Darrell Nelson Kotton, MD
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

MD, Washington University School of Medicine

Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Boston University School of Medicine
Center for Regenerative Medicine

Boston University School of Medicine
Pathology & Laboratory Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Active Staff Privileges
Boston Medical Center
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

2010 American Society of Clinical Investigation, Elected Member
2009 Co-Director, Boston University Center for Regenerative Medicine (CReM)
2007 Boston University Pulmonary Center: L. Jack Faling Award for Excellence in Teaching
2001 Massachusetts Thoracic Society, 1st Place, Science Research Award
2001 Boston University School of Medicine: Evans Days Research Award, 1st Runner Up
1999 Boston University Department of Medicine: Fellow of the Year Award
1997 University of Pennsylvania School of Medicine: Penn Pearls Teaching Award
1990-1994 Washington University School of Medicine Class President
1990 Washington University School of Medicine: Distinguished Student Scholarship Award
1989 University of Pennsylvania: Phi Beta Kappa
1985 University of Pennsylvania: Benjamin Franklin Scholar

MLSC Phase 2 Proposal 2014: The Lung Regeneration Initiative (LRI)
09/24/2015 - 09/23/2020 (PI)
Massachusetts Life Sciences Center

Modelling AATD Lung Disease Using Alveolar Epithelial Cells Derived from Gene-Edited iPSC
07/01/2017 - 06/30/2019 (PI)
Alpha 1 Foundation

A National iPS cell network with deep phenotyping for translational research
09/15/2016 - 06/30/2018 (PI)
NIH/National Center for Advancing Transl

Editing alveolar progenitor cells for correction of monogenic disease
09/23/2016 - 05/31/2018 (PI)
Cincinnati Children's Hospital Medical C NIH NHLBI

Derivation of Transplantable Lung Epithelial Progenitors from IPS Cells
06/01/2016 - 05/31/2018 (PI)
NIH/National Heart, Lung, and Blood Inst

A National Resource for Lung disease-specific IPS cells
08/15/2014 - 04/30/2018 (PI)
NIH/National Heart, Lung, and Blood Inst

The Boston University Clinical and Transitional Science Institute (All Components)
08/13/2015 - 03/31/2018 (PI)
NIH/National Center for Advancing Transl

iPSC Modeling of the Role of NKX2-1 in Human Lung Development and Disease
04/01/2014 - 02/28/2018 (PI)
NIH/National Heart, Lung, and Blood Inst

Derivation of proximal airway basal stem cells for treatment of Cystic Fibrosis
01/01/2016 - 12/31/2017 (PI)
University of Texas Cystic Fibrosis Fdn

Thyroid Follicular Cell development in mouse and humans
12/01/2015 - 11/30/2017 (PI)
Beth Israel Deaconess Medical Center, In NIH NIDDK

Showing 10 of 30 results. Show All Results

Yr Title Project-Sub Proj Pubs
2017 Thyroid Follicular Cell Development in Mice and Humans 5R01DK105029-02 1
2017 A National Resource for Lung disease-specific iPS cells 5R24HL123828-04
2017 iPSC Modeling of the Role of NKX2-1 in Human Lung Development and Disease 5R01HL122442-04
2016 Editing Alveolar Progenitor Cells for Correction of Monogenic Disease 1U01HL134745-01 2
2016 Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage 1U01HL134766-01
2016 A National iPS Cell Network with Deep Phenotyping for Translational Research 1U01TR001810-01
2016 Thyroid Follicular Cell Development in Mice and Humans 1R01DK105029-01A1 1
2016 Epigenenomic and transcriptomic networks in normal and defective lung development 5R01HL128172-02
2016 Boston University Clinical and Translational Science Institute 5TL1TR001410-02
2016 A National Resource for Lung disease-specific iPS cells 5R24HL123828-03
Showing 10 of 45 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. J Clin Invest. 2017 Jun 01; 127(6):2277-2294.View Related Profiles. PMID: 28463226.
  2. Rashid S, Kotton DN, Bar-Joseph Z. TASIC: Determining branching models from time series single cell data. Bioinformatics. 2017 Apr 04. PMID: 28379537; DOI: 10.1093/bioinformatics/btx173;.
  3. McCauley KB, Hawkins F, Serra M, Thomas DC, Jacob A, Kotton DN. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 2017 Jun 01; 20(6):844-857.e6.View Related Profiles. PMID: 28366587; DOI: 10.1016/j.stem.2017.03.001;.
  4. Hollenberg AN, Choi J, Serra M, Kotton DN. Regenerative therapy for hypothyroidism: Mechanisms and possibilities. Mol Cell Endocrinol. 2017 Apr 15; 445:35-41. PMID: 27876515; DOI: 10.1016/j.mce.2016.11.012;.
  5. Liberti WA, Markowitz JE, Perkins LN, Liberti DC, Leman DP, Guitchounts G, Velho T, Kotton DN, Lois C, Gardner TJ. Unstable neurons underlie a stable learned behavior. Nat Neurosci. 2016 Dec; 19(12):1665-1671. PMID: 27723744; DOI: 10.1038/nn.4405;.
  6. Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015 Nov 5; 17(5):527-42.View Related Profiles. PMID: 26593959; PMCID: PMC4666682; DOI: 10.1016/j.stem.2015.09.004;.
  7. Tafaleng EN, Chakraborty S, Han B, Hale P, Wu W, Soto-Gutierrez A, Feghali-Bostwick CA, Wilson AA, Kotton DN, Nagaya M, Strom SC, Roy-Chowdhury J, Stolz DB, Perlmutter DH, Fox IJ. Induced pluripotent stem cells model personalized variations in liver disease resulting from a1-antitrypsin deficiency. Hepatology. 2015 Jul; 62(1):147-57.View Related Profiles. PMID: 25690322; PMCID: PMC4482790; DOI: 10.1002/hep.27753;.
  8. Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.View Related Profiles. PMID: 25843048; PMCID: PMC4437473; DOI: 10.1016/j.stemcr.2015.02.021;.
  9. Weiss DJ, Chambers D, Giangreco A, Keating A, Kotton D, Lelkes PI, Wagner DE, Prockop DJ. An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases. Ann Am Thorac Soc. 2015 Apr; 12(4):S79-97. PMID: 25897748; DOI: 10.1513/AnnalsATS.201502-086ST;.
  10. Crane AM, Kramer P, Bui JH, Chung WJ, Li XS, Gonzalez-Garay ML, Hawkins F, Liao W, Mora D, Choi S, Wang J, Sun HC, Paschon DE, Guschin DY, Gregory PD, Kotton DN, Holmes MC, Sorscher EJ, Davis BR. Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells. Stem Cell Reports. 2015 Apr 14; 4(4):569-77.View Related Profiles. PMID: 25772471; PMCID: PMC4400651; DOI: 10.1016/j.stemcr.2015.02.005;.
Showing 10 of 73 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 73 publications over 16 distinct years, with a maximum of 12 publications in 2012

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Stem Cells

Available to Mentor as: (Review Mentor Role Definitions):
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670 Albany St Biosquare III
Boston MA 02118
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