Keywords
Last Name

Carl J O'Hara, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
DivisionAnatomic Pathology
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 414-5182
ORCID ORCID Icon0000-0001-7404-3597
 Research Expertise & Professional Interests
My primary expertise is in Hematopathology and in Immunohistochemistry. Concentrated areas of interest include amylodosis and pulmonary pathology (lung cancer).

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bhatt N, Sloan JM, O'Hara CJ, Oommen R, Steiling K, Litle VR. Extranodal Marginal Zone Endobronchial Lymphoma Associated With Hepatitis C. Ann Thorac Surg. 2016 Nov; 102(5):e407-e408. PMID: 27772593.
    View in: PubMed
  2. Muñoz-Largacha JA, O'Hara CJ, Sloan JM, Fernando HC, Litle VR. Surgical Management of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Associated With Light-Chain Deposition Disease. Ann Thorac Surg. 2016 Jun; 101(6):e207-10. PMID: 27211983.
    View in: PubMed
  3. Sarosiek S, Seldin DC, Connors LH, Spencer B, Murakami A, O'Hara C, Sanchorawala V. Vertebral compression fractures as the initial presentation of AL amyloidosis: case series and review of literature. Amyloid. 2015; 22(3):156-62. PMID: 26104853.
    View in: PubMed
  4. Fu J, Seldin DC, Berk JL, Sun F, O'Hara C, Cui H, Sanchorawala V. Lymphadenopathy as a manifestation of amyloidosis: a case series. Amyloid. 2014 Dec; 21(4):256-60. PMID: 25208081.
    View in: PubMed
  5. von Keudell G, Sanchorawala V, O'Hara C, C Seldin D, Sloan JM. Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis. Amyloid. 2014 Jun; 21(2):124-7. PMID: 24471777.
    View in: PubMed
  6. Eisenstein A, Vaisman L, Johnston-Cox H, Gallan A, Shaffer K, Vaughan D, O'Hara C, Joseph L. Integration of basic science and clinical medicine: the innovative approach of the cadaver biopsy project at the Boston University School of Medicine. Acad Med. 2014 Jan; 89(1):50-3. PMID: 24280854.
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  7. Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18946-51. PMID: 24158479.
    View in: PubMed
  8. Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol. 2013 Mar; 8(3):279-86. PMID: 23399959.
    View in: PubMed
  9. Girnius S, Skinner M, Spencer B, Prokaeva T, Bartholomew C, O'Hara C, Seldin DC, Connors LH. A new lysozyme tyr54asn mutation causing amyloidosis in a family of Swedish ancestry with gastrointestinal symptoms. Amyloid. 2012 Dec; 19(4):182-5. PMID: 22978355.
    View in: PubMed
  10. Rosenzweig MA, Landau H, Seldin D, O'Hara C, Girnius S, Hanson N, Frosina D, Sedrak C, Arcila M, Comenzo RL, Giralt S, Gnjatic S, Jungbluth AA, Koehne G. Cancer-testis antigen expression and immunogenicity in AL amyloidosis. Blood Cancer J. 2012; 2:e90. PMID: 22983433.
    View in: PubMed
  11. Lee JC, Wu H, Prokaeva TB, O'Hara C, Seldin DC. Expression of D-type cyclins in AL amyloidosis plasma cells. J Clin Pathol. 2012 Nov; 65(11):1052-5. PMID: 22859391.
    View in: PubMed
  12. Cowan AJ, Seldin DC, Skinner M, Quillen K, Doros G, Tan J, O'Hara C, Finn KT, Sanchorawala V. Amyloid deposits in the bone marrow of patients with immunoglobulin light chain amyloidosis do not impact stem cell mobilization or engraftment. Biol Blood Marrow Transplant. 2012 Dec; 18(12):1935-8. PMID: 22842332.
    View in: PubMed
  13. Cowan AJ, Skinner M, Seldin DC, Berk JL, Lichtenstein DR, O'Hara CJ, Doros G, Sanchorawala V. Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience. Haematologica. 2013 Jan; 98(1):141-6. PMID: 22733017.
