Keywords
Last Name

Maria Isabel Ramirez, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 638-8264
ORCID ORCID Icon0000-0001-6294-4419
Other Positions
TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
DivisionOther Pathology

TitleAssistant Dean
InstitutionBoston University School of Medicine
DepartmentDiversity & Multicultural Affairs

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

TitleCenter Faculty Member
InstitutionBoston University School of Medicine
DepartmentPulmonary Center

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
The main goal of the research in our lab is to identify and understand genetic and epigenetic mechanisms of gene regulation driving the differentiation of distinct epithelial cell lineages during development, and the potential alteration of these mechanisms in lung disease. Correct spatial and temporal patterns of gene expression during lung development are critical for the formation of a functional lung ready for the first breath at birth. In adults, patterns of gene expression also have to be maintained to preserve a healthy lung. Dissecting these basic mechanisms in development will provide the basis to accurately differentiate embryonic stem cells into lung epithelial cell lineages in vitro, to improve fetal lung maturation and to understand altered cell phenotypes in lung disease.

 Self-Described Keywords
  • Lung development
  • Lung epithelium
  • Epigenetics
  • Chromatin remodeling
  • Gene regulation
  • Mouse models
  • Non-coding RNA
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):407-18. PMID: 27064756.
    View in: PubMed
  2. Krishnan H, Retzbach EP, Ramirez MI, Liu T, Li H, Miller WT, Goldberg GS. PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility. Exp Cell Res. 2015 Jul 1; 335(1):115-22. PMID: 25959509.
    View in: PubMed
  3. Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85. PMID: 25843048.
    View in: PubMed
  4. Tagne JB, Mohtar OR, Campbell JD, Lakshminarayanan M, Huang J, Hinds AC, Lu J, Ramirez MI. Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb. Respir Res. 2015; 16:22. PMID: 25763778.
    View in: PubMed
  5. Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D. Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1; 306(5):L405-19. PMID: 24375798.
    View in: PubMed
  6. Krishnan H, Ochoa-Alvarez JA, Shen Y, Nevel E, Lakshminarayanan M, Williams MC, Ramirez MI, Miller WT, Goldberg GS. Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility. J Biol Chem. 2013 Apr 26; 288(17):12215-21. PMID: 23530051.
    View in: PubMed
  7. Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI. The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem. 2012 Oct 26; 287(44):37282-95. PMID: 22955271.
    View in: PubMed
  8. Yamamoto K, Ferrari JD, Cao Y, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol. 2012 Sep 1; 189(5):2450-9. PMID: 22844121.
    View in: PubMed
  9. Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 6; 10(4):398-411. PMID: 22482505.
    View in: PubMed
  10. Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI. Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors. PLoS One. 2012; 7(1):e29907. PMID: 22242187.
    View in: PubMed
  11. Cao Y, Vo T, Millien G, Tagne JB, Kotton D, Mason RJ, Williams MC, Ramirez MI. Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene. J Biol Chem. 2010 Jan 15; 285(3):2152-64. PMID: 19906647.
    View in: PubMed
  12. Sloan KA, Marquez HA, Li J, Cao Y, Hinds A, O'Hara CJ, Kathuria S, Ramirez MI, Williams MC, Kathuria H. Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines. Carcinogenesis. 2009 Aug; 30(8):1433-42. PMID: 19483189.
    View in: PubMed
  13. Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Proc Am Thorac Soc. 2009 Jan 15; 6(1):1-10. PMID: 19131525.
    View in: PubMed
  14. Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan; 44(1):2-13. PMID: 19086051.
    View in: PubMed
  15. Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu L, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 2008 Nov; 118(11):3725-37. PMID: 18924607.
    View in: PubMed
  16. Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan; 8(2):124-39. PMID: 18023262.
    View in: PubMed
  17. Kathuria H, Cao Y, Hinds A, Ramirez MI, Williams MC. ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines. J Cell Biochem. 2007 Sep 1; 102(1):13-27. PMID: 17390339.
    View in: PubMed
