R, Khanna D, Lafyatis R, Fuschiotti P. Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis. Ann Rheum Dis. 2021 11; 80(11):1453-1460. PMID: 34031030; PMCID: PMC8516708; DOI: 10.1136/annrheumdis-2021-220209;

Mirizio E, Tabib T, Wang X, Chen W, Liu C, Lafyatis R, Jacobe H, Torok KS. Correction to: Single-cell transcriptome conservation in a comparative analysis of fresh and cryopreserved human skin tissue: pilot in localized scleroderma. Arthritis Res Ther. 2021 Apr 06; 23(1):101. PMID: 33823906; PMCID: PMC8022423; DOI: 10.1186/s13075-021-02490-2;

Li X, Noell G, Tabib T, Gregory AD, Trejo Bittar HE, Vats R, Kaminski TW, Sembrat J, Snyder ME, Chandra D, Chen K, Zou C, Zhang Y, Sundd P, McDyer JF, Sciurba F, Rojas M, Lafyatis R, Shapiro SD, Faner R, Nyunoya T. Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD. Respir Res. 2021 Apr 06; 22(1):100. PMID: 33823868; PMCID: PMC8022543; DOI: 10.1186/s12931-021-01675-2;

Valenzi E, Tabib T, Papazoglou A, Sembrat J, Trejo Bittar HE, Rojas M, Lafyatis R. Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease. Front Immunol. 2021; 12:595811. PMID: 33859634; PMCID: PMC8042271; DOI: 10.3389/fimmu.2021.595811;

Mirizio E, Tabib T, Wang X, Chen W, Liu C, Lafyatis R, Jacobe H, Torok KS. Single-cell transcriptome conservation in a comparative analysis of fresh and cryopreserved human skin tissue: pilot in localized scleroderma. Arthritis Res Ther. 2020 11 09; 22(1):263. PMID: 33168063; PMCID: PMC7654179; DOI: 10.1186/s13075-020-02343-4;

Chung L, Spino C, McLain R, Johnson SR, Denton CP, Molitor JA, Steen VD, Lafyatis R, Simms RW, Kafaja S, Frech TM, Hsu V, Domsic RT, Pope JE, Gordon JK, Mayes MD, Sandorfi N, Hant FN, Bernstein EJ, Chatterjee S, Castelino FV, Ajam A, Allanore Y, Matucci-Cerinic M, Whitfield ML, Distler O, Singer O, Young A, Nagaraja V, Fox DA, Furst DE, Khanna D. Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial. Lancet Rheumatol. 2020 Dec; 2(12):e743-e753.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 34966900; PMCID: PMC8713509; DOI: 10.1016/s2665-9913(20)30237-x;

Chakraborty D, Zhu H, Jüngel A, Summa L, Li YN, Matei AE, Zhou X, Huang J, Trinh-Minh T, Chen CW, Lafyatis R, Dees C, Bergmann C, Soare A, Luo H, Ramming A, Schett G, Distler O, Distler JHW. Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis. Sci Transl Med. 2020 09 30; 12(563). PMID: 32998972

Pachera E, Assassi S, Salazar GA, Stellato M, Renoux F, Wunderlin A, Blyszczuk P, Lafyatis R, Kurreeman F, de Vries-Bouwstra J, Messemaker T, Feghali-Bostwick CA, Rogler G, van Haaften WT, Dijkstra G, Oakley F, Calcagni M, Schniering J, Maurer B, Distler JH, Kania G, Frank-Bertoncelj M, Distler O. Long noncoding RNA H19X is a key mediator of TGF-ß-driven fibrosis. J Clin Invest. 2020 09 01; 130(9):4888-4905. PMID: 32603313; PMCID: PMC7456219; DOI: 10.1172/JCI135439;

Spiera R, Hummers L, Chung L, Frech TM, Domsic R, Hsu V, Furst DE, Gordon J, Mayes M, Simms R, Lafyatis R, Martyanov V, Wood T, Whitfield ML, Constantine S, Lee E, Dgetluck N, White B. Safety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo-Controlled Trial in Adults With Systemic Sclerosis. Arthritis Rheumatol. 2020 08; 72(8):1350-1360.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 32336038; PMCID: PMC7497006; DOI: 10.1002/art.41294;

Li X, Kim SE, Chen TY, Wang J, Yang X, Tabib T, Tan J, Guo B, Fung S, Zhao J, Sembrat J, Rojas M, Shiva S, Lafyatis R, St Croix C, Alder JK, Di YP, Kass DJ, Zhang Y. Toll interacting protein protects bronchial epithelial cells from bleomycin-induced apoptosis. FASEB J. 2020 08; 34(8):9884-9898. PMID: 32596871; PMCID: PMC8175118; DOI: 10.1096/fj.201902636RR;

Bueno M, Papazoglou A, Valenzi E, Rojas M, Lafyatis R, Mora AL. Mitochondria, Aging, and Cellular Senescence: Implications for Scleroderma. Curr Rheumatol Rep. 2020 06 19; 22(8):37. PMID: 32562128; PMCID: PMC8008485; DOI: 10.1007/s11926-020-00920-9;

Maehara T, Kaneko N, Perugino CA, Mattoo H, Kers J, Allard-Chamard H, Mahajan VS, Liu H, Murphy SJ, Ghebremichael M, Fox D, Payne AS, Lafyatis R, Stone JH, Khanna D, Pillai S. Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis. J Clin Invest. 2020 05 01; 130(5):2451-2464. PMID: 31990684; PMCID: PMC7190971; DOI: 10.1172/JCI131700;

Lear TB, Lockwood KC, Larsen M, Tuncer F, Kennerdell JR, Morse C, Valenzi E, Tabib T, Jurczak MJ, Kass DJ, Evankovich JW, Finkel T, Lafyatis R, Liu Y, Chen BB. Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis. J Biol Chem. 2020 Mar 27; 295(13):4171-4180. PMID: 33506775

Saygin D, Tabib T, Bittar HET, Valenzi E, Sembrat J, Chan SY, Rojas M, Lafyatis R. Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension. Pulm Circ. 2020 Jan-Mar; 10(1). PMID: 32166015; PMCID: PMC7052475; DOI: 10.1177/2045894020908782;

Mallampalli RK, Li X, Jang JH, Kaminski T, Hoji A, Coon T, Chandra D, Welty S, Teng Y, Sembrat J, Rojas M, Zhao Y, Lafyatis R, Zou C, Sciurba F, Sundd P, Lan L, Nyunoya T. Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema. JCI Insight. 2020 01 30; 5(2). PMID: 31996486; PMCID: PMC7098723; DOI: 10.1172/jci.insight.125895;

Cillo AR, Kürten CHL, Tabib T, Qi Z, Onkar S, Wang T, Liu A, Duvvuri U, Kim S, Soose RJ, Oesterreich S, Chen W, Lafyatis R, Bruno TC, Ferris RL, Vignali DAA. Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer. Immunity. 2020 01 14; 52(1):183-199.e9. PMID: 31924475; PMCID: PMC7201194; DOI: 10.1016/j.immuni.2019.11.014;

Khanna D, Spino C, Johnson S, Chung L, Whitfield ML, Denton CP, Berrocal V, Franks J, Mehta B, Molitor J, Steen VD, Lafyatis R, Simms RW, Gill A, Kafaja S, Frech TM, Hsu V, Domsic RT, Pope JE, Gordon JK, Mayes MD, Schiopu E, Young A, Sandorfi N, Park J, Hant FN, Bernstein EJ, Chatterjee S, Castelino FV, Ajam A, Wang Y, Wood T, Allanore Y, Matucci-Cerinic M, Distler O, Singer O, Bush E, Fox DA, Furst DE. Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator-Initiated, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial. Arthritis Rheumatol. 2020 01; 72(1):125-136.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 31342624; PMCID: PMC6935399; DOI: 10.1002/art.41055;

Xue D, Tabib T, Morse C, Lafyatis R. Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors. J Dermatol Sci. 2020 Jan; 97(1):41-49. PMID: 31836271

Distler JHW, Györfi AH, Ramanujam M, Whitfield ML, Königshoff M, Lafyatis R. Shared and distinct mechanisms of fibrosis. Nat Rev Rheumatol. 2019 12; 15(12):705-730. PMID: 31712723