    View in: PubMed
  14. Tan JN, Kroll MH, O'Hara CJ, Everett PC, Erdogan E. Gamma heavy chain disease in a patient with underlying lymphoplasmacytic lymphoma of the thyroid. Report of a case and comparison with other reported cases with thyroid involvement. Clin Chim Acta. 2012 Oct 9; 413(19-20):1696-9. PMID: 22561184.
    View in: PubMed
  15. Ward JE, Ren R, Toraldo G, Soohoo P, Guan J, O'Hara C, Jasuja R, Trinkaus-Randall V, Liao R, Connors LH, Seldin DC. Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood. 2011 Dec 15; 118(25):6610-7. PMID: 21998211.
    View in: PubMed
  16. Weng L, Spencer BH, SoohHoo PT, Connors LH, O'Hara CJ, Seldin DC. Dysregulation of miRNAs in AL amyloidosis. Amyloid. 2011 Sep; 18(3):128-35. PMID: 21834602.
    View in: PubMed
  17. Roehrl MH, Alexander MP, Hammond SB, Ruzinova M, Wang JY, O'Hara CJ. Eosinophilic myocarditis in hypereosinophilic syndrome. Am J Hematol. 2011 Jul; 86(7):607-8. PMID: 21681785.
    View in: PubMed
  18. Ward JE, SooHoo P, Toraldo G, Jasuja R, Connors LH, O'Hara C, Seldin DC. Metabolic phenotype in an AL amyloidosis transgenic mouse model. Amyloid. 2011 Jun; 18 Suppl 1:40-1. PMID: 21838426.
    View in: PubMed
  19. Seldin DC, Andrea N, Berenbaum I, Berk JL, Connors L, Dember LM, Doros G, Fennessey S, Finn K, Girnius S, Lerner A, Libbey C, Meier-Ewert HK, O'Connell R, O'Hara C, Quillen K, Ruberg FL, Sam F, Segal A, Shelton A, Skinner M, Sloan JM, Wiesman JF, Sanchorawala V. High-dose melphalan and autologous stem cell transplantation for AL amyloidosis: recent trends in treatment-related mortality and 1-year survival at a single institution. Amyloid. 2011 Jun; 18 Suppl 1:127-9. PMID: 21838459.
    View in: PubMed
  20. Hovey BM, Ward JE, Soo Hoo P, O'Hara CJ, Connors LH, Seldin DC. Preclinical development of siRNA therapeutics for AL amyloidosis. Gene Ther. 2011 Dec; 18(12):1150-6. PMID: 21562591.
    View in: PubMed
  21. Tsai SB, Seldin DC, Wu H, O'Hara C, Ruberg FL, Sanchorawala V. Myocardial infarction with "clean coronaries" caused by amyloid light-chain AL amyloidosis: a case report and literature review. Amyloid. 2011 Sep; 18(3):160-4. PMID: 21504342.
    View in: PubMed
  22. Charlot M, Seldin DC, O'hara C, Skinner M, Sanchorawala V. Localized amyloidosis of the breast: a case series. Amyloid. 2011 Jun; 18(2):72-5. PMID: 21501022.
    View in: PubMed
  23. Cowan AJ, Skinner M, Berk JL, Sloan JM, O'hara C, Seldin DC, Sanchorawala V. Macroglossia - not always AL amyloidosis. Amyloid. 2011 Jun; 18(2):83-6. PMID: 21401321.
    View in: PubMed
  24. Toshkezi G, Edalat F, O'Hara C, Delalle I, Chin LS. Primary intramedullary histiocytic sarcoma. World Neurosurg. 2010 Oct-Nov; 74(4-5):523-7. PMID: 21492606.
    View in: PubMed
  25. Connors LH, Prokaeva T, Lim A, Théberge R, Falk RH, Doros G, Berg A, Costello CE, O'Hara C, Seldin DC, Skinner M. Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis. Am Heart J. 2009 Oct; 158(4):607-14. PMID: 19781421.
    View in: PubMed
  26. Sloan KA, Marquez HA, Li J, Cao Y, Hinds A, O'Hara CJ, Kathuria S, Ramirez MI, Williams MC, Kathuria H. Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines. Carcinogenesis. 2009 Aug; 30(8):1433-42. PMID: 19483189.
