Tamar R. Aprahamian, PhD
|Institution||Boston University School of Medicine|
|Address||650 Albany St Evans Biomed Research Ctr|
Boston MA 02118
|Institution||Boston Medical Center|
I have a broad background in the generation and analysis of mutant mice beginning from my time as a technician in the Department of Cardiovascular Research at St. Elizabeth’s Medical Center in Boston. My graduate training allowed me to employ my experience in complex mouse genetics to develop a novel mouse model of accelerated atherosclerosis and autoimmune disease. Working in a lab which studied predominantly cardiovascular diseases, analysis of this new mouse model required expertise from beyond our laboratory walls, and also turned the lab in a new direction, namely the study of how immunologic processes might contribute to the development of cardiovascular disease. During my postdoctoral training, I continued this work on interactions between the two disease processes, and also began to explore the possibility that PPARgamma agonists may be beneficial to lupus. My long-term career goal is to build an academic research group focused on understanding the basic immunologic mechanisms involved in the pathogenesis of systemic autoimmune diseases such as SLE, and of their complications including nephritis and atherosclerosis.
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