Paul A. Monach, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology (Arthritis) Section

MD, University of Chicago
PhD, University of Chicago



My research is focused on clinical and translational research in vasculitis: biomarkers, genetics, and clinical trials.

I have led studies aimed at identifying new markers that could improve diagnosis, staging, assessment of current disease activity, and predicting the future course of disease, using proteins detectable in the blood or urine and gene expression profiles in blood cells.

I have also led candidate genes studies in vasculitis and has been involved in the planning and recruitment for genome-wide association studies in multiple forms of vasculitis.

I have participated in most multi-center clinical trials conducted over the past 10 years in the US, in various vasculitides.

This work has been conducted through NIH-funded consortia: the Vasculitis Clinical Research Consortium and the RAVE/ITN Study Group. In addition, I have been a member of the Immunological Genome Project Consortium and contributed data on gene expression in mouse neutrophils to that effort.


Abatacept (CTLA4_Ig) For the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyaugiitis (Wegener's) (ABROGATE)
03/10/2015 - 03/09/2020 (PI)
Cleveland Clinic Foundation Bristol-Myers Squibb

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of CCX168 (Avacopan) in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculiti
02/28/2017 - 02/27/2020 (PI)
ChemoCentryx, Inc.

Mepolizumab Long-term Access Programme for Subjects who Participated in Study MEA115921
12/24/2015 - 06/30/2018 (PI)
GlaxoSmithKline, Inc.

Prospective, Observational Safety Study of Patients with Wegener's Granulomatosis (Granulomatosis with Polyangitis) or Microscopic Polyangitis Treated with Rituximab
03/01/2012 - 02/28/2018 (PI)
Hoffmann-La Roche Inc (Foreign)

Vasculitis Clinical Research Consortium
09/01/2016 - 08/31/2017 (PI)
Trustees of the University of Pennsylvania NIH NIAMS
5U54AR057319-14

Vasculitis Clinical Research Foundation
09/01/2015 - 08/31/2017 (PI)
Trustees of the University of Pennsylvania NIH NIAMS
5U54AR057319-13

Adaptation and Validation of PROMIS for use in Vasculitis
09/15/2012 - 08/31/2017 (PI)
Trustees of the University of Pennsylvania NIH NIAMS
5R01AR064153-04

Novel Methods for the Conduct of Clinical Trials
06/01/2016 - 05/31/2017 (PI)
Trustees of the University of Pennsylvania NIH NHLBI
4R01HL115041-04

A Double-blind, Randomised, Placebo-controlled Study to Investigate the Efficacy and Safety of Mepolizumab in the Treatment of Eosinophilic Granulomatosis with Polyangiitis in Subjects Receiving Stand
09/24/2014 - 09/23/2016 (PI)
GlaxoSmithKline, Inc.

Vasculitis Clinical Research Consortium
09/01/2014 - 08/31/2016 (PI)
Trustees of the University of Pennsylvania NIH NIAMS
2U54AR057319-12

Showing 10 of 21 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Merkel PA, Xie G, Monach PA, Ji X, Ciavatta DJ, Byun J, Pinder BD, Zhao A, Zhang J, Tadesse Y, Qian D, Weirauch M, Nair R, Tsoi A, Pagnoux C, Carette S, Chung S, Cuthbertson D, Davis JC, Dellaripa PF, Forbess L, Gewurz-Singer O, Hoffman GS, Khalidi N, Koening C, Langford CA, Mahr AD, McAlear C, Moreland L, Seo EP, Specks U, Spiera RF, Sreih A, St Clair EW, Stone JH, Ytterberg SR, Elder JT, Qu J, Ochi T, Hirano N, Edberg JC, Falk RJ, Amos CI, Siminovitch KA. Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. Arthritis Rheumatol. 2017 May; 69(5):1054-1066. PMID: 28029757; DOI: 10.1002/art.40034;.
  2. Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest. 2017 May 01; 127(5):1714-1724. PMID: 28375155; DOI: 10.1172/JCI84598;.
  3. Monach PA. Assessing Performance of Internal Medicine Residents. JAMA. 2017 03 28; 317(12):1276-1277. PMID: 28350919; DOI: 10.1001/jama.2017.0890;.
  4. Langford CA, Cuthbertson D, Ytterberg SR, Khalidi N, Monach PA, Carette S, Seo P, Moreland LW, Weisman M, Koening CL, Sreih AG, Spiera R, McAlear CA, Warrington KJ, Pagnoux C, McKinnon K, Forbess LJ, Hoffman GS, Borchin R, Krischer JP, Merkel PA. A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Takayasu Arteritis. Arthritis Rheumatol. 2017 Apr; 69(4):846-853. PMID: 28133931; DOI: 10.1002/art.40037;.
  5. Langford CA, Cuthbertson D, Ytterberg SR, Khalidi N, Monach PA, Carette S, Seo P, Moreland LW, Weisman M, Koening CL, Sreih AG, Spiera R, McAlear CA, Warrington KJ, Pagnoux C, McKinnon K, Forbess LJ, Hoffman GS, Borchin R, Krischer JP, Merkel PA. A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Giant Cell Arteritis. Arthritis Rheumatol. 2017 Apr; 69(4):837-845. PMID: 28133925; DOI: 10.1002/art.40044;.
  6. Oommen E, Hummel A, Allmannsberger L, Cuthbertson D, Carette S, Pagnoux C, Hoffman GS, Jenne DE, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland L, Seo P, Sreih A, Ytterberg SR, Merkel PA, Specks U, Monach PA. IgA antibodies to myeloperoxidase in patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Clin Exp Rheumatol. 2017 Mar-Apr; 35 Suppl 103(1):98-101. PMID: 28281453.
  7. Krischer J, Cronholm PF, Burroughs C, McAlear CA, Borchin R, Easley E, Davis T, Kullman J, Carette S, Khalidi N, Koening C, Langford CA, Monach P, Moreland L, Pagnoux C, Specks U, Sreih AG, Ytterberg S, Merkel PA. Experience With Direct-to-Patient Recruitment for Enrollment Into a Clinical Trial in a Rare Disease: A Web-Based Study. J Med Internet Res. 2017 Feb 28; 19(2):e50. PMID: 28246067; DOI: 10.2196/jmir.6798;.
  8. Monach PA, Stone JH, Sharma A, Nazarian RM. Case 6-2017. A 57-year-old woman with fatigue, sweats, weight loss, headache, and skin lesions. N Engl J Med. 2017 Feb 23; 376(8):775-786. PMID: 28225681; DOI: 10.1056/NEJMcpc1613461;.
  9. Clain JM, Hummel AM, Stone JH, Fervenza FC, Hoffman GS, Kallenberg CG, Langford CA, McCune WJ, Merkel PA, Monach PA, Seo P, Spiera RF, St Clair EW, Ytterberg SR, Specks U. Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis. Clin Exp Immunol. 2017 Apr; 188(1):174-181. PMID: 28076879; DOI: 10.1111/cei.12925;.
  10. Monach PA. Editorial: Defining and Refining the Risk of Venous Thromboembolism in Giant Cell Arteritis. Arthritis Rheumatol. 2017 Jan; 69(1):3-5. PMID: 28029235; DOI: 10.1002/art.39846;.
Showing 10 of 86 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 86 publications over 21 distinct years, with a maximum of 14 publications in 2015

YearPublications
19901
19911
19931
19951
19961
19991
20011
20031
20041
20052
20074
20081
20093
20105
20114
20127
201313
20146
201514
20166
201712
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biomarkers
Vasculitis

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:


75 E. Newton St Evans Building
Boston MA 02118
Google Map


Monach's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department