    View in: PubMed
  27. Lee JC, Christensen T, O'Hara CJ. Metastatic interdigitating dendritic cell sarcoma masquerading as a skin primary tumor: a case report and review of the literature. Am J Dermatopathol. 2009 Feb; 31(1):88-93. PMID: 19155734.
    View in: PubMed
  28. Biolo A, Ramamurthy S, Connors LH, O'Hara CJ, Meier-Ewert HK, Soo Hoo PT, Sawyer DB, Seldin DC, Seldin DS, Sam F. Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition. Circ Heart Fail. 2008 Nov; 1(4):249-57. PMID: 19808299.
    View in: PubMed
  29. Nanda A, Dias-Santagata DC, Stubbs H, O'Hara CJ, Zaner KS, Lynch TJ, Willers H. Unusual tumor response and toxicity from radiation and concurrent erlotinib for non-small-cell lung cancer. Clin Lung Cancer. 2008 Sep; 9(5):285-7. PMID: 18824451.
    View in: PubMed
  30. Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, Violette SM. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med. 2008 Jan 1; 177(1):56-65. PMID: 17916809.
    View in: PubMed
  31. Lafyatis R, O'Hara C, Feghali-Bostwick CA, Matteson E. B cell infiltration in systemic sclerosis-associated interstitial lung disease. Arthritis Rheum. 2007 Sep; 56(9):3167-8. PMID: 17763433.
    View in: PubMed
  32. Kemp S, Gallagher G, Kabani S, Noonan V, O'Hara C. Oral non-Hodgkin's lymphoma: review of the literature and World Health Organization classification with reference to 40 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Feb; 105(2):194-201. PMID: 17604660.
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  33. Kos CA, Ward JE, Malek K, Sanchorawala V, Wright DG, O'Hara C, Connors L, Skinner M, Seldin DC. Association of acquired von Willebrand syndrome with AL amyloidosis. Am J Hematol. 2007 May; 82(5):363-7. PMID: 17205535.
    View in: PubMed
  34. Sanchorawala V, Blanchard E, Seldin DC, O'Hara C, Skinner M, Wright DG. AL amyloidosis associated with B-cell lymphoproliferative disorders: frequency and treatment outcomes. Am J Hematol. 2006 Sep; 81(9):692-5. PMID: 16795060.
    View in: PubMed
  35. Toor AA, Ramdane BA, Joseph J, Thomas M, O'Hara C, Barlogie B, Walker P, Joseph L. Cardiac nonamyloidotic immunoglobulin deposition disease. Mod Pathol. 2006 Feb; 19(2):233-7. PMID: 16341150.
    View in: PubMed
  36. Akar H, Seldin DC, Magnani B, O'Hara C, Berk JL, Schoonmaker C, Cabral H, Dember LM, Sanchorawala V, Connors LH, Falk RH, Skinner M. Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis. Amyloid. 2005 Dec; 12(4):210-5. PMID: 16399645.
    View in: PubMed
  37. Skinner M, Sanchorawala V, Seldin DC, Dember LM, Falk RH, Berk JL, Anderson JJ, O'Hara C, Finn KT, Libbey CA, Wiesman J, Quillen K, Swan N, Wright DG. High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study. Ann Intern Med. 2004 Jan 20; 140(2):85-93. PMID: 14734330.
    View in: PubMed
  38. Swan N, Skinner M, O'Hara CJ. Bone marrow core biopsy specimens in AL (primary) amyloidosis. A morphologic and immunohistochemical study of 100 cases. Am J Clin Pathol. 2003 Oct; 120(4):610-6. PMID: 14560572.
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  39. Maecker B, Sherr DH, Vonderheide RH, von Bergwelt-Baildon MS, Hirano N, Anderson KS, Xia Z, Butler MO, Wucherpfennig KW, O'Hara C, Cole G, Kwak SS, Ramstedt U, Tomlinson AJ, Chicz RM, Nadler LM, Schultze JL. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. 2003 Nov 1; 102(9):3287-94. PMID: 12869499.