  18. Wiener RS, Cao YX, Hinds A, Ramirez MI, Williams MC. Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung. J Cell Biochem. 2007 Aug 1; 101(5):1278-91. PMID: 17340620.
    View in: PubMed
  19. Pogach MS, Cao Y, Millien G, Ramirez MI, Williams MC. Key developmental regulators change during hyperoxia-induced injury and recovery in adult mouse lung. J Cell Biochem. 2007 Apr 15; 100(6):1415-29. PMID: 17167788.
    View in: PubMed
  20. Millien G, Spira A, Hinds A, Wang J, Williams MC, Ramirez MI. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol. 2006; 6:35. PMID: 16869965.
    View in: PubMed
  21. Kathuria H, Cao YX, Ramirez MI, Williams MC. Transcription of the caveolin-1 gene is differentially regulated in lung type I epithelial and endothelial cell lines. A role for ETS proteins in epithelial cell expression. J Biol Chem. 2004 Jul 16; 279(29):30028-36. PMID: 15138262.
    View in: PubMed
  22. Wongtrakool C, Malpel S, Gorenstein J, Sedita J, Ramirez MI, Underhill TM, Cardoso WV. Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung. J Biol Chem. 2003 Nov 21; 278(47):46911-8. PMID: 12947094.
    View in: PubMed
  23. Cao YX, Ramirez MI, Williams MC. Enhanced binding of Sp1/Sp3 transcription factors mediates the hyperoxia-induced increased expression of the lung type I cell gene T1alpha. J Cell Biochem. 2003 Aug 1; 89(5):887-901. PMID: 12874823.
    View in: PubMed
  24. Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003 Jul 15; 22(14):3546-56. PMID: 12853470.
    View in: PubMed
  25. Ramirez MI, Millien G, Hinds A, Cao Y, Seldin DC, Williams MC. T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth. Dev Biol. 2003 Apr 1; 256(1):61-72. PMID: 12654292.
    View in: PubMed
  26. Ramirez MI, Pollack L, Millien G, Cao YX, Hinds A, Williams MC. The alpha-isoform of caveolin-1 is a marker of vasculogenesis in early lung development. J Histochem Cytochem. 2002 Jan; 50(1):33-42. PMID: 11748292.
    View in: PubMed
  27. Ramirez MI, Chung UI, Williams MC. Aquaporin-5 expression, but not other peripheral lung marker genes, is reduced in PTH/PTHrP receptor null mutant fetal mice. Am J Respir Cell Mol Biol. 2000 Mar; 22(3):367-72. PMID: 10696074.
    View in: PubMed
  28. Ramirez MI, Cao YX, Williams MC. 1.3 kilobases of the lung type I cell T1alpha gene promoter mimics endogenous gene expression patterns during development but lacks sequences to enhance expression in perinatal and adult lung. Dev Dyn. 1999 Aug; 215(4):319-31. PMID: 10417821.
    View in: PubMed
  29. Ramirez MI, Rishi AK, Cao YX, Williams MC. TGT3, thyroid transcription factor I, and Sp1 elements regulate transcriptional activity of the 1.3-kilobase pair promoter of T1alpha, a lung alveolar type I cell gene. J Biol Chem. 1997 Oct 17; 272(42):26285-94. PMID: 9334198.
    View in: PubMed
  30. Vila MC, Cozza EN, Lima C, Ramirez MI, De Lederkremer RM. An inositol phosphoglycan from Trypanosoma cruzi inhibits ACTH action in calf adrenocortical cells. Cell Signal. 1995 May; 7(4):331-9. PMID: 8527302.
    View in: PubMed
  31. Ramirez MI, Karaoglu D, Haro D, Barillas C, Bashirzadeh R, Gil G. Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice. Mol Cell Biol. 1994 Apr; 14(4):2809-21. PMID: 8139578.
    View in: PubMed
  32. de Lederkremer RM, Lima CE, Ramirez MI, Gonçalvez MF, Colli W. Hexadecylpalmitoylglycerol or ceramide is linked to similar glycophosphoinositol anchor-like structures in Trypanosoma cruzi. Eur J Biochem. 1993 Dec 15; 218(3):929-36. PMID: 8281945.
    View in: PubMed
  33. Ramirez MI, Lima C, Lederkremer RM. Use of the lipopeptidophosphoglycan (LPPG) from Trypanosoma cruzi for the preparation and easy detection of the oligosaccharide core in glycolipid membrane anchors. Anales. Asoc. Quim. Argentina. 1992; 80:57-64.
  34. de Lederkremer RM, Lima C, Ramirez MI, Ferguson MA, Homans SW, Thomas-Oates J. Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi Epimastigotes. J Biol Chem. 1991 Dec 15; 266(35):23670-5. PMID: 1748644.
    View in: PubMed
  35. de Lederkremer RM, Lima C, Ramirez MI, Casal OL. Structural features of the lipopeptidophosphoglycan from Trypanosoma cruzi common with the glycophosphatidylinositol anchors. Eur J Biochem. 1990 Sep 11; 192(2):337-45. PMID: 2145155.
    View in: PubMed
  36. Lux VA, Ramírez MI, Libertun C. Natural and artificially induced ovulatory models related to lactation in the rat: role of prolactin. Proc Soc Exp Biol Med. 1988 Jul; 188(3):301-7. PMID: 3134659.
    View in: PubMed
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