Lear TB, McKelvey AC, Evankovich JW, Rajbhandari S, Coon TA, Dunn SR, Londino JD, McVerry BJ, Zhang Y, Valenzi E, Burton CL, Gordon R, Gingras S, Lockwood KC, Jurczak MJ, Lafyatis R, Shlomchik MJ, Liu Y, Chen BB. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019 10 03; 4(19). PMID: 31578312; PMCID: PMC6795399; DOI: 10.1172/jci.insight.129110;

Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D. A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers. Arthritis Res Ther. 2019 09 03; 21(1):202. PMID: 31481106; PMCID: PMC6724329; DOI: 10.1186/s13075-019-1979-7;

Rivadeneira DB, DePeaux K, Wang Y, Kulkarni A, Tabib T, Menk AV, Sampath P, Lafyatis R, Ferris RL, Sarkar SN, Thorne SH, Delgoffe GM. Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance. Immunity. 2019 09 17; 51(3):548-560.e4. PMID: 31471106; PMCID: PMC6903394; DOI: 10.1016/j.immuni.2019.07.003;

Morse C, Tabib T, Sembrat J, Buschur KL, Bittar HT, Valenzi E, Jiang Y, Kass DJ, Gibson K, Chen W, Mora A, Benos PV, Rojas M, Lafyatis R. Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis. Eur Respir J. 2019 08; 54(2). PMID: 31221805; PMCID: PMC8025672; DOI: 10.1183/13993003.02441-2018;

Zhang Y, Jiang M, Nouraie M, Roth MG, Tabib T, Winters S, Chen X, Sembrat J, Chu Y, Cardenes N, Tuder RM, Herzog EL, Ryu C, Rojas M, Lafyatis R, Gibson KF, McDyer JF, Kass DJ, Alder JK. GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2019 10 01; 317(4):L510-L521. PMID: 31432710; PMCID: PMC6842909; DOI: 10.1152/ajplung.00062.2019;

Valenzi E, Bulik M, Tabib T, Morse C, Sembrat J, Trejo Bittar H, Rojas M, Lafyatis R. Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease. Ann Rheum Dis. 2019 10; 78(10):1379-1387. PMID: 31405848; PMCID: PMC7255436; DOI: 10.1136/annrheumdis-2018-214865;

Liu C, Chikina M, Deshpande R, Menk AV, Wang T, Tabib T, Brunazzi EA, Vignali KM, Sun M, Stolz DB, Lafyatis RA, Chen W, Delgoffe GM, Workman CJ, Wendell SG, Vignali DAA. Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-?. Immunity. 2019 08 20; 51(2):381-397.e6. PMID: 31350177; PMCID: PMC6703933; DOI: 10.1016/j.immuni.2019.06.017;

Gaydosik AM, Tabib T, Geskin LJ, Bayan CA, Conway JF, Lafyatis R, Fuschiotti P. Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors. Clin Cancer Res. 2019 07 15; 25(14):4443-4454. PMID: 31010835; PMCID: PMC6635080; DOI: 10.1158/1078-0432.CCR-19-0148;

Sun Z, Chen L, Xin H, Jiang Y, Huang Q, Cillo AR, Tabib T, Kolls JK, Bruno TC, Lafyatis R, Vignali DAA, Chen K, Ding Y, Hu M, Chen W. A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies. Nat Commun. 2019 04 09; 10(1):1649. PMID: 30967541; PMCID: PMC6456731; DOI: 10.1038/s41467-019-09639-3;

Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA. Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion. Nat Immunol. 2019 06; 20(6):724-735. PMID: 30936494; PMCID: PMC6531353; DOI: 10.1038/s41590-019-0346-9;

Barron AMS, Mantero JC, Ho JD, Nazari B, Horback KL, Bhawan J, Lafyatis R, Lam C, Browning JL. Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis. J Immunol. 2019 01 01; 202(1):56-68.View Related Profiles.

Barron, Alexander
Bhawan, Jag
Browning, Jeffrey
Lafyatis, Robert

PMID: 30510068; PMCID: PMC6305793; DOI: 10.4049/jimmunol.1801209;

Apostolidis SA, Stifano G, Tabib T, Rice LM, Morse CM, Kahaleh B, Lafyatis R. Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin. Front Immunol. 2018; 9:2191.View Related Profiles.

Rice, Lisa
Lafyatis, Robert

PMID: 30327649; PMCID: PMC6174292; DOI: 10.3389/fimmu.2018.02191;

Mantero JC, Kishore N, Ziemek J, Stifano G, Zammitti C, Khanna D, Gordon JK, Spiera R, Zhang Y, Simms RW, Lafyatis R. Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I/II biomarker trial. Clin Exp Rheumatol. 2018 Jul-Aug; 36 Suppl 113(4):146-149.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 30277862

Stifano G, Sornasse T, Rice LM, Na L, Chen-Harris H, Khanna D, Jahreis A, Zhang Y, Siegel J, Lafyatis R. Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis. Arthritis Rheumatol. 2018 06; 70(6):912-919.View Related Profiles.

Rice, Lisa
Lafyatis, Robert

PMID: 29858547; PMCID: PMC6731768; DOI: 10.1002/art.40455;

Denton CP, Ong VH, Xu S, Chen-Harris H, Modrusan Z, Lafyatis R, Khanna D, Jahreis A, Siegel J, Sornasse T. Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis. Ann Rheum Dis. 2018 09; 77(9):1362-1371. PMID: 29853453; PMCID: PMC6104680; DOI: 10.1136/annrheumdis-2018-213031;

Moll M, Christmann RB, Zhang Y, Whitfield ML, Wang YM, Rice L, Stratton E, Lafyatis R, Farber HW. Patients with systemic sclerosis-associated pulmonary arterial hypertension express a genomic signature distinct from patients with interstitial lung disease. J Scleroderma Relat Disord. 2018 Oct; 3(3):242-248.View Related Profiles.

Rice, Lisa
Lafyatis, Robert

PMID: 30498788; PMCID: PMC6258027; DOI: 10.1177/2397198318764780;

Fleury M, Belkina AC, Proctor EA, Zammitti C, Simms RW, Lauffenburger DA, Snyder-Cappione JE, Lafyatis R, Dooms H. Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis. Arthritis Rheumatol. 2018 04; 70(4):566-577.View Related Profiles.

Belkina, Anna
Dooms, Hans
Snyder-Cappione , Jennifer
Fleury, Michelle
Lafyatis, Robert
Simms, Robert

PMID: 29245183; PMCID: PMC5876093; DOI: 10.1002/art.40399;

Gorlova OY, Li Y, Gorlov I, Ying J, Chen WV, Assassi S, Reveille JD, Arnett FC, Zhou X, Bossini-Castillo L, Lopez-Isac E, Acosta-Herrera M, Gregersen PK, Lee AT, Steen VD, Fessler BJ, Khanna D, Schiopu E, Silver RM, Molitor JA, Furst DE, Kafaja S, Simms RW, Lafyatis RA, Carreira P, Simeon CP, Castellvi I, Beltran E, Ortego N, Amos CI, Martin J, Mayes MD. Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations. PLoS One. 2018; 13(1):e0189498.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 29293537; PMCID: PMC5749683; DOI: 10.1371/journal.pone.0189498;

Moll M, Christmann RB, Zhang Y, Whitfield ML, Wang YM, Rice LM, Stratton E, Lafyatis R, Farber HW. Patients with systemic sclerosis-associated pulmonary arterial hypertension express a genomic signature distinct from patients with interstitial lung disease. 2018. View Publication

Sun Z, Wang T, Deng K, Wang XF, Lafyatis R, Ding Y, Hu M, Chen W. DIMM-SC: a Dirichlet mixture model for clustering droplet-based single cell transcriptomic data. Bioinformatics. 2018 01 01; 34(1):139-146. PMID: 29036318; PMCID: PMC6454475; DOI: 10.1093/bioinformatics/btx490;

Tabib T, Morse C, Wang T, Chen W, Lafyatis R. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin. J Invest Dermatol. 2018 04; 138(4):802-810. PMID: 29080679; PMCID: PMC7444611; DOI: 10.1016/j.jid.2017.09.045;

Cascio S, Medsger TA, Hawse WF, Watkins SC, Milcarek C, Moreland LW, Lafyatis RA, Fuschiotti P. 14-3-3z sequesters cytosolic T-bet, upregulating IL-13 levels in TC2 and CD8+ lymphocytes from patients with scleroderma. J Allergy Clin Immunol. 2018 07; 142(1):109-119.e6. PMID: 29155097; PMCID: PMC5953767; DOI: 10.1016/j.jaci.2017.10.029;

