Keywords
Last Name

Jining Lu, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-6180
ORCID ORCID Icon0000-0001-9263-9212
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
I am a trained developmental biologist with background and expertise in genome-wide expression profiling of miRNAs and mRNA, and functional genomics. I have been working on the lung development and diseases for 8 years since I joined Pulmonary Center at Boston University School of Medicine.
I have carried out three screens for mRNA expression profiles in developing lungs by using oligonucleotide arrays and large scale in situ hybridization. First, I have characterized the molecular signatures of the branching and non-branching regions of E11.5 lungs (Lu et. al. 2004, Developmental Biology). Second, we characterized downstream targets of Fgf10 signaling pathway in the embryonic lung epithelium (Lu et. al. 2005, JBC). Furthermore, I identified that Cathespin H, one of the identified FGF10 targets is involved in Bmp4 protein degradation during lung branching morphogenesis (Lu et. al. 2007, JBC). Finally, together with Dr. Felicia Chen, we screened the downstream targets of retinoic acid (RA) in developing foregut (Chen et. al. 2007, Development). This screen allows us to identify large number of RA targets in developing organs and to characterize the regulatory relationship of RA-TGFß-Fgf10 in the developing foregut. Meanwhile, I have developed an independent line of research focus on the role of miRNA pathway in lung development and diseases (Lu et. al. 2005, BBRC). We have carried out several large-scale expression and functional screenings to identify miRNAs important for lung development and diseases.
I was appointed as Assistant Professor in 2006. I have authored more than two-dozen scientific papers. I have successfully obtained a RO1 grant (R01 HL081800, 2006-2011) on miRNA-mediated Gene Regulation in Lung Development. I am also the PI of Project 2 (Title: miRNA pathway in Proximal-Distal Differentiation during Mouse Lung Development) in a recently renewed Program Project Grant. We were also awarded a RO3 grant focus on the role of miRNA in human lung fibrosis.
My long-term research objective is to understand the regulatory networks that control mouse lung formation, especially the role of non-coding RNAs including miRNAs in lung development. My future research goals are: 1) study the role of miRNAs in the mouse lung development; 2) characterization of miRNAs involved in the signaling pathways, important for lung development and diseases; 3) study the role of miRNAs in the lung progenitor cell differentiation and maintenance; 4) study the role of miRNAs in human lung diseases, such as lung fibrosis.

 Self-Described Keywords
  • functional genomics
  • genome-wide screening
  • lung development
  • microRNA
  • pulmonary fibrosis
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J. Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genet. 2015 May; 11(5):e1005238. PMID: 26020233.
    View in: PubMed
  2. Tagne JB, Mohtar OR, Campbell JD, Lakshminarayanan M, Huang J, Hinds AC, Lu J, Ramirez MI. Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb. Respir Res. 2015; 16:22. PMID: 25763778.
    View in: PubMed
  3. Jiang Z, Cushing L, Ai X, Lü J. miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):273-83. PMID: 24617895.
    View in: PubMed
  4. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469. PMID: 24040256.
    View in: PubMed
  5. Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lü J. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17; 287(8):5979-87. PMID: 22187428.
    View in: PubMed
  6. Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K, Lu J, Fine A, Ai X. A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci. 2011 Oct 26; 31(43):15407-15. PMID: 22031887.
    View in: PubMed
  7. Hannafon BN, Sebastiani P, de las Morenas A, Lu J, Rosenberg CL. Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res. 2011; 13(2):R24. PMID: 21375733.
    View in: PubMed
  8. Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV, Lü J. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):287-94. PMID: 20971881.
    View in: PubMed
  9. Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle. 2010 May; 9(9):1809-18. PMID: 20404570.
    View in: PubMed
  10. Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX. TAp63 is a transcriptional target of NF-kappaB. J Cell Biochem. 2010 Mar 1; 109(4):702-10. PMID: 20052674.
    View in: PubMed
  11. Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV. Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development. 2009 Jul; 136(13):2297-307. PMID: 19502490.
    View in: PubMed
  12. Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2319-24. PMID: 19168627.
    View in: PubMed
  13. Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.
    View in: PubMed
  14. Jean JC, Lü J, Joyce-Brady M, Cardoso WV. Regulation of Fgf10 gene expression in murine mesenchymal cells. J Cell Biochem. 2008 Apr 15; 103(6):1886-94. PMID: 18022820.
    View in: PubMed
  15. Izvolsky KI, Lu J, Martin G, Albrecht KH, Cardoso WV. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan; 46(1):8-18. PMID: 18196599.
    View in: PubMed
  16. Liu P, Lu J, Cardoso WV, Vaziri C. The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell. 2008 Jan; 19(1):248-61. PMID: 17989364.
    View in: PubMed
  17. Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan; 8(2):124-39. PMID: 18023262.
    View in: PubMed
  18. Chen F, Desai TJ, Qian J, Niederreither K, Lü J, Cardoso WV. Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug; 134(16):2969-79. PMID: 17634193.
    View in: PubMed
  19. Lü J, Qian J, Keppler D, Cardoso WV. Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J Biol Chem. 2007 Jul 27; 282(30):22176-84. PMID: 17500053.
    View in: PubMed
  20. Cardoso WV, Lü J. Regulation of early lung morphogenesis: questions, facts and controversies. Development. 2006 May; 133(9):1611-24. PMID: 16613830.
    View in: PubMed
  21. Desai TJ, Chen F, Lü J, Qian J, Niederreither K, Dollé P, Chambon P, Cardoso WV. Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1; 291(1):12-24. PMID: 16427040.
    View in: PubMed
  22. Lü J, Qian J, Chen F, Tang X, Li C, Cardoso WV. Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):319-23. PMID: 16036130.
    View in: PubMed
  23. Lü J, Izvolsky KI, Qian J, Cardoso WV. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J Biol Chem. 2005 Feb 11; 280(6):4834-41. PMID: 15556938.
    View in: PubMed
  24. Lü J, Qian J, Izvolsky KI, Cardoso WV. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004 Sep 15; 273(2):418-35. PMID: 15328023.
    View in: PubMed
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