Jining Lu, PhD
|Institution||Boston University School of Medicine|
|Division||Pulmonary, Allergy, Sleep & Critical Care Medicine|
|Address||72 E. Concord St Housman (R)|
Boston MA 02118
|Title||Graduate Faculty (Primary Mentor of Grad Students)|
|Institution||Boston University School of Medicine, Division of Graduate Medical Sciences|
I am a trained developmental biologist with background and expertise in genome-wide expression profiling of miRNAs and mRNA, and functional genomics. I have been working on the lung development and diseases for 8 years since I joined Pulmonary Center at Boston University School of Medicine.
I have carried out three screens for mRNA expression profiles in developing lungs by using oligonucleotide arrays and large scale in situ hybridization. First, I have characterized the molecular signatures of the branching and non-branching regions of E11.5 lungs (Lu et. al. 2004, Developmental Biology). Second, we characterized downstream targets of Fgf10 signaling pathway in the embryonic lung epithelium (Lu et. al. 2005, JBC). Furthermore, I identified that Cathespin H, one of the identified FGF10 targets is involved in Bmp4 protein degradation during lung branching morphogenesis (Lu et. al. 2007, JBC). Finally, together with Dr. Felicia Chen, we screened the downstream targets of retinoic acid (RA) in developing foregut (Chen et. al. 2007, Development). This screen allows us to identify large number of RA targets in developing organs and to characterize the regulatory relationship of RA-TGFß-Fgf10 in the developing foregut. Meanwhile, I have developed an independent line of research focus on the role of miRNA pathway in lung development and diseases (Lu et. al. 2005, BBRC). We have carried out several large-scale expression and functional screenings to identify miRNAs important for lung development and diseases.
I was appointed as Assistant Professor in 2006. I have authored more than two-dozen scientific papers. I have successfully obtained a RO1 grant (R01 HL081800, 2006-2011) on miRNA-mediated Gene Regulation in Lung Development. I am also the PI of Project 2 (Title: miRNA pathway in Proximal-Distal Differentiation during Mouse Lung Development) in a recently renewed Program Project Grant. We were also awarded a RO3 grant focus on the role of miRNA in human lung fibrosis.
My long-term research objective is to understand the regulatory networks that control mouse lung formation, especially the role of non-coding RNAs including miRNAs in lung development. My future research goals are: 1) study the role of miRNAs in the mouse lung development; 2) characterization of miRNAs involved in the signaling pathways, important for lung development and diseases; 3) study the role of miRNAs in the lung progenitor cell differentiation and maintenance; 4) study the role of miRNAs in human lung diseases, such as lung fibrosis.
- functional genomics
- genome-wide screening
- lung development
- pulmonary fibrosis
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