Lafyatis R, Mantero JC, Gordon J, Kishore N, Carns M, Dittrich H, Spiera R, Simms RW, Varga J. Inhibition of ß-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82. J Invest Dermatol. 2017 Dec; 137(12):2473-2483.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 28807667; PMCID: PMC5701831; DOI: 10.1016/j.jid.2017.06.032;

Derrett-Smith EC, Martyanov V, Chighizola CB, Moinzadeh P, Campochiaro C, Khan K, Wood TA, Meroni PL, Abraham DJ, Ong VH, Lafyatis R, Whitfield ML, Denton CP. Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature. Arthritis Res Ther. 2017 Jul 04; 19(1):156. PMID: 28676069; PMCID: PMC5496265; DOI: 10.1186/s13075-017-1360-7;

Cao L, Lafyatis R, Burkly LC. Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs. PLoS One. 2017; 12(6):e0180751. PMID: 28662216; PMCID: PMC5491269; DOI: 10.1371/journal.pone.0180751;

Makino K, Makino T, Stawski L, Mantero JC, Lafyatis R, Simms R, Trojanowska M. Blockade of PDGF Receptors by Crenolanib Has Therapeutic Effect in Patient Fibroblasts and in Preclinical Models of Systemic Sclerosis. J Invest Dermatol. 2017 Aug; 137(8):1671-1681.View Related Profiles.

Stawski, Lukasz
Trojanowska, Maria
Lafyatis, Robert
Simms, Robert

PMID: 28433542; PMCID: PMC5560111; DOI: 10.1016/j.jid.2017.03.032;

Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML. A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis. Genome Med. 2017 Mar 23; 9(1):27.View Related Profiles.

Farber, Harrison
Lafyatis, Robert

PMID: 28330499; PMCID: PMC5363043; DOI: 10.1186/s13073-017-0417-1;

Man A, Correa JK, Ziemek J, Simms RW, Felson DT, Lafyatis R. Development and validation of a patient-reported outcome instrument for skin involvement in patients with systemic sclerosis. Ann Rheum Dis. 2017 Aug; 76(8):1374-1380.View Related Profiles.

Felson, David
Lafyatis, Robert
Simms, Robert

PMID: 28213563; DOI: 10.1136/annrheumdis-2016-210534;

Xiong Y, Berrueta L, Urso K, Olenich S, Muskaj I, Badger GJ, Aliprantis A, Lafyatis R, Langevin HM. Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis. Front Immunol. 2017; 8:124. PMID: 28261202; PMCID: PMC5311037; DOI: 10.3389/fimmu.2017.00124;

Li G, Larregina AT, Domsic RT, Stolz DB, Medsger TA, Lafyatis R, Fuschiotti P. Skin-Resident Effector Memory CD8+CD28- T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis. J Invest Dermatol. 2017 May; 137(5):1042-1050. PMID: 28012718; PMCID: PMC5433864; DOI: 10.1016/j.jid.2016.11.037;

Castelino FV, Bain G, Pace VA, Black KE, George L, Probst CK, Goulet L, Lafyatis R, Tager AM. An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. Arthritis Rheumatol. 2016 Dec; 68(12):2964-2974. PMID: 27390295; PMCID: PMC5125861; DOI: 10.1002/art.39797;

Lafyatis R. Editorial: Epigenetics in Systemic Sclerosis. Arthritis Rheumatol. 2016 12; 68(12):2841-2844. PMID: 27482953; DOI: 10.1002/art.39830;

Goswami R, Cohen J, Sharma S, Zhang DX, Lafyatis R, Bhawan J, Rahaman SO. TRPV4 ION Channel Is Associated with Scleroderma. J Invest Dermatol. 2017 04; 137(4):962-965.View Related Profiles.

Bhawan, Jag
Lafyatis, Robert

PMID: 27889423; DOI: 10.1016/j.jid.2016.10.045;

Gardet A, Chou WC, Reynolds TL, Velez DB, Fu K, Czerkowicz JM, Bajko J, Ranger AM, Allaire N, Kerns HM, Ryan S, Legault HM, Dunstan RW, Lafyatis R, Lukashev M, Viney JL, Browning JL, Rabah D. Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis. PLoS One. 2016; 11(10):e0164423.View Related Profiles.

Browning, Jeffrey
Lafyatis, Robert

PMID: 27760209; PMCID: PMC5070861; DOI: 10.1371/journal.pone.0164423;

Chia JJ, Zhu T, Chyou S, Dasoveanu DC, Carballo C, Tian S, Magro CM, Rodeo S, Spiera RF, Ruddle NH, McGraw TE, Browning JL, Lafyatis R, Gordon JK, Lu TT. Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis. J Clin Invest. 2016 Nov 01; 126(11):4331-4345.View Related Profiles.

Browning, Jeffrey
Lafyatis, Robert

PMID: 27721238; PMCID: PMC5096920; DOI: 10.1172/JCI85740;

Rice LM, Mantero JC, Stifano G, Ziemek J, Simms RW, Gordon J, Domsic R, Lafyatis R. A Proteome-Derived Longitudinal Pharmacodynamic Biomarker for Diffuse Systemic Sclerosis Skin. J Invest Dermatol. 2017 Jan; 137(1):62-70.View Related Profiles.

Stifano, Giuseppina
Rice, Lisa
Lafyatis, Robert
Simms, Robert

PMID: 27640094; DOI: 10.1016/j.jid.2016.08.027;

Nazari B, Rice LM, Stifano G, Barron AM, Wang YM, Korndorf T, Lee J, Bhawan J, Lafyatis R, Browning JL. Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90. Am J Pathol. 2016 Oct; 186(10):2650-64.View Related Profiles.

Barron, Alexander
Stifano, Giuseppina
Bhawan, Jag
Browning, Jeffrey
Rice, Lisa
Lafyatis, Robert
Wang, Yu

PMID: 27565038; PMCID: PMC5222985; DOI: 10.1016/j.ajpath.2016.06.020;

Urso K, Alvarez D, Cremasco V, Tsang K, Grauel A, Lafyatis R, von Andrian UH, Ermann J, Aliprantis AO. IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease. JCI Insight. 2016 Aug 04; 1(12). PMID: 27547823; PMCID: PMC4988402; DOI: 10.1172/jci.insight.88057;

Sargent JL, Li Z, Aliprantis AO, Greenblatt M, Lemaire R, Wu MH, Wei J, Taroni J, Harris A, Long KB, Burgwin C, Artlett CM, Blankenhorn EP, Lafyatis R, Varga J, Clark SH, Whitfield ML. Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics. Arthritis Rheumatol. 2016 Aug; 68(8):2003-15. PMID: 26945694; PMCID: PMC5695038; DOI: 10.1002/art.39658;

Christmann RB, Wooten A, Sampaio-Barros P, Borges CL, Carvalho CR, Kairalla RA, Feghali-Bostwick C, Ziemek J, Mei Y, Goummih S, Tan J, Alvarez D, Kass DJ, Rojas M, de Mattos TL, Parra E, Stifano G, Capelozzi VL, Simms RW, Lafyatis R. miR-155 in the progression of lung fibrosis in systemic sclerosis. Arthritis Res Ther. 2016 Jul 05; 18(1):155.View Related Profiles.

Wooten, Alicia
Stifano, Giuseppina
Lafyatis, Robert
Simms, Robert

PMID: 27377409; PMCID: PMC4932708; DOI: 10.1186/s13075-016-1054-6;

Bhattacharyya S, Wang W, Morales-Nebreda L, Feng G, Wu M, Zhou X, Lafyatis R, Lee J, Hinchcliff M, Feghali-Bostwick C, Lakota K, Budinger GR, Raparia K, Tamaki Z, Varga J. Tenascin-C drives persistence of organ fibrosis. Nat Commun. 2016 06 03; 7:11703. PMID: 27256716; PMCID: PMC4895803; DOI: 10.1038/ncomms11703;

Khanna D, Denton CP, Jahreis A, van Laar JM, Frech TM, Anderson ME, Baron M, Chung L, Fierlbeck G, Lakshminarayanan S, Allanore Y, Pope JE, Riemekasten G, Steen V, Müller-Ladner U, Lafyatis R, Stifano G, Spotswood H, Chen-Harris H, Dziadek S, Morimoto A, Sornasse T, Siegel J, Furst DE. Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial. Lancet. 2016 Jun 25; 387(10038):2630-40.View Related Profiles.