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  40. O'Hara CJ, Falk RH. The diagnosis and typing of cardiac amyloidosis. Amyloid. 2003 Jun; 10(2):127-9. PMID: 12964421.
    View in: PubMed
  41. Seldin DC, Choufani EB, Dember LM, Wiesman JF, Berk JL, Falk RH, O'Hara C, Fennessey S, Finn KT, Wright DG, Skinner M, Sanchorawala V. Tolerability and efficacy of thalidomide for the treatment of patients with light chain-associated (AL) amyloidosis. Clin Lymphoma. 2003 Mar; 3(4):241-6. PMID: 12672274.
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  42. Jones D, O'Hara C, Kraus MD, Perez-Atayde AR, Shahsafaei A, Wu L, Dorfman DM. Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma. Blood. 2000 Jul 15; 96(2):685-90. PMID: 10887135.
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  43. Akpek G, Koh HK, Bogen S, O'Hara C, Foss FM. Chemotherapy with etoposide, vincristine, doxorubicin, bolus cyclophosphamide, and oral prednisone in patients with refractory cutaneous T-cell lymphoma. Cancer. 1999 Oct 1; 86(7):1368-76. PMID: 10506727.
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  44. Shuja S, Cai J, Iacobuzio-Donahue C, Zacks J, Beazley RM, Kasznica JM, O'Hara CJ, Heimann R, Murnane MJ. Cathepsin B activity and protein levels in thyroid carcinoma, Graves' disease, and multinodular goiters. Thyroid. 1999 Jun; 9(6):569-77. PMID: 10411119.
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  45. Comenzo RL, Vosburgh E, Falk RH, Sanchorawala V, Reisinger J, Dubrey S, Dember LM, Berk JL, Akpek G, LaValley M, O'hara C, Arkin CF, Wright DG, Skinner M. Dose-intensive melphalan with blood stem-cell support for the treatment of AL (amyloid light-chain) amyloidosis: survival and responses in 25 patients. Blood. 1998 May 15; 91(10):3662-70. PMID: 9573002.
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  46. Wyandt HE, Chinnappan D, Ioannidou S, Salama M, O'Hara C. Fluorescence in situ hybridization to assess aneuploidy for chromosomes 7 and 8 in hematologic disorders. Cancer Genet Cytogenet. 1998 Apr 15; 102(2):114-24. PMID: 9546063.
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  47. Craven DE, Duncan RA, Stram JR, O'Hara CJ, Steger KA, Jhamb K, Hirschhorn LR. Response of lymphoepithelial parotid cysts to antiretroviral treatment in HIV-infected adults. Ann Intern Med. 1998 Mar 15; 128(6):455-9. PMID: 9499329.
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  48. Elias AD, Skarin AT, Gonin R, Oliynyk P, Stomper PC, O'Hara C, Socinski MA, Sheldon T, Maggs P, Frei E. Neoadjuvant treatment of stage IIIA non-small cell lung cancer. Long-term results. Am J Clin Oncol. 1994 Feb; 17(1):26-36. PMID: 8311004.
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  49. Andrews CW, Jessup JM, Goldman H, Hayes DF, Kufe DW, O'Hara CJ, Steele GD. Localization of tumor-associated glycoprotein DF3 in normal, inflammatory, and neoplastic lesions of the colon. Cancer. 1993 Dec 1; 72(11):3185-90. PMID: 7694786.
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  50. Khettry U, Federman M, O'Hara CJ, Landis WJ. Intracytoplasmic inclusion bodies of erythrocyte origin within hepatocytes in a hepatic allograft. Ultrastruct Pathol. 1993 Nov-Dec; 17(6):593-8. PMID: 8122325.
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  51. Jessup JM, Petrick AT, Toth CA, Ford R, Meterissian S, O'Hara CJ, Steele G, Thomas P. Carcinoembryonic antigen: enhancement of liver colonisation through retention of human colorectal carcinoma cells. Br J Cancer. 1993 Mar; 67(3):464-70. PMID: 8439497.
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  52. Andrews CW, O'Hara CJ, Goldman H, Mercurio AM, Silverman ML, Steele GD. Sucrase-isomaltase expression in chronic ulcerative colitis and dysplasia. Hum Pathol. 1992 Jul; 23(7):774-9. PMID: 1612577.