Stifano, Giuseppina
Lafyatis, Robert

PMID: 27156934; DOI: 10.1016/S0140-6736(16)00232-4;

Ziemek J, Man A, Hinchcliff M, Varga J, Simms RW, Lafyatis R. The relationship between skin symptoms and the scleroderma modification of the health assessment questionnaire, the modified Rodnan skin score, and skin pathology in patients with systemic sclerosis. Rheumatology (Oxford). 2016 May; 55(5):911-7.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 26880832; PMCID: PMC5854039; DOI: 10.1093/rheumatology/kew003;

Lemaire R, Burwell T, Sun H, Delaney T, Bakken J, Cheng L, Rebelatto MC, Czapiga M, de-Mendez I, Coyle AJ, Herbst R, Lafyatis R, Connor J. Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1. Arthritis Rheumatol. 2016 Feb; 68(2):473-83. PMID: 26414805; DOI: 10.1002/art.39443;

Johnson ME, Grassetti AV, Taroni JN, Lyons SM, Schweppe D, Gordon JK, Spiera RF, Lafyatis R, Anderson PJ, Gerber SA, Whitfield ML. Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis. Arthritis Res Ther. 2016 Jan 22; 18:27.View Related Profiles.

Lafyatis, Robert
Lyons, Shawn

PMID: 26801089; PMCID: PMC4724133; DOI: 10.1186/s13075-016-0914-4;

Furst D, Pope JE, Seibold JR, Bombardieri CP, Distler O, Kahaleh B, Kennedy AT, Khanna D, Lafyatis R, Tyndall AD, Matucci-Cerinic M. Progress and Priorities in Systemic Sclerosis: The Next 10 Years – Report from the World Scleroderma Foundation. 2016. View Publication

Lenna S, Assassi S, Farina GA, Mantero JC, Scorza R, Lafyatis R, Farber HW, Trojanowska M. The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients. Arthritis Res Ther. 2015; 17:363.View Related Profiles.

Farina, Giuseppina
Farber, Harrison
Trojanowska, Maria
Lafyatis, Robert

PMID: 26669670; PMCID: PMC4704539; DOI: 10.1186/s13075-015-0881-1;

Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57.View Related Profiles.

Watkins, Amanda
Menn-Josephy, Hanni
Rifkin, Ian
Yasuda, Kei
Rice, Lisa
Monach, Paul
Bonegio, Ramon
Lafyatis, Robert
Aprahamian, Tamar

PMID: 26315890; PMCID: PMC4661118; DOI: 10.1002/art.39321;

Rice LM, Ziemek J, Stratton EA, McLaughlin SR, Padilla CM, Mathes AL, Christmann RB, Stifano G, Browning JL, Whitfield ML, Spiera RF, Gordon JK, Simms RW, Zhang Y, Lafyatis R. A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheumatol. 2015 Nov; 67(11):3004-15.View Related Profiles.

Stifano, Giuseppina
Browning, Jeffrey
Rice, Lisa
Lafyatis, Robert
Simms, Robert
Zhang, Yuqing

PMID: 26240058; PMCID: PMC5522178; DOI: 10.1002/art.39287;

Rice LM, Stifano G, Ziemek J, Lafyatis R. Local skin gene expression reflects both local and systemic skin disease in patients with systemic sclerosis. Rheumatology (Oxford). 2016 Feb; 55(2):377-9.View Related Profiles.

Stifano, Giuseppina
Rice, Lisa
Lafyatis, Robert

PMID: 26342226; PMCID: PMC4939726; DOI: 10.1093/rheumatology/kev335;

Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest. 2015 Jul 1; 125(7):2795-807.View Related Profiles.

Farina, Giuseppina
Weinberg, Janice
Rice, Lisa
York, Michael
Lafyatis, Robert
Simms, Robert
Nakerakanti, Sashidhar

PMID: 26098215; PMCID: PMC4563675; DOI: 10.1172/JCI77958;

Shiwen X, Stratton R, Nikitorowicz-Buniak J, Ahmed-Abdi B, Ponticos M, Denton C, Abraham D, Takahashi A, Suki B, Layne MD, Lafyatis R, Smith BD. A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. PLoS One. 2015; 10(5):e0126015.View Related Profiles.

Smith, Barbara
Suki, Bela
Layne, Matthew
Lafyatis, Robert

PMID: 25955164; PMCID: PMC4425676; DOI: 10.1371/journal.pone.0126015;

Mathes AL, Rice L, Affandi AJ, DiMarzio M, Rifkin IR, Stifano G, Christmann RB, Lafyatis R. CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin. Exp Dermatol. 2015 Feb; 24(2):133-9.View Related Profiles.

Stifano, Giuseppina
Rifkin, Ian
Rice, Lisa
Lafyatis, Robert

PMID: 25425469; PMCID: PMC4474603; DOI: 10.1111/exd.12603;

Hamburg-Shields E, DiNuoscio GJ, Mullin NK, Lafyatis R, Atit RP. Sustained ß-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes. J Pathol. 2015 Apr; 235(5):686-97. PMID: 25385294; PMCID: PMC4357547; DOI: 10.1002/path.4481;

Belkina AC, Fleury M, Vazques Mateo C, Raval F, Lafyatis R, Dooms H, Snyder-Cappione JE. CYTO 2015 International Society for Advancement of Cytometry Annual Meeting. Automated Analysis of 16-Color Polychromatic Flow Cytometry Data Maps Immune Cell Populations and Reveals a Distinct Inhibitory Receptor Signature in Systemic Sclerosis. 2015.

Lafyatis R. Transforming growth factor ß--at the centre of systemic sclerosis. Nat Rev Rheumatol. 2014 Dec; 10(12):706-19. PMID: 25136781; DOI: 10.1038/nrrheum.2014.137;

Stifano G, Affandi AJ, Mathes AL, Rice LM, Nakerakanti S, Nazari B, Lee J, Christmann RB, Lafyatis R. Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis. Arthritis Res Ther. 2014; 16(4):R136.View Related Profiles.

Stifano, Giuseppina
Rice, Lisa
Lafyatis, Robert
Nakerakanti, Sashidhar

PMID: 24984848; PMCID: PMC4227089; DOI: 10.1186/ar4598;

Wu M, Pedroza M, Lafyatis R, George AT, Mayes MD, Assassi S, Tan FK, Brenner MB, Agarwal SK. Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis. Arthritis Rheumatol. 2014 Apr; 66(4):1010-21. PMID: 24757152; PMCID: PMC4154539; DOI: 10.1002/art.38275;

Arron ST, Dimon MT, Li Z, Johnson ME, A Wood T, Feeney L, G Angeles J, Lafyatis R, Whitfield ML. High Rhodotorula sequences in skin transcriptome of patients with diffuse systemic sclerosis. J Invest Dermatol. 2014 Aug; 134(8):2138-45. PMID: 24608988; PMCID: PMC4102619; DOI: 10.1038/jid.2014.127;

Christmann RB, Sampaio-Barros P, Stifano G, Borges CL, de Carvalho CR, Kairalla R, Parra ER, Spira A, Simms R, Capellozzi VL, Lafyatis R. Association of Interferon- and transforming growth factor ß-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis. Arthritis Rheumatol. 2014 Mar; 66(3):714-25.View Related Profiles.

Spira, Avrum
Stifano, Giuseppina
Lafyatis, Robert
Simms, Robert
Christmann de Souza, Romy

PMID: 24574232; PMCID: PMC4439004; DOI: 10.1002/art.38288;

Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X, Chen WV, Assassi S, Ying J, Tan FK, Arnett FC, Reveille JD, Guerra S, Teruel M, Carmona FD, Gregersen PK, Lee AT, López-Isac E, Ochoa E, Carreira P, Simeón CP, Castellví I, González-Gay MÁ, Zhernakova A, Padyukov L, Alarcón-Riquelme M, Wijmenga C, Brown M, Beretta L, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, Schuerwegh AJ, Hesselstrand R, Nordin A, Airó P, Lunardi C, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Wigley FM, Hummers LK, Varga J, Hinchcliff ME, Baron M, Hudson M, Pope JE, Furst DE, Khanna D, Phillips K, Schiopu E, Segal BM, Molitor JA, Silver RM, Steen VD, Simms RW, Lafyatis RA, Fessler BJ, Frech TM, Alkassab F, Docherty P, Kaminska E, Khalidi N, Jones HN, Markland J, Robinson D, Broen J, Radstake TR, Fonseca C, Koeleman BP, Martin J. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am J Hum Genet. 2014 Jan 2; 94(1):47-61.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 24387989; PMCID: PMC3882906; DOI: 10.1016/j.ajhg.2013.12.002;

Broen J, Mcglynn LM, van Bon L, Lafyatis R, Radstake TRD, Shiels PG. Clinical Phenotypes of Systemic Sclerosis Impact Telomere and Telosome Function in Distinct Patterns. Annals of the Rheumatic Diseases. 2014; 72(suppl 3):A183. View Publication
Varga J, Lafyatis R. Etiology and pathogenesis of systemic sclerosis. 2014. View Publication
Castelino FV, George LM, Bain G, Goulet L, Lafyatis R, Tager AM. OP0241 Autotaxin is Over-Expressed in Systemic Sclerosis (SSC) Skin, Mediates Bleomycin-Induced Dermal Fibrosis via IL-6, and is A Target for SSC Therapy. Annals of the Rheumatic Diseases. 2014; 73(suppl 2):153. View Publication

van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014 Jan 30; 370(5):433-43.View Related Profiles.

Farina, Giuseppina
Stifano, Giuseppina
Stawski, Lukasz
Trojanowska, Maria
York, Michael
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 24350901; PMCID: PMC4040466; DOI: 10.1056/NEJMoa1114576;

Vacca A, Meune C, Gordon J, Chung L, Proudman S, Assassi S, Nikpour M, Rodriguez-Reyna TS, Khanna D, Lafyatis R, Matucci-Cerinic M, Distler O, Allanore Y. Cardiac arrhythmias and conduction defects in systemic sclerosis. Rheumatology (Oxford). 2014 Jul; 53(7):1172-7. PMID: 24241036; PMCID: PMC4065005; DOI: 10.1093/rheumatology/ket377;

Farina A, Cirone M, York M, Lenna S, Padilla C, McLaughlin S, Faggioni A, Lafyatis R, Trojanowska M, Farina GA. Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma. J Invest Dermatol. 2014 Apr; 134(4):954-64.View Related Profiles.

Farina, Giuseppina
Trojanowska, Maria
York, Michael
Lafyatis, Robert
Lenna, Stefania

PMID: 24129067; PMCID: PMC3961515; DOI: 10.1038/jid.2013.423;

Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R. Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin. Ann Rheum Dis. 2014 Oct; 73(10):1864-72.View Related Profiles.

Farina, Giuseppina
Stifano, Giuseppina
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 23873879; PMCID: PMC4076390; DOI: 10.1136/annrheumdis-2012-202814;

Lenna S, Farina AG, Martyanov V, Christmann RB, Wood TA, Farber HW, Scorza R, Whitfield ML, Lafyatis R, Trojanowska M. Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum. 2013 May; 65(5):1357-66.View Related Profiles.

Farber, Harrison
Trojanowska, Maria
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 23400395; PMCID: PMC3636187; DOI: 10.1002/art.37891;

Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R. Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor ß. Arthritis Rheum. 2013 May; 65(5):1335-46.View Related Profiles.

Bujor, Andreea
Stifano, Giuseppina
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 23335246; PMCID: PMC4437575; DOI: 10.1002/art.37859;

Hinchcliff M, Huang CC, Wood TA, Matthew Mahoney J, Martyanov V, Bhattacharyya S, Tamaki Z, Lee J, Carns M, Podlusky S, Sirajuddin A, Shah SJ, Chang RW, Lafyatis R, Varga J, Whitfield ML. Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis. J Invest Dermatol. 2013 Aug; 133(8):1979-89. PMID: 23677167; PMCID: PMC3714324; DOI: 10.1038/jid.2013.130;

Lenna S, Chrobak I, Farina GA, Rodriguez-Pascual F, Lamas S, Lafyatis R, Scorza R, Trojanowska M. HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One. 2013; 8(2):e56123.View Related Profiles.

Farina, Giuseppina
Chrobak, Izabela
Trojanowska, Maria
Lafyatis, Robert

PMID: 23441162; PMCID: PMC3575387; DOI: 10.1371/journal.pone.0056123;

Ghosh AK, Bhattacharyya S, Lafyatis R, Farina G, Yu J, Thimmapaya B, Wei J, Varga J. p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-ß: epigenetic feed-forward amplification of fibrosis. J Invest Dermatol. 2013 May; 133(5):1302-10.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 23303459; PMCID: PMC3626729; DOI: 10.1038/jid.2012.479;

Lafyatis R, Liu Z, Yao Y. Type I interferons in systemic sclerosis. 2013.

Bhattacharyya S, Kelley K, Melichian DS, Tamaki Z, Fang F, Su Y, Feng G, Pope RM, Budinger GR, Mutlu GM, Lafyatis R, Radstake T, Feghali-Bostwick C, Varga J. Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol. 2013 Jan; 182(1):192-205. PMID: 23141927; PMCID: PMC3538029; DOI: 10.1016/j.ajpath.2012.09.007;

Bujor AM, Haines P, Padilla C, Christmann RB, Junie M, Sampaio-Barros PD, Lafyatis R, Trojanowska M. Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1. Int J Mol Med. 2012 Dec; 30(6):1473-80.View Related Profiles.

Bujor, Andreea
Trojanowska, Maria
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 23041765; PMCID: PMC4035782; DOI: 10.3892/ijmm.2012.1150;

Haines P, Hant FN, Lafyatis R, Trojanowska M, Bujor AM. Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation. J Cell Mol Med. 2012 Sep; 16(9):2238-46.View Related Profiles.

Bujor, Andreea
Trojanowska, Maria
Lafyatis, Robert

PMID: 22277251; PMCID: PMC3822993; DOI: 10.1111/j.1582-4934.2012.01537.x;

Lafyatis R. Connective tissue disease: SSc-fibrosis takes flight with Wingless inhibition. Nat Rev Rheumatol. 2012 Aug; 8(8):441-2. PMID: 22751566; PMCID: PMC3792167; DOI: 10.1038/nrrheum.2012.99;

Samuel GH, Lenna S, Bujor AM, Lafyatis R, Trojanowska M. Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis. J Dermatol Sci. 2012 Sep; 67(3):166-72.View Related Profiles.

Bujor, Andreea
Trojanowska, Maria
Lafyatis, Robert
Lenna, Stefania

PMID: 22771321; PMCID: PMC3423203; DOI: 10.1016/j.jdermsci.2012.06.001;

Lafyatis R, Farina A. New insights into the mechanisms of innate immune receptor signalling in fibrosis. Open Rheumatol J. 2012; 6:72-9. PMID: 22802904; PMCID: PMC3396286; DOI: 10.2174/1874312901206010072;

Pendergrass SA, Lemaire R, Francis IP, Mahoney JM, Lafyatis R, Whitfield ML. Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies. J Invest Dermatol. 2012 May; 132(5):1363-73.View Related Profiles.

Francis, Ian
Lafyatis, Robert

PMID: 22318389; PMCID: PMC3326181; DOI: 10.1038/jid.2011.472;

Lafyatis R. Application of biomarkers to clinical trials in systemic sclerosis. Curr Rheumatol Rep. 2012 Feb; 14(1):47-55. PMID: 22052444; PMCID: PMC3261634; DOI: 10.1007/s11926-011-0216-4;

Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO. Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol. 2012 Mar; 180(3):1080-94.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 22245215; PMCID: PMC3349888; DOI: 10.1016/j.ajpath.2011.11.024;

Dimarzio M, Farina G, Lafyatis R. Modeling innate immunity in murine skin: utilization of subcutaneous osmotic pumps for inflammatory and fibrotic skin disease. Methods Mol Biol. 2012; 900:317-26.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 22933076; DOI: 10.1007/978-1-60761-720-4_15;

Christmann RB, Hayes E, Pendergrass S, Padilla C, Farina G, Affandi AJ, Whitfield ML, Farber HW, Lafyatis R. Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum. 2011 Jun; 63(6):1718-28.View Related Profiles.

Farina, Giuseppina
Farber, Harrison
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 21425123; PMCID: PMC4030759; DOI: 10.1002/art.30318;

Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum. 2011 Jun; 63(6):1707-17. PMID: 21370225; PMCID: PMC3124699; DOI: 10.1002/art.30312;

Bujor AM, Asano Y, Haines P, Lafyatis R, Trojanowska M. The c-Abl tyrosine kinase controls protein kinase Cd-induced Fli-1 phosphorylation in human dermal fibroblasts. Arthritis Rheum. 2011 Jun; 63(6):1729-37.View Related Profiles.