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  53. Chern YJ, O'Hara C, Sytkowski AJ. Induction of hemoglobin synthesis by downregulation of MYB protein with an antisense oligodeoxynucleotide. Blood. 1991 Aug 15; 78(4):991-6. PMID: 1868255.
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  54. Waibel R, O'Hara CJ, Stahel RA. Monoclonal antibodies defining the cluster-5A small cell lung carcinoma antigen. Br J Cancer Suppl. 1991 Jun; 14:29-32. PMID: 1645566.
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  55. Wiltz O, O'Hara CJ, Steele GD, Mercurio AM. Expression of enzymatically active sucrase-isomaltase is a ubiquitous property of colon adenocarcinomas. Gastroenterology. 1991 May; 100(5 Pt 1):1266-78. PMID: 1707385.
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  56. Marasco WJ, Hergreuter CA, Pritchard E, O'Hara CJ, Steele GD. Surgical resection of a solitary liver metastasis in a 46-year-old patient with a malignant thymoma. J Surg Oncol. 1991 Feb; 46(2):139-40. PMID: 1992219.
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  57. Wiltz O, O'Hara CJ, Steele GD, Mercurio AM. Sucrase-isomaltase: a marker associated with the progression of adenomatous polyps to adenocarcinomas. Surgery. 1990 Aug; 108(2):269-75; discussion 275-6. PMID: 1696400.
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  58. Pinkus GS, O'Hara CJ, Said JW. Peripheral/post-thymic T-cell lymphomas: a spectrum of disease. Clinical, pathologic, and immunologic features of 78 cases. Cancer. 1990 Feb 15; 65(4):971-98. PMID: 2297666.
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  59. Sytkowski AJ, O'Hara C, Vanasse G, Armstrong MJ, Kreczko S, Dainiak N. Characterization of biologically active, platelet-derived growth factor-like molecules produced by murine erythroid cells in vitro and in vivo. J Clin Invest. 1990 Jan; 85(1):40-6. PMID: 2295703.
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  60. Waibel R, O'Hara CJ, Smith A, Stahel RA. Tumor-associated membrane sialoglycoprotein on human small cell lung carcinoma identified by the IgG2a monoclonal antibody SWA20. Cancer Res. 1988 Aug 1; 48(15):4318-23. PMID: 2839290.
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  61. O'Hara CJ, Groopman JE, Federman M. The ultrastructural and immunohistochemical demonstration of viral particles in lymph nodes from human immunodeficiency virus-related and non-human immunodeficiency virus-related lymphadenopathy syndromes. Hum Pathol. 1988 May; 19(5):545-9. PMID: 3371979.
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  62. Benotti PN, Jenkins RL, Cady B, O'Hara C, Groopman JE. Surgical approach to generalized lymphadenopathy in homosexual men. J Surg Oncol. 1987 Dec; 36(4):231-4. PMID: 3695526.
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  63. Waibel R, O'Hara CJ, Stahel RA. Characterization of an epithelial and a tumor-associated human small cell lung carcinoma glycoprotein antigen. Cancer Res. 1987 Jul 15; 47(14):3766-70. PMID: 2439198.
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  64. O'Hara CJ, Said JW, Pinkus GS. Non-Hodgkin's lymphoma, multilobated B-cell type: report of nine cases with immunohistochemical and immunoultrastructural evidence for a follicular center cell derivation. Hum Pathol. 1986 Jun; 17(6):593-9. PMID: 3486810.
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  65. Groopman JE, Sullivan JL, Mulder C, Ginsburg D, Orkin SH, O'Hara CJ, Falchuk K, Wong-Staal F, Gallo RC. Pathogenesis of B cell lymphoma in a patient with AIDS. Blood. 1986 Mar; 67(3):612-5. PMID: 3004617.
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  66. Dean PJ, Haggitt RC, O'Hara CJ. Malignant epithelioid hemangioendothelioma of the liver in young women. Relationship to oral contraceptive use. Am J Surg Pathol. 1985 Oct; 9(10):695-704. PMID: 3904492.
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