Bujor, Andreea
Trojanowska, Maria
Lafyatis, Robert

PMID: 21321929; PMCID: PMC3381734; DOI: 10.1002/art.30284;

Walker KM, Pope J. Expert agreement on EULAR/EUSTAR recommendations for the management of systemic sclerosis. J Rheumatol. 2011 Jul; 38(7):1326-8. PMID: 21459952; DOI: 10.3899/jrheum.101262;

Mathes AL, Lafyatis R. Role for Toll-like receptor 3 in muscle regeneration after cardiotoxin injury. Muscle Nerve. 2011 May; 43(5):733-40. PMID: 21462209; DOI: 10.1002/mus.21959;

Farina G, York M, Collins C, Lafyatis R. dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts. Ann Rheum Dis. 2011 Mar; 70(3):544-50.View Related Profiles.

Farina, Giuseppina
York, Michael
Lafyatis, Robert

PMID: 21068089; PMCID: PMC3086552; DOI: 10.1136/ard.2010.132464;

Christmann RB, Lafyatis R. The cytokine language of monocytes and macrophages in systemic sclerosis. Arthritis Res Ther. 2010; 12(5):146.View Related Profiles.

Lafyatis, Robert
Christmann de Souza, Romy

PMID: 21067557; PMCID: PMC2991032; DOI: 10.1186/ar3167;

Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells. 2010 Oct; 28(10):1728-40.View Related Profiles.

Somers, Aba
Sommer, Cesar
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo
Jean, Jyh-Chang
Lafyatis, Robert

PMID: 20715179; PMCID: PMC3422663; DOI: 10.1002/stem.495;

Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R. Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PLoS One. 2010; 5(8):e12106.View Related Profiles.

Farina, Giuseppina
Farber, Harrison
Lafyatis, Robert

PMID: 20808962; PMCID: PMC2923145; DOI: 10.1371/journal.pone.0012106;

Broen JC, Wolvers-Tettero IL, Geurts-van Bon L, Vonk MC, Coenen MJ, Lafyatis R, Radstake TR, Langerak AW. Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis. Ann Rheum Dis. 2010 Dec; 69(12):2213-6. PMID: 20699236; DOI: 10.1136/ard.2010.129999;

Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R. Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010 Nov; 130(11):2583-93.View Related Profiles.

Marshak-Rothstein, Ann
Farina, Giuseppina
Rifkin, Ian
York, Michael
Lafyatis, Robert

PMID: 20613770; PMCID: PMC3086558; DOI: 10.1038/jid.2010.200;

Farber HW, Simms RW, Lafyatis R. Care of patients with scleroderma in the intensive care setting. J Intensive Care Med. 2010 Sep; 25(5):247-58.View Related Profiles.

Farber, Harrison
Lafyatis, Robert
Simms, Robert

PMID: 20542965; DOI: 10.1177/0885066610371181;

van Bon L, Popa C, Huijbens R, Vonk M, York M, Simms R, Hesselstrand R, Wuttge DM, Lafyatis R, Radstake TR. Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2010 Aug; 69(8):1539-47.View Related Profiles.

York, Michael
Lafyatis, Robert
Simms, Robert

PMID: 20498209; DOI: 10.1136/ard.2009.128207;

Lemaire R, Farina G, Bayle J, Dimarzio M, Pendergrass SA, Milano A, Perbal B, Whitfield ML, Lafyatis R. Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J Invest Dermatol. 2010 Jun; 130(6):1514-23.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 20182440; PMCID: PMC3071475; DOI: 10.1038/jid.2010.15;

Farina G, Lafyatis D, Lemaire R, Lafyatis R. A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2010 Feb; 62(2):580-8.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 20112379; PMCID: PMC3018285; DOI: 10.1002/art.27220;

Hinchciff M, Lafyatis R, Varga J, Huang CC, Whitfield M. Microarray analyses of systemic sclerosis skin biopsies to identify gene expression biomarkers. Journal of Women's Health. 2010; 19(10):1785.
Bujor AM, Haines P, Lafyatis R, Trojanowska M. Caveolin-1 overexpression in a subset of SSc dermal fibroblasts promotes TGF beta/Smad1 signaling and contributes to MMPI down-regulation. Clinical and experimental rheumatology. 2010; 28(5):S60.
Buhaescu I, Lafyatis R, Trojanowska M, Bujor AM. The role of PTEN down-regulation on PPM1A expression in scleroderma fibroblasts. Clinical and experimental rheumatology. 2010; 28(5):S60.
Aliprantis AO, Greenblatt MB, Sargent J, Lafyatis R, Lemaire R, Whitfield M, Glimcher LH. INTERLEUKIN 13: A COMMON PATHOGENIC CYTOKINE IN MOUSE MODELS OF SCLERODERMA. Clinical and experimental rheumatology. 2010; 28(2):S81.

Simms RW, Lafyatis R. Rituximab: a potential therapeutic advance in scleroderma: what is the evidence? Rheumatology (Oxford). 2010 Feb; 49(2):201-2.View Related Profiles.

Lafyatis, Robert
Simms, Robert

PMID: 20032221; DOI: 10.1093/rheumatology/kep421;

Lafyatis R, York M. Innate immunity and inflammation in systemic sclerosis. Curr Opin Rheumatol. 2009 Nov; 21(6):617-22.View Related Profiles.

York, Michael
Lafyatis, Robert

PMID: 19633559; PMCID: PMC2848972; DOI: 10.1097/BOR.0b013e32832fd69e;

Radstake TR, van Bon L, Broen J, Wenink M, Santegoets K, Deng Y, Hussaini A, Simms R, Cruikshank WW, Lafyatis R. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One. 2009; 4(6):e5981.View Related Profiles.

Lafyatis, Robert
Simms, Robert
Cruikshank, William

PMID: 19543397; PMCID: PMC2695559; DOI: 10.1371/journal.pone.0005981;

Radstake TR, van Bon L, Broen J, Hussiani A, Hesselstrand R, Wuttge DM, Deng Y, Simms R, Lubberts E, Lafyatis R. The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One. 2009; 4(6):e5903. PMID: 19536281; PMCID: PMC2691991; DOI: 10.1371/journal.pone.0005903;

Lafyatis R, Kissin E, York M, Farina G, Viger K, Fritzler MJ, Merkel PA, Simms RW. B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2009 Feb; 60(2):578-83.View Related Profiles.

Kissin, Eugene
Farina, Giuseppina
York, Michael
Merkel, Peter
Lafyatis, Robert
Simms, Robert
Amar, Salomon

PMID: 19180481; PMCID: PMC2637937; DOI: 10.1002/art.24249;

Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol. 2009 Jan 15; 182(2):820-8.View Related Profiles.

Watkins, Amanda
Rifkin, Ian
van Seventer, Jean
Yasuda, Kei
Lafyatis, Robert

PMID: 19124725; PMCID: PMC2858919; DOI: 10.4049/jimmunol.182.2.820;

Van Bon L, Popa C, Hujibens R, Vonk MC, York M, Simms R, Hesselstrand R, Wuttge DM, Lafyatis R, Radstake TRD. Distinct Temporal Evolution of TLR-mediated Dendritic Cell Cytokine Secretion in Patients with Limitied and Diffuse Cutaneous Systemic Sclerosis. Clinical Immunology. 2009; 131:S153-S154. View Publication

van Lieshout AW, Vonk MC, Bredie SJ, Joosten LB, Netea MG, van Riel PL, Lafyatis R, van den Hoogen FH, Radstake TR. Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion. Scand J Rheumatol. 2009; 38(4):282-90. PMID: 19255934; DOI: 10.1080/03009740802572467;

Radstake TR, Vonk MC, Dekkers M, Schijvenaars MM, Treppichio WL, Lafyatis R, Riemekasten G, van den Hoogen F, Coenen MJ. The -2518A>G promoter polymorphism in the CCL2 gene is not associated with systemic sclerosis susceptibility or phenotype: results from a multicenter study of European Caucasian patients. Hum Immunol. 2009 Feb; 70(2):130-3. PMID: 19032966; DOI: 10.1016/j.humimm.2008.10.012;

Farina G, Lemaire R, Pancari P, Bayle J, Widom RL, Lafyatis R. Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor beta. Ann Rheum Dis. 2009 Mar; 68(3):435-41.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 18408251; DOI: 10.1136/ard.2007.086850;

Fleming JN, Nash RA, McLeod DO, Fiorentino DF, Shulman HM, Connolly MK, Molitor JA, Henstorf G, Lafyatis R, Pritchard DK, Adams LD, Furst DE, Schwartz SM. Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS One. 2008; 3(1):e1452. PMID: 18197262; PMCID: PMC2175530; DOI: 10.1371/journal.pone.0001452;

Fleming J, Nash RA, McLeod DO, Shulman HM, Connolly K, Molitor JA, Henstorf G, Lafyatis R, Pritchard D, Adams L, Furst D, Schwartz SM. Erratum. PLoSONE. 2008; 3(8). View Publication

Bayle J, Fitch J, Jacobsen K, Kumar R, Lafyatis R, Lemaire R. Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol. 2008 Apr; 128(4):871-81. PMID: 17943183

Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, Violette SM. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med. 2008 Jan 1; 177(1):56-65.View Related Profiles.

O'Hara, Carl
Lafyatis, Robert

PMID: 17916809

Lafyatis R, O'Hara C, Feghali-Bostwick CA, Matteson E. B cell infiltration in systemic sclerosis-associated interstitial lung disease. Arthritis Rheum. 2007 Sep; 56(9):3167-8.View Related Profiles.

O'Hara, Carl
Lafyatis, Robert

PMID: 17763433

Mangini AJ, Lafyatis R, Van Seventer JM. Type I interferons inhibition of inflammatory T helper cell responses in systemic lupus erythematosus. Ann N Y Acad Sci. 2007 Jun; 1108:11-23.View Related Profiles.

van Seventer, Jean
Lafyatis, Robert

PMID: 17893966

York MR, Nagai T, Mangini AJ, Lemaire R, van Seventer JM, Lafyatis R. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum. 2007 Mar; 56(3):1010-20.View Related Profiles.

van Seventer, Jean
York, Michael
Lafyatis, Robert

PMID: 17328080

Aliprantis AO, Wang J, Fathman JW, Lemaire R, Dorfman DM, Lafyatis R, Glimcher LH. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2827-30. PMID: 17307869; PMCID: PMC1815266; DOI: 10.1073/pnas.0700021104;

Krieg T, Abraham D, Lafyatis R. Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions. Arthritis Res Ther. 2007; 9 Suppl 2:S4. PMID: 17767742; PMCID: PMC2072888; DOI: 10.1186/ar2188;

Lafyatis R, Marshak-Rothstein A. Toll-like receptors and innate immune responses in systemic lupus erythematosus. Arthritis Res Ther. 2007; 9(6):222.View Related Profiles.

Marshak-Rothstein, Ann
Lafyatis, Robert

PMID: 18086320; PMCID: PMC2246252; DOI: 10.1186/ar2321;

Lafyatis R. Targeting fibrosis in systemic sclerosis. Endocr Metab Immune Disord Drug Targets. 2006 Dec; 6(4):395-400. PMID: 17214585

Lemaire R, Bayle J, Mecham RP, Lafyatis R. Microfibril-associated MAGP-2 stimulates elastic fiber assembly. J Biol Chem. 2007 Jan 5; 282(1):800-8. PMID: 17099216

Kissin EY, Merkel PA, Lafyatis R. Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis. Arthritis Rheum. 2006 Nov; 54(11):3655-60.View Related Profiles.

Kissin, Eugene
Merkel, Peter
Lafyatis, Robert

PMID: 17075814

Lemaire R, Bayle J, Lafyatis R. Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis. Curr Opin Rheumatol. 2006 Nov; 18(6):582-7. PMID: 17053502

Behera AK, Hildebrand E, Szafranski J, Hung HH, Grodzinsky AJ, Lafyatis R, Koch AE, Kalish R, Perides G, Steere AC, Hu LT. Role of aggrecanase 1 in Lyme arthritis. Arthritis Rheum. 2006 Oct; 54(10):3319-29. PMID: 17009305

Lafyatis R, York M, Marshak-Rothstein A. Antimalarial agents: closing the gate on Toll-like receptors? Arthritis Rheum. 2006 Oct; 54(10):3068-70.View Related Profiles.

Marshak-Rothstein, Ann
York, Michael
Lafyatis, Robert

PMID: 17009223

Bayle J, Lemaire R, Lafyatis R. Potential role of SFRP4 in Tsk mice and scleroderma skin fibrosis. Matrix Biology. 2006; 25. View Publication

Lemaire R, Korn JH, Shipley JM, Lafyatis R. Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma. Arthritis Rheum. 2005 Jun; 52(6):1812-23. PMID: 15934076

Wang Y, Wang J, Gao L, Lafyatis R, Stamm S, Andreadis A. Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. J Biol Chem. 2005 Apr 8; 280(14):14230-9. PMID: 15695522

Lemaire R, Korn JH, Schiemann WP, Lafyatis R. Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering. J Invest Dermatol. 2004 Dec; 123(6):1063-9. PMID: 15610515

Wang J, Gao QS, Wang Y, Lafyatis R, Stamm S, Andreadis A. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J Neurochem. 2004 Mar; 88(5):1078-90. PMID: 15009664

Lemaire R, Farina G, Kissin E, Shipley JM, Bona C, Korn JH, Lafyatis R. Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen. Arthritis Rheum. 2004 Mar; 50(3):915-26.View Related Profiles.

Kissin, Eugene
Lafyatis, Robert

PMID: 15022335

McAlindon TE, Formica M, Palmer JR, Lafyatis R, Rosenberg L. Assessment of strategies for identifying diagnosed cases of systemic lupus erythematosus through self-report. Lupus. 2003; 12(10):754-9.View Related Profiles.

Palmer, Julie
Lafyatis, Robert

PMID: 14596424

Jodo S, Kung JT, Xiao S, Chan DV, Kobayashi S, Tateno M, Lafyatis R, Ju ST. Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure. J Biol Chem. 2003 Feb 28; 278(9):7553-7. PMID: 12477718

Kissin EY, Lemaire R, Korn JH, Lafyatis R. Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation. Arthritis Rheum. 2002 Nov; 46(11):3000-9.View Related Profiles.

Kissin, Eugene
Lafyatis, Robert

PMID: 12428243

Arikan MC, Memmott J, Broderick JA, Lafyatis R, Screaton G, Stamm S, Andreadis A. Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3. Brain Res Mol Brain Res. 2002 May 30; 101(1-2):109-21. PMID: 12007838

Lemaire R, Prasad J, Kashima T, Gustafson J, Manley JL, Lafyatis R. Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes Dev. 2002 Mar 1; 16(5):594-607. PMID: 11877379; PMCID: PMC155348

Gao QS, Memmott J, Lafyatis R, Stamm S, Screaton G, Andreadis A. Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia. J Neurochem. 2000 Feb; 74(2):490-500. PMID: 10646499

Lemaire R, Winne A, Sarkissian M, Lafyatis R. SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation. Eur J Immunol. 1999 Mar; 29(3):823-37. PMID: 10092085

Sarkissian M, Lafyatis R. Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts. J Immunol. 1999 Feb 1; 162(3):1772-9. PMID: 9973441

Felson D, Lafyatis R, Korn J. Rheumatology. Biological agents--is the promise realised? Lancet. 1998 Dec 19-26; 352 Suppl 4:SIV25.View Related Profiles.

Felson, David
Lafyatis, Robert

PMID: 9872172

Sarkissian M, Lafyatis R. Transforming growth factor-beta and platelet derived growth factor regulation of fibrillar fibronectin matrix formation by synovial fibroblasts. J Rheumatol. 1998 Apr; 25(4):613-22. PMID: 9558159

Lemaire R, Flipo RM, Migaud H, Fontaine C, Huet G, Dacquembronne E, Lafyatis R. Alternative splicing of the 5' region of cathepsin B pre-messenger RNA in rheumatoid synovial tissue. Arthritis Rheum. 1997 Aug; 40(8):1540-2. PMID: 9259437

Sarkissian M, Winne A, Lafyatis R. The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS. J Biol Chem. 1996 Dec 6; 271(49):31106-14. PMID: 8940107

Lemaire R, Flipo RM, Monté D, Dupressoir T, Duquesnoy B, Cesbron JY, Janin A, Capron A, Lafyatis R. Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice. J Rheumatol. 1994 Aug; 21(8):1409-19. PMID: 7983639

Huet G, Zerimech F, Dieu MC, Hemon B, Grard G, Balduyck M, Janin A, Lafyatis R, Degand P. The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator. Int J Cancer. 1994 Jun 15; 57(6):875-82. PMID: 7911458

Denhez F, Lafyatis R. Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot. J Biol Chem. 1994 Jun 10; 269(23):16170-9. PMID: 8206918

Hebbar M, Janin A, Huglo D, Copin MC, Lafyatis R, Devulder B, Marchandise X, Gosset D. Xerostomia in systemic sclerosis: systematic evaluation by salivary scintigraphy and lip biopsy in thirty-four patients. Arthritis Rheum. 1994 Mar; 37(3):439-41. PMID: 8129803

Geiser AG, Busam KJ, Kim SJ, Lafyatis R, O'Reilly MA, Webbink R, Roberts AB, Sporn MB. Regulation of the transforming growth factor-beta 1 and -beta 3 promoters by transcription factor Sp1. Gene. 1993 Jul 30; 129(2):223-8. PMID: 8325508

Huet G, Flipo RM, Colin C, Janin A, Hemon B, Collyn-d'Hooghe M, Lafyatis R, Duquesnoy B, Degand P. Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1. Arthritis Rheum. 1993 Jun; 36(6):772-80. PMID: 8507218

Lafyatis R, Flipo RM, Duquesnoy B, Capron A. Antibodies in rheumatoid synovial fluids bind to a restricted series of protein antigens in rheumatoid synovial tissue. Arthritis Rheum. 1992 Sep; 35(9):1016-27. PMID: 1418017

Lafyatis R, Denhez F, Williams T, Sporn M, Roberts A. Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif. Nucleic Acids Res. 1991 Dec 11; 19(23):6419-25. PMID: 1754378; PMCID: PMC329187

Flanders KC, Lüdecke G, Engels S, Cissel DS, Roberts AB, Kondaiah P, Lafyatis R, Sporn MB, Unsicker K. Localization and actions of transforming growth factor-beta s in the embryonic nervous system. Development. 1991 Sep; 113(1):183-91. PMID: 1764993

Lafyatis R, Lechleider R, Roberts AB, Sporn MB. Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis. Mol Cell Biol. 1991 Jul; 11(7):3795-803. PMID: 1710772; PMCID: PMC361150

Wilder RL, Case JP, Crofford LJ, Kumkumian GK, Lafyatis R, Remmers EF, Sano H, Sternberg EM, Yocum DE. Endothelial cells and the pathogenesis of rheumatoid arthritis in humans and streptococcal cell wall arthritis in Lewis rats. J Cell Biochem. 1991 Feb; 45(2):162-6. PMID: 2055944

Lorberboum-Galski H, Lafyatis R, Case JP, FitzGerald D, Wilder RL, Pastan I. Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion. Int J Immunopharmacol. 1991; 13(2-3):305-15. PMID: 2071302

Wilder RL, Remmers EF, Sano H, Case JP, Lafyatis R. The cytokine network in rheumatoid arthritis. Br J Rheumatol. 1991; 30 Suppl 2:44-7. PMID: 1993258

Roberts AB, Kim SJ, Noma T, Glick AB, Lafyatis R, Lechleider R, Jakowlew SB, Geiser A, O'Reilly MA, Danielpour D, et al. Multiple forms of TGF-beta: distinct promoters and differential expression. Ciba Found Symp. 1991; 157:7-15; discussion 15-28. PMID: 1906395

Unsicker K, Flanders KC, Cissel DS, Lafyatis R, Sporn MB. Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system. Neuroscience. 1991; 44(3):613-25. PMID: 1754055

Remmers EF, Sano H, Lafyatis R, Case JP, Kumkumian GK, Hla T, Maciag T, Wilder RL. Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. J Rheumatol. 1991 Jan; 18(1):7-13. PMID: 1708827

Case JP, Lafyatis R, Kumkumian GK, Remmers EF, Wilder RL. IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway. J Immunol. 1990 Dec 1; 145(11):3755-61. PMID: 2174073

Lafyatis R, Lechleider R, Kim SJ, Jakowlew S, Roberts AB, Sporn MB. Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription. J Biol Chem. 1990 Nov 5; 265(31):19128-36. PMID: 2146270

Lafyatis R, Kim SJ, Angel P, Roberts AB, Sporn MB, Karin M, Wilder RL. Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site. Mol Endocrinol. 1990 Jul; 4(7):973-80. PMID: 2178224

Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB. Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol. 1990 Apr; 10(4):1492-7. PMID: 2108318; PMCID: PMC362252

Kim SJ, Lafyatis R, Kim KY, Angel P, Fujiki H, Karin M, Sporn MB, Roberts AB. Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regul. 1990 Feb; 1(3):269-78. PMID: 1966042; PMCID: PMC361469

Denhez F, Lafyatis R, Kondaiah P, Roberts AB, Sporn MB. Cloning by polymerase chain reaction of a new mouse TGF-beta, mTGF-beta 3. Growth Factors. 1990; 3(2):139-46. PMID: 2206556

Remmers EF, Lafyatis R, Kumkumian GK, Case JP, Roberts AB, Sporn MB, Wilder RL. Cytokines and growth regulation of synoviocytes from patients with rheumatoid arthritis and rats with streptococcal cell wall arthritis. Growth Factors. 1990; 2(2-3):179-88. PMID: 2187494

Wilder RL, Lafyatis R, Roberts AB, Case JP, Kumkumian GK, Sano H, Sporn MB, Remmers EF. Transforming growth factor-beta in rheumatoid arthritis. Ann N Y Acad Sci. 1990; 593:197-207. PMID: 2165375

Case JP, Sano H, Lafyatis R, Remmers EF, Kumkumian GK, Wilder RL. Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats. J Clin Invest. 1989 Dec; 84(6):1731-40. PMID: 2687329; PMCID: PMC304049

Case JP, Lafyatis R, Remmers EF, Kumkumian GK, Wilder RL. Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am J Pathol. 1989 Dec; 135(6):1055-64. PMID: 2596570; PMCID: PMC1880506

Wilder RL, Lafyatis R, Yocum DE, Case JP, Kumkumian GK, Remmers EF. Mechanisms of bone and cartilage destruction in rheumatoid arthritis: lessons from the streptococcal cell wall arthritis model in LEW/N rats. Clin Exp Rheumatol. 1989 Sep-Oct; 7 Suppl 3:S123-7. PMID: 2691148

Lafyatis R, Thompson NL, Remmers EF, Flanders KC, Roche NS, Kim SJ, Case JP, Sporn MB, Roberts AB, Wilder RL. Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization. J Immunol. 1989 Aug 15; 143(4):1142-8. PMID: 2663990

Kumkumian GK, Lafyatis R, Remmers EF, Case JP, Kim SJ, Wilder RL. Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. J Immunol. 1989 Aug 1; 143(3):833-7. PMID: 2545778

Lafyatis R, Remmers EF, Roberts AB, Yocum DE, Sporn MB, Wilder RL. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J Clin Invest. 1989 Apr; 83(4):1267-76. PMID: 2784799; PMCID: PMC303817

Case JP, Lorberboum-Galski H, Lafyatis R, FitzGerald D, Wilder RL, Pastan I. Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats. Proc Natl Acad Sci U S A. 1989 Jan; 86(1):287-91. PMID: 2492102; PMCID: PMC286449

Yocum DE, Lafyatis R, Remmers EF, Schumacher HR, Wilder RL. Hyperplastic synoviocytes from rats with streptococcal cell wall-induced arthritis exhibit a transformed phenotype that is thymic-dependent and retinoid inhibitable. Am J Pathol. 1988 Jul; 132(1):38-48. PMID: 3260752; PMCID: PMC1880616

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 258 publications over 35 distinct years, with a maximum of 19 publications in 2023

Bar chart showing 258 publications over 35 distinct years, with a maximum of 19 publications in 2023

Year	Publications
1988	1
1989	7
1990	8
1991	9
1992	1
1993	2
1994	4
1996	1
1997	1
1998	2
1999	2
2000	1
2002	4
2003	1
2004	3
2005	2
2006	7
2007	8
2008	4
2009	8
2010	14
2011	5
2012	10
2013	10
2014	9
2015	9
2016	17
2017	9
2018	10
2019	13
2020	13
2021	16
2022	15
2023	19
2024